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Protein

Ribosomal L1 domain-containing protein 1

Gene

RSL1D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.2 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: GO_Central

GO - Biological processi

  • maturation of LSU-rRNA Source: GO_Central
  • osteoblast differentiation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of cellular senescence Source: UniProtKB
  • regulation of protein localization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal L1 domain-containing protein 1
Alternative name(s):
CATX-11
Cellular senescence-inhibited gene protein1 Publication
Protein PBK1
Gene namesi
Name:RSL1D1
Synonyms:CATX11, CSIG1 Publication, PBK1
ORF Names:L12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24534. RSL1D1.

Subcellular locationi

GO - Cellular componenti

  • 90S preribosome Source: GO_Central
  • cell-cell adherens junction Source: BHF-UCL
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670966.

Chemistry

ChEMBLiCHEMBL1075139.

Polymorphism and mutation databases

BioMutaiRSL1D1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Ribosomal L1 domain-containing protein 1PRO_0000125844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources1 Publication
Modified residuei340 – 3401PhosphothreonineCombined sources
Modified residuei358 – 3581PhosphothreonineCombined sources
Modified residuei361 – 3611PhosphoserineCombined sources
Modified residuei375 – 3751PhosphothreonineCombined sources
Modified residuei392 – 3921PhosphoserineCombined sources
Modified residuei396 – 3961PhosphoserineCombined sources
Modified residuei415 – 4151PhosphothreonineCombined sources
Modified residuei423 – 4231PhosphothreonineCombined sources
Modified residuei427 – 4271PhosphoserineCombined sources
Cross-linki435 – 435Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei443 – 4431PhosphoserineCombined sources
Modified residuei465 – 4651PhosphothreonineCombined sources
Modified residuei468 – 4681N6-acetyllysineCombined sources
Modified residuei469 – 4691PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO76021.
MaxQBiO76021.
PaxDbiO76021.
PeptideAtlasiO76021.
PRIDEiO76021.

2D gel databases

SWISS-2DPAGEO76021.

PTM databases

iPTMnetiO76021.
PhosphoSiteiO76021.
SwissPalmiO76021.

Expressioni

Tissue specificityi

Expressed at high intensities in the heart, skeletal muscle, and placenta.2 Publications

Inductioni

Down-regulated during cellular senescence.1 Publication

Gene expression databases

BgeeiENSG00000171490.
CleanExiHS_RSL1D1.
ExpressionAtlasiO76021. baseline and differential.
GenevisibleiO76021. HS.

Organism-specific databases

HPAiHPA043483.

Interactioni

Subunit structurei

Interacts with ING1 (isoform 2).1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi117587. 69 interactions.
IntActiO76021. 36 interactions.
MINTiMINT-1139726.
STRINGi9606.ENSP00000460871.

Structurei

3D structure databases

ProteinModelPortaliO76021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili280 – 31334Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1685. Eukaryota.
ENOG4111W39. LUCA.
GeneTreeiENSGT00440000038603.
HOVERGENiHBG054786.
InParanoidiO76021.
KOiK14775.
OMAiNENFFLM.
OrthoDBiEOG091G0MY8.
PhylomeDBiO76021.
TreeFamiTF354254.

Family and domain databases

CDDicd00403. Ribosomal_L1. 1 hit.
Gene3Di3.30.190.20. 1 hit.
InterProiIPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
SUPFAMiSSF56808. SSF56808. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O76021-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDSASASLS SAAATGTSTS TPAAPTARKQ LDKEQVRKAV DALLTHCKSR
60 70 80 90 100
KNNYGLLLNE NESLFLMVVL WKIPSKELRV RLTLPHSIRS DSEDICLFTK
110 120 130 140 150
DEPNSTPEKT EQFYRKLLNK HGIKTVSQII SLQTLKKEYK SYEAKLRLLS
160 170 180 190 200
SFDFFLTDAR IRRLLPSLIG RHFYQRKKVP VSVNLLSKNL SREINDCIGG
210 220 230 240 250
TVLNISKSGS CSAIRIGHVG MQIEHIIENI VAVTKGLSEK LPEKWESVKL
260 270 280 290 300
LFVKTEKSAA LPIFSSFVSN WDEATKRSLL NKKKKEARRK RRERNFEKQK
310 320 330 340 350
ERKKKRQQAR KTASVLSKDD VAPESGDTTV KKPESKKEQT PEHGKKKRGR
360 370 380 390 400
GKAQVKATNE SEDEIPQLVP IGKKTPANEK VEIQKHATGK KSPAKSPNPS
410 420 430 440 450
TPRGKKRKAL PASETPKAAE SETPGKSPEK KPKIKEEAVK EKSPSLGKKD
460 470 480 490
ARQTPKKPEA KFFTTPSKSV RKASHTPKKW PKKPKVPQST
Length:490
Mass (Da):54,973
Last modified:April 26, 2005 - v3
Checksum:i5E5CDB8AA8BC3709
GO
Isoform 2 (identifier: O76021-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-220: Missing.

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):30,354
Checksum:i83491FBC2D92689C
GO

Sequence cautioni

The sequence AAF98239 differs from that shown. Reason: Frameshift at position 394. Curated
The sequence AAH19069 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA07491 differs from that shown. Reason: Frameshift at position 486. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501R → G in AAN46298 (Ref. 3) Curated
Sequence conflicti189 – 1891N → D in CAB43231 (PubMed:17974005).Curated
Sequence conflicti294 – 2941R → G in AAN46298 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 220220Missing in isoform 2. 1 PublicationVSP_056143Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007398 mRNA. Translation: CAA07491.1. Frameshift.
AY598331 mRNA. Translation: AAT06742.1.
AY154473 mRNA. Translation: AAN46298.1.
AK295935 mRNA. Translation: BAG58720.1.
AC010654 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85133.1.
CH471112 Genomic DNA. Translation: EAW85135.1.
BC019069 mRNA. Translation: AAH19069.2. Different initiation.
BC112228 mRNA. Translation: AAI12229.1.
BC113699 mRNA. Translation: AAI13700.1.
AL049999 mRNA. Translation: CAB43231.2.
AF083127 mRNA. Translation: AAF98239.1. Frameshift.
CCDSiCCDS10551.1. [O76021-1]
PIRiT08693.
RefSeqiNP_056474.2. NM_015659.2. [O76021-1]
UniGeneiHs.401842.

Genome annotation databases

EnsembliENST00000571133; ENSP00000460871; ENSG00000171490. [O76021-1]
GeneIDi26156.
KEGGihsa:26156.
UCSCiuc002dbp.3. human. [O76021-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007398 mRNA. Translation: CAA07491.1. Frameshift.
AY598331 mRNA. Translation: AAT06742.1.
AY154473 mRNA. Translation: AAN46298.1.
AK295935 mRNA. Translation: BAG58720.1.
AC010654 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85133.1.
CH471112 Genomic DNA. Translation: EAW85135.1.
BC019069 mRNA. Translation: AAH19069.2. Different initiation.
BC112228 mRNA. Translation: AAI12229.1.
BC113699 mRNA. Translation: AAI13700.1.
AL049999 mRNA. Translation: CAB43231.2.
AF083127 mRNA. Translation: AAF98239.1. Frameshift.
CCDSiCCDS10551.1. [O76021-1]
PIRiT08693.
RefSeqiNP_056474.2. NM_015659.2. [O76021-1]
UniGeneiHs.401842.

3D structure databases

ProteinModelPortaliO76021.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117587. 69 interactions.
IntActiO76021. 36 interactions.
MINTiMINT-1139726.
STRINGi9606.ENSP00000460871.

Chemistry

ChEMBLiCHEMBL1075139.

PTM databases

iPTMnetiO76021.
PhosphoSiteiO76021.
SwissPalmiO76021.

Polymorphism and mutation databases

BioMutaiRSL1D1.

2D gel databases

SWISS-2DPAGEO76021.

Proteomic databases

EPDiO76021.
MaxQBiO76021.
PaxDbiO76021.
PeptideAtlasiO76021.
PRIDEiO76021.

Protocols and materials databases

DNASUi26156.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000571133; ENSP00000460871; ENSG00000171490. [O76021-1]
GeneIDi26156.
KEGGihsa:26156.
UCSCiuc002dbp.3. human. [O76021-1]

Organism-specific databases

CTDi26156.
GeneCardsiRSL1D1.
HGNCiHGNC:24534. RSL1D1.
HPAiHPA043483.
MIMi615874. gene.
neXtProtiNX_O76021.
PharmGKBiPA142670966.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1685. Eukaryota.
ENOG4111W39. LUCA.
GeneTreeiENSGT00440000038603.
HOVERGENiHBG054786.
InParanoidiO76021.
KOiK14775.
OMAiNENFFLM.
OrthoDBiEOG091G0MY8.
PhylomeDBiO76021.
TreeFamiTF354254.

Miscellaneous databases

ChiTaRSiRSL1D1. human.
GeneWikiiRSL1D1.
GenomeRNAii26156.
PROiO76021.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171490.
CleanExiHS_RSL1D1.
ExpressionAtlasiO76021. baseline and differential.
GenevisibleiO76021. HS.

Family and domain databases

CDDicd00403. Ribosomal_L1. 1 hit.
Gene3Di3.30.190.20. 1 hit.
InterProiIPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
SUPFAMiSSF56808. SSF56808. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL1D1_HUMAN
AccessioniPrimary (citable) accession number: O76021
Secondary accession number(s): B4DJ58
, D3DUG7, Q2M1T7, Q6PL22, Q8IWS7, Q8WUZ1, Q9HDA9, Q9Y3Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.