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O76070

- SYUG_HUMAN

UniProt

O76070 - SYUG_HUMAN

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Protein

Gamma-synuclein

Gene

SNCG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).By similarity

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. aggressive behavior Source: Ensembl
  3. cellular response to hydrostatic pressure Source: Ensembl
  4. protein secretion Source: Ensembl
  5. regulation of dopamine secretion Source: Ensembl
  6. regulation of neurotransmitter secretion Source: Ensembl
  7. response to cocaine Source: Ensembl
  8. response to drug Source: Ensembl
  9. synapse organization Source: Ensembl
  10. synaptic transmission Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-synuclein
Alternative name(s):
Breast cancer-specific gene 1 protein
Persyn
Synoretin
Short name:
SR
Gene namesi
Name:SNCG
Synonyms:BCSG1, PERSYN, PRSN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:11141. SNCG.

Subcellular locationi

Cytoplasmperinuclear region 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication
Note: Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. cytoplasm Source: ParkinsonsUK-UCL
  3. cytoskeleton Source: UniProtKB-KW
  4. extracellular vesicular exosome Source: UniProt
  5. neuronal cell body Source: Ensembl
  6. perinuclear region of cytoplasm Source: Ensembl
  7. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Gamma-synucleinPRO_0000184038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241Phosphoserine; by BARK1, CaMK2 and CK21 Publication

Post-translational modificationi

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO76070.
PaxDbiO76070.
PeptideAtlasiO76070.
PRIDEiO76070.

PTM databases

PhosphoSiteiO76070.

Expressioni

Tissue specificityi

Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

Gene expression databases

BgeeiO76070.
CleanExiHS_SNCG.
ExpressionAtlasiO76070. baseline and differential.
GenevestigatoriO76070.

Organism-specific databases

HPAiCAB001452.
CAB040581.
HPA014404.

Interactioni

Subunit structurei

May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggegation (By similarity).By similarity

Protein-protein interaction databases

BioGridi112507. 26 interactions.
STRINGi9606.ENSP00000361087.

Structurei

3D structure databases

DisProtiDP00630.
ProteinModelPortaliO76070.
SMRiO76070. Positions 1-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 30111Add
BLAST
Repeati31 – 41112Add
BLAST
Repeati42 – 56153; approximateAdd
BLAST
Repeati57 – 67114Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 67484 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)Add
BLAST

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG45431.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiO76070.
OMAiIVERIDW.
PhylomeDBiO76070.
TreeFamiTF332776.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002462. Synuclein_gamma.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01214. GSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

O76070-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ
60 70 80 90 100
SVTSVAEKTK EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL
110 120
RPSAPQQEGE ASKEKEEVAE EAQSGGD
Length:127
Mass (Da):13,331
Last modified:March 21, 2006 - v2
Checksum:iF183DEF302DBE688
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131E → K in AAB64109. (PubMed:9044857)Curated
Sequence conflicti17 – 171G → D in AAL05870. 1 PublicationCurated
Sequence conflicti68 – 681E → K in AAB64109. (PubMed:9044857)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101E → V.2 Publications
Corresponds to variant rs9864 [ dbSNP | Ensembl ].
VAR_007455

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010126 mRNA. Translation: AAB64109.1.
AF037207 Genomic DNA. Translation: AAC36586.1.
AF017256 mRNA. Translation: AAC36550.1.
AF044311 Genomic DNA. Translation: AAC27738.1.
AF411524 mRNA. Translation: AAL05870.1.
BC014098 mRNA. Translation: AAH14098.1.
CCDSiCCDS7380.1.
RefSeqiNP_003078.2. NM_003087.2.
UniGeneiHs.349470.

Genome annotation databases

EnsembliENST00000372017; ENSP00000361087; ENSG00000173267.
GeneIDi6623.
KEGGihsa:6623.
UCSCiuc001keb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010126 mRNA. Translation: AAB64109.1 .
AF037207 Genomic DNA. Translation: AAC36586.1 .
AF017256 mRNA. Translation: AAC36550.1 .
AF044311 Genomic DNA. Translation: AAC27738.1 .
AF411524 mRNA. Translation: AAL05870.1 .
BC014098 mRNA. Translation: AAH14098.1 .
CCDSi CCDS7380.1.
RefSeqi NP_003078.2. NM_003087.2.
UniGenei Hs.349470.

3D structure databases

DisProti DP00630.
ProteinModelPortali O76070.
SMRi O76070. Positions 1-100.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112507. 26 interactions.
STRINGi 9606.ENSP00000361087.

PTM databases

PhosphoSitei O76070.

Proteomic databases

MaxQBi O76070.
PaxDbi O76070.
PeptideAtlasi O76070.
PRIDEi O76070.

Protocols and materials databases

DNASUi 6623.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372017 ; ENSP00000361087 ; ENSG00000173267 .
GeneIDi 6623.
KEGGi hsa:6623.
UCSCi uc001keb.2. human.

Organism-specific databases

CTDi 6623.
GeneCardsi GC10P088708.
HGNCi HGNC:11141. SNCG.
HPAi CAB001452.
CAB040581.
HPA014404.
MIMi 602998. gene.
neXtProti NX_O76070.
PharmGKBi PA35989.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45431.
HOGENOMi HOG000008691.
HOVERGENi HBG000481.
InParanoidi O76070.
OMAi IVERIDW.
PhylomeDBi O76070.
TreeFami TF332776.

Miscellaneous databases

ChiTaRSi SNCG. human.
GeneWikii Gamma-synuclein.
GenomeRNAii 6623.
NextBioi 25797.
PROi O76070.
SOURCEi Search...

Gene expression databases

Bgeei O76070.
CleanExi HS_SNCG.
ExpressionAtlasi O76070. baseline and differential.
Genevestigatori O76070.

Family and domain databases

Gene3Di 1.10.287.700. 1 hit.
InterProi IPR001058. Synuclein.
IPR002462. Synuclein_gamma.
[Graphical view ]
PANTHERi PTHR13820. PTHR13820. 1 hit.
Pfami PF01387. Synuclein. 1 hit.
[Graphical view ]
PRINTSi PR01214. GSYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing."
    Ji H., Liu Y.E., Jia T., Wang M., Liu J., Xiao G., Joseph B.K., Rosen C., Shi Y.E.
    Cancer Res. 57:759-764(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary cancer.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Identification, localization and characterization of the human gamma-synuclein gene."
    Lavedan C., Leroy E., Dehejia A., Buchholtz S., Dutra A., Nussbaum R.L., Polymeropoulos M.H.
    Hum. Genet. 103:106-112(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-110.
  4. Han C., Zhang B., Peng X., Yuan J., Qiang B.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-110.
    Tissue: Colon.
  6. "Synucleins are a novel class of substrates for G protein-coupled receptor kinases."
    Pronin A.N., Morris A.J., Surguchov A., Benovic J.L.
    J. Biol. Chem. 275:26515-26522(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-124 BY BARK1; CAMK2 AND CK2.
  7. "Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction."
    Surguchov A., Palazzo R.E., Surgucheva I.
    Cell Motil. Cytoskeleton 49:218-228(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYUG_HUMAN
AccessioniPrimary (citable) accession number: O76070
Secondary accession number(s): O15104, Q96P61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3