O76027 (ANXA9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Annexin A9

Alternative name(s):
Annexin XXXI
Annexin-31
Annexin-9
Pemphaxin

Gene names

Name:	ANXA9
Synonyms:	ANX31

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes. Ref.2
Subunit structure	Homodimer. Ref.2
Tissue specificity	Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level). Ref.2
Sequence similarities	Belongs to the annexin family. Contains 4 annexin repeats.
Sequence caution	The sequence AAH05830.2 differs from that shown. Reason: Erroneous initiation. The sequence CAA08933.1 differs from that shown. Reason: Frameshift at position 7.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Annexin Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell adhesion Inferred from direct assay Ref.2. Source: UniProtKB
Cellular_component	cell surface Inferred from direct assay Ref.2. Source: UniProtKB cytosol Inferred from direct assay PubMed 12832069. Source: UniProtKB
Molecular_function	acetylcholine receptor activity Inferred from direct assay Ref.2. Source: UniProtKB calcium ion binding Inferred from electronic annotation. Source: InterPro calcium-dependent phospholipid binding Inferred from electronic annotation. Source: InterPro phosphatidylserine binding Inferred from direct assay PubMed 12832069. Source: UniProtKB protein homodimerization activity Traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Annexin A9		PRO_0000067505
Regions
	Repeat	43 – 110	68	Annexin 1
	Repeat	115 – 182	68	Annexin 2
	Repeat	199 – 264	66	Annexin 3
	Repeat	272 – 339	68	Annexin 4
Natural variations
	Natural variant	28	1	A → T. Corresponds to variant rs16832595 [ dbSNP | Ensembl ].		VAR_048255
	Natural variant	114	1	T → A. Corresponds to variant rs7536645 [ dbSNP | Ensembl ].		VAR_048256
	Natural variant	119	1	A → T. Corresponds to variant rs16832602 [ dbSNP | Ensembl ].		VAR_048257
	Natural variant	166	1	D → G. Ref.1 Ref.2 Ref.5 Corresponds to variant rs267733 [ dbSNP | Ensembl ].		VAR_022814
	Natural variant	225	1	R → Q. Corresponds to variant rs7542365 [ dbSNP | Ensembl ].		VAR_031212
	Natural variant	232	1	R → Q. Corresponds to variant rs7542365 [ dbSNP | Ensembl ].		VAR_048258

Sequences

	Sequence		Length	Mass (Da)
	O76027 [UniParc]. Last modified March 20, 2007. Version 3. Checksum: DF0FE611CA6D56B9	FASTA	345	38,364
	10 20 30 40 50 60 MSVTGGKMAP SLTQEILSHL GLASKTAAWG TLGTLRTFLN FSVDKDAQRL LRAITGQGVD 70 80 90 100 110 120 RSAIVDVLTN RSREQRQLIS RNFQERTQQD LMKSLQAALS GNLERIVMAL LQPTAQFDAQ 130 140 150 160 170 180 ELRTALKASD SAVDVAIEIL ATRTPPQLQE CLAVYKHNFQ VEAVDDITSE TSGILQDLLL 190 200 210 220 230 240 ALAKGGRDSY SGIIDYNLAE QDVQALQRAE GPSREETWVP VFTQRNPEHL IRVFDQYQRS 250 260 270 280 290 300 TGQELEEAVQ NRFHGDAQVA LLGLASVIKN TPLYFADKLH QALQETEPNY QVLIRILISR 310 320 330 340 CETDLLSIRA EFRKKFGKSL YSSLQDAVKG DCQSALLALC RAEDM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression profile and structural divergence of novel human annexin 31." Morgan R.O., Fernandez M.-P. FEBS Lett. 434:300-304(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-166. Tissue: Liver and Spleen.
[2]	"Pemphigus vulgaris antibody identifies pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine." Nguyen V.T., Ndoye A., Grando S.A. J. Biol. Chem. 275:29466-29476(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-166, TISSUE SPECIFICITY, FUNCTION, SUBUNIT, IDENTIFICATION AS AN AUTOANTIGEN IN PV.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-345, VARIANT GLY-166.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ009985 mRNA. Translation: CAA08933.1. Frameshift. AF230929 mRNA. Translation: AAG16780.1. AL590133 Genomic DNA. Translation: CAI13335.1. BC005830 mRNA. Translation: AAH05830.2. Different initiation. CR536481 mRNA. Translation: CAG38720.1.
IPI	IPI00008714.
RefSeq	NP_003559.2. NM_003568.2.
UniGene	Hs.3346.
3D structure databases
ProteinModelPortal	O76027.
ModBase	Search...
Protein-protein interaction databases
IntAct	O76027. 2 interactions.
MINT	MINT-1415446.
STRING	9606.ENSP00000357943.
PTM databases
PhosphoSite	O76027.
Proteomic databases
PaxDb	O76027.
PRIDE	O76027.
Protocols and materials databases
DNASU	8416.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368947; ENSP00000357943; ENSG00000143412.
GeneID	8416.
KEGG	hsa:8416.
UCSC	uc001ewa.2. human.
Organism-specific databases
CTD	8416.
GeneCards	GC01P150954.
HGNC	HGNC:547. ANXA9.
HPA	HPA028404. HPA028698.
MIM	603319. gene.
neXtProt	NX_O76027.
PharmGKB	PA24837.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303047.
HOGENOM	HOG000158803.
HOVERGEN	HBG061815.
InParanoid	O76027.
OMA	LQETEPN.
OrthoDB	EOG490799.
Gene expression databases
Bgee	O76027.
CleanEx	HS_ANXA9.
Genevestigator	O76027.
GermOnline	ENSG00000143412. Homo sapiens.
Family and domain databases
Gene3D	1.10.220.10. 4 hits.
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR009116. AnnexinXXXI. [Graphical view]
PANTHER	PTHR10502. PTHR10502. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR01812. ANNEXINXXXI.
SMART	SM00335. ANX. 4 hits. [Graphical view]
SUPFAM	SSF47874. Annexin. 1 hit.
PROSITE	PS00223. ANNEXIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8416.
NextBio	31500.
SOURCE	Search...

Entry information

Entry name

ANXA9_HUMAN

Accession

Primary (citable) accession number: O76027
Secondary accession number(s): Q5SZF1 , Q6FI55, Q9BS00, Q9HBJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	March 20, 2007
Last modified:	May 1, 2013
This is version 116 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.