Reviewed, UniProtKB/Swiss-Prot O76038 (SEGN_HUMAN)

Names and origin

Protein names

Recommended name:
    Secretagogin

Gene names

Name:	SCGN
Synonyms:	SECRET

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cytoplasm. SecretedBy similarity. Cytoplasmic vesicle › secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic sideBy similarity. Note= Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions By similarity. Detectable in human serum after ischemic neuronal damage.
Tissue specificity	Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons.
Sequence similarities	Contains 6 EF-hand domains.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoplasmic vesicle Membrane Secreted
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calcium
Gene Ontology (GO)
Cellular component	cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW extracellular region Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Secretagogin		PRO_0000073636
Regions
	Domain	12 – 47	36	EF-hand 1
	Domain	58 – 93	36	EF-hand 2
	Domain	105 – 140	36	EF-hand 3
	Domain	149 – 184	36	EF-hand 4
	Domain	197 – 232	36	EF-hand 5
	Domain	240 – 276	37	EF-hand 6
	Calcium binding	25 – 36	12	1 Potential
	Calcium binding	71 – 82	12	2 Potential
	Calcium binding	118 – 129	12	3 Potential
	Calcium binding	162 – 173	12	4 Potential
	Calcium binding	210 – 221	12	5 Potential
	Calcium binding	254 – 265	12	6 Potential
Natural variations
	Natural variant	216	1	A → V: dbSNP rs6942245.		VAR_042710
Experimental info
	Sequence conflict	22	1	Q → R in CAA76365. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O76038-1 [UniParc]. Last modified May 27, 2002. Version 2. Checksum: EB970BF7B8763F33	FASTA	276	32,040
	10 20 30 40 50 60 MDSSREPTLG RLDAAGFWQV WQRFDADEKG YIEEKELDAF FLHMLMKLGT DDTVMKANLH 70 80 90 100 110 120 KVKQQFMTTQ DASKDGRIRM KELAGMFLSE DENFLLLFRR ENPLDSSVEF MQIWRKYDAD 130 140 150 160 170 180 SSGFISAAEL RNFLRDLFLH HKKAISEAKL EEYTGTMMKI FDRNKDGRLD LNDLARILAL 190 200 210 220 230 240 QENFLLQFKM DACSTEERKR DFEKIFAYYD VSKTGALEGP EVDGFVKDMM ELVQPSISGV 250 260 270 DLDKFREILL RHCDVNKDGK IQKSELALCL GLKINP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein." Wagner L., Oliyarnyk O., Gartner W., Nowotny P., Groeger M., Kaserer K., Waldhaeusl W., Pasternack M.S. J. Biol. Chem. 275:24740-24751(2000) [PubMed: 10811645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreatic islet.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein." Gartner W., Lang W., Leutmetzer F., Domanovits H., Waldhaeusl W., Wagner L. Cereb. Cortex 11:1161-1169(2001) [PubMed: 11709487] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y16752 mRNA. Translation: CAA76365.1. AL512384, AL022170 Genomic DNA. Translation: CAH72415.1. AL022170, AL512384 Genomic DNA. Translation: CAI21585.1. BC000336 mRNA. Translation: AAH00336.1. BC003036 mRNA. Translation: AAH03036.1.
RefSeq	NP_008929.2.
UniGene	Hs.116428
3D structure databases
HSSP	HSSP built from PDB template 1TNX based on UniProtKB P02588.
SMR	O76038. Positions 9-276.
ModBase	Search...
Protein-protein interaction databases
IntAct	O76038.
PTM databases
PhosphoSite	O76038.
Genome annotation databases
Ensembl	ENSG00000079689. Homo sapiens. [Contig view]
GeneID	10590.
KEGG	hsa:10590.
Organism-specific databases
H-InvDB	HIX0005633.
HGNC	HGNC:16941. SCGN.
HPA	CAB004005. HPA006641.
MIM	609202. gene.
PharmGKB	PA38428.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	O76038.
HOVERGEN	O76038.
Gene expression databases
ArrayExpress	O76038.
CleanEx	HS_SCGN.
GermOnline	ENSG00000079689. Homo sapiens.
Family and domain databases
InterPro	IPR011992. EF-Hand_type. IPR002048. EF_hand_Ca_bd. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 2 hits.
Pfam	PF00036. efhand. 5 hits. [Graphical view]
ProDom	PD000012. EF-hand. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00054. EFh. 5 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 4 hits. PS50222. EF_HAND_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40215.
SOURCE	Search...

Entry information

Entry name

SEGN_HUMAN

Accession

Primary (citable) accession number: O76038
Secondary accession number(s): Q5VV44, Q96QV7, Q9UJF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 27, 2002
Last modified:	November 25, 2008
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)