O76015 (KRT38_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cuticular Ha8

Alternative name(s):
Hair keratin, type I Ha8
Keratin-38
Short name=K38

Gene names

Name:	KRT38
Synonyms:	HHA8, HKA8, KRTHA8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural molecule activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Keratin, type I cuticular Ha8		PRO_0000063695
Regions
	Region	1 – 104	104	Head
	Region	105 – 411	307	Rod
	Region	105 – 139	35	Coil 1A
	Region	140 – 150	11	Linker 1
	Region	151 – 251	101	Coil 1B
	Region	252 – 267	16	Linker 12
	Region	268 – 411	144	Coil 2
	Region	412 – 456	45	Tail
Sites
	Site	353	1	Stutter
Natural variations
	Natural variant	423	1	S → P. Ref.1 Ref.4 Ref.5 Ref.6 Corresponds to variant rs897416 [ dbSNP | Ensembl ].		VAR_055137
Experimental info
	Sequence conflict	113	1	D → G in CAH10351. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	O76015 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: 8AE2E9BE95FC8E72	FASTA	456	50,480
	10 20 30 40 50 60 MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA HANRVRVGST 70 80 90 100 110 120 PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL NGHEKETMQF LNDRLANYLE 130 140 150 160 170 180 KVRQLEQENA ELEATLLERS KCHESTVCPD YQSYFHTIEE LQQKILCSKA ENARLIVQID 190 200 210 220 230 240 NAKLAADDFR IKLESERSLR QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS 250 260 270 280 290 300 NHEQEVKILR SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE 310 320 330 340 350 360 GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRFGTELA 370 380 390 400 410 420 QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE IATYRNLLES EDCKLPCNPC 430 440 450 STSPSCVTAP CAPRPSCGPC TTCGPTCGAS TTGSRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-423.
[2]	Schweizer J. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-423.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-423.
[6]	"The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain." Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J. Differentiation 72:527-540(2004) [PubMed: 15617563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-456, VARIANT PRO-423. Tissue: Scalp.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y16794 Genomic DNA. Translation: CAA76390.2. AC019349 Genomic DNA. No translation available. CH471152 Genomic DNA. Translation: EAW60734.1. BC131715 mRNA. Translation: AAI31716.1. AJ786656 mRNA. Translation: CAH10351.1.
IPI	IPI00297641.
RefSeq	NP_006762.3. NM_006771.3.
UniGene	Hs.248188.
3D structure databases
ProteinModelPortal	O76015.
SMR	O76015. Positions 102-139, 149-252, 267-410.
ModBase	Search...
Protein-protein interaction databases
STRING	O76015.
Proteomic databases
PRIDE	O76015.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000246646; ENSP00000246646; ENSG00000171360.
GeneID	8687.
KEGG	hsa:8687.
Organism-specific databases
CTD	8687.
GeneCards	GC17M039592.
H-InvDB	HIX0039116.
HGNC	HGNC:6456. KRT38.
MIM	604542. gene.
neXtProt	NX_O76015.
PharmGKB	PA30245.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07374.
GeneTree	ENSGT00560000076638.
HOGENOM	HBG715391.
HOVERGEN	HBG013015.
InParanoid	O76015.
OMA	HESELSL.
OrthoDB	EOG4DNF4J.
PhylomeDB	O76015.
Gene expression databases
ArrayExpress	O76015.
CleanEx	HS_KRT38.
Genevestigator	O76015.
GermOnline	ENSG00000171360. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
KO	K07604.
PANTHER	PTHR23239. IF. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

KRT38_HUMAN

Accession

Primary (citable) accession number: O76015
Secondary accession number(s): A2RRM5, Q6A164

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 5, 2009
Last modified:	January 25, 2012
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.