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O76038

- SEGN_HUMAN

UniProt

O76038 - SEGN_HUMAN

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Protein

Secretagogin

Gene

SCGN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi25 – 36121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi71 – 82122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi118 – 129123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi162 – 173124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi210 – 221125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi254 – 265126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Secretagogin
Gene namesi
Name:SCGN
Synonyms:SECRET
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:16941. SCGN.

Subcellular locationi

Cytoplasm. Secreted By similarity. Cytoplasmic vesiclesecretory vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). Detectable in human serum after ischemic neuronal damage.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. extracellular region Source: UniProtKB-KW
  4. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276SecretagoginPRO_0000073636Add
BLAST

Proteomic databases

MaxQBiO76038.
PaxDbiO76038.
PRIDEiO76038.

PTM databases

PhosphoSiteiO76038.

Expressioni

Tissue specificityi

Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons.1 Publication

Gene expression databases

BgeeiO76038.
CleanExiHS_SCGN.
ExpressionAtlasiO76038. baseline and differential.
GenevestigatoriO76038.

Organism-specific databases

HPAiCAB004005.
CAB062563.
HPA006641.

Interactioni

Protein-protein interaction databases

BioGridi115839. 23 interactions.
IntActiO76038. 1 interaction.
STRINGi9606.ENSP00000367197.

Structurei

3D structure databases

ProteinModelPortaliO76038.
SMRiO76038. Positions 9-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini58 – 9336EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini105 – 14036EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 18436EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini197 – 23236EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini240 – 27637EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG299305.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiO76038.
OMAiMMELVQP.
OrthoDBiEOG71G9VB.
PhylomeDBiO76038.
TreeFamiTF325083.

Family and domain databases

Gene3Di1.10.238.10. 5 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76038 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSSREPTLG RLDAAGFWQV WQRFDADEKG YIEEKELDAF FLHMLMKLGT
60 70 80 90 100
DDTVMKANLH KVKQQFMTTQ DASKDGRIRM KELAGMFLSE DENFLLLFRR
110 120 130 140 150
ENPLDSSVEF MQIWRKYDAD SSGFISAAEL RNFLRDLFLH HKKAISEAKL
160 170 180 190 200
EEYTGTMMKI FDRNKDGRLD LNDLARILAL QENFLLQFKM DACSTEERKR
210 220 230 240 250
DFEKIFAYYD VSKTGALEGP EVDGFVKDMM ELVQPSISGV DLDKFREILL
260 270
RHCDVNKDGK IQKSELALCL GLKINP
Length:276
Mass (Da):32,040
Last modified:May 27, 2002 - v2
Checksum:iEB970BF7B8763F33
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221Q → R in CAA76365. (PubMed:10811645)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti216 – 2161A → V.
Corresponds to variant rs6942245 [ dbSNP | Ensembl ].
VAR_042710

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16752 mRNA. Translation: CAA76365.1.
AK289477 mRNA. Translation: BAF82166.1.
AL512384, AL022170 Genomic DNA. Translation: CAH72415.1.
AL022170, AL512384 Genomic DNA. Translation: CAI21585.1.
CH471087 Genomic DNA. Translation: EAW55487.1.
BC000336 mRNA. Translation: AAH00336.1.
BC003036 mRNA. Translation: AAH03036.1.
CCDSiCCDS4561.1.
RefSeqiNP_008929.2. NM_006998.3.
UniGeneiHs.116428.

Genome annotation databases

EnsembliENST00000377961; ENSP00000367197; ENSG00000079689.
GeneIDi10590.
KEGGihsa:10590.
UCSCiuc003nfb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16752 mRNA. Translation: CAA76365.1 .
AK289477 mRNA. Translation: BAF82166.1 .
AL512384 , AL022170 Genomic DNA. Translation: CAH72415.1 .
AL022170 , AL512384 Genomic DNA. Translation: CAI21585.1 .
CH471087 Genomic DNA. Translation: EAW55487.1 .
BC000336 mRNA. Translation: AAH00336.1 .
BC003036 mRNA. Translation: AAH03036.1 .
CCDSi CCDS4561.1.
RefSeqi NP_008929.2. NM_006998.3.
UniGenei Hs.116428.

3D structure databases

ProteinModelPortali O76038.
SMRi O76038. Positions 9-276.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115839. 23 interactions.
IntActi O76038. 1 interaction.
STRINGi 9606.ENSP00000367197.

PTM databases

PhosphoSitei O76038.

Proteomic databases

MaxQBi O76038.
PaxDbi O76038.
PRIDEi O76038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377961 ; ENSP00000367197 ; ENSG00000079689 .
GeneIDi 10590.
KEGGi hsa:10590.
UCSCi uc003nfb.3. human.

Organism-specific databases

CTDi 10590.
GeneCardsi GC06P025652.
HGNCi HGNC:16941. SCGN.
HPAi CAB004005.
CAB062563.
HPA006641.
MIMi 609202. gene.
neXtProti NX_O76038.
PharmGKBi PA38428.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299305.
GeneTreei ENSGT00390000013118.
HOGENOMi HOG000231866.
HOVERGENi HBG000855.
InParanoidi O76038.
OMAi MMELVQP.
OrthoDBi EOG71G9VB.
PhylomeDBi O76038.
TreeFami TF325083.

Miscellaneous databases

ChiTaRSi SCGN. human.
GeneWikii SCGN.
GenomeRNAii 10590.
NextBioi 40215.
PROi O76038.
SOURCEi Search...

Gene expression databases

Bgeei O76038.
CleanExi HS_SCGN.
ExpressionAtlasi O76038. baseline and differential.
Genevestigatori O76038.

Family and domain databases

Gene3Di 1.10.238.10. 5 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 5 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein."
    Wagner L., Oliyarnyk O., Gartner W., Nowotny P., Groeger M., Kaserer K., Waldhaeusl W., Pasternack M.S.
    J. Biol. Chem. 275:24740-24751(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreatic islet.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein."
    Gartner W., Lang W., Leutmetzer F., Domanovits H., Waldhaeusl W., Wagner L.
    Cereb. Cortex 11:1161-1169(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSEGN_HUMAN
AccessioniPrimary (citable) accession number: O76038
Secondary accession number(s): A8K0B2
, Q5VV44, Q96QV7, Q9UJF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 27, 2002
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3