Reviewed,
UniProtKB/Swiss-Prot O76015 (KRT38_HUMAN)
Last modified
July 7, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Keratin, type I cuticular Ha8 Alternative name(s): Hair keratin, type I Ha8 Keratin-38 Short name=K38 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 456 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Miscellaneous | There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). |
| Sequence similarities | Belongs to the intermediate filament family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Intermediate filament Keratin |
| Coding sequence diversity | Polymorphism |
| Domain | Coiled coil |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | structural molecule activity Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 456 | 456 | Keratin, type I cuticular Ha8 | PRO_0000063695 | |||||
Regions | |||||||||
| Region | 1 – 104 | 104 | Head | ||||||
| Region | 105 – 411 | 307 | Rod | ||||||
| Region | 105 – 139 | 35 | Coil 1A | ||||||
| Region | 140 – 150 | 11 | Linker 1 | ||||||
| Region | 151 – 251 | 101 | Coil 1B | ||||||
| Region | 252 – 267 | 16 | Linker 12 | ||||||
| Region | 268 – 411 | 144 | Coil 2 | ||||||
| Region | 412 – 456 | 45 | Tail | ||||||
Sites | |||||||||
| Site | 353 | 1 | Stutter | ||||||
Natural variations | |||||||||
| Natural variant | 423 | 1 | S → P: dbSNP rs897416. Ref.1 Ref.4 Ref.5 Ref.6 | VAR_055137 | |||||
Experimental info | |||||||||
| Sequence conflict | 113 | 1 | D → G in CAH10351. Ref.6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-423. |
| [2] | Schweizer J. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
| [3] | "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. Nusbaum C.Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-423. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-423. |
| [6] | "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain." Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J. Differentiation 72:527-540(2004) [PubMed: 15617563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-456, VARIANT PRO-423. Tissue: Scalp. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Y16794 Genomic DNA. Translation: CAA76390.2. AC019349 Genomic DNA. No translation available. CH471152 Genomic DNA. Translation: EAW60734.1. BC131715 mRNA. Translation: AAI31716.1. AJ786656 mRNA. Translation: CAH10351.1. | |
| IPI | IPI00297641. |
| RefSeq | NP_006762.3. |
| UniGene | Hs.248188 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GK7 based on UniProtKB P08670. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O76015. 1 interaction. |
Genome annotation databases | |
| Ensembl | ENSG00000171360. Homo sapiens. [Contig view] |
| GeneID | 8687. |
Organism-specific databases | |
| GeneCards | GC17M036847. |
| HGNC | HGNC:6456. KRT38. |
| MIM | 604542. gene. |
| PharmGKB | PA30245. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O76015. |
| HOVERGEN | O76015. |
Gene expression databases | |
| ArrayExpress | O76015. |
| Bgee | O76015. |
| CleanEx | HS_KRT38. |
| GermOnline | ENSG00000171360. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view] |
| PANTHER | PTHR23239. IF. 1 hit. |
| Pfam | PF00038. Filament. 1 hit. [Graphical view] |
| PRINTS | PR01248. TYPE1KERATIN. |
| PROSITE | PS00226. IF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | KRT38_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O76015 Secondary accession number(s): A2RRM5, Q6A164 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


