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O76036

- NCTR1_HUMAN

UniProt

O76036 - NCTR1_HUMAN

Protein

Natural cytotoxicity triggering receptor 1

Gene

NCR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.1 Publication

    GO - Molecular functioni

    1. receptor signaling protein activity Source: ProtInc

    GO - Biological processi

    1. cellular defense response Source: ProtInc
    2. intracellular signal transduction Source: GOC
    3. natural killer cell activation Source: UniProtKB
    4. regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
    5. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Natural cytotoxicity triggering receptor 1
    Alternative name(s):
    Lymphocyte antigen 94 homolog
    NK cell-activating receptor
    Natural killer cell p46-related protein
    Short name:
    NK-p46
    Short name:
    NKp46
    Short name:
    hNKp46
    CD_antigen: CD335
    Gene namesi
    Name:NCR1
    Synonyms:LY94
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6731. NCR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. SWI/SNF complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30495.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 304283Natural cytotoxicity triggering receptor 1PRO_0000015027Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 98
    Disulfide bondi144 ↔ 190
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication
    O-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO76036.
    PRIDEiO76036.

    Expressioni

    Tissue specificityi

    Selectively expressed by both resting and activated NK cells.1 Publication

    Gene expression databases

    ArrayExpressiO76036.
    BgeeiO76036.
    CleanExiHS_NCR1.
    GenevestigatoriO76036.

    Interactioni

    Subunit structurei

    Interacts with CD247 and FCER1G.1 Publication

    Protein-protein interaction databases

    BioGridi114828. 3 interactions.
    STRINGi9606.ENSP00000291890.

    Structurei

    Secondary structure

    1
    304
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 356
    Beta strandi37 – 404
    Beta strandi45 – 506
    Beta strandi57 – 626
    Beta strandi65 – 706
    Beta strandi80 – 878
    Helixi90 – 923
    Beta strandi94 – 1029
    Beta strandi113 – 1197
    Beta strandi125 – 1306
    Beta strandi132 – 1354
    Beta strandi139 – 1457
    Beta strandi147 – 1493
    Beta strandi151 – 16111
    Beta strandi163 – 1686
    Beta strandi170 – 17910
    Helixi182 – 1843
    Beta strandi186 – 1916
    Beta strandi193 – 1953
    Beta strandi206 – 2116

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OLLX-ray1.93A25-212[»]
    1P6FX-ray2.20A22-263[»]
    ProteinModelPortaliO76036.
    SMRiO76036. Positions 25-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO76036.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 258237ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 30425CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei259 – 27921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 11885Ig-like 1Add
    BLAST
    Domaini129 – 21183Ig-like 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40040.
    HOGENOMiHOG000234395.
    HOVERGENiHBG074353.
    InParanoidiO76036.
    KOiK06741.
    OMAiKFYIPDM.
    PhylomeDBiO76036.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O76036-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSTLPALLC VGLCLSQRIS AQQQTLPKPF IWAEPHFMVP KEKQVTICCQ    50
    GNYGAVEYQL HFEGSLFAVD RPKPPERINK VKFYIPDMNS RMAGQYSCIY 100
    RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEKV TFYCRLDTAT 150
    SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRC FGSYNNHAWS 200
    FPSEPVKLLV TGDIENTSLA PEDPTFPADT WGTYLLTTET GLQKDHALWD 250
    HTAQNLLRMG LAFLVLVALV WFLVEDWLSR KRTRERASRA STWEGRRRLN 300
    TQTL 304

    Note: No experimental confirmation available.

    Length:304
    Mass (Da):34,481
    Last modified:November 1, 1998 - v1
    Checksum:iFBCBDE50D2F34CD3
    GO
    Isoform 2 (identifier: O76036-2) [UniParc]FASTAAdd to Basket

    Also known as: b

    The sequence of this isoform differs from the canonical sequence as follows:
         228-244: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:287
    Mass (Da):32,600
    Checksum:i52EB1B062B35C1C4
    GO
    Isoform 3 (identifier: O76036-3) [UniParc]FASTAAdd to Basket

    Also known as: c

    The sequence of this isoform differs from the canonical sequence as follows:
         25-119: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:209
    Mass (Da):23,505
    Checksum:i2C0C8C6AB8B50CF5
    GO
    Isoform 4 (identifier: O76036-4) [UniParc]FASTAAdd to Basket

    Also known as: d

    The sequence of this isoform differs from the canonical sequence as follows:
         25-119: Missing.
         228-244: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:192
    Mass (Da):21,625
    Checksum:i172BD05CED2D8D01
    GO
    Isoform 5 (identifier: O76036-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         12-118: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:197
    Mass (Da):22,220
    Checksum:iC509AAB68DB7F731
    GO
    Isoform 6 (identifier: O76036-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         228-228: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:303
    Mass (Da):34,409
    Checksum:i94220C5410D12FE4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821K → Q.
    Corresponds to variant rs2278428 [ dbSNP | Ensembl ].
    VAR_018633
    Natural varianti87 – 871D → Y in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035527

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei12 – 118107Missing in isoform 5. 1 PublicationVSP_010406Add
    BLAST
    Alternative sequencei25 – 11995Missing in isoform 3 and isoform 4. 1 PublicationVSP_010407Add
    BLAST
    Alternative sequencei228 – 24417Missing in isoform 2 and isoform 4. 1 PublicationVSP_010408Add
    BLAST
    Alternative sequencei228 – 2281Missing in isoform 6. 1 PublicationVSP_038384

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006121 mRNA. Translation: CAA06872.1.
    AJ006122 mRNA. Translation: CAA06873.1.
    AJ006123 mRNA. Translation: CAA06874.1.
    AJ001383 mRNA. Translation: CAA04714.1.
    AY346373 mRNA. Translation: AAQ54328.1.
    CU151839 Genomic DNA. Translation: CAQ09214.1.
    CU151839 Genomic DNA. Translation: CAQ09215.1.
    CU151839 Genomic DNA. Translation: CAQ09216.1.
    CU151839 Genomic DNA. Translation: CAQ09217.1.
    CU459006 Genomic DNA. Translation: CAX14949.1.
    CU459006 Genomic DNA. Translation: CAX14950.1.
    CU459006 Genomic DNA. Translation: CAX14951.1.
    CU459006 Genomic DNA. Translation: CAX14952.1.
    CH471135 Genomic DNA. Translation: EAW72308.1.
    CH471135 Genomic DNA. Translation: EAW72310.1.
    CH471135 Genomic DNA. Translation: EAW72311.1.
    BC064806 mRNA. Translation: AAH64806.1.
    CCDSiCCDS12911.1. [O76036-1]
    CCDS46181.1. [O76036-6]
    CCDS46182.1. [O76036-2]
    CCDS56103.1. [O76036-3]
    RefSeqiNP_001138929.2. NM_001145457.2.
    NP_001138930.2. NM_001145458.2.
    NP_001229285.1. NM_001242356.2. [O76036-3]
    NP_001229286.1. NM_001242357.2. [O76036-4]
    NP_004820.2. NM_004829.6.
    UniGeneiHs.97084.

    Genome annotation databases

    EnsembliENST00000291890; ENSP00000291890; ENSG00000189430. [O76036-1]
    ENST00000338835; ENSP00000339515; ENSG00000189430. [O76036-2]
    ENST00000350790; ENSP00000344358; ENSG00000189430. [O76036-3]
    ENST00000357397; ENSP00000349972; ENSG00000189430. [O76036-5]
    ENST00000594765; ENSP00000471986; ENSG00000189430. [O76036-6]
    GeneIDi9437.
    KEGGihsa:9437.
    UCSCiuc002qib.2. human. [O76036-1]
    uc002qic.2. human. [O76036-6]
    uc002qid.2. human. [O76036-3]
    uc002qie.2. human. [O76036-2]
    uc002qif.2. human. [O76036-4]
    uc010esj.2. human. [O76036-5]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006121 mRNA. Translation: CAA06872.1 .
    AJ006122 mRNA. Translation: CAA06873.1 .
    AJ006123 mRNA. Translation: CAA06874.1 .
    AJ001383 mRNA. Translation: CAA04714.1 .
    AY346373 mRNA. Translation: AAQ54328.1 .
    CU151839 Genomic DNA. Translation: CAQ09214.1 .
    CU151839 Genomic DNA. Translation: CAQ09215.1 .
    CU151839 Genomic DNA. Translation: CAQ09216.1 .
    CU151839 Genomic DNA. Translation: CAQ09217.1 .
    CU459006 Genomic DNA. Translation: CAX14949.1 .
    CU459006 Genomic DNA. Translation: CAX14950.1 .
    CU459006 Genomic DNA. Translation: CAX14951.1 .
    CU459006 Genomic DNA. Translation: CAX14952.1 .
    CH471135 Genomic DNA. Translation: EAW72308.1 .
    CH471135 Genomic DNA. Translation: EAW72310.1 .
    CH471135 Genomic DNA. Translation: EAW72311.1 .
    BC064806 mRNA. Translation: AAH64806.1 .
    CCDSi CCDS12911.1. [O76036-1 ]
    CCDS46181.1. [O76036-6 ]
    CCDS46182.1. [O76036-2 ]
    CCDS56103.1. [O76036-3 ]
    RefSeqi NP_001138929.2. NM_001145457.2.
    NP_001138930.2. NM_001145458.2.
    NP_001229285.1. NM_001242356.2. [O76036-3 ]
    NP_001229286.1. NM_001242357.2. [O76036-4 ]
    NP_004820.2. NM_004829.6.
    UniGenei Hs.97084.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OLL X-ray 1.93 A 25-212 [» ]
    1P6F X-ray 2.20 A 22-263 [» ]
    ProteinModelPortali O76036.
    SMRi O76036. Positions 25-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114828. 3 interactions.
    STRINGi 9606.ENSP00000291890.

    Proteomic databases

    PaxDbi O76036.
    PRIDEi O76036.

    Protocols and materials databases

    DNASUi 9437.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291890 ; ENSP00000291890 ; ENSG00000189430 . [O76036-1 ]
    ENST00000338835 ; ENSP00000339515 ; ENSG00000189430 . [O76036-2 ]
    ENST00000350790 ; ENSP00000344358 ; ENSG00000189430 . [O76036-3 ]
    ENST00000357397 ; ENSP00000349972 ; ENSG00000189430 . [O76036-5 ]
    ENST00000594765 ; ENSP00000471986 ; ENSG00000189430 . [O76036-6 ]
    GeneIDi 9437.
    KEGGi hsa:9437.
    UCSCi uc002qib.2. human. [O76036-1 ]
    uc002qic.2. human. [O76036-6 ]
    uc002qid.2. human. [O76036-3 ]
    uc002qie.2. human. [O76036-2 ]
    uc002qif.2. human. [O76036-4 ]
    uc010esj.2. human. [O76036-5 ]

    Organism-specific databases

    CTDi 9437.
    GeneCardsi GC19P055417.
    HGNCi HGNC:6731. NCR1.
    MIMi 604530. gene.
    neXtProti NX_O76036.
    PharmGKBi PA30495.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40040.
    HOGENOMi HOG000234395.
    HOVERGENi HBG074353.
    InParanoidi O76036.
    KOi K06741.
    OMAi KFYIPDM.
    PhylomeDBi O76036.
    TreeFami TF336644.

    Miscellaneous databases

    ChiTaRSi NCR1. human.
    EvolutionaryTracei O76036.
    GeneWikii NCR1.
    GenomeRNAii 9437.
    NextBioi 35340.
    PROi O76036.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O76036.
    Bgeei O76036.
    CleanExi HS_NCR1.
    Genevestigatori O76036.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity."
      Pessino A., Sivori S., Bottino C., Malaspina A., Morelli L., Moretta L., Biassoni R., Moretta A.
      J. Exp. Med. 188:953-960(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION, INTERACTION WITH CD247.
      Tissue: Lymphoid tissue.
    2. Lin L., Yu R., Zhong J., Li H., Zhou G., Shen C., Ke R., Zheng G., Yang S.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
      Tissue: Blood.
    6. "Human natural killer cell receptors: insights into their molecular function and structure."
      Biassoni R., Cantoni C., Marras D., Giron-Michel J., Falco M., Moretta L., Dimasi N.
      J. Cell. Mol. Med. 7:376-387(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. Cited for: X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) OF 25-212, DISULFIDE BONDS.
    8. "Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors."
      Foster C.E., Colonna M., Sun P.D.
      J. Biol. Chem. 278:46081-46086(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-212, DISULFIDE BONDS.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-87.

    Entry informationi

    Entry nameiNCTR1_HUMAN
    AccessioniPrimary (citable) accession number: O76036
    Secondary accession number(s): B0V3L2
    , B0V3L3, B0V3L4, B0V3L5, B8JL03, O76016, O76017, O76018
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3