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O76015

- KRT38_HUMAN

UniProt

O76015 - KRT38_HUMAN

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Protein

Keratin, type I cuticular Ha8

Gene

KRT38

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei353 – 3531Stutter

GO - Molecular functioni

  1. structural molecule activity Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha8
Alternative name(s):
Hair keratin, type I Ha8
Keratin-38
Short name:
K38
Gene namesi
Name:KRT38
Synonyms:HHA8, HKA8, KRTHA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6456. KRT38.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Keratin, type I cuticular Ha8PRO_0000063695Add
BLAST

Proteomic databases

MaxQBiO76015.
PaxDbiO76015.
PRIDEiO76015.

Expressioni

Gene expression databases

BgeeiO76015.
CleanExiHS_KRT38.
GenevestigatoriO76015.

Organism-specific databases

HPAiHPA049150.

Interactioni

Protein-protein interaction databases

BioGridi114234. 1 interaction.
STRINGi9606.ENSP00000246646.

Structurei

3D structure databases

ProteinModelPortaliO76015.
SMRiO76015. Positions 322-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 104104HeadAdd
BLAST
Regioni105 – 411307RodAdd
BLAST
Regioni105 – 13935Coil 1AAdd
BLAST
Regioni140 – 15011Linker 1Add
BLAST
Regioni151 – 251101Coil 1BAdd
BLAST
Regioni252 – 26716Linker 12Add
BLAST
Regioni268 – 411144Coil 2Add
BLAST
Regioni412 – 45645TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG145883.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76015.
KOiK07604.
OMAiMVEADMC.
OrthoDBiEOG7S21XX.
PhylomeDBiO76015.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76015-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA
60 70 80 90 100
HANRVRVGST PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL
110 120 130 140 150
NGHEKETMQF LNDRLANYLE KVRQLEQENA ELEATLLERS KCHESTVCPD
160 170 180 190 200
YQSYFHTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLR
210 220 230 240 250
QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR
260 270 280 290 300
SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE
310 320 330 340 350
GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE
360 370 380 390 400
AEDRFGTELA QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE
410 420 430 440 450
IATYRNLLES EDCKLPCNPC STSPSCVTAP CAPRPSCGPC TTCGPTCGAS

TTGSRF
Length:456
Mass (Da):50,480
Last modified:May 5, 2009 - v3
Checksum:i8AE2E9BE95FC8E72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131D → G in CAH10351. (PubMed:15617563)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti423 – 4231S → P.4 Publications
Corresponds to variant rs897416 [ dbSNP | Ensembl ].
VAR_055137

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16794 Genomic DNA. Translation: CAA76390.2.
AC019349 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60734.1.
BC131715 mRNA. Translation: AAI31716.1.
AJ786656 mRNA. Translation: CAH10351.1.
CCDSiCCDS11392.1.
RefSeqiNP_006762.3. NM_006771.3.
UniGeneiHs.248188.

Genome annotation databases

EnsembliENST00000246646; ENSP00000246646; ENSG00000171360.
GeneIDi8687.
KEGGihsa:8687.
UCSCiuc002hwq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16794 Genomic DNA. Translation: CAA76390.2 .
AC019349 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60734.1 .
BC131715 mRNA. Translation: AAI31716.1 .
AJ786656 mRNA. Translation: CAH10351.1 .
CCDSi CCDS11392.1.
RefSeqi NP_006762.3. NM_006771.3.
UniGenei Hs.248188.

3D structure databases

ProteinModelPortali O76015.
SMRi O76015. Positions 322-409.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114234. 1 interaction.
STRINGi 9606.ENSP00000246646.

Proteomic databases

MaxQBi O76015.
PaxDbi O76015.
PRIDEi O76015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246646 ; ENSP00000246646 ; ENSG00000171360 .
GeneIDi 8687.
KEGGi hsa:8687.
UCSCi uc002hwq.1. human.

Organism-specific databases

CTDi 8687.
GeneCardsi GC17M039592.
H-InvDB HIX0039116.
HGNCi HGNC:6456. KRT38.
HPAi HPA049150.
MIMi 604542. gene.
neXtProti NX_O76015.
PharmGKBi PA30245.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145883.
GeneTreei ENSGT00760000118808.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi O76015.
KOi K07604.
OMAi MVEADMC.
OrthoDBi EOG7S21XX.
PhylomeDBi O76015.
TreeFami TF332742.

Miscellaneous databases

GenomeRNAii 8687.
NextBioi 32579.
PROi O76015.
SOURCEi Search...

Gene expression databases

Bgeei O76015.
CleanExi HS_KRT38.
Genevestigatori O76015.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-423.
  2. Schweizer J.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-423.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-423.
  6. "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
    Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
    Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-456, VARIANT PRO-423.
    Tissue: Scalp.

Entry informationi

Entry nameiKRT38_HUMAN
AccessioniPrimary (citable) accession number: O76015
Secondary accession number(s): A2RRM5, Q6A164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3