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O76050 (NEU1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuralized-like protein 1A
Short name=h-neu
Short name=h-neuralized 1
EC=6.3.2.-
Alternative name(s):
RING finger protein 67
Gene names
Name:NEURL
Synonyms:NEURL1, NEURL1A, RNF67
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length574 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 By similarity.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity. Cytoplasm › perinuclear region Ref.5.

Tissue specificity

Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Ref.1 Ref.5

Post-translational modification

Myristoylation is a determinant of membrane targeting By similarity.

Sequence similarities

Contains 2 NHR (neuralized homology repeat) domains.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence CAI13958.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI13959.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCell membrane
Cytoplasm
Membrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
   PTMLipoprotein
Myristate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processnervous system development

Traceable author statement. Source: ProtInc

   Cellular componentperinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O76050-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O76050-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MGNNFSSIPSLPRGNPSRAPRGHPQNLK → MGGQITRSTLH
Note: Gene prediction confirmed by EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 574573Neuralized-like protein 1A
PRO_0000181255

Regions

Domain61 – 217157NHR 1
Domain292 – 447156NHR 2
Zinc finger520 – 56041RING-type

Amino acid modifications

Lipidation21N-myristoyl glycine By similarity

Natural variations

Alternative sequence1 – 2828MGNNF…PQNLK → MGGQITRSTLH in isoform 2.
VSP_013151

Experimental info

Sequence conflict611T → A in AAH26336. Ref.4
Sequence conflict2701G → S in AAH26336. Ref.4
Sequence conflict4761R → G in AAH26336. Ref.4
Sequence conflict5661D → G in AAH26336. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: D9699F08F7443EBB

FASTA57461,860
        10         20         30         40         50         60 
MGNNFSSIPS LPRGNPSRAP RGHPQNLKDS IGGPFPVTSH RCHHKQKHCP AVLPSGGLPA 

        70         80         90        100        110        120 
TPLLFHPHTK GSQILMDLSH KAVKRQASFC NAITFSNRPV LIYEQVRLKI TKKQCCWSGA 

       130        140        150        160        170        180 
LRLGFTSKDP SRIHPDSLPK YACPDLVSQS GFWAKALPEE FANEGNIIAF WVDKKGRVFH 

       190        200        210        220        230        240 
RINDSAVMLF FSGVRTADPL WALVDVYGLT RGVQLLDSEL VLPDCLRPRS FTALRRPSLR 

       250        260        270        280        290        300 
READDARLSV SLCDLNVPGA DGDEAAPAAG CPIPQNSLNS QHSRALPAQL DGDLRFHALR 

       310        320        330        340        350        360 
AGAHVRILDE QTVARVEHGR DERALVFTSR PVRVAETIFV KVTRSGGARP GALSFGVTTC 

       370        380        390        400        410        420 
DPGTLRPADL PFSPEALVDR KEFWAVCRVP GPLHSGDILG LVVNADGELH LSHNGAAAGM 

       430        440        450        460        470        480 
QLCVDASQPL WMLFGLHGTI TQIRILGSTI LAERGIPSLP CSPASTPTSP SALGSRLSDP 

       490        500        510        520        530        540 
LLSTCSSGPL GSSAGGTAPN SPVSLPESPV TPGLGQWSDE CTICYEHAVD TVIYTCGHMC 

       550        560        570 
LCYACGLRLK KALHACCPIC RRPIKDIIKT YRSS

« Hide

Isoform 2 [UniParc].

Checksum: 0983D61C1800F279
Show »

FASTA55760,030

References

« Hide 'large scale' references
[1]"Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region."
Nakamura H., Yoshida M., Tsuiki H., Ito K., Ueno M., Nakao M., Oka K., Tada M., Kochi M., Kuratsu J., Ushio Y., Saya H.
Oncogene 16:1009-1019(1998) [PubMed: 9519875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]Prinos P., Kilpatrick M.W., Tsipouras P.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland."
Vollrath B., Pudney J., Asa S., Leder P., Fitzgerald K.
Mol. Cell. Biol. 21:7481-7494(2001) [PubMed: 11585928] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U87864 mRNA. Translation: AAC17474.1.
AF029729 mRNA. Translation: AAD01887.1.
AL121929 Genomic DNA. Translation: CAI13958.1. Sequence problems.
AL121929 Genomic DNA. Translation: CAI13959.1. Sequence problems.
AL121929, AL139339 Genomic DNA. Translation: CAI13960.1.
AL139339, AL121929 Genomic DNA. Translation: CAH71486.1.
BC026336 mRNA. Translation: AAH26336.1.
IPIIPI00003483.
IPI00554624.
RefSeqNP_004201.3. NM_004210.4.
UniGeneHs.594708.

3D structure databases

ProteinModelPortalO76050.
SMRO76050. Positions 58-223, 291-450, 520-565.
ModBaseSearch...

Protein-protein interaction databases

IntActO76050. 2 interactions.
STRINGO76050.

Proteomic databases

PRIDEO76050.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369780; ENSP00000358795; ENSG00000107954.
GeneID9148.
KEGGhsa:9148.
UCSCuc001kxh.1. human.

Organism-specific databases

CTD9148.
GeneCardsGC10P105244.
H-InvDBHIX0009178.
HGNCHGNC:7761. NEURL.
HPAHPA044204.
MIM603804. gene.
neXtProtNX_O76050.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG12630.
GeneTreeENSGT00530000063117.
HOGENOMHBG444604.
InParanoidO76050.
OMATIFVKVT.
OrthoDBEOG4BRWKC.
PhylomeDBO76050.

Gene expression databases

ArrayExpressO76050.
BgeeO76050.
CleanExHS_NEURL.
GenevestigatorO76050.
GermOnlineENSG00000107954. Homo sapiens.

Family and domain databases

InterProIPR006573. Neu_Z.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
Gene3DG3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KOK01931.
PfamPF07177. Neuralized. 2 hits.
[Graphical view]
SMARTSM00588. NEUZ. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEPS51065. NHR. 2 hits.
PS00518. ZF_RING_1. False negative.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio34315.
SOURCESearch...

Entry information

Entry nameNEU1A_HUMAN
AccessionPrimary (citable) accession number: O76050
Secondary accession number(s): Q5TDR2 expand/collapse secondary AC list , Q5TDR3, Q8TAN0, Q9H463
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1998
Last modified: January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents