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Protein

Keratin, type I cuticular Ha8

Gene

KRT38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei353Stutter1

GO - Molecular functioni

  • structural molecule activity Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171360-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha8
Alternative name(s):
Hair keratin, type I Ha8
Keratin-38
Short name:
K38
Gene namesi
Name:KRT38
Synonyms:HHA8, HKA8, KRTHA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6456. KRT38.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171360.
PharmGKBiPA30245.

Polymorphism and mutation databases

BioMutaiKRT38.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636951 – 456Keratin, type I cuticular Ha8Add BLAST456

Proteomic databases

PaxDbiO76015.
PeptideAtlasiO76015.
PRIDEiO76015.

PTM databases

iPTMnetiO76015.
PhosphoSitePlusiO76015.

Expressioni

Gene expression databases

BgeeiENSG00000171360.
CleanExiHS_KRT38.
GenevisibleiO76015. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K2R33EBI-1047263,EBI-9977437
AMOTL2Q9Y2J4-43EBI-1047263,EBI-10187270
ANKRD36BP1Q96IX95EBI-1047263,EBI-744859
BEX2Q9BXY83EBI-1047263,EBI-745073
C19orf57Q0VDD73EBI-1047263,EBI-741210
C1orf216Q8TAB55EBI-1047263,EBI-747505
CCDC146Q8IYE0-24EBI-1047263,EBI-10247802
CD300AQ9UGN43EBI-1047263,EBI-10320732
CEP57L1Q8IYX8-23EBI-1047263,EBI-10181988
DKFZp451B226Q5HYH73EBI-1047263,EBI-10173842
FAM90A1Q86YD73EBI-1047263,EBI-6658203
GLRX3O760033EBI-1047263,EBI-374781
GNG10P501513EBI-1047263,EBI-10211741
HAUS1Q96CS23EBI-1047263,EBI-2514791
HDAC4P565243EBI-1047263,EBI-308629
HGSO149645EBI-1047263,EBI-740220
HMG20BQ9P0W24EBI-1047263,EBI-713401
HOXA1P496395EBI-1047263,EBI-740785
KLHL38Q2WGJ65EBI-1047263,EBI-6426443
KRT2P359085EBI-1047263,EBI-1247312
KRT4P190135EBI-1047263,EBI-2371606
KRT5P136475EBI-1047263,EBI-702187
KRT6AP025385EBI-1047263,EBI-702198
KRT6BP042595EBI-1047263,EBI-740907
KRT6CP486683EBI-1047263,EBI-2564105
KRT71Q3SY845EBI-1047263,EBI-2952676
KRT79Q5XKE53EBI-1047263,EBI-2514135
KRT8P057875EBI-1047263,EBI-297852
KRT81Q145337EBI-1047263,EBI-739648
KRT83P783855EBI-1047263,EBI-10221390
MAGEB4O154813EBI-1047263,EBI-751857
PIK3R2O004593EBI-1047263,EBI-346930
PIN1Q135265EBI-1047263,EBI-714158
PSMA1P257865EBI-1047263,EBI-359352
PSMC5P621953EBI-1047263,EBI-357745
PTGER3Q147X83EBI-1047263,EBI-10234038
RHPN1-AS1Q9BWJ23EBI-1047263,EBI-10300934
SCNM1Q9BWG65EBI-1047263,EBI-748391
TXLNAP402223EBI-1047263,EBI-359793
TXNDC5Q86UY05EBI-1047263,EBI-2825190
USHBP1Q8N6Y05EBI-1047263,EBI-739895
ZFYVE21Q9BQ243EBI-1047263,EBI-2849569
ZNF20P170243EBI-1047263,EBI-717634
ZNF417Q8TAU33EBI-1047263,EBI-740727
ZNF587Q96SQ53EBI-1047263,EBI-6427977

Protein-protein interaction databases

BioGridi114234. 46 interactors.
IntActiO76015. 69 interactors.

Structurei

3D structure databases

ProteinModelPortaliO76015.
SMRiO76015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 104HeadAdd BLAST104
Regioni105 – 411RodAdd BLAST307
Regioni105 – 139Coil 1AAdd BLAST35
Regioni140 – 150Linker 1Add BLAST11
Regioni151 – 251Coil 1BAdd BLAST101
Regioni252 – 267Linker 12Add BLAST16
Regioni268 – 411Coil 2Add BLAST144
Regioni412 – 456TailAdd BLAST45

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J94T. Eukaryota.
ENOG4111D61. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76015.
KOiK07604.
OMAiCGPCTTC.
OrthoDBiEOG091G05GB.
PhylomeDBiO76015.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA
60 70 80 90 100
HANRVRVGST PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL
110 120 130 140 150
NGHEKETMQF LNDRLANYLE KVRQLEQENA ELEATLLERS KCHESTVCPD
160 170 180 190 200
YQSYFHTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLR
210 220 230 240 250
QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR
260 270 280 290 300
SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE
310 320 330 340 350
GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE
360 370 380 390 400
AEDRFGTELA QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE
410 420 430 440 450
IATYRNLLES EDCKLPCNPC STSPSCVTAP CAPRPSCGPC TTCGPTCGAS

TTGSRF
Length:456
Mass (Da):50,480
Last modified:May 5, 2009 - v3
Checksum:i8AE2E9BE95FC8E72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113D → G in CAH10351 (PubMed:15617563).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055137423S → P.4 PublicationsCorresponds to variant rs897416dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16794 Genomic DNA. Translation: CAA76390.2.
AC019349 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60734.1.
BC131715 mRNA. Translation: AAI31716.1.
AJ786656 mRNA. Translation: CAH10351.1.
CCDSiCCDS11392.1.
RefSeqiNP_006762.3. NM_006771.3.
UniGeneiHs.248188.

Genome annotation databases

EnsembliENST00000246646; ENSP00000246646; ENSG00000171360.
GeneIDi8687.
KEGGihsa:8687.
UCSCiuc002hwq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16794 Genomic DNA. Translation: CAA76390.2.
AC019349 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60734.1.
BC131715 mRNA. Translation: AAI31716.1.
AJ786656 mRNA. Translation: CAH10351.1.
CCDSiCCDS11392.1.
RefSeqiNP_006762.3. NM_006771.3.
UniGeneiHs.248188.

3D structure databases

ProteinModelPortaliO76015.
SMRiO76015.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114234. 46 interactors.
IntActiO76015. 69 interactors.

PTM databases

iPTMnetiO76015.
PhosphoSitePlusiO76015.

Polymorphism and mutation databases

BioMutaiKRT38.

Proteomic databases

PaxDbiO76015.
PeptideAtlasiO76015.
PRIDEiO76015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246646; ENSP00000246646; ENSG00000171360.
GeneIDi8687.
KEGGihsa:8687.
UCSCiuc002hwq.2. human.

Organism-specific databases

CTDi8687.
GeneCardsiKRT38.
H-InvDBHIX0039116.
HGNCiHGNC:6456. KRT38.
MIMi604542. gene.
neXtProtiNX_O76015.
OpenTargetsiENSG00000171360.
PharmGKBiPA30245.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J94T. Eukaryota.
ENOG4111D61. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76015.
KOiK07604.
OMAiCGPCTTC.
OrthoDBiEOG091G05GB.
PhylomeDBiO76015.
TreeFamiTF332742.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171360-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii8687.
PROiO76015.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171360.
CleanExiHS_KRT38.
GenevisibleiO76015. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRT38_HUMAN
AccessioniPrimary (citable) accession number: O76015
Secondary accession number(s): A2RRM5, Q6A164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.