Reviewed,
UniProtKB/Swiss-Prot O76038 (SEGN_HUMAN)
Last modified
November 25, 2008.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Secretagogin | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 276 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subcellular location | Cytoplasm. SecretedBy similarity. Cytoplasmic vesicle › secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic sideBy similarity. Note= Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions By similarity. Detectable in human serum after ischemic neuronal damage. |
| Tissue specificity | Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. |
| Sequence similarities | Contains 6 EF-hand domains. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoplasmic vesicle Membrane Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat |
| Ligand | Calcium |
Gene Ontology (GO) | |
| Cellular component | cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW extracellular regionInferred from electronic annotation. Source: UniProtKB-KW membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | calcium ion binding Ref.1 Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 276 | 276 | Secretagogin | PRO_0000073636 | |||||
Regions | |||||||||
| Domain | 12 – 47 | 36 | EF-hand 1 | ||||||
| Domain | 58 – 93 | 36 | EF-hand 2 | ||||||
| Domain | 105 – 140 | 36 | EF-hand 3 | ||||||
| Domain | 149 – 184 | 36 | EF-hand 4 | ||||||
| Domain | 197 – 232 | 36 | EF-hand 5 | ||||||
| Domain | 240 – 276 | 37 | EF-hand 6 | ||||||
| Calcium binding | 25 – 36 | 12 | 1 Potential | ||||||
| Calcium binding | 71 – 82 | 12 | 2 Potential | ||||||
| Calcium binding | 118 – 129 | 12 | 3 Potential | ||||||
| Calcium binding | 162 – 173 | 12 | 4 Potential | ||||||
| Calcium binding | 210 – 221 | 12 | 5 Potential | ||||||
| Calcium binding | 254 – 265 | 12 | 6 Potential | ||||||
Natural variations | |||||||||
| Natural variant | 216 | 1 | A → V: dbSNP rs6942245. | VAR_042710 | |||||
Experimental info | |||||||||
| Sequence conflict | 22 | 1 | Q → R in CAA76365. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein." Wagner L., Oliyarnyk O., Gartner W., Nowotny P., Groeger M., Kaserer K., Waldhaeusl W., Pasternack M.S. J. Biol. Chem. 275:24740-24751(2000) [PubMed: 10811645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreatic islet. |
| [2] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [4] | "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein." Gartner W., Lang W., Leutmetzer F., Domanovits H., Waldhaeusl W., Wagner L. Cereb. Cortex 11:1161-1169(2001) [PubMed: 11709487] [Abstract] Cited for: TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Y16752 mRNA. Translation: CAA76365.1. AL512384, AL022170 Genomic DNA. Translation: CAH72415.1. AL022170, AL512384 Genomic DNA. Translation: CAI21585.1. BC000336 mRNA. Translation: AAH00336.1. BC003036 mRNA. Translation: AAH03036.1. | |
| RefSeq | NP_008929.2. |
| UniGene | Hs.116428 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1TNX based on UniProtKB P02588. |
| SMR | O76038. Positions 9-276. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O76038. |
PTM databases | |
| PhosphoSite | O76038. |
Genome annotation databases | |
| Ensembl | ENSG00000079689. Homo sapiens. [Contig view] |
| GeneID | 10590. |
| KEGG | hsa:10590. |
Organism-specific databases | |
| H-InvDB | HIX0005633. |
| HGNC | HGNC:16941. SCGN. |
| HPA | CAB004005. HPA006641. |
| MIM | 609202. gene. |
| PharmGKB | PA38428. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | O76038. |
| HOVERGEN | O76038. |
Gene expression databases | |
| ArrayExpress | O76038. |
| CleanEx | HS_SCGN. |
| GermOnline | ENSG00000079689. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011992. EF-Hand_type. IPR002048. EF_hand_Ca_bd. [Graphical view] |
| Gene3D | G3DSA:1.10.238.10. EF-Hand_type. 2 hits. |
| Pfam | PF00036. efhand. 5 hits. [Graphical view] |
| ProDom | PD000012. EF-hand. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00054. EFh. 5 hits. [Graphical view] |
| PROSITE | PS00018. EF_HAND_1. 4 hits. PS50222. EF_HAND_2. 6 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 40215. |
| SOURCE | Search... |
Entry information
| Entry name | SEGN_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O76038 Secondary accession number(s): Q5VV44, Q96QV7, Q9UJF6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


