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O76038

- SEGN_HUMAN

UniProt

O76038 - SEGN_HUMAN

Protein

Secretagogin

Gene

SCGN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (27 May 2002)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi25 – 36121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi71 – 82122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi118 – 129123PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi162 – 173124PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi210 – 221125PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi254 – 265126PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secretagogin
    Gene namesi
    Name:SCGN
    Synonyms:SECRET
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:16941. SCGN.

    Subcellular locationi

    Cytoplasm. Secreted By similarity. Cytoplasmic vesiclesecretory vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions By similarity. Detectable in human serum after ischemic neuronal damage.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular region Source: UniProtKB-SubCell
    3. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38428.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276SecretagoginPRO_0000073636Add
    BLAST

    Proteomic databases

    MaxQBiO76038.
    PaxDbiO76038.
    PRIDEiO76038.

    PTM databases

    PhosphoSiteiO76038.

    Expressioni

    Tissue specificityi

    Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons.1 Publication

    Gene expression databases

    ArrayExpressiO76038.
    BgeeiO76038.
    CleanExiHS_SCGN.
    GenevestigatoriO76038.

    Organism-specific databases

    HPAiCAB004005.
    CAB062563.
    HPA006641.

    Interactioni

    Protein-protein interaction databases

    BioGridi115839. 1 interaction.
    IntActiO76038. 1 interaction.
    STRINGi9606.ENSP00000367197.

    Structurei

    3D structure databases

    ProteinModelPortaliO76038.
    SMRiO76038. Positions 9-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini58 – 9336EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini105 – 14036EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini149 – 18436EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini197 – 23236EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini240 – 27637EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG299305.
    HOGENOMiHOG000231866.
    HOVERGENiHBG000855.
    InParanoidiO76038.
    OMAiMMELVQP.
    OrthoDBiEOG71G9VB.
    PhylomeDBiO76038.
    TreeFamiTF325083.

    Family and domain databases

    Gene3Di1.10.238.10. 5 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 5 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76038-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSSREPTLG RLDAAGFWQV WQRFDADEKG YIEEKELDAF FLHMLMKLGT    50
    DDTVMKANLH KVKQQFMTTQ DASKDGRIRM KELAGMFLSE DENFLLLFRR 100
    ENPLDSSVEF MQIWRKYDAD SSGFISAAEL RNFLRDLFLH HKKAISEAKL 150
    EEYTGTMMKI FDRNKDGRLD LNDLARILAL QENFLLQFKM DACSTEERKR 200
    DFEKIFAYYD VSKTGALEGP EVDGFVKDMM ELVQPSISGV DLDKFREILL 250
    RHCDVNKDGK IQKSELALCL GLKINP 276
    Length:276
    Mass (Da):32,040
    Last modified:May 27, 2002 - v2
    Checksum:iEB970BF7B8763F33
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221Q → R in CAA76365. (PubMed:10811645)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti216 – 2161A → V.
    Corresponds to variant rs6942245 [ dbSNP | Ensembl ].
    VAR_042710

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16752 mRNA. Translation: CAA76365.1.
    AK289477 mRNA. Translation: BAF82166.1.
    AL512384, AL022170 Genomic DNA. Translation: CAH72415.1.
    AL022170, AL512384 Genomic DNA. Translation: CAI21585.1.
    CH471087 Genomic DNA. Translation: EAW55487.1.
    BC000336 mRNA. Translation: AAH00336.1.
    BC003036 mRNA. Translation: AAH03036.1.
    CCDSiCCDS4561.1.
    RefSeqiNP_008929.2. NM_006998.3.
    UniGeneiHs.116428.

    Genome annotation databases

    EnsembliENST00000377961; ENSP00000367197; ENSG00000079689.
    GeneIDi10590.
    KEGGihsa:10590.
    UCSCiuc003nfb.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16752 mRNA. Translation: CAA76365.1 .
    AK289477 mRNA. Translation: BAF82166.1 .
    AL512384 , AL022170 Genomic DNA. Translation: CAH72415.1 .
    AL022170 , AL512384 Genomic DNA. Translation: CAI21585.1 .
    CH471087 Genomic DNA. Translation: EAW55487.1 .
    BC000336 mRNA. Translation: AAH00336.1 .
    BC003036 mRNA. Translation: AAH03036.1 .
    CCDSi CCDS4561.1.
    RefSeqi NP_008929.2. NM_006998.3.
    UniGenei Hs.116428.

    3D structure databases

    ProteinModelPortali O76038.
    SMRi O76038. Positions 9-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115839. 1 interaction.
    IntActi O76038. 1 interaction.
    STRINGi 9606.ENSP00000367197.

    PTM databases

    PhosphoSitei O76038.

    Proteomic databases

    MaxQBi O76038.
    PaxDbi O76038.
    PRIDEi O76038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377961 ; ENSP00000367197 ; ENSG00000079689 .
    GeneIDi 10590.
    KEGGi hsa:10590.
    UCSCi uc003nfb.3. human.

    Organism-specific databases

    CTDi 10590.
    GeneCardsi GC06P025652.
    HGNCi HGNC:16941. SCGN.
    HPAi CAB004005.
    CAB062563.
    HPA006641.
    MIMi 609202. gene.
    neXtProti NX_O76038.
    PharmGKBi PA38428.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299305.
    HOGENOMi HOG000231866.
    HOVERGENi HBG000855.
    InParanoidi O76038.
    OMAi MMELVQP.
    OrthoDBi EOG71G9VB.
    PhylomeDBi O76038.
    TreeFami TF325083.

    Miscellaneous databases

    ChiTaRSi SCGN. human.
    GeneWikii SCGN.
    GenomeRNAii 10590.
    NextBioi 40215.
    PROi O76038.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O76038.
    Bgeei O76038.
    CleanExi HS_SCGN.
    Genevestigatori O76038.

    Family and domain databases

    Gene3Di 1.10.238.10. 5 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 5 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein."
      Wagner L., Oliyarnyk O., Gartner W., Nowotny P., Groeger M., Kaserer K., Waldhaeusl W., Pasternack M.S.
      J. Biol. Chem. 275:24740-24751(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreatic islet.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein."
      Gartner W., Lang W., Leutmetzer F., Domanovits H., Waldhaeusl W., Wagner L.
      Cereb. Cortex 11:1161-1169(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSEGN_HUMAN
    AccessioniPrimary (citable) accession number: O76038
    Secondary accession number(s): A8K0B2
    , Q5VV44, Q96QV7, Q9UJF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3