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O76070

- SYUG_HUMAN

UniProt

O76070 - SYUG_HUMAN

Protein

Gamma-synuclein

Gene

SNCG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases By similarity. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway By similarity.By similarity

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. aggressive behavior Source: Ensembl
    3. cellular response to hydrostatic pressure Source: Ensembl
    4. regulation of dopamine secretion Source: Ensembl
    5. regulation of neurotransmitter secretion Source: Ensembl
    6. response to cocaine Source: Ensembl
    7. response to drug Source: Ensembl
    8. synapse organization Source: Ensembl
    9. synaptic transmission Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-synuclein
    Alternative name(s):
    Breast cancer-specific gene 1 protein
    Persyn
    Synoretin
    Short name:
    SR
    Gene namesi
    Name:SNCG
    Synonyms:BCSG1, PERSYN, PRSN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:11141. SNCG.

    Subcellular locationi

    Cytoplasmperinuclear region 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication
    Note: Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. microtubule organizing center Source: UniProtKB-SubCell
    4. neuronal cell body Source: Ensembl
    5. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    6. plasma membrane Source: Ensembl
    7. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35989.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127Gamma-synucleinPRO_0000184038Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei124 – 1241Phosphoserine; by BARK1, CaMK2 and CK21 Publication

    Post-translational modificationi

    Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO76070.
    PaxDbiO76070.
    PeptideAtlasiO76070.
    PRIDEiO76070.

    PTM databases

    PhosphoSiteiO76070.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

    Gene expression databases

    ArrayExpressiO76070.
    BgeeiO76070.
    CleanExiHS_SNCG.
    GenevestigatoriO76070.

    Organism-specific databases

    HPAiCAB001452.
    CAB040581.
    HPA014404.

    Interactioni

    Subunit structurei

    May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggegation By similarity.By similarity

    Protein-protein interaction databases

    BioGridi112507. 26 interactions.
    STRINGi9606.ENSP00000361087.

    Structurei

    3D structure databases

    DisProtiDP00630.
    ProteinModelPortaliO76070.
    SMRiO76070. Positions 1-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati20 – 30111Add
    BLAST
    Repeati31 – 41112Add
    BLAST
    Repeati42 – 56153; approximateAdd
    BLAST
    Repeati57 – 67114Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 67484 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)Add
    BLAST

    Sequence similaritiesi

    Belongs to the synuclein family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG45431.
    HOGENOMiHOG000008691.
    HOVERGENiHBG000481.
    InParanoidiO76070.
    OMAiIVERIDW.
    PhylomeDBiO76070.
    TreeFamiTF332776.

    Family and domain databases

    Gene3Di1.10.287.700. 1 hit.
    InterProiIPR001058. Synuclein.
    IPR002462. Synuclein_gamma.
    [Graphical view]
    PANTHERiPTHR13820. PTHR13820. 1 hit.
    PfamiPF01387. Synuclein. 1 hit.
    [Graphical view]
    PRINTSiPR01214. GSYNUCLEIN.
    PR01211. SYNUCLEIN.

    Sequencei

    Sequence statusi: Complete.

    O76070-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ    50
    SVTSVAEKTK EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL 100
    RPSAPQQEGE ASKEKEEVAE EAQSGGD 127
    Length:127
    Mass (Da):13,331
    Last modified:March 21, 2006 - v2
    Checksum:iF183DEF302DBE688
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131E → K in AAB64109. (PubMed:9044857)Curated
    Sequence conflicti17 – 171G → D in AAL05870. 1 PublicationCurated
    Sequence conflicti68 – 681E → K in AAB64109. (PubMed:9044857)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101E → V.2 Publications
    Corresponds to variant rs9864 [ dbSNP | Ensembl ].
    VAR_007455

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010126 mRNA. Translation: AAB64109.1.
    AF037207 Genomic DNA. Translation: AAC36586.1.
    AF017256 mRNA. Translation: AAC36550.1.
    AF044311 Genomic DNA. Translation: AAC27738.1.
    AF411524 mRNA. Translation: AAL05870.1.
    BC014098 mRNA. Translation: AAH14098.1.
    CCDSiCCDS7380.1.
    RefSeqiNP_003078.2. NM_003087.2.
    UniGeneiHs.349470.

    Genome annotation databases

    EnsembliENST00000372017; ENSP00000361087; ENSG00000173267.
    GeneIDi6623.
    KEGGihsa:6623.
    UCSCiuc001keb.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010126 mRNA. Translation: AAB64109.1 .
    AF037207 Genomic DNA. Translation: AAC36586.1 .
    AF017256 mRNA. Translation: AAC36550.1 .
    AF044311 Genomic DNA. Translation: AAC27738.1 .
    AF411524 mRNA. Translation: AAL05870.1 .
    BC014098 mRNA. Translation: AAH14098.1 .
    CCDSi CCDS7380.1.
    RefSeqi NP_003078.2. NM_003087.2.
    UniGenei Hs.349470.

    3D structure databases

    DisProti DP00630.
    ProteinModelPortali O76070.
    SMRi O76070. Positions 1-100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112507. 26 interactions.
    STRINGi 9606.ENSP00000361087.

    PTM databases

    PhosphoSitei O76070.

    Proteomic databases

    MaxQBi O76070.
    PaxDbi O76070.
    PeptideAtlasi O76070.
    PRIDEi O76070.

    Protocols and materials databases

    DNASUi 6623.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372017 ; ENSP00000361087 ; ENSG00000173267 .
    GeneIDi 6623.
    KEGGi hsa:6623.
    UCSCi uc001keb.2. human.

    Organism-specific databases

    CTDi 6623.
    GeneCardsi GC10P088708.
    HGNCi HGNC:11141. SNCG.
    HPAi CAB001452.
    CAB040581.
    HPA014404.
    MIMi 602998. gene.
    neXtProti NX_O76070.
    PharmGKBi PA35989.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45431.
    HOGENOMi HOG000008691.
    HOVERGENi HBG000481.
    InParanoidi O76070.
    OMAi IVERIDW.
    PhylomeDBi O76070.
    TreeFami TF332776.

    Miscellaneous databases

    ChiTaRSi SNCG. human.
    GeneWikii Gamma-synuclein.
    GenomeRNAii 6623.
    NextBioi 25797.
    PROi O76070.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O76070.
    Bgeei O76070.
    CleanExi HS_SNCG.
    Genevestigatori O76070.

    Family and domain databases

    Gene3Di 1.10.287.700. 1 hit.
    InterProi IPR001058. Synuclein.
    IPR002462. Synuclein_gamma.
    [Graphical view ]
    PANTHERi PTHR13820. PTHR13820. 1 hit.
    Pfami PF01387. Synuclein. 1 hit.
    [Graphical view ]
    PRINTSi PR01214. GSYNUCLEIN.
    PR01211. SYNUCLEIN.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing."
      Ji H., Liu Y.E., Jia T., Wang M., Liu J., Xiao G., Joseph B.K., Rosen C., Shi Y.E.
      Cancer Res. 57:759-764(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary cancer.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Identification, localization and characterization of the human gamma-synuclein gene."
      Lavedan C., Leroy E., Dehejia A., Buchholtz S., Dutra A., Nussbaum R.L., Polymeropoulos M.H.
      Hum. Genet. 103:106-112(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-110.
    4. Han C., Zhang B., Peng X., Yuan J., Qiang B.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-110.
      Tissue: Colon.
    6. "Synucleins are a novel class of substrates for G protein-coupled receptor kinases."
      Pronin A.N., Morris A.J., Surguchov A., Benovic J.L.
      J. Biol. Chem. 275:26515-26522(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-124 BY BARK1; CAMK2 AND CK2.
    7. "Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction."
      Surguchov A., Palazzo R.E., Surgucheva I.
      Cell Motil. Cytoskeleton 49:218-228(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSYUG_HUMAN
    AccessioniPrimary (citable) accession number: O76070
    Secondary accession number(s): O15104, Q96P61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3