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Protein

Natural cytotoxicity triggering receptor 1

Gene

NCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.1 Publication

GO - Molecular functioni

  • signal transducer activity, downstream of receptor Source: ProtInc

GO - Biological processi

  • cellular defense response Source: ProtInc
  • natural killer cell activation Source: UniProtKB
  • regulation of immune response Source: Reactome
  • regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160436-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Natural cytotoxicity triggering receptor 1
Alternative name(s):
Lymphocyte antigen 94 homolog
NK cell-activating receptor
Natural killer cell p46-related protein
Short name:
NK-p46
Short name:
NKp46
Short name:
hNKp46
CD_antigen: CD335
Gene namesi
Name:NCR1
Synonyms:LY94
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6731. NCR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 258ExtracellularSequence analysisAdd BLAST237
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 304CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • SWI/SNF complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9437.
OpenTargetsiENSG00000189430.
ENSG00000273506.
ENSG00000273535.
ENSG00000273916.
ENSG00000274053.
ENSG00000275156.
ENSG00000275822.
ENSG00000277629.
ENSG00000277824.
ENSG00000278362.
PharmGKBiPA30495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001502722 – 304Natural cytotoxicity triggering receptor 1Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98Combined sources2 Publications
Disulfide bondi144 ↔ 190Combined sources2 Publications
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication
O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76036.
PeptideAtlasiO76036.
PRIDEiO76036.

PTM databases

iPTMnetiO76036.
PhosphoSitePlusiO76036.

Expressioni

Tissue specificityi

Selectively expressed by both resting and activated NK cells.1 Publication

Gene expression databases

BgeeiENSG00000189430.
CleanExiHS_NCR1.
ExpressionAtlasiO76036. baseline and differential.
GenevisibleiO76036. HS.

Interactioni

Subunit structurei

Interacts with CD247 and FCER1G.1 Publication

Protein-protein interaction databases

BioGridi114828. 5 interactors.
STRINGi9606.ENSP00000291890.

Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi37 – 40Combined sources4
Beta strandi45 – 50Combined sources6
Beta strandi57 – 62Combined sources6
Beta strandi65 – 70Combined sources6
Beta strandi80 – 87Combined sources8
Helixi90 – 92Combined sources3
Beta strandi94 – 102Combined sources9
Beta strandi113 – 119Combined sources7
Beta strandi125 – 130Combined sources6
Beta strandi132 – 135Combined sources4
Beta strandi139 – 145Combined sources7
Beta strandi147 – 149Combined sources3
Beta strandi151 – 161Combined sources11
Beta strandi163 – 168Combined sources6
Beta strandi170 – 179Combined sources10
Helixi182 – 184Combined sources3
Beta strandi186 – 191Combined sources6
Beta strandi193 – 195Combined sources3
Beta strandi206 – 211Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OLLX-ray1.93A25-212[»]
1P6FX-ray2.20A22-263[»]
ProteinModelPortaliO76036.
SMRiO76036.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO76036.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 118Ig-like 1Add BLAST85
Domaini129 – 211Ig-like 2Add BLAST83

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX2G. Eukaryota.
ENOG4111ACT. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO76036.
KOiK06741.
OMAiYAWSFPS.
OrthoDBiEOG091G0JXB.
PhylomeDBiO76036.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O76036-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSTLPALLC VGLCLSQRIS AQQQTLPKPF IWAEPHFMVP KEKQVTICCQ
60 70 80 90 100
GNYGAVEYQL HFEGSLFAVD RPKPPERINK VKFYIPDMNS RMAGQYSCIY
110 120 130 140 150
RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEKV TFYCRLDTAT
160 170 180 190 200
SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRC FGSYNNHAWS
210 220 230 240 250
FPSEPVKLLV TGDIENTSLA PEDPTFPADT WGTYLLTTET GLQKDHALWD
260 270 280 290 300
HTAQNLLRMG LAFLVLVALV WFLVEDWLSR KRTRERASRA STWEGRRRLN

TQTL
Note: No experimental confirmation available.
Length:304
Mass (Da):34,481
Last modified:November 1, 1998 - v1
Checksum:iFBCBDE50D2F34CD3
GO
Isoform 2 (identifier: O76036-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     228-244: Missing.

Note: No experimental confirmation available.
Show »
Length:287
Mass (Da):32,600
Checksum:i52EB1B062B35C1C4
GO
Isoform 3 (identifier: O76036-3) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.

Note: No experimental confirmation available.
Show »
Length:209
Mass (Da):23,505
Checksum:i2C0C8C6AB8B50CF5
GO
Isoform 4 (identifier: O76036-4) [UniParc]FASTAAdd to basket
Also known as: d

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.
     228-244: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,625
Checksum:i172BD05CED2D8D01
GO
Isoform 5 (identifier: O76036-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-118: Missing.

Note: No experimental confirmation available.
Show »
Length:197
Mass (Da):22,220
Checksum:iC509AAB68DB7F731
GO
Isoform 6 (identifier: O76036-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: Missing.

Note: No experimental confirmation available.
Show »
Length:303
Mass (Da):34,409
Checksum:i94220C5410D12FE4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01863382K → Q.Corresponds to variant rs2278428dbSNPEnsembl.1
Natural variantiVAR_03552787D → Y in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01040612 – 118Missing in isoform 5. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_01040725 – 119Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_010408228 – 244Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_038384228Missing in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006121 mRNA. Translation: CAA06872.1.
AJ006122 mRNA. Translation: CAA06873.1.
AJ006123 mRNA. Translation: CAA06874.1.
AJ001383 mRNA. Translation: CAA04714.1.
AY346373 mRNA. Translation: AAQ54328.1.
CU151839 Genomic DNA. Translation: CAQ09214.1.
CU151839 Genomic DNA. Translation: CAQ09215.1.
CU151839 Genomic DNA. Translation: CAQ09216.1.
CU151839 Genomic DNA. Translation: CAQ09217.1.
CU459006 Genomic DNA. Translation: CAX14949.1.
CU459006 Genomic DNA. Translation: CAX14950.1.
CU459006 Genomic DNA. Translation: CAX14951.1.
CU459006 Genomic DNA. Translation: CAX14952.1.
CH471135 Genomic DNA. Translation: EAW72308.1.
CH471135 Genomic DNA. Translation: EAW72310.1.
CH471135 Genomic DNA. Translation: EAW72311.1.
BC064806 mRNA. Translation: AAH64806.1.
CCDSiCCDS12911.1. [O76036-1]
CCDS46181.1. [O76036-6]
CCDS46182.1. [O76036-2]
CCDS56103.1. [O76036-3]
RefSeqiNP_001138929.2. NM_001145457.2.
NP_001138930.2. NM_001145458.2.
NP_001229285.1. NM_001242356.2. [O76036-3]
NP_001229286.1. NM_001242357.2. [O76036-4]
NP_004820.2. NM_004829.6.
UniGeneiHs.97084.

Genome annotation databases

EnsembliENST00000350790; ENSP00000344358; ENSG00000189430. [O76036-3]
ENST00000357397; ENSP00000349972; ENSG00000189430. [O76036-5]
ENST00000610621; ENSP00000483452; ENSG00000273535. [O76036-1]
ENST00000610753; ENSP00000484377; ENSG00000273535. [O76036-3]
ENST00000611098; ENSP00000479222; ENSG00000275156. [O76036-5]
ENST00000611105; ENSP00000483028; ENSG00000278362. [O76036-3]
ENST00000611561; ENSP00000478731; ENSG00000274053. [O76036-1]
ENST00000611942; ENSP00000483723; ENSG00000275156. [O76036-2]
ENST00000612239; ENSP00000481692; ENSG00000275156. [O76036-6]
ENST00000612384; ENSP00000482554; ENSG00000273506. [O76036-3]
ENST00000612403; ENSP00000479525; ENSG00000277629. [O76036-1]
ENST00000612577; ENSP00000479705; ENSG00000273916. [O76036-3]
ENST00000612645; ENSP00000481540; ENSG00000275156. [O76036-3]
ENST00000612896; ENSP00000484520; ENSG00000278362. [O76036-1]
ENST00000613135; ENSP00000480145; ENSG00000278362. [O76036-5]
ENST00000613294; ENSP00000482677; ENSG00000274053. [O76036-5]
ENST00000613556; ENSP00000482092; ENSG00000273535. [O76036-5]
ENST00000613768; ENSP00000483840; ENSG00000277824. [O76036-5]
ENST00000614638; ENSP00000479048; ENSG00000273916. [O76036-2]
ENST00000615207; ENSP00000479600; ENSG00000275822. [O76036-5]
ENST00000615622; ENSP00000478507; ENSG00000273535. [O76036-1]
ENST00000615651; ENSP00000482380; ENSG00000273916. [O76036-5]
ENST00000615717; ENSP00000480947; ENSG00000277824. [O76036-1]
ENST00000616307; ENSP00000481747; ENSG00000275822. [O76036-1]
ENST00000616677; ENSP00000479388; ENSG00000273506. [O76036-5]
ENST00000617145; ENSP00000484779; ENSG00000277824. [O76036-3]
ENST00000617154; ENSP00000481971; ENSG00000275156. [O76036-1]
ENST00000617304; ENSP00000480010; ENSG00000273506. [O76036-2]
ENST00000617784; ENSP00000482423; ENSG00000278362. [O76036-1]
ENST00000617861; ENSP00000479809; ENSG00000277824. [O76036-2]
ENST00000617973; ENSP00000481618; ENSG00000275822. [O76036-2]
ENST00000618973; ENSP00000483611; ENSG00000273535. [O76036-2]
ENST00000619067; ENSP00000484071; ENSG00000273506. [O76036-1]
ENST00000619077; ENSP00000484221; ENSG00000273535. [O76036-1]
ENST00000619451; ENSP00000482536; ENSG00000278362. [O76036-6]
ENST00000619679; ENSP00000479416; ENSG00000274053. [O76036-2]
ENST00000620180; ENSP00000482541; ENSG00000274053. [O76036-3]
ENST00000620296; ENSP00000484067; ENSG00000278362. [O76036-2]
ENST00000620757; ENSP00000481235; ENSG00000277629. [O76036-2]
ENST00000620921; ENSP00000482189; ENSG00000275822. [O76036-3]
ENST00000621059; ENSP00000484831; ENSG00000278362. [O76036-4]
ENST00000621164; ENSP00000480657; ENSG00000277629. [O76036-5]
ENST00000621652; ENSP00000477625; ENSG00000273535. [O76036-4]
ENST00000621792; ENSP00000480002; ENSG00000273916. [O76036-1]
ENST00000622270; ENSP00000483184; ENSG00000277629. [O76036-3]
GeneIDi9437.
KEGGihsa:9437.
UCSCiuc002qid.3. human. [O76036-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006121 mRNA. Translation: CAA06872.1.
AJ006122 mRNA. Translation: CAA06873.1.
AJ006123 mRNA. Translation: CAA06874.1.
AJ001383 mRNA. Translation: CAA04714.1.
AY346373 mRNA. Translation: AAQ54328.1.
CU151839 Genomic DNA. Translation: CAQ09214.1.
CU151839 Genomic DNA. Translation: CAQ09215.1.
CU151839 Genomic DNA. Translation: CAQ09216.1.
CU151839 Genomic DNA. Translation: CAQ09217.1.
CU459006 Genomic DNA. Translation: CAX14949.1.
CU459006 Genomic DNA. Translation: CAX14950.1.
CU459006 Genomic DNA. Translation: CAX14951.1.
CU459006 Genomic DNA. Translation: CAX14952.1.
CH471135 Genomic DNA. Translation: EAW72308.1.
CH471135 Genomic DNA. Translation: EAW72310.1.
CH471135 Genomic DNA. Translation: EAW72311.1.
BC064806 mRNA. Translation: AAH64806.1.
CCDSiCCDS12911.1. [O76036-1]
CCDS46181.1. [O76036-6]
CCDS46182.1. [O76036-2]
CCDS56103.1. [O76036-3]
RefSeqiNP_001138929.2. NM_001145457.2.
NP_001138930.2. NM_001145458.2.
NP_001229285.1. NM_001242356.2. [O76036-3]
NP_001229286.1. NM_001242357.2. [O76036-4]
NP_004820.2. NM_004829.6.
UniGeneiHs.97084.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OLLX-ray1.93A25-212[»]
1P6FX-ray2.20A22-263[»]
ProteinModelPortaliO76036.
SMRiO76036.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114828. 5 interactors.
STRINGi9606.ENSP00000291890.

PTM databases

iPTMnetiO76036.
PhosphoSitePlusiO76036.

Proteomic databases

PaxDbiO76036.
PeptideAtlasiO76036.
PRIDEiO76036.

Protocols and materials databases

DNASUi9437.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350790; ENSP00000344358; ENSG00000189430. [O76036-3]
ENST00000357397; ENSP00000349972; ENSG00000189430. [O76036-5]
ENST00000610621; ENSP00000483452; ENSG00000273535. [O76036-1]
ENST00000610753; ENSP00000484377; ENSG00000273535. [O76036-3]
ENST00000611098; ENSP00000479222; ENSG00000275156. [O76036-5]
ENST00000611105; ENSP00000483028; ENSG00000278362. [O76036-3]
ENST00000611561; ENSP00000478731; ENSG00000274053. [O76036-1]
ENST00000611942; ENSP00000483723; ENSG00000275156. [O76036-2]
ENST00000612239; ENSP00000481692; ENSG00000275156. [O76036-6]
ENST00000612384; ENSP00000482554; ENSG00000273506. [O76036-3]
ENST00000612403; ENSP00000479525; ENSG00000277629. [O76036-1]
ENST00000612577; ENSP00000479705; ENSG00000273916. [O76036-3]
ENST00000612645; ENSP00000481540; ENSG00000275156. [O76036-3]
ENST00000612896; ENSP00000484520; ENSG00000278362. [O76036-1]
ENST00000613135; ENSP00000480145; ENSG00000278362. [O76036-5]
ENST00000613294; ENSP00000482677; ENSG00000274053. [O76036-5]
ENST00000613556; ENSP00000482092; ENSG00000273535. [O76036-5]
ENST00000613768; ENSP00000483840; ENSG00000277824. [O76036-5]
ENST00000614638; ENSP00000479048; ENSG00000273916. [O76036-2]
ENST00000615207; ENSP00000479600; ENSG00000275822. [O76036-5]
ENST00000615622; ENSP00000478507; ENSG00000273535. [O76036-1]
ENST00000615651; ENSP00000482380; ENSG00000273916. [O76036-5]
ENST00000615717; ENSP00000480947; ENSG00000277824. [O76036-1]
ENST00000616307; ENSP00000481747; ENSG00000275822. [O76036-1]
ENST00000616677; ENSP00000479388; ENSG00000273506. [O76036-5]
ENST00000617145; ENSP00000484779; ENSG00000277824. [O76036-3]
ENST00000617154; ENSP00000481971; ENSG00000275156. [O76036-1]
ENST00000617304; ENSP00000480010; ENSG00000273506. [O76036-2]
ENST00000617784; ENSP00000482423; ENSG00000278362. [O76036-1]
ENST00000617861; ENSP00000479809; ENSG00000277824. [O76036-2]
ENST00000617973; ENSP00000481618; ENSG00000275822. [O76036-2]
ENST00000618973; ENSP00000483611; ENSG00000273535. [O76036-2]
ENST00000619067; ENSP00000484071; ENSG00000273506. [O76036-1]
ENST00000619077; ENSP00000484221; ENSG00000273535. [O76036-1]
ENST00000619451; ENSP00000482536; ENSG00000278362. [O76036-6]
ENST00000619679; ENSP00000479416; ENSG00000274053. [O76036-2]
ENST00000620180; ENSP00000482541; ENSG00000274053. [O76036-3]
ENST00000620296; ENSP00000484067; ENSG00000278362. [O76036-2]
ENST00000620757; ENSP00000481235; ENSG00000277629. [O76036-2]
ENST00000620921; ENSP00000482189; ENSG00000275822. [O76036-3]
ENST00000621059; ENSP00000484831; ENSG00000278362. [O76036-4]
ENST00000621164; ENSP00000480657; ENSG00000277629. [O76036-5]
ENST00000621652; ENSP00000477625; ENSG00000273535. [O76036-4]
ENST00000621792; ENSP00000480002; ENSG00000273916. [O76036-1]
ENST00000622270; ENSP00000483184; ENSG00000277629. [O76036-3]
GeneIDi9437.
KEGGihsa:9437.
UCSCiuc002qid.3. human. [O76036-1]

Organism-specific databases

CTDi9437.
DisGeNETi9437.
GeneCardsiNCR1.
HGNCiHGNC:6731. NCR1.
MIMi604530. gene.
neXtProtiNX_O76036.
OpenTargetsiENSG00000189430.
ENSG00000273506.
ENSG00000273535.
ENSG00000273916.
ENSG00000274053.
ENSG00000275156.
ENSG00000275822.
ENSG00000277629.
ENSG00000277824.
ENSG00000278362.
PharmGKBiPA30495.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX2G. Eukaryota.
ENOG4111ACT. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO76036.
KOiK06741.
OMAiYAWSFPS.
OrthoDBiEOG091G0JXB.
PhylomeDBiO76036.
TreeFamiTF336644.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160436-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiNCR1. human.
EvolutionaryTraceiO76036.
GeneWikiiNCR1.
GenomeRNAii9437.
PROiO76036.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189430.
CleanExiHS_NCR1.
ExpressionAtlasiO76036. baseline and differential.
GenevisibleiO76036. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNCTR1_HUMAN
AccessioniPrimary (citable) accession number: O76036
Secondary accession number(s): B0V3L2
, B0V3L3, B0V3L4, B0V3L5, B8JL03, O76016, O76017, O76018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.