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Protein

Gamma-synuclein

Gene

SNCG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).By similarity

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. aggressive behavior Source: Ensembl
  3. cellular response to hydrostatic pressure Source: Ensembl
  4. protein secretion Source: Ensembl
  5. regulation of dopamine secretion Source: Ensembl
  6. regulation of neurotransmitter secretion Source: Ensembl
  7. response to cocaine Source: Ensembl
  8. response to drug Source: Ensembl
  9. synapse organization Source: Ensembl
  10. synaptic transmission Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-synuclein
Alternative name(s):
Breast cancer-specific gene 1 protein
Persyn
Synoretin
Short name:
SR
Gene namesi
Name:SNCG
Synonyms:BCSG1, PERSYN, PRSN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11141. SNCG.

Subcellular locationi

Cytoplasmperinuclear region 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication
Note: Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. cytoplasm Source: ParkinsonsUK-UCL
  3. extracellular vesicular exosome Source: UniProtKB
  4. microtubule organizing center Source: UniProtKB-SubCell
  5. neuronal cell body Source: Ensembl
  6. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  7. plasma membrane Source: Ensembl
  8. spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35989.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Gamma-synucleinPRO_0000184038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241Phosphoserine; by BARK1, CaMK2 and CK21 Publication

Post-translational modificationi

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO76070.
PaxDbiO76070.
PeptideAtlasiO76070.
PRIDEiO76070.

PTM databases

PhosphoSiteiO76070.

Expressioni

Tissue specificityi

Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.

Gene expression databases

BgeeiO76070.
CleanExiHS_SNCG.
ExpressionAtlasiO76070. baseline and differential.
GenevestigatoriO76070.

Organism-specific databases

HPAiCAB001452.
CAB040581.
HPA014404.

Interactioni

Subunit structurei

May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggegation (By similarity).By similarity

Protein-protein interaction databases

BioGridi112507. 26 interactions.
STRINGi9606.ENSP00000361087.

Structurei

3D structure databases

DisProtiDP00630.
SMRiO76070. Positions 1-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 30111Add
BLAST
Repeati31 – 41112Add
BLAST
Repeati42 – 56153; approximateAdd
BLAST
Repeati57 – 67114Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 67484 X 11 AA tandem repeats of [EGSA]-K-T-K-[EQ]-[GQ]-V-X(4)Add
BLAST

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG45431.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiO76070.
OMAiKEQANMV.
PhylomeDBiO76070.
TreeFamiTF332776.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002462. Synuclein_gamma.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01214. GSYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Complete.

O76070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ
60 70 80 90 100
SVTSVAEKTK EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL
110 120
RPSAPQQEGE ASKEKEEVAE EAQSGGD
Length:127
Mass (Da):13,331
Last modified:March 21, 2006 - v2
Checksum:iF183DEF302DBE688
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131E → K in AAB64109 (PubMed:9044857).Curated
Sequence conflicti17 – 171G → D in AAL05870 (Ref. 4) Curated
Sequence conflicti68 – 681E → K in AAB64109 (PubMed:9044857).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101E → V.2 Publications
Corresponds to variant rs9864 [ dbSNP | Ensembl ].
VAR_007455

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010126 mRNA. Translation: AAB64109.1.
AF037207 Genomic DNA. Translation: AAC36586.1.
AF017256 mRNA. Translation: AAC36550.1.
AF044311 Genomic DNA. Translation: AAC27738.1.
AF411524 mRNA. Translation: AAL05870.1.
BC014098 mRNA. Translation: AAH14098.1.
CCDSiCCDS7380.1.
RefSeqiNP_003078.2. NM_003087.2.
UniGeneiHs.349470.

Genome annotation databases

EnsembliENST00000372017; ENSP00000361087; ENSG00000173267.
GeneIDi6623.
KEGGihsa:6623.
UCSCiuc001keb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010126 mRNA. Translation: AAB64109.1.
AF037207 Genomic DNA. Translation: AAC36586.1.
AF017256 mRNA. Translation: AAC36550.1.
AF044311 Genomic DNA. Translation: AAC27738.1.
AF411524 mRNA. Translation: AAL05870.1.
BC014098 mRNA. Translation: AAH14098.1.
CCDSiCCDS7380.1.
RefSeqiNP_003078.2. NM_003087.2.
UniGeneiHs.349470.

3D structure databases

DisProtiDP00630.
SMRiO76070. Positions 1-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112507. 26 interactions.
STRINGi9606.ENSP00000361087.

PTM databases

PhosphoSiteiO76070.

Proteomic databases

MaxQBiO76070.
PaxDbiO76070.
PeptideAtlasiO76070.
PRIDEiO76070.

Protocols and materials databases

DNASUi6623.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372017; ENSP00000361087; ENSG00000173267.
GeneIDi6623.
KEGGihsa:6623.
UCSCiuc001keb.2. human.

Organism-specific databases

CTDi6623.
GeneCardsiGC10P088708.
HGNCiHGNC:11141. SNCG.
HPAiCAB001452.
CAB040581.
HPA014404.
MIMi602998. gene.
neXtProtiNX_O76070.
PharmGKBiPA35989.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45431.
HOGENOMiHOG000008691.
HOVERGENiHBG000481.
InParanoidiO76070.
OMAiKEQANMV.
PhylomeDBiO76070.
TreeFamiTF332776.

Miscellaneous databases

ChiTaRSiSNCG. human.
GeneWikiiGamma-synuclein.
GenomeRNAii6623.
NextBioi25797.
PROiO76070.
SOURCEiSearch...

Gene expression databases

BgeeiO76070.
CleanExiHS_SNCG.
ExpressionAtlasiO76070. baseline and differential.
GenevestigatoriO76070.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002462. Synuclein_gamma.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01214. GSYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing."
    Ji H., Liu Y.E., Jia T., Wang M., Liu J., Xiao G., Joseph B.K., Rosen C., Shi Y.E.
    Cancer Res. 57:759-764(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary cancer.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Identification, localization and characterization of the human gamma-synuclein gene."
    Lavedan C., Leroy E., Dehejia A., Buchholtz S., Dutra A., Nussbaum R.L., Polymeropoulos M.H.
    Hum. Genet. 103:106-112(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-110.
  4. Han C., Zhang B., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-110.
    Tissue: Colon.
  6. "Synucleins are a novel class of substrates for G protein-coupled receptor kinases."
    Pronin A.N., Morris A.J., Surguchov A., Benovic J.L.
    J. Biol. Chem. 275:26515-26522(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-124 BY BARK1; CAMK2 AND CK2.
  7. "Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction."
    Surguchov A., Palazzo R.E., Surgucheva I.
    Cell Motil. Cytoskeleton 49:218-228(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYUG_HUMAN
AccessioniPrimary (citable) accession number: O76070
Secondary accession number(s): O15104, Q96P61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 21, 2006
Last modified: April 1, 2015
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.