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Protein

Annexin A9

Gene

ANXA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.1 Publication

GO - Molecular functioni

  • acetylcholine receptor activity Source: UniProtKB
  • calcium-dependent phospholipid binding Source: InterPro
  • calcium ion binding Source: InterPro
  • phosphatidylserine binding Source: UniProtKB
  • phospholipid binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143412-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A9
Alternative name(s):
Annexin XXXI
Annexin-31
Annexin-9
Pemphaxin
Gene namesi
Name:ANXA9
Synonyms:ANX31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:547. ANXA9.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi8416.
OpenTargetsiENSG00000143412.
PharmGKBiPA24837.

Polymorphism and mutation databases

BioMutaiANXA9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675051 – 345Annexin A9Add BLAST345

Proteomic databases

MaxQBiO76027.
PaxDbiO76027.
PeptideAtlasiO76027.
PRIDEiO76027.

PTM databases

iPTMnetiO76027.
PhosphoSitePlusiO76027.

Expressioni

Tissue specificityi

Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000143412.
CleanExiHS_ANXA9.
GenevisibleiO76027. HS.

Organism-specific databases

HPAiHPA028404.
HPA028698.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPLO604376EBI-720960,EBI-368321

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi114002. 5 interactors.
IntActiO76027. 3 interactors.
MINTiMINT-1415446.
STRINGi9606.ENSP00000357943.

Structurei

3D structure databases

ProteinModelPortaliO76027.
SMRiO76027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 110Annexin 1Add BLAST68
Repeati115 – 182Annexin 2Add BLAST68
Repeati199 – 264Annexin 3Add BLAST66
Repeati272 – 339Annexin 4Add BLAST68

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiO76027.
KOiK17090.
OMAiTQRNPEH.
OrthoDBiEOG091G0B7B.
PhylomeDBiO76027.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009116. AnnexinXXXI.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01812. ANNEXINXXXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTGGKMAP SLTQEILSHL GLASKTAAWG TLGTLRTFLN FSVDKDAQRL
60 70 80 90 100
LRAITGQGVD RSAIVDVLTN RSREQRQLIS RNFQERTQQD LMKSLQAALS
110 120 130 140 150
GNLERIVMAL LQPTAQFDAQ ELRTALKASD SAVDVAIEIL ATRTPPQLQE
160 170 180 190 200
CLAVYKHNFQ VEAVDDITSE TSGILQDLLL ALAKGGRDSY SGIIDYNLAE
210 220 230 240 250
QDVQALQRAE GPSREETWVP VFTQRNPEHL IRVFDQYQRS TGQELEEAVQ
260 270 280 290 300
NRFHGDAQVA LLGLASVIKN TPLYFADKLH QALQETEPNY QVLIRILISR
310 320 330 340
CETDLLSIRA EFRKKFGKSL YSSLQDAVKG DCQSALLALC RAEDM
Length:345
Mass (Da):38,364
Last modified:March 20, 2007 - v3
Checksum:iDF0FE611CA6D56B9
GO

Sequence cautioni

The sequence AAH05830 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA08933 differs from that shown. Reason: Frameshift at position 7.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04825528A → T.Corresponds to variant rs16832595dbSNPEnsembl.1
Natural variantiVAR_048256114T → A.Corresponds to variant rs7536645dbSNPEnsembl.1
Natural variantiVAR_048257119A → T.Corresponds to variant rs16832602dbSNPEnsembl.1
Natural variantiVAR_022814166D → G.3 PublicationsCorresponds to variant rs267733dbSNPEnsembl.1
Natural variantiVAR_031212225R → Q.Corresponds to variant rs7542365dbSNPEnsembl.1
Natural variantiVAR_048258232R → Q.Corresponds to variant rs7542365dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009985 mRNA. Translation: CAA08933.1. Frameshift.
AF230929 mRNA. Translation: AAG16780.1.
AL590133 Genomic DNA. Translation: CAI13335.1.
BC005830 mRNA. Translation: AAH05830.2. Different initiation.
CR536481 mRNA. Translation: CAG38720.1.
CCDSiCCDS975.2.
RefSeqiNP_003559.2. NM_003568.2.
UniGeneiHs.3346.

Genome annotation databases

EnsembliENST00000368947; ENSP00000357943; ENSG00000143412.
GeneIDi8416.
KEGGihsa:8416.
UCSCiuc001ewa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009985 mRNA. Translation: CAA08933.1. Frameshift.
AF230929 mRNA. Translation: AAG16780.1.
AL590133 Genomic DNA. Translation: CAI13335.1.
BC005830 mRNA. Translation: AAH05830.2. Different initiation.
CR536481 mRNA. Translation: CAG38720.1.
CCDSiCCDS975.2.
RefSeqiNP_003559.2. NM_003568.2.
UniGeneiHs.3346.

3D structure databases

ProteinModelPortaliO76027.
SMRiO76027.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114002. 5 interactors.
IntActiO76027. 3 interactors.
MINTiMINT-1415446.
STRINGi9606.ENSP00000357943.

PTM databases

iPTMnetiO76027.
PhosphoSitePlusiO76027.

Polymorphism and mutation databases

BioMutaiANXA9.

Proteomic databases

MaxQBiO76027.
PaxDbiO76027.
PeptideAtlasiO76027.
PRIDEiO76027.

Protocols and materials databases

DNASUi8416.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368947; ENSP00000357943; ENSG00000143412.
GeneIDi8416.
KEGGihsa:8416.
UCSCiuc001ewa.3. human.

Organism-specific databases

CTDi8416.
DisGeNETi8416.
GeneCardsiANXA9.
HGNCiHGNC:547. ANXA9.
HPAiHPA028404.
HPA028698.
MIMi603319. gene.
neXtProtiNX_O76027.
OpenTargetsiENSG00000143412.
PharmGKBiPA24837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiO76027.
KOiK17090.
OMAiTQRNPEH.
OrthoDBiEOG091G0B7B.
PhylomeDBiO76027.
TreeFamiTF105452.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143412-MONOMER.

Miscellaneous databases

ChiTaRSiANXA9. human.
GeneWikiiANXA9.
GenomeRNAii8416.
PROiO76027.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143412.
CleanExiHS_ANXA9.
GenevisibleiO76027. HS.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009116. AnnexinXXXI.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01812. ANNEXINXXXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA9_HUMAN
AccessioniPrimary (citable) accession number: O76027
Secondary accession number(s): Q5SZF1
, Q6FI55, Q9BS00, Q9HBJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.