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O76015

- KRT38_HUMAN

UniProt

O76015 - KRT38_HUMAN

Protein

Keratin, type I cuticular Ha8

Gene

KRT38

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei353 – 3531Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cuticular Ha8
    Alternative name(s):
    Hair keratin, type I Ha8
    Keratin-38
    Short name:
    K38
    Gene namesi
    Name:KRT38
    Synonyms:HHA8, HKA8, KRTHA8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6456. KRT38.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30245.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Keratin, type I cuticular Ha8PRO_0000063695Add
    BLAST

    Proteomic databases

    MaxQBiO76015.
    PaxDbiO76015.
    PRIDEiO76015.

    Expressioni

    Gene expression databases

    BgeeiO76015.
    CleanExiHS_KRT38.
    GenevestigatoriO76015.

    Organism-specific databases

    HPAiHPA049150.

    Interactioni

    Protein-protein interaction databases

    BioGridi114234. 1 interaction.
    STRINGi9606.ENSP00000246646.

    Structurei

    3D structure databases

    ProteinModelPortaliO76015.
    SMRiO76015. Positions 322-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 104104HeadAdd
    BLAST
    Regioni105 – 411307RodAdd
    BLAST
    Regioni105 – 13935Coil 1AAdd
    BLAST
    Regioni140 – 15011Linker 1Add
    BLAST
    Regioni151 – 251101Coil 1BAdd
    BLAST
    Regioni252 – 26716Linker 12Add
    BLAST
    Regioni268 – 411144Coil 2Add
    BLAST
    Regioni412 – 45645TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG145883.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiO76015.
    KOiK07604.
    OMAiMVEADMC.
    OrthoDBiEOG7S21XX.
    PhylomeDBiO76015.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76015-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA    50
    HANRVRVGST PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL 100
    NGHEKETMQF LNDRLANYLE KVRQLEQENA ELEATLLERS KCHESTVCPD 150
    YQSYFHTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLR 200
    QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR 250
    SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE 300
    GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE 350
    AEDRFGTELA QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE 400
    IATYRNLLES EDCKLPCNPC STSPSCVTAP CAPRPSCGPC TTCGPTCGAS 450
    TTGSRF 456
    Length:456
    Mass (Da):50,480
    Last modified:May 5, 2009 - v3
    Checksum:i8AE2E9BE95FC8E72
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti113 – 1131D → G in CAH10351. (PubMed:15617563)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti423 – 4231S → P.4 Publications
    Corresponds to variant rs897416 [ dbSNP | Ensembl ].
    VAR_055137

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16794 Genomic DNA. Translation: CAA76390.2.
    AC019349 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60734.1.
    BC131715 mRNA. Translation: AAI31716.1.
    AJ786656 mRNA. Translation: CAH10351.1.
    CCDSiCCDS11392.1.
    RefSeqiNP_006762.3. NM_006771.3.
    UniGeneiHs.248188.

    Genome annotation databases

    EnsembliENST00000246646; ENSP00000246646; ENSG00000171360.
    GeneIDi8687.
    KEGGihsa:8687.
    UCSCiuc002hwq.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16794 Genomic DNA. Translation: CAA76390.2 .
    AC019349 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60734.1 .
    BC131715 mRNA. Translation: AAI31716.1 .
    AJ786656 mRNA. Translation: CAH10351.1 .
    CCDSi CCDS11392.1.
    RefSeqi NP_006762.3. NM_006771.3.
    UniGenei Hs.248188.

    3D structure databases

    ProteinModelPortali O76015.
    SMRi O76015. Positions 322-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114234. 1 interaction.
    STRINGi 9606.ENSP00000246646.

    Proteomic databases

    MaxQBi O76015.
    PaxDbi O76015.
    PRIDEi O76015.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246646 ; ENSP00000246646 ; ENSG00000171360 .
    GeneIDi 8687.
    KEGGi hsa:8687.
    UCSCi uc002hwq.1. human.

    Organism-specific databases

    CTDi 8687.
    GeneCardsi GC17M039592.
    H-InvDB HIX0039116.
    HGNCi HGNC:6456. KRT38.
    HPAi HPA049150.
    MIMi 604542. gene.
    neXtProti NX_O76015.
    PharmGKBi PA30245.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145883.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi O76015.
    KOi K07604.
    OMAi MVEADMC.
    OrthoDBi EOG7S21XX.
    PhylomeDBi O76015.
    TreeFami TF332742.

    Miscellaneous databases

    GenomeRNAii 8687.
    NextBioi 32579.
    PROi O76015.
    SOURCEi Search...

    Gene expression databases

    Bgeei O76015.
    CleanExi HS_KRT38.
    Genevestigatori O76015.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
      Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
      J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-423.
    2. Schweizer J.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-423.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-423.
    6. "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
      Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
      Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-456, VARIANT PRO-423.
      Tissue: Scalp.

    Entry informationi

    Entry nameiKRT38_HUMAN
    AccessioniPrimary (citable) accession number: O76015
    Secondary accession number(s): A2RRM5, Q6A164
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3