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Protein

Cyclin-dependent kinase-like 5

Gene

CDKL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates phosphorylation of MECP2.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei135Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: HGNC
  • cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  • kinase activity Source: MGI
  • protein kinase activity Source: HGNC
  • protein serine/threonine kinase activity Source: ProtInc
  • Rac GTPase binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS00230-MONOMER.
BRENDAi2.7.11.22. 2681.
SignaLinkiO76039.
SIGNORiO76039.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 5 (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase 9
Gene namesi
Name:CDKL5
Synonyms:STK9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11411. CDKL5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • dendrite cytoplasm Source: BHF-UCL
  • dendritic growth cone Source: BHF-UCL
  • nucleoplasm Source: HPA
  • nucleus Source: HGNC
  • ruffle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).

Epileptic encephalopathy, early infantile, 2 (EIEE2)13 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients with epileptic encephalopathy early infantile type 2 manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. However, EIEE2 and Rett syndrome are considered two distinct entities.
See also OMIM:300672
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05802240A → V in EIEE2; causes mislocalization of the protein in the cytoplasm. 2 PublicationsCorresponds to variant rs122460159dbSNPEnsembl.1
Natural variantiVAR_05802372I → N in EIEE2. 1 PublicationCorresponds to variant rs62641235dbSNPEnsembl.1
Natural variantiVAR_05802472I → T in EIEE2. 1 PublicationCorresponds to variant rs62641235dbSNPEnsembl.1
Natural variantiVAR_058025127H → R in EIEE2. 1 PublicationCorresponds to variant rs267608468dbSNPEnsembl.1
Natural variantiVAR_023560152C → F in EIEE2; affect activity; causes mislocalization of the protein in the cytoplasm. 2 PublicationsCorresponds to variant rs122460157dbSNPEnsembl.1
Natural variantiVAR_023561175R → S in EIEE2; affect activity; does not affect the cellular distribution of the protein. 2 PublicationsCorresponds to variant rs61749700dbSNPEnsembl.1
Natural variantiVAR_058026178R → P in EIEE2. 1 PublicationCorresponds to variant rs267606715dbSNPEnsembl.1
Natural variantiVAR_071103178R → Q in EIEE2. 1 PublicationCorresponds to variant rs267606715dbSNPEnsembl.1
Natural variantiVAR_037635180P → L in EIEE2. 1 PublicationCorresponds to variant rs61749704dbSNPEnsembl.1
Natural variantiVAR_058027220L → P in EIEE2; causes mislocalization of the protein in the cytoplasm. 2 PublicationsCorresponds to variant rs267608511dbSNPEnsembl.1
Natural variantiVAR_058028288T → I in EIEE2. 1 PublicationCorresponds to variant rs267606713dbSNPEnsembl.1
Natural variantiVAR_058029291C → Y in EIEE2. 1 PublicationCorresponds to variant rs267606714dbSNPEnsembl.1
Natural variantiVAR_058030399N → T in EIEE2. 1 PublicationCorresponds to variant rs267608611dbSNPEnsembl.1
Natural variantiVAR_058032718V → M in EIEE2. 1 PublicationCorresponds to variant rs267608653dbSNPEnsembl.1
Natural variantiVAR_037636793V → A in EIEE2; unknown pathological significance. 1 PublicationCorresponds to variant rs62643617dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNETi6792.
MalaCardsiCDKL5.
MIMi300672. phenotype.
OpenTargetsiENSG00000008086.
PharmGKBiPA36218.

Chemistry databases

ChEMBLiCHEMBL1163112.

Polymorphism and mutation databases

BioMutaiCDKL5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858261 – 1030Cyclin-dependent kinase-like 5Add BLAST1030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407PhosphoserineCombined sources1
Modified residuei479PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO76039.
PaxDbiO76039.
PeptideAtlasiO76039.
PRIDEiO76039.

PTM databases

iPTMnetiO76039.
PhosphoSitePlusiO76039.

Expressioni

Tissue specificityi

Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis.

Gene expression databases

BgeeiENSG00000008086.
CleanExiHS_CDKL5.
ExpressionAtlasiO76039. baseline and differential.
GenevisibleiO76039. HS.

Organism-specific databases

HPAiCAB011577.
HPA002847.

Interactioni

Subunit structurei

Interacts with MECP2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112668. 17 interactors.
IntActiO76039. 7 interactors.
MINTiMINT-7241055.
STRINGi9606.ENSP00000369325.

Chemistry databases

BindingDBiO76039.

Structurei

Secondary structure

11030
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni10 – 12Combined sources3
Beta strandi13 – 24Combined sources12
Beta strandi26 – 32Combined sources7
Turni33 – 35Combined sources3
Beta strandi38 – 43Combined sources6
Helixi55 – 66Combined sources12
Beta strandi75 – 81Combined sources7
Beta strandi84 – 90Combined sources7
Beta strandi93 – 95Combined sources3
Helixi96 – 102Combined sources7
Helixi109 – 128Combined sources20
Helixi138 – 140Combined sources3
Beta strandi141 – 143Combined sources3
Beta strandi149 – 151Combined sources3
Helixi180 – 183Combined sources4
Helixi191 – 206Combined sources16
Helixi216 – 227Combined sources12
Helixi232 – 240Combined sources9
Helixi242 – 244Combined sources3
Helixi258 – 262Combined sources5
Turni263 – 265Combined sources3
Helixi268 – 277Combined sources10
Helixi282 – 284Combined sources3
Helixi288 – 292Combined sources5
Helixi295 – 298Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGQX-ray2.00A1-303[»]
ProteinModelPortaliO76039.
SMRiO76039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 297Protein kinasePROSITE-ProRule annotationAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi784 – 789Poly-Lys6

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000049181.
HOVERGENiHBG050863.
InParanoidiO76039.
KOiK08824.
OMAiKSEVGLY.
OrthoDBiEOG091G01A9.
PhylomeDBiO76039.
TreeFamiTF101032.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O76039-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN
60 70 80 90 100
EEVKETTLRE LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL
110 120 130 140 150
EEMPNGVPPE KVKSYIYQLI KAIHWCHKND IVHRDIKPEN LLISHNDVLK
160 170 180 190 200
LCDFGFARNL SEGNNANYTE YVATRWYRSP ELLLGAPYGK SVDMWSVGCI
210 220 230 240 250
LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS NPRFHGLRFP
260 270 280 290 300
AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ
310 320 330 340 350
RLLDRSPSRS AKRKPYHVES STLSNRNQAG KSTALQSHHR SNSKDIQNLS
360 370 380 390 400
VGLPRADEGL PANESFLNGN LAGASLSPLH TKTYQASSQP GSTSKDLTNN
410 420 430 440 450
NIPHLLSPKE AKSKTEFDFN IDPKPSEGPG TKYLKSNSRS QQNRHSFMES
460 470 480 490 500
SQSKAGTLQP NEKQSRHSYI DTIPQSSRSP SYRTKAKSHG ALSDSKSVSN
510 520 530 540 550
LSEARAQIAE PSTSRYFPSS CLDLNSPTSP TPTRHSDTRT LLSPSGRNNR
560 570 580 590 600
NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS
610 620 630 640 650
PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG
660 670 680 690 700
EQLPPEMTVA RSSVKETSRE GTSSFHTRQK SEGGVYHDPH SDDGTAPKEN
710 720 730 740 750
RHLYNDPVPR RVGSFYRVPS PRPDNSFHEN NVSTRVSSLP SESSSGTNHS
760 770 780 790 800
KRQPAFDPWK SPENISHSEQ LKEKEKQGFF RSMKKKKKKS QTVPNSDSPD
810 820 830 840 850
LLTLQKSIHS ASTPSSRPKE WRPEKISDLQ TQSQPLKSLR KLLHLSSASN
860 870 880 890 900
HPASSDPRFQ PLTAQQTKNS FSEIRIHPLS QASGGSSNIR QEPAPKGRPA
910 920 930 940 950
LQLPDGGCDG RRQRHHSGPQ DRRFMLRTTE QQGEYFCCGD PKKPHTPCVP
960 970 980 990 1000
NRALHRPISS PAPYPVLQVR GTSMCPTLQV RGTDAFSCPT QQSGFSFFVR
1010 1020 1030
HVMREALIHR AQVNQAALLT YHENAALTGK
Length:1,030
Mass (Da):115,538
Last modified:November 1, 1998 - v1
Checksum:i8A1C9C438610EF08
GO
Isoform 2 (identifier: O76039-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     905-1030: DGGCDGRRQR...YHENAALTGK → GQMDPGWHVS...NLNDLKETAL

Note: Predominant transcript in brain.
Show »
Length:960
Mass (Da):107,519
Checksum:i6E955E0B40DBC1B8
GO

Sequence cautioni

The sequence CAA61445 differs from that shown. Reason: Frameshift at position 415.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti339 – 340HR → GT in CAA61445 (PubMed:8864140).Curated2
Sequence conflicti541L → W in CAA61445 (PubMed:8864140).Curated1
Sequence conflicti731 – 764Missing in CAA61445 (PubMed:8864140).CuratedAdd BLAST34

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05802240A → V in EIEE2; causes mislocalization of the protein in the cytoplasm. 2 PublicationsCorresponds to variant rs122460159dbSNPEnsembl.1
Natural variantiVAR_05802372I → N in EIEE2. 1 PublicationCorresponds to variant rs62641235dbSNPEnsembl.1
Natural variantiVAR_05802472I → T in EIEE2. 1 PublicationCorresponds to variant rs62641235dbSNPEnsembl.1
Natural variantiVAR_058025127H → R in EIEE2. 1 PublicationCorresponds to variant rs267608468dbSNPEnsembl.1
Natural variantiVAR_023560152C → F in EIEE2; affect activity; causes mislocalization of the protein in the cytoplasm. 2 PublicationsCorresponds to variant rs122460157dbSNPEnsembl.1
Natural variantiVAR_023561175R → S in EIEE2; affect activity; does not affect the cellular distribution of the protein. 2 PublicationsCorresponds to variant rs61749700dbSNPEnsembl.1
Natural variantiVAR_058026178R → P in EIEE2. 1 PublicationCorresponds to variant rs267606715dbSNPEnsembl.1
Natural variantiVAR_071103178R → Q in EIEE2. 1 PublicationCorresponds to variant rs267606715dbSNPEnsembl.1
Natural variantiVAR_037635180P → L in EIEE2. 1 PublicationCorresponds to variant rs61749704dbSNPEnsembl.1
Natural variantiVAR_058027220L → P in EIEE2; causes mislocalization of the protein in the cytoplasm. 2 PublicationsCorresponds to variant rs267608511dbSNPEnsembl.1
Natural variantiVAR_058028288T → I in EIEE2. 1 PublicationCorresponds to variant rs267606713dbSNPEnsembl.1
Natural variantiVAR_058029291C → Y in EIEE2. 1 PublicationCorresponds to variant rs267606714dbSNPEnsembl.1
Natural variantiVAR_036578368N → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_041997374A → T in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_058030399N → T in EIEE2. 1 PublicationCorresponds to variant rs267608611dbSNPEnsembl.1
Natural variantiVAR_058031444R → C.1 PublicationCorresponds to variant rs61753977dbSNPEnsembl.1
Natural variantiVAR_041998574P → Q in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_058032718V → M in EIEE2. 1 PublicationCorresponds to variant rs267608653dbSNPEnsembl.1
Natural variantiVAR_041999734T → A.1 PublicationCorresponds to variant rs55803460dbSNPEnsembl.1
Natural variantiVAR_023562791Q → P.4 PublicationsCorresponds to variant rs35478150dbSNPEnsembl.1
Natural variantiVAR_037636793V → A in EIEE2; unknown pathological significance. 1 PublicationCorresponds to variant rs62643617dbSNPEnsembl.1
Natural variantiVAR_058033923R → C.1 PublicationCorresponds to variant rs267608664dbSNPEnsembl.1
Natural variantiVAR_037637999V → M.Corresponds to variant rs35693326dbSNPEnsembl.1
Natural variantiVAR_0420001023E → G.1 PublicationCorresponds to variant rs34166184dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044082905 – 1030DGGCD…ALTGK → GQMDPGWHVSSVTRSATEGP SYSEQLGAKSGPNGHPYNRT NRSRMPNLNDLKETAL in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15057 mRNA. Translation: CAA75342.1.
AY217744 mRNA. Translation: AAO64440.1.
HQ171445 mRNA. Translation: ADN38258.1.
Z92542, AL109798 Genomic DNA. Translation: CAI42485.1.
AL109798, Z92542 Genomic DNA. Translation: CAI41159.1.
X89059 mRNA. Translation: CAA61445.1. Frameshift.
CCDSiCCDS14186.1. [O76039-1]
CCDS83458.1. [O76039-2]
PIRiS58296.
RefSeqiNP_001032420.1. NM_001037343.1. [O76039-1]
NP_001310218.1. NM_001323289.1. [O76039-2]
NP_003150.1. NM_003159.2. [O76039-1]
UniGeneiHs.659851.
Hs.696079.

Genome annotation databases

EnsembliENST00000379989; ENSP00000369325; ENSG00000008086. [O76039-1]
ENST00000379996; ENSP00000369332; ENSG00000008086. [O76039-1]
ENST00000623535; ENSP00000485244; ENSG00000008086. [O76039-2]
GeneIDi6792.
KEGGihsa:6792.
UCSCiuc004cym.4. human. [O76039-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15057 mRNA. Translation: CAA75342.1.
AY217744 mRNA. Translation: AAO64440.1.
HQ171445 mRNA. Translation: ADN38258.1.
Z92542, AL109798 Genomic DNA. Translation: CAI42485.1.
AL109798, Z92542 Genomic DNA. Translation: CAI41159.1.
X89059 mRNA. Translation: CAA61445.1. Frameshift.
CCDSiCCDS14186.1. [O76039-1]
CCDS83458.1. [O76039-2]
PIRiS58296.
RefSeqiNP_001032420.1. NM_001037343.1. [O76039-1]
NP_001310218.1. NM_001323289.1. [O76039-2]
NP_003150.1. NM_003159.2. [O76039-1]
UniGeneiHs.659851.
Hs.696079.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGQX-ray2.00A1-303[»]
ProteinModelPortaliO76039.
SMRiO76039.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112668. 17 interactors.
IntActiO76039. 7 interactors.
MINTiMINT-7241055.
STRINGi9606.ENSP00000369325.

Chemistry databases

BindingDBiO76039.
ChEMBLiCHEMBL1163112.

PTM databases

iPTMnetiO76039.
PhosphoSitePlusiO76039.

Polymorphism and mutation databases

BioMutaiCDKL5.

Proteomic databases

MaxQBiO76039.
PaxDbiO76039.
PeptideAtlasiO76039.
PRIDEiO76039.

Protocols and materials databases

DNASUi6792.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379989; ENSP00000369325; ENSG00000008086. [O76039-1]
ENST00000379996; ENSP00000369332; ENSG00000008086. [O76039-1]
ENST00000623535; ENSP00000485244; ENSG00000008086. [O76039-2]
GeneIDi6792.
KEGGihsa:6792.
UCSCiuc004cym.4. human. [O76039-1]

Organism-specific databases

CTDi6792.
DisGeNETi6792.
GeneCardsiCDKL5.
HGNCiHGNC:11411. CDKL5.
HPAiCAB011577.
HPA002847.
MalaCardsiCDKL5.
MIMi300203. gene.
300672. phenotype.
neXtProtiNX_O76039.
OpenTargetsiENSG00000008086.
PharmGKBiPA36218.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000049181.
HOVERGENiHBG050863.
InParanoidiO76039.
KOiK08824.
OMAiKSEVGLY.
OrthoDBiEOG091G01A9.
PhylomeDBiO76039.
TreeFamiTF101032.

Enzyme and pathway databases

BioCyciZFISH:HS00230-MONOMER.
BRENDAi2.7.11.22. 2681.
SignaLinkiO76039.
SIGNORiO76039.

Miscellaneous databases

ChiTaRSiCDKL5. human.
GeneWikiiCDKL5.
GenomeRNAii6792.
PROiO76039.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000008086.
CleanExiHS_CDKL5.
ExpressionAtlasiO76039. baseline and differential.
GenevisibleiO76039. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKL5_HUMAN
AccessioniPrimary (citable) accession number: O76039
Secondary accession number(s): G9B9X4
, Q14198, Q5H985, Q8IYC7, Q9UJL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 168 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.