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O76068

- O76068_HUMAN

UniProt

O76068 - O76068_HUMAN

Protein
Submitted name:

Peripheral-type benzodiazepine receptor

Gene

PBR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. androgen binding Source: Ensembl
    2. benzodiazepine receptor activity Source: Ensembl
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. adrenal gland development Source: Ensembl
    2. aging Source: Ensembl
    3. behavioral response to pain Source: Ensembl
    4. cellular hypotonic response Source: Ensembl
    5. cellular response to lipopolysaccharide Source: Ensembl
    6. cellular response to zinc ion Source: Ensembl
    7. chloride transport Source: Ensembl
    8. contact inhibition Source: Ensembl
    9. glial cell migration Source: Ensembl
    10. negative regulation of glial cell proliferation Source: Ensembl
    11. negative regulation of nitric oxide biosynthetic process Source: Ensembl
    12. negative regulation of tumor necrosis factor production Source: Ensembl
    13. peripheral nervous system axon regeneration Source: Ensembl
    14. positive regulation of apoptotic process Source: Ensembl
    15. positive regulation of calcium ion transport Source: Ensembl
    16. positive regulation of glial cell proliferation Source: Ensembl
    17. positive regulation of mitochondrial depolarization Source: Ensembl
    18. positive regulation of necrotic cell death Source: Ensembl
    19. positive regulation of reactive oxygen species metabolic process Source: Ensembl
    20. regulation of steroid biosynthetic process Source: Ensembl
    21. response to drug Source: Ensembl
    22. response to manganese ion Source: Ensembl
    23. response to progesterone Source: Ensembl
    24. response to testosterone Source: Ensembl
    25. response to vitamin B1 Source: Ensembl
    26. steroid biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peripheral-type benzodiazepine receptorImported
    Gene namesi
    Name:PBRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro
    2. mitochondrial outer membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiO76068.

    Expressioni

    Gene expression databases

    ArrayExpressiO76068.
    BgeeiO76068.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG001296.
    KOiK05770.

    Family and domain databases

    InterProiIPR004307. TspO_MBR.
    [Graphical view]
    PANTHERiPTHR10057. PTHR10057. 1 hit.
    PfamiPF03073. TspO_MBR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005859. PBR. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    O76068-1 [UniParc]FASTAAdd to Basket

    « Hide

    HGEGLRWYAG LQKPSWHPPH WVLGPVWGTL YSAMGYGSYL VWKELGGFTE    50
    KAVVPLGLYT GQLALNWAWP PIFFGARQMG WALVDLLLVS GAAAATTVAW 100
    YQVSPLAARL LYPYLAWLAF TTTLNYCVWR DNHGWRGGRR LPE 143
    Length:143
    Mass (Da):16,107
    Last modified:November 1, 1998 - v1
    Checksum:iDEAF74A8415C65A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075589 mRNA. Translation: AAC31172.1.
    AF075590 mRNA. Translation: AAC31173.1.
    RefSeqiNP_000705.2. NM_000714.5.
    NP_001243459.1. NM_001256530.1.
    NP_001243460.1. NM_001256531.1.
    UniGeneiHs.202.

    Genome annotation databases

    GeneIDi706.
    KEGGihsa:706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075589 mRNA. Translation: AAC31172.1 .
    AF075590 mRNA. Translation: AAC31173.1 .
    RefSeqi NP_000705.2. NM_000714.5.
    NP_001243459.1. NM_001256530.1.
    NP_001243460.1. NM_001256531.1.
    UniGenei Hs.202.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O76068.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 706.
    KEGGi hsa:706.

    Organism-specific databases

    CTDi 706.

    Phylogenomic databases

    HOVERGENi HBG001296.
    KOi K05770.

    Miscellaneous databases

    ChiTaRSi TSPO. human.
    GenomeRNAii 706.
    NextBioi 2874.

    Gene expression databases

    ArrayExpressi O76068.
    Bgeei O76068.

    Family and domain databases

    InterProi IPR004307. TspO_MBR.
    [Graphical view ]
    PANTHERi PTHR10057. PTHR10057. 1 hit.
    Pfami PF03073. TspO_MBR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005859. PBR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Peripheral-type Benzodiazepine Receptor (PBR) in Human Breast Cancer."
      Hardwick M.J., Papadopoulos V.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BreastImported.

    Entry informationi

    Entry nameiO76068_HUMAN
    AccessioniPrimary (citable) accession number: O76068
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.