Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Peripheral-type benzodiazepine receptor

Gene

PBR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. androgen binding Source: Ensembl
  2. benzodiazepine receptor activity Source: Ensembl

GO - Biological processi

  1. adrenal gland development Source: Ensembl
  2. aging Source: Ensembl
  3. behavioral response to pain Source: Ensembl
  4. cellular hypotonic response Source: Ensembl
  5. cellular response to lipopolysaccharide Source: Ensembl
  6. cellular response to zinc ion Source: Ensembl
  7. chloride transport Source: Ensembl
  8. contact inhibition Source: Ensembl
  9. glial cell migration Source: Ensembl
  10. negative regulation of glial cell proliferation Source: Ensembl
  11. negative regulation of nitric oxide biosynthetic process Source: Ensembl
  12. negative regulation of tumor necrosis factor production Source: Ensembl
  13. peripheral nervous system axon regeneration Source: Ensembl
  14. positive regulation of apoptotic process Source: Ensembl
  15. positive regulation of calcium ion transport Source: Ensembl
  16. positive regulation of glial cell proliferation Source: Ensembl
  17. positive regulation of mitochondrial depolarization Source: Ensembl
  18. positive regulation of necrotic cell death Source: Ensembl
  19. positive regulation of reactive oxygen species metabolic process Source: Ensembl
  20. regulation of steroid biosynthetic process Source: Ensembl
  21. response to drug Source: Ensembl
  22. response to manganese ion Source: Ensembl
  23. response to progesterone Source: Ensembl
  24. response to testosterone Source: Ensembl
  25. response to vitamin B1 Source: Ensembl
  26. steroid biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Peripheral-type benzodiazepine receptorImported
Gene namesi
Name:PBRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiO76068.

Expressioni

Gene expression databases

BgeeiO76068.
ExpressionAtlasiO76068. baseline and differential.

Interactioni

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG001296.
KOiK05770.

Family and domain databases

InterProiIPR030164. TSPO.
IPR004307. TspO_MBR.
[Graphical view]
PANTHERiPTHR10057. PTHR10057. 1 hit.
PTHR10057:SF2. PTHR10057:SF2. 1 hit.
PfamiPF03073. TspO_MBR. 1 hit.
[Graphical view]
PIRSFiPIRSF005859. PBR. 1 hit.

Sequencei

Sequence statusi: Fragment.

O76068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
HGEGLRWYAG LQKPSWHPPH WVLGPVWGTL YSAMGYGSYL VWKELGGFTE
60 70 80 90 100
KAVVPLGLYT GQLALNWAWP PIFFGARQMG WALVDLLLVS GAAAATTVAW
110 120 130 140
YQVSPLAARL LYPYLAWLAF TTTLNYCVWR DNHGWRGGRR LPE
Length:143
Mass (Da):16,107
Last modified:October 31, 1998 - v1
Checksum:iDEAF74A8415C65A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075589 mRNA. Translation: AAC31172.1.
AF075590 mRNA. Translation: AAC31173.1.
RefSeqiNP_000705.2. NM_000714.5.
NP_001243459.1. NM_001256530.1.
NP_001243460.1. NM_001256531.1.
UniGeneiHs.202.

Genome annotation databases

GeneIDi706.
KEGGihsa:706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075589 mRNA. Translation: AAC31172.1.
AF075590 mRNA. Translation: AAC31173.1.
RefSeqiNP_000705.2. NM_000714.5.
NP_001243459.1. NM_001256530.1.
NP_001243460.1. NM_001256531.1.
UniGeneiHs.202.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiO76068.

Proteomic databases

PRIDEiO76068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi706.
KEGGihsa:706.

Organism-specific databases

CTDi706.

Phylogenomic databases

HOVERGENiHBG001296.
KOiK05770.

Miscellaneous databases

ChiTaRSiTSPO. human.
GenomeRNAii706.
NextBioi2874.

Gene expression databases

BgeeiO76068.
ExpressionAtlasiO76068. baseline and differential.

Family and domain databases

InterProiIPR030164. TSPO.
IPR004307. TspO_MBR.
[Graphical view]
PANTHERiPTHR10057. PTHR10057. 1 hit.
PTHR10057:SF2. PTHR10057:SF2. 1 hit.
PfamiPF03073. TspO_MBR. 1 hit.
[Graphical view]
PIRSFiPIRSF005859. PBR. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Peripheral-type Benzodiazepine Receptor (PBR) in Human Breast Cancer."
    Hardwick M.J., Papadopoulos V.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BreastImported.

Entry informationi

Entry nameiO76068_HUMAN
AccessioniPrimary (citable) accession number: O76068
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 1998
Last sequence update: October 31, 1998
Last modified: January 6, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.