Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Stanniocalcin-2

Gene

STC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • heme binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Stanniocalcin-2
Short name:
STC-2
Alternative name(s):
Stanniocalcin-related protein
Short name:
STC-related protein
Short name:
STCRP
Gene namesi
Name:STC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:11374. STC2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • extracellular space Source: UniProtKB
  • Golgi apparatus Source: Ensembl
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36191.

Polymorphism and mutation databases

BioMutaiSTC2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 302278Stanniocalcin-2PRO_0000033303Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Modified residuei250 – 2501Phosphoserine; by FAM20C1 Publication
Modified residuei251 – 2511Phosphoserine; by FAM20C1 Publication
Modified residuei254 – 2541Phosphothreonine; by FAM20C1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO76061.
PeptideAtlasiO76061.
PRIDEiO76061.

PTM databases

iPTMnetiO76061.
PhosphoSiteiO76061.

Expressioni

Tissue specificityi

Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.

Gene expression databases

BgeeiO76061.
CleanExiHS_STC2.
ExpressionAtlasiO76061. baseline and differential.
GenevisibleiO76061. HS.

Organism-specific databases

HPAiHPA045372.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi114172. 15 interactions.
IntActiO76061. 11 interactions.
MINTiMINT-1428184.
STRINGi9606.ENSP00000265087.

Structurei

3D structure databases

ProteinModelPortaliO76061.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the stanniocalcin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIGP. Eukaryota.
ENOG410XT17. LUCA.
HOGENOMiHOG000220830.
HOVERGENiHBG001048.
InParanoidiO76061.
OMAiEDEQSEY.
OrthoDBiEOG76T9S0.
PhylomeDBiO76061.
TreeFamiTF324693.

Family and domain databases

InterProiIPR004978. Stanniocalcin.
[Graphical view]
PANTHERiPTHR11245. PTHR11245. 2 hits.
PfamiPF03298. Stanniocalcin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O76061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAERLGQFM TLALVLATFD PARGTDATNP PEGPQDRSSQ QKGRLSLQNT
60 70 80 90 100
AEIQHCLVNA GDVGCGVFEC FENNSCEIRG LHGICMTFLH NAGKFDAQGK
110 120 130 140 150
SFIKDALKCK AHALRHRFGC ISRKCPAIRE MVSQLQRECY LKHDLCAAAQ
160 170 180 190 200
ENTRVIVEMI HFKDLLLHEP YVDLVNLLLT CGEEVKEAIT HSVQVQCEQN
210 220 230 240 250
WGSLCSILSF CTSAIQKPPT APPERQPQVD RTKLSRAHHG EAGHHLPEPS
260 270 280 290 300
SRETGRGAKG ERGSKSHPNA HARGRVGGLG AQGPSGSSEW EDEQSEYSDI

RR
Length:302
Mass (Da):33,249
Last modified:November 1, 1998 - v1
Checksum:i9B90D8911524FA22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055460 mRNA. Translation: AAC27036.1.
AB012664 mRNA. Translation: BAA33489.1.
AF098462 mRNA. Translation: AAC97948.1.
AF031036 mRNA. Translation: AAD01922.1.
BT019591 mRNA. Translation: AAV38398.1.
BC000658 mRNA. Translation: AAH00658.1.
BC006352 mRNA. Translation: AAH06352.1.
BC013958 mRNA. Translation: AAH13958.1.
CCDSiCCDS4388.1.
PIRiJE0357.
RefSeqiNP_003705.1. NM_003714.2.
UniGeneiHs.233160.

Genome annotation databases

EnsembliENST00000265087; ENSP00000265087; ENSG00000113739.
GeneIDi8614.
KEGGihsa:8614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055460 mRNA. Translation: AAC27036.1.
AB012664 mRNA. Translation: BAA33489.1.
AF098462 mRNA. Translation: AAC97948.1.
AF031036 mRNA. Translation: AAD01922.1.
BT019591 mRNA. Translation: AAV38398.1.
BC000658 mRNA. Translation: AAH00658.1.
BC006352 mRNA. Translation: AAH06352.1.
BC013958 mRNA. Translation: AAH13958.1.
CCDSiCCDS4388.1.
PIRiJE0357.
RefSeqiNP_003705.1. NM_003714.2.
UniGeneiHs.233160.

3D structure databases

ProteinModelPortaliO76061.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114172. 15 interactions.
IntActiO76061. 11 interactions.
MINTiMINT-1428184.
STRINGi9606.ENSP00000265087.

PTM databases

iPTMnetiO76061.
PhosphoSiteiO76061.

Polymorphism and mutation databases

BioMutaiSTC2.

Proteomic databases

PaxDbiO76061.
PeptideAtlasiO76061.
PRIDEiO76061.

Protocols and materials databases

DNASUi8614.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265087; ENSP00000265087; ENSG00000113739.
GeneIDi8614.
KEGGihsa:8614.

Organism-specific databases

CTDi8614.
GeneCardsiSTC2.
HGNCiHGNC:11374. STC2.
HPAiHPA045372.
MIMi603665. gene.
neXtProtiNX_O76061.
PharmGKBiPA36191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIGP. Eukaryota.
ENOG410XT17. LUCA.
HOGENOMiHOG000220830.
HOVERGENiHBG001048.
InParanoidiO76061.
OMAiEDEQSEY.
OrthoDBiEOG76T9S0.
PhylomeDBiO76061.
TreeFamiTF324693.

Miscellaneous databases

ChiTaRSiSTC2. human.
GeneWikiiSTC2.
GenomeRNAii8614.
NextBioi32283.
PROiO76061.
SOURCEiSearch...

Gene expression databases

BgeeiO76061.
CleanExiHS_STC2.
ExpressionAtlasiO76061. baseline and differential.
GenevisibleiO76061. HS.

Family and domain databases

InterProiIPR004978. Stanniocalcin.
[Graphical view]
PANTHERiPTHR11245. PTHR11245. 2 hits.
PfamiPF03298. Stanniocalcin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2."
    Chang A.C.-M., Reddel R.R.
    Mol. Cell. Endocrinol. 141:95-99(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Osteosarcoma.
  3. "Molecular cloning and characterization of stanniocalcin-related protein."
    DiMattia G.E., Varghese R., Wagner G.F.
    Mol. Cell. Endocrinol. 146:137-140(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells."
    Moore E.E., Kuestner R.E., Conklin D.C., Whitmore T.E., Downey W., Buddle M.M., Adams R.L., Bell L.A., Thompson D.L., Wolf A., Chen L., Stamm M.R., Grant F.J., Lok S., Ren H., de Jongh K.S.
    Horm. Metab. Res. 31:406-414(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Mammary carcinoma.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Muscle.
  7. Cited for: PHOSPHORYLATION AT SER-250; SER-251 AND THR-254.

Entry informationi

Entry nameiSTC2_HUMAN
AccessioniPrimary (citable) accession number: O76061
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.