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Protein

Keratin, type I cuticular Ha8

Gene

KRT38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei353 – 3531Stutter

GO - Molecular functioni

  1. structural molecule activity Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha8
Alternative name(s):
Hair keratin, type I Ha8
Keratin-38
Short name:
K38
Gene namesi
Name:KRT38
Synonyms:HHA8, HKA8, KRTHA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6456. KRT38.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30245.

Polymorphism and mutation databases

BioMutaiKRT38.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Keratin, type I cuticular Ha8PRO_0000063695Add
BLAST

Proteomic databases

MaxQBiO76015.
PaxDbiO76015.
PRIDEiO76015.

Expressioni

Gene expression databases

BgeeiO76015.
CleanExiHS_KRT38.
GenevestigatoriO76015.

Organism-specific databases

HPAiHPA049150.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K2R33EBI-1047263,EBI-9977437
AMOTL2Q9Y2J4-43EBI-1047263,EBI-10187270
ANKRD36BP1Q96IX93EBI-1047263,EBI-744859
BEX2Q9BXY83EBI-1047263,EBI-745073
C19orf57Q0VDD73EBI-1047263,EBI-741210
C1orf216Q8TAB53EBI-1047263,EBI-747505
CCDC146Q8IYE0-24EBI-1047263,EBI-10247802
CD300AQ9UGN43EBI-1047263,EBI-10320732
CEP57L1Q8IYX8-23EBI-1047263,EBI-10181988
DKFZp451B226Q5HYH73EBI-1047263,EBI-10173842
FAM90A1Q86YD73EBI-1047263,EBI-6658203
GLRX3O760033EBI-1047263,EBI-374781
GNG10P501513EBI-1047263,EBI-10211741
HAUS1Q96CS23EBI-1047263,EBI-2514791
HDAC4P565243EBI-1047263,EBI-308629
HGSO149643EBI-1047263,EBI-740220
HMG20BQ9P0W24EBI-1047263,EBI-713401
HOXA1P496393EBI-1047263,EBI-740785
KLHL38Q2WGJ63EBI-1047263,EBI-6426443
KRT2P359083EBI-1047263,EBI-1247312
KRT4P190133EBI-1047263,EBI-2371606
KRT5P136473EBI-1047263,EBI-702187
KRT6AP025383EBI-1047263,EBI-702198
KRT6BP042593EBI-1047263,EBI-740907
KRT6CP486683EBI-1047263,EBI-2564105
KRT71Q3SY843EBI-1047263,EBI-2952676
KRT79Q5XKE53EBI-1047263,EBI-2514135
KRT8P057873EBI-1047263,EBI-297852
KRT81Q145335EBI-1047263,EBI-739648
KRT83P783853EBI-1047263,EBI-10221390
MAGEB4O154813EBI-1047263,EBI-751857
PIK3R2O004593EBI-1047263,EBI-346930
PIN1Q135263EBI-1047263,EBI-714158
PSMA1P257863EBI-1047263,EBI-359352
PSMC5P621953EBI-1047263,EBI-357745
PTGER3Q147X83EBI-1047263,EBI-10234038
RHPN1-AS1Q9BWJ23EBI-1047263,EBI-10300934
SCNM1Q9BWG63EBI-1047263,EBI-748391
TXLNAP402223EBI-1047263,EBI-359793
TXNDC5Q86UY03EBI-1047263,EBI-2825190
USHBP1Q8N6Y03EBI-1047263,EBI-739895
ZFYVE21Q9BQ243EBI-1047263,EBI-2849569
ZNF20P170243EBI-1047263,EBI-717634
ZNF417Q8TAU33EBI-1047263,EBI-740727
ZNF587Q96SQ53EBI-1047263,EBI-6427977

Protein-protein interaction databases

BioGridi114234. 46 interactions.
IntActiO76015. 45 interactions.
STRINGi9606.ENSP00000246646.

Structurei

3D structure databases

ProteinModelPortaliO76015.
SMRiO76015. Positions 322-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 104104HeadAdd
BLAST
Regioni105 – 411307RodAdd
BLAST
Regioni105 – 13935Coil 1AAdd
BLAST
Regioni140 – 15011Linker 1Add
BLAST
Regioni151 – 251101Coil 1BAdd
BLAST
Regioni252 – 26716Linker 12Add
BLAST
Regioni268 – 411144Coil 2Add
BLAST
Regioni412 – 45645TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG145883.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76015.
KOiK07604.
OMAiMVEADMC.
OrthoDBiEOG7S21XX.
PhylomeDBiO76015.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA
60 70 80 90 100
HANRVRVGST PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL
110 120 130 140 150
NGHEKETMQF LNDRLANYLE KVRQLEQENA ELEATLLERS KCHESTVCPD
160 170 180 190 200
YQSYFHTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLR
210 220 230 240 250
QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR
260 270 280 290 300
SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE
310 320 330 340 350
GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE
360 370 380 390 400
AEDRFGTELA QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE
410 420 430 440 450
IATYRNLLES EDCKLPCNPC STSPSCVTAP CAPRPSCGPC TTCGPTCGAS

TTGSRF
Length:456
Mass (Da):50,480
Last modified:May 5, 2009 - v3
Checksum:i8AE2E9BE95FC8E72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131D → G in CAH10351 (PubMed:15617563).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti423 – 4231S → P.4 Publications
Corresponds to variant rs897416 [ dbSNP | Ensembl ].
VAR_055137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16794 Genomic DNA. Translation: CAA76390.2.
AC019349 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60734.1.
BC131715 mRNA. Translation: AAI31716.1.
AJ786656 mRNA. Translation: CAH10351.1.
CCDSiCCDS11392.1.
RefSeqiNP_006762.3. NM_006771.3.
UniGeneiHs.248188.

Genome annotation databases

EnsembliENST00000246646; ENSP00000246646; ENSG00000171360.
GeneIDi8687.
KEGGihsa:8687.
UCSCiuc002hwq.1. human.

Polymorphism and mutation databases

BioMutaiKRT38.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16794 Genomic DNA. Translation: CAA76390.2.
AC019349 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60734.1.
BC131715 mRNA. Translation: AAI31716.1.
AJ786656 mRNA. Translation: CAH10351.1.
CCDSiCCDS11392.1.
RefSeqiNP_006762.3. NM_006771.3.
UniGeneiHs.248188.

3D structure databases

ProteinModelPortaliO76015.
SMRiO76015. Positions 322-409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114234. 46 interactions.
IntActiO76015. 45 interactions.
STRINGi9606.ENSP00000246646.

Polymorphism and mutation databases

BioMutaiKRT38.

Proteomic databases

MaxQBiO76015.
PaxDbiO76015.
PRIDEiO76015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246646; ENSP00000246646; ENSG00000171360.
GeneIDi8687.
KEGGihsa:8687.
UCSCiuc002hwq.1. human.

Organism-specific databases

CTDi8687.
GeneCardsiGC17M039592.
H-InvDBHIX0039116.
HGNCiHGNC:6456. KRT38.
HPAiHPA049150.
MIMi604542. gene.
neXtProtiNX_O76015.
PharmGKBiPA30245.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG145883.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76015.
KOiK07604.
OMAiMVEADMC.
OrthoDBiEOG7S21XX.
PhylomeDBiO76015.
TreeFamiTF332742.

Miscellaneous databases

GenomeRNAii8687.
NextBioi32579.
PROiO76015.
SOURCEiSearch...

Gene expression databases

BgeeiO76015.
CleanExiHS_KRT38.
GenevestigatoriO76015.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-423.
  2. Schweizer J.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-423.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-423.
  6. "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
    Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
    Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-456, VARIANT PRO-423.
    Tissue: Scalp.

Entry informationi

Entry nameiKRT38_HUMAN
AccessioniPrimary (citable) accession number: O76015
Secondary accession number(s): A2RRM5, Q6A164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: April 29, 2015
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.