O76021 (RL1D1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal L1 domain-containing protein 1

Alternative name(s):
CATX-11
Cellular senescence-inhibited gene protein
Protein PBK1

Gene names

Name:	RSL1D1
Synonyms:	CATX11, CSIG, PBK1
ORF Names:	L12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus › nucleolus Ref.9 Ref.10.
Tissue specificity	Placenta. Ref.1
Sequence similarities	Belongs to the ribosomal protein L1P family. Highly divergent.
Sequence caution	The sequence AAF98239.1 differs from that shown. Reason: Frameshift at position 394. The sequence AAH19069.2 differs from that shown. Reason: Erroneous initiation. The sequence CAA07491.1 differs from that shown. Reason: Frameshift at position 486.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Coiled coil
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	regulation of protein localization Inferred from mutant phenotype PubMed 17158916. Source: MGI translation Inferred from electronic annotation. Source: InterPro
Cellular_component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Ribosomal L1 domain-containing protein 1		PRO_0000125844
Regions
	Coiled coil	280 – 313	34	Potential
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.7
	Modified residue	340	1	Phosphothreonine Ref.11 Ref.18
	Modified residue	358	1	Phosphothreonine Ref.15 Ref.20
	Modified residue	361	1	Phosphoserine Ref.15 Ref.16 Ref.18 Ref.20
	Modified residue	375	1	Phosphothreonine Ref.18
	Modified residue	392	1	Phosphoserine Ref.12 Ref.15 Ref.18
	Modified residue	396	1	Phosphoserine Ref.12 Ref.15 Ref.20
	Modified residue	415	1	Phosphothreonine Ref.15
	Modified residue	423	1	Phosphothreonine Ref.12 Ref.15
	Modified residue	427	1	Phosphoserine Ref.11 Ref.12 Ref.14 Ref.15 Ref.18 Ref.20
	Modified residue	443	1	Phosphoserine Ref.15
	Modified residue	465	1	Phosphothreonine Ref.15
	Modified residue	468	1	N6-acetyllysine Ref.17
	Modified residue	469	1	Phosphoserine Ref.12 Ref.15
Experimental info
	Sequence conflict	50	1	R → G in AAN46298. Ref.3
	Sequence conflict	189	1	N → D in CAB43231. Ref.6
	Sequence conflict	294	1	R → G in AAN46298. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O76021 [UniParc]. Last modified April 26, 2005. Version 3. Checksum: 5E5CDB8AA8BC3709	FASTA	490	54,973
	10 20 30 40 50 60 MEDSASASLS SAAATGTSTS TPAAPTARKQ LDKEQVRKAV DALLTHCKSR KNNYGLLLNE 70 80 90 100 110 120 NESLFLMVVL WKIPSKELRV RLTLPHSIRS DSEDICLFTK DEPNSTPEKT EQFYRKLLNK 130 140 150 160 170 180 HGIKTVSQII SLQTLKKEYK SYEAKLRLLS SFDFFLTDAR IRRLLPSLIG RHFYQRKKVP 190 200 210 220 230 240 VSVNLLSKNL SREINDCIGG TVLNISKSGS CSAIRIGHVG MQIEHIIENI VAVTKGLSEK 250 260 270 280 290 300 LPEKWESVKL LFVKTEKSAA LPIFSSFVSN WDEATKRSLL NKKKKEARRK RRERNFEKQK 310 320 330 340 350 360 ERKKKRQQAR KTASVLSKDD VAPESGDTTV KKPESKKEQT PEHGKKKRGR GKAQVKATNE 370 380 390 400 410 420 SEDEIPQLVP IGKKTPANEK VEIQKHATGK KSPAKSPNPS TPRGKKRKAL PASETPKAAE 430 440 450 460 470 480 SETPGKSPEK KPKIKEEAVK EKSPSLGKKD ARQTPKKPEA KFFTTPSKSV RKASHTPKKW 490 PKKPKVPQST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of differentially expressed genes in human trophoblast cells by DDRT-PCR." Huch G., Hohn H.-P., Denker H.-W. Placenta 19:557-567(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer." Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P. Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification of a new gene associated with cellular senescence in human diploid fibroblast." Guo S.-Z., Zhang Z.-Y., Tong T.-J. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-290. Tissue: Brain.
[7]	Bienvenut W.V., Waridel P., Quadroni M. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1-28; 90-100; 125-136; 148-160; 164-171; 179-188; 193-207 AND 258-276, ACETYLATION AT MET-1, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Isolation of novel genes from human colonic epithelial cells." Kairo A., Wang L., Gao Z.Q., Gao Z.P., Boman B.M. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 76-401. Tissue: Colon.
[9]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Directed proteomic analysis of the human nucleolus." Andersen J.S., Lyon C.E., Fox A.H., Leung A.K.L., Lam Y.W., Steen H., Mann M., Lamond A.I. Curr. Biol. 12:1-11(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-340 AND SER-427, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392; SER-396; THR-423; SER-427 AND SER-469, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: T-cell.
[14]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-358; SER-361; SER-392; SER-396; THR-415; THR-423; SER-427; SER-443; THR-465 AND SER-469, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[17]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-468, MASS SPECTROMETRY.
[18]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-340; SER-361; THR-375; SER-392 AND SER-427, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[19]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-358; SER-361; SER-396 AND SER-427, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ007398 mRNA. Translation: CAA07491.1. Frameshift. AY598331 mRNA. Translation: AAT06742.1. AY154473 mRNA. Translation: AAN46298.1. CH471112 Genomic DNA. Translation: EAW85133.1. CH471112 Genomic DNA. Translation: EAW85135.1. BC019069 mRNA. Translation: AAH19069.2. Different initiation. BC112228 mRNA. Translation: AAI12229.1. BC113699 mRNA. Translation: AAI13700.1. AL049999 mRNA. Translation: CAB43231.2. AF083127 mRNA. Translation: AAF98239.1. Frameshift.
IPI	IPI00008708.
PIR	T08693.
RefSeq	NP_056474.2. NM_015659.2.
UniGene	Hs.401842.
3D structure databases
ProteinModelPortal	O76021.
ModBase	Search...
Protein-protein interaction databases
IntAct	O76021. 17 interactions.
MINT	MINT-1139726.
STRING	9606.ENSP00000379760.
PTM databases
PhosphoSite	O76021.
2D gel databases
SWISS-2DPAGE	O76021.
Proteomic databases
PaxDb	O76021.
PRIDE	O76021.
Protocols and materials databases
DNASU	26156.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000571133; ENSP00000460871; ENSG00000171490.
GeneID	26156.
KEGG	hsa:26156.
UCSC	uc002dbp.1. human.
Organism-specific databases
CTD	26156.
GeneCards	GC16M011930.
HGNC	HGNC:24534. RSL1D1.
HPA	HPA043483.
neXtProt	NX_O76021.
PharmGKB	PA142670966.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG247516.
HOVERGEN	HBG054786.
InParanoid	O76021.
KO	K14775.
OMA	VLWKIPS.
OrthoDB	EOG4V9TQR.
Gene expression databases
ArrayExpress	O76021.
Bgee	O76021.
CleanEx	HS_RSL1D1.
Genevestigator	O76021.
GermOnline	ENSG00000171490. Homo sapiens.
Family and domain databases
Gene3D	3.30.190.20. 1 hit.
InterPro	IPR002143. Ribosomal_L1. IPR016094. Ribosomal_L1_2-a/b-sand. IPR023674. Ribosomal_L1_SF. [Graphical view]
Pfam	PF00687. Ribosomal_L1. 1 hit. [Graphical view]
SUPFAM	SSF56808. Ribosomal_L1. 1 hit.
ProtoNet	Search...
Other
ChEMBL	CHEMBL1075139.
GenomeRNAi	26156.
NextBio	48251.

Entry information

Entry name

RL1D1_HUMAN

Accession

Primary (citable) accession number: O76021
Secondary accession number(s): D3DUG7 , Q2M1T7, Q6PL22, Q8IWS7, Q8WUZ1, Q9HDA9, Q9Y3Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 113 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.