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O76036 (NCTR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Natural cytotoxicity triggering receptor 1
Alternative name(s):
Lymphocyte antigen 94 homolog
NK cell-activating receptor
Natural killer cell p46-related protein
Short name=NK-p46
Short name=NKp46
Short name=hNKp46
CD_antigen=CD335
Gene names
Name:NCR1
Synonyms:LY94
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Ref.1

Subunit structure

Interacts with CD247 and FCER1G. Ref.1

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Selectively expressed by both resting and activated NK cells. Ref.1

Post-translational modification

N-glycosylated. Ref.1

O-glycosylated. Ref.1

Sequence similarities

Belongs to the natural cytotoxicity receptor (NCR) family.

Contains 2 Ig-like (immunoglobulin-like) domains.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O76036-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: O76036-2)

Also known as: b;

The sequence of this isoform differs from the canonical sequence as follows:
     228-244: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: O76036-3)

Also known as: c;

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: O76036-4)

Also known as: d;

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.
     228-244: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: O76036-5)

The sequence of this isoform differs from the canonical sequence as follows:
     12-118: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: O76036-6)

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 304283Natural cytotoxicity triggering receptor 1
PRO_0000015027

Regions

Topological domain22 – 258237Extracellular Potential
Transmembrane259 – 27921Helical; Potential
Topological domain280 – 30425Cytoplasmic Potential
Domain34 – 11885Ig-like 1
Domain129 – 21183Ig-like 2

Amino acid modifications

Glycosylation2161N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 98 Ref.7 Ref.8
Disulfide bond144 ↔ 190 Ref.7 Ref.8

Natural variations

Alternative sequence12 – 118107Missing in isoform 5.
VSP_010406
Alternative sequence25 – 11995Missing in isoform 3 and isoform 4.
VSP_010407
Alternative sequence228 – 24417Missing in isoform 2 and isoform 4.
VSP_010408
Alternative sequence2281Missing in isoform 6.
VSP_038384
Natural variant821K → Q.
Corresponds to variant rs2278428 [ dbSNP | Ensembl ].
VAR_018633
Natural variant871D → Y in a colorectal cancer sample; somatic mutation. Ref.9
VAR_035527

Secondary structure

......................................... 304
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: FBCBDE50D2F34CD3

FASTA30434,481
        10         20         30         40         50         60 
MSSTLPALLC VGLCLSQRIS AQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL 

        70         80         90        100        110        120 
HFEGSLFAVD RPKPPERINK VKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM 

       130        140        150        160        170        180 
YDTPTLSVHP GPEVISGEKV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV 

       190        200        210        220        230        240 
TTAHRGTYRC FGSYNNHAWS FPSEPVKLLV TGDIENTSLA PEDPTFPADT WGTYLLTTET 

       250        260        270        280        290        300 
GLQKDHALWD HTAQNLLRMG LAFLVLVALV WFLVEDWLSR KRTRERASRA STWEGRRRLN 


TQTL 

« Hide

Isoform 2 (b) [UniParc].

Checksum: 52EB1B062B35C1C4
Show »

FASTA28732,600
Isoform 3 (c) [UniParc].

Checksum: 2C0C8C6AB8B50CF5
Show »

FASTA20923,505
Isoform 4 (d) [UniParc].

Checksum: 172BD05CED2D8D01
Show »

FASTA19221,625
Isoform 5 [UniParc].

Checksum: C509AAB68DB7F731
Show »

FASTA19722,220
Isoform 6 [UniParc].

Checksum: 94220C5410D12FE4
Show »

FASTA30334,409

References

« Hide 'large scale' references
[1]"Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity."
Pessino A., Sivori S., Bottino C., Malaspina A., Morelli L., Moretta L., Biassoni R., Moretta A.
J. Exp. Med. 188:953-960(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION, INTERACTION WITH CD247.
Tissue: Lymphoid tissue.
[2]Lin L., Yu R., Zhong J., Li H., Zhou G., Shen C., Ke R., Zheng G., Yang S.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
Tissue: Blood.
[6]"Human natural killer cell receptors: insights into their molecular function and structure."
Biassoni R., Cantoni C., Marras D., Giron-Michel J., Falco M., Moretta L., Dimasi N.
J. Cell. Mol. Med. 7:376-387(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Structure of the human NK cell triggering receptor NKp46 ectodomain."
Ponassi M., Cantoni C., Biassoni R., Conte R., Spallarossa A., Pesce A., Moretta A., Moretta L., Bolognesi M., Bordo D.
Biochem. Biophys. Res. Commun. 309:317-323(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) OF 25-212, DISULFIDE BONDS.
[8]"Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors."
Foster C.E., Colonna M., Sun P.D.
J. Biol. Chem. 278:46081-46086(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-212, DISULFIDE BONDS.
[9]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-87.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ006121 mRNA. Translation: CAA06872.1.
AJ006122 mRNA. Translation: CAA06873.1.
AJ006123 mRNA. Translation: CAA06874.1.
AJ001383 mRNA. Translation: CAA04714.1.
AY346373 mRNA. Translation: AAQ54328.1.
CU151839 Genomic DNA. Translation: CAQ09214.1.
CU151839 Genomic DNA. Translation: CAQ09215.1.
CU151839 Genomic DNA. Translation: CAQ09216.1.
CU151839 Genomic DNA. Translation: CAQ09217.1.
CU459006 Genomic DNA. Translation: CAX14949.1.
CU459006 Genomic DNA. Translation: CAX14950.1.
CU459006 Genomic DNA. Translation: CAX14951.1.
CU459006 Genomic DNA. Translation: CAX14952.1.
CH471135 Genomic DNA. Translation: EAW72308.1.
CH471135 Genomic DNA. Translation: EAW72310.1.
CH471135 Genomic DNA. Translation: EAW72311.1.
BC064806 mRNA. Translation: AAH64806.1.
RefSeqNP_001138929.2. NM_001145457.2.
NP_001138930.2. NM_001145458.2.
NP_001229285.1. NM_001242356.2.
NP_001229286.1. NM_001242357.2.
NP_004820.2. NM_004829.6.
UniGeneHs.97084.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OLLX-ray1.93A25-212[»]
1P6FX-ray2.20A22-263[»]
ProteinModelPortalO76036.
SMRO76036. Positions 25-239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114828. 3 interactions.
STRING9606.ENSP00000291890.

Proteomic databases

PaxDbO76036.
PRIDEO76036.

Protocols and materials databases

DNASU9437.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000291890; ENSP00000291890; ENSG00000189430. [O76036-1]
ENST00000338835; ENSP00000339515; ENSG00000189430. [O76036-2]
ENST00000350790; ENSP00000344358; ENSG00000189430. [O76036-3]
ENST00000357397; ENSP00000349972; ENSG00000189430. [O76036-5]
ENST00000447255; ENSP00000404434; ENSG00000189430. [O76036-6]
ENST00000570317; ENSP00000459017; ENSG00000263100. [O76036-6]
ENST00000570787; ENSP00000461881; ENSG00000262661. [O76036-2]
ENST00000571016; ENSP00000461253; ENSG00000262923. [O76036-5]
ENST00000571087; ENSP00000459242; ENSG00000263100. [O76036-5]
ENST00000571110; ENSP00000458577; ENSG00000262923. [O76036-2]
ENST00000571446; ENSP00000461875; ENSG00000262717. [O76036-5]
ENST00000571521; ENSP00000461012; ENSG00000262661. [O76036-5]
ENST00000571635; ENSP00000461547; ENSG00000263100. [O76036-1]
ENST00000571651; ENSP00000459018; ENSG00000262717. [O76036-1]
ENST00000572000; ENSP00000458808; ENSG00000262923. [O76036-3]
ENST00000572024; ENSP00000458755; ENSG00000262832. [O76036-3]
ENST00000572535; ENSP00000458207; ENSG00000262923. [O76036-6]
ENST00000572783; ENSP00000460928; ENSG00000261880. [O76036-5]
ENST00000572865; ENSP00000459679; ENSG00000262717. [O76036-6]
ENST00000572896; ENSP00000458281; ENSG00000262923. [O76036-1]
ENST00000572957; ENSP00000460627; ENSG00000262182. [O76036-3]
ENST00000573041; ENSP00000461727; ENSG00000262680. [O76036-3]
ENST00000573111; ENSP00000459786; ENSG00000262182. [O76036-1]
ENST00000573217; ENSP00000461159; ENSG00000262661. [O76036-6]
ENST00000573445; ENSP00000458952; ENSG00000262717. [O76036-2]
ENST00000573638; ENSP00000459639; ENSG00000262832. [O76036-2]
ENST00000573642; ENSP00000460698; ENSG00000261880. [O76036-3]
ENST00000573696; ENSP00000461573; ENSG00000262182. [O76036-6]
ENST00000574036; ENSP00000458730; ENSG00000262661. [O76036-1]
ENST00000574055; ENSP00000459041; ENSG00000262182. [O76036-5]
ENST00000574101; ENSP00000461789; ENSG00000262717. [O76036-3]
ENST00000574562; ENSP00000461704; ENSG00000262832. [O76036-6]
ENST00000575004; ENSP00000461863; ENSG00000262832. [O76036-5]
ENST00000575278; ENSP00000460046; ENSG00000261880. [O76036-2]
ENST00000575539; ENSP00000461679; ENSG00000262661. [O76036-3]
ENST00000575901; ENSP00000460232; ENSG00000262680. [O76036-1]
ENST00000576029; ENSP00000461420; ENSG00000262680. [O76036-2]
ENST00000576128; ENSP00000459628; ENSG00000262832. [O76036-1]
ENST00000576385; ENSP00000461094; ENSG00000263100. [O76036-3]
ENST00000576561; ENSP00000460566; ENSG00000262680. [O76036-6]
ENST00000576597; ENSP00000459598; ENSG00000262182. [O76036-2]
ENST00000576773; ENSP00000461161; ENSG00000261880. [O76036-6]
ENST00000576786; ENSP00000459942; ENSG00000262680. [O76036-5]
ENST00000576881; ENSP00000458756; ENSG00000263100. [O76036-2]
ENST00000576897; ENSP00000461381; ENSG00000261880. [O76036-1]
ENST00000593509; ENSP00000470697; ENSG00000262661. [O76036-6]
ENST00000594615; ENSP00000470311; ENSG00000262717. [O76036-6]
ENST00000594765; ENSP00000471986; ENSG00000189430. [O76036-6]
ENST00000595175; ENSP00000469326; ENSG00000262923. [O76036-6]
ENST00000595694; ENSP00000469226; ENSG00000262832. [O76036-6]
ENST00000596087; ENSP00000472012; ENSG00000261880. [O76036-6]
ENST00000599079; ENSP00000469174; ENSG00000262182. [O76036-6]
ENST00000601558; ENSP00000471188; ENSG00000262680. [O76036-6]
ENST00000602031; ENSP00000471301; ENSG00000263100. [O76036-6]
ENST00000603763; ENSP00000474460; ENSG00000271000. [O76036-3]
ENST00000605399; ENSP00000474531; ENSG00000271000. [O76036-5]
GeneID9437.
KEGGhsa:9437.
UCSCuc002qib.2. human. [O76036-1]
uc002qic.2. human. [O76036-6]
uc002qid.2. human. [O76036-3]
uc002qie.2. human. [O76036-2]
uc002qif.2. human. [O76036-4]
uc010esj.2. human. [O76036-5]

Organism-specific databases

CTD9437.
GeneCardsGC19P055417.
HGNCHGNC:6731. NCR1.
MIM604530. gene.
neXtProtNX_O76036.
PharmGKBPA30495.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40040.
HOGENOMHOG000234395.
HOVERGENHBG074353.
InParanoidO76036.
KOK06741.
OMAYGAVEYQ.
PhylomeDBO76036.
TreeFamTF336644.

Gene expression databases

ArrayExpressO76036.
BgeeO76036.
CleanExHS_NCR1.
GenevestigatorO76036.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNCR1. human.
EvolutionaryTraceO76036.
GeneWikiNCR1.
GenomeRNAi9437.
NextBio35340.
PROO76036.
SOURCESearch...

Entry information

Entry nameNCTR1_HUMAN
AccessionPrimary (citable) accession number: O76036
Secondary accession number(s): B0V3L2 expand/collapse secondary AC list , B0V3L3, B0V3L4, B0V3L5, B8JL03, O76016, O76017, O76018
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries