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O76070 (SYUG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-synuclein
Alternative name(s):
Breast cancer-specific gene 1 protein
Persyn
Synoretin
Short name=SR
Gene names
Name:SNCG
Synonyms:BCSG1, PERSYN, PRSN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases By similarity. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway By similarity.

Subunit structure

May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggegation By similarity.

Subcellular location

Cytoplasmperinuclear region. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmcytoskeletonspindle. Note: Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. Ref.7

Tissue specificity

Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

Post-translational modification

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. Ref.6

Sequence similarities

Belongs to the synuclein family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityPolymorphism
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult locomotory behavior

Inferred from electronic annotation. Source: Ensembl

aggressive behavior

Inferred from electronic annotation. Source: Ensembl

cellular response to hydrostatic pressure

Inferred from electronic annotation. Source: Ensembl

regulation of dopamine secretion

Inferred from electronic annotation. Source: Ensembl

regulation of neurotransmitter secretion

Inferred from electronic annotation. Source: Ensembl

response to cocaine

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

synapse organization

Inferred from electronic annotation. Source: Ensembl

synaptic transmission

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon terminus

Inferred from electronic annotation. Source: Ensembl

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: Ensembl

spindle

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 127127Gamma-synuclein
PRO_0000184038

Regions

Repeat20 – 30111
Repeat31 – 41112
Repeat42 – 56153; approximate
Repeat57 – 67114
Region20 – 67484 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)

Amino acid modifications

Modified residue1241Phosphoserine; by BARK1, CaMK2 and CK2 Ref.6

Natural variations

Natural variant1101E → V. Ref.3 Ref.5
Corresponds to variant rs9864 [ dbSNP | Ensembl ].
VAR_007455

Experimental info

Sequence conflict131E → K in AAB64109. Ref.1
Sequence conflict171G → D in AAL05870. Ref.4
Sequence conflict681E → K in AAB64109. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O76070 [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: F183DEF302DBE688

FASTA12713,331
        10         20         30         40         50         60 
MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ SVTSVAEKTK 

        70         80         90        100        110        120 
EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL RPSAPQQEGE ASKEKEEVAE 


EAQSGGD 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing."
Ji H., Liu Y.E., Jia T., Wang M., Liu J., Xiao G., Joseph B.K., Rosen C., Shi Y.E.
Cancer Res. 57:759-764(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mammary cancer.
[2]"Organization, expression and polymorphism of the human persyn gene."
Ninkina N.N., Alimova-Kost M.V., Paterson J.W.E., Delaney L., Cohen B.B., Imreh S., Gnuchev N.V., Davies A.M., Buchman V.L.
Hum. Mol. Genet. 7:1417-1424(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Identification, localization and characterization of the human gamma-synuclein gene."
Lavedan C., Leroy E., Dehejia A., Buchholtz S., Dutra A., Nussbaum R.L., Polymeropoulos M.H.
Hum. Genet. 103:106-112(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-110.
[4]Han C., Zhang B., Peng X., Yuan J., Qiang B.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-110.
Tissue: Colon.
[6]"Synucleins are a novel class of substrates for G protein-coupled receptor kinases."
Pronin A.N., Morris A.J., Surguchov A., Benovic J.L.
J. Biol. Chem. 275:26515-26522(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-124 BY BARK1; CAMK2 AND CK2.
[7]"Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction."
Surguchov A., Palazzo R.E., Surgucheva I.
Cell Motil. Cytoskeleton 49:218-228(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF010126 mRNA. Translation: AAB64109.1.
AF037207 Genomic DNA. Translation: AAC36586.1.
AF017256 mRNA. Translation: AAC36550.1.
AF044311 Genomic DNA. Translation: AAC27738.1.
AF411524 mRNA. Translation: AAL05870.1.
BC014098 mRNA. Translation: AAH14098.1.
CCDSCCDS7380.1.
RefSeqNP_003078.2. NM_003087.2.
UniGeneHs.349470.

3D structure databases

DisProtDP00630.
ProteinModelPortalO76070.
SMRO76070. Positions 1-100.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112507. 25 interactions.
STRING9606.ENSP00000361087.

PTM databases

PhosphoSiteO76070.

Proteomic databases

MaxQBO76070.
PaxDbO76070.
PeptideAtlasO76070.
PRIDEO76070.

Protocols and materials databases

DNASU6623.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372017; ENSP00000361087; ENSG00000173267.
GeneID6623.
KEGGhsa:6623.
UCSCuc001keb.2. human.

Organism-specific databases

CTD6623.
GeneCardsGC10P088708.
HGNCHGNC:11141. SNCG.
HPACAB001452.
CAB040581.
HPA014404.
MIM602998. gene.
neXtProtNX_O76070.
PharmGKBPA35989.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45431.
HOGENOMHOG000008691.
HOVERGENHBG000481.
InParanoidO76070.
OMAIVERIDW.
PhylomeDBO76070.
TreeFamTF332776.

Gene expression databases

ArrayExpressO76070.
BgeeO76070.
CleanExHS_SNCG.
GenevestigatorO76070.

Family and domain databases

Gene3D1.10.287.700. 1 hit.
InterProIPR001058. Synuclein.
IPR002462. Synuclein_gamma.
[Graphical view]
PANTHERPTHR13820. PTHR13820. 1 hit.
PfamPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSPR01214. GSYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetSearch...

Other

ChiTaRSSNCG. human.
GeneWikiGamma-synuclein.
GenomeRNAi6623.
NextBio25797.
PROO76070.
SOURCESearch...

Entry information

Entry nameSYUG_HUMAN
AccessionPrimary (citable) accession number: O76070
Secondary accession number(s): O15104, Q96P61
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM