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Protein

Annexin A9

Gene

ANXA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.1 Publication

GO - Molecular functioni

  • acetylcholine receptor activity Source: UniProtKB
  • calcium-dependent phospholipid binding Source: InterPro
  • calcium ion binding Source: InterPro
  • phosphatidylserine binding Source: UniProtKB
  • phospholipid binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • chemical synaptic transmission, postsynaptic Source: GOC
  • signal transduction Source: GOC
  • single organismal cell-cell adhesion Source: UniProtKB
  • synaptic transmission Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A9
Alternative name(s):
Annexin XXXI
Annexin-31
Annexin-9
Pemphaxin
Gene namesi
Name:ANXA9
Synonyms:ANX31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:547. ANXA9.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • postsynapse Source: GOC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24837.

Polymorphism and mutation databases

BioMutaiANXA9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Annexin A9PRO_0000067505Add
BLAST

Proteomic databases

EPDiO76027.
MaxQBiO76027.
PaxDbiO76027.
PRIDEiO76027.

PTM databases

iPTMnetiO76027.
PhosphoSiteiO76027.

Expressioni

Tissue specificityi

Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).1 Publication

Gene expression databases

BgeeiO76027.
CleanExiHS_ANXA9.
GenevisibleiO76027. HS.

Organism-specific databases

HPAiHPA028404.
HPA028698.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPLO604376EBI-720960,EBI-368321

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi114002. 5 interactions.
IntActiO76027. 3 interactions.
MINTiMINT-1415446.
STRINGi9606.ENSP00000357943.

Structurei

3D structure databases

ProteinModelPortaliO76027.
SMRiO76027. Positions 11-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 11068Annexin 1Add
BLAST
Repeati115 – 18268Annexin 2Add
BLAST
Repeati199 – 26466Annexin 3Add
BLAST
Repeati272 – 33968Annexin 4Add
BLAST

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiO76027.
KOiK17090.
OMAiTQRNPEH.
OrthoDBiEOG74XS72.
PhylomeDBiO76027.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009116. AnnexinXXXI.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01812. ANNEXINXXXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTGGKMAP SLTQEILSHL GLASKTAAWG TLGTLRTFLN FSVDKDAQRL
60 70 80 90 100
LRAITGQGVD RSAIVDVLTN RSREQRQLIS RNFQERTQQD LMKSLQAALS
110 120 130 140 150
GNLERIVMAL LQPTAQFDAQ ELRTALKASD SAVDVAIEIL ATRTPPQLQE
160 170 180 190 200
CLAVYKHNFQ VEAVDDITSE TSGILQDLLL ALAKGGRDSY SGIIDYNLAE
210 220 230 240 250
QDVQALQRAE GPSREETWVP VFTQRNPEHL IRVFDQYQRS TGQELEEAVQ
260 270 280 290 300
NRFHGDAQVA LLGLASVIKN TPLYFADKLH QALQETEPNY QVLIRILISR
310 320 330 340
CETDLLSIRA EFRKKFGKSL YSSLQDAVKG DCQSALLALC RAEDM
Length:345
Mass (Da):38,364
Last modified:March 20, 2007 - v3
Checksum:iDF0FE611CA6D56B9
GO

Sequence cautioni

The sequence AAH05830.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA08933.1 differs from that shown. Reason: Frameshift at position 7. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281A → T.
Corresponds to variant rs16832595 [ dbSNP | Ensembl ].
VAR_048255
Natural varianti114 – 1141T → A.
Corresponds to variant rs7536645 [ dbSNP | Ensembl ].
VAR_048256
Natural varianti119 – 1191A → T.
Corresponds to variant rs16832602 [ dbSNP | Ensembl ].
VAR_048257
Natural varianti166 – 1661D → G.3 Publications
Corresponds to variant rs267733 [ dbSNP | Ensembl ].
VAR_022814
Natural varianti225 – 2251R → Q.
Corresponds to variant rs7542365 [ dbSNP | Ensembl ].
VAR_031212
Natural varianti232 – 2321R → Q.
Corresponds to variant rs7542365 [ dbSNP | Ensembl ].
VAR_048258

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009985 mRNA. Translation: CAA08933.1. Frameshift.
AF230929 mRNA. Translation: AAG16780.1.
AL590133 Genomic DNA. Translation: CAI13335.1.
BC005830 mRNA. Translation: AAH05830.2. Different initiation.
CR536481 mRNA. Translation: CAG38720.1.
CCDSiCCDS975.2.
RefSeqiNP_003559.2. NM_003568.2.
UniGeneiHs.3346.

Genome annotation databases

EnsembliENST00000368947; ENSP00000357943; ENSG00000143412.
GeneIDi8416.
KEGGihsa:8416.
UCSCiuc001ewa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009985 mRNA. Translation: CAA08933.1. Frameshift.
AF230929 mRNA. Translation: AAG16780.1.
AL590133 Genomic DNA. Translation: CAI13335.1.
BC005830 mRNA. Translation: AAH05830.2. Different initiation.
CR536481 mRNA. Translation: CAG38720.1.
CCDSiCCDS975.2.
RefSeqiNP_003559.2. NM_003568.2.
UniGeneiHs.3346.

3D structure databases

ProteinModelPortaliO76027.
SMRiO76027. Positions 11-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114002. 5 interactions.
IntActiO76027. 3 interactions.
MINTiMINT-1415446.
STRINGi9606.ENSP00000357943.

PTM databases

iPTMnetiO76027.
PhosphoSiteiO76027.

Polymorphism and mutation databases

BioMutaiANXA9.

Proteomic databases

EPDiO76027.
MaxQBiO76027.
PaxDbiO76027.
PRIDEiO76027.

Protocols and materials databases

DNASUi8416.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368947; ENSP00000357943; ENSG00000143412.
GeneIDi8416.
KEGGihsa:8416.
UCSCiuc001ewa.3. human.

Organism-specific databases

CTDi8416.
GeneCardsiANXA9.
HGNCiHGNC:547. ANXA9.
HPAiHPA028404.
HPA028698.
MIMi603319. gene.
neXtProtiNX_O76027.
PharmGKBiPA24837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiO76027.
KOiK17090.
OMAiTQRNPEH.
OrthoDBiEOG74XS72.
PhylomeDBiO76027.
TreeFamiTF105452.

Miscellaneous databases

ChiTaRSiANXA9. human.
GeneWikiiANXA9.
GenomeRNAii8416.
NextBioi31500.
PROiO76027.
SOURCEiSearch...

Gene expression databases

BgeeiO76027.
CleanExiHS_ANXA9.
GenevisibleiO76027. HS.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009116. AnnexinXXXI.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01812. ANNEXINXXXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression profile and structural divergence of novel human annexin 31."
    Morgan R.O., Fernandez M.-P.
    FEBS Lett. 434:300-304(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-166.
    Tissue: Liver and Spleen.
  2. "Pemphigus vulgaris antibody identifies pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine."
    Nguyen V.T., Ndoye A., Grando S.A.
    J. Biol. Chem. 275:29466-29476(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-166, TISSUE SPECIFICITY, FUNCTION, SUBUNIT, IDENTIFICATION AS AN AUTOANTIGEN IN PV.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-345, VARIANT GLY-166.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiANXA9_HUMAN
AccessioniPrimary (citable) accession number: O76027
Secondary accession number(s): Q5SZF1
, Q6FI55, Q9BS00, Q9HBJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: March 20, 2007
Last modified: May 11, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.