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O76015 (KRT38_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cuticular Ha8
Alternative name(s):
Hair keratin, type I Ha8
Keratin-38
Short name=K38
Gene names
Name:KRT38
Synonyms:HHA8, HKA8, KRTHA8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Keratin, type I cuticular Ha8
PRO_0000063695

Regions

Region1 – 104104Head
Region105 – 411307Rod
Region105 – 13935Coil 1A
Region140 – 15011Linker 1
Region151 – 251101Coil 1B
Region252 – 26716Linker 12
Region268 – 411144Coil 2
Region412 – 45645Tail

Sites

Site3531Stutter

Natural variations

Natural variant4231S → P. Ref.1 Ref.4 Ref.5 Ref.6
Corresponds to variant rs897416 [ dbSNP | Ensembl ].
VAR_055137

Experimental info

Sequence conflict1131D → G in CAH10351. Ref.6

Sequences

Sequence LengthMass (Da)Tools
O76015 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: 8AE2E9BE95FC8E72

FASTA45650,480
        10         20         30         40         50         60 
MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA HANRVRVGST 

        70         80         90        100        110        120 
PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL NGHEKETMQF LNDRLANYLE 

       130        140        150        160        170        180 
KVRQLEQENA ELEATLLERS KCHESTVCPD YQSYFHTIEE LQQKILCSKA ENARLIVQID 

       190        200        210        220        230        240 
NAKLAADDFR IKLESERSLR QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS 

       250        260        270        280        290        300 
NHEQEVKILR SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE 

       310        320        330        340        350        360 
GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRFGTELA 

       370        380        390        400        410        420 
QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE IATYRNLLES EDCKLPCNPC 

       430        440        450 
STSPSCVTAP CAPRPSCGPC TTCGPTCGAS TTGSRF 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-423.
[2]Schweizer J.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PRO-423.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-423.
[6]"The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-456, VARIANT PRO-423.
Tissue: Scalp.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y16794 Genomic DNA. Translation: CAA76390.2.
AC019349 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60734.1.
BC131715 mRNA. Translation: AAI31716.1.
AJ786656 mRNA. Translation: CAH10351.1.
RefSeqNP_006762.3. NM_006771.3.
UniGeneHs.248188.

3D structure databases

ProteinModelPortalO76015.
SMRO76015. Positions 102-253, 268-409.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114234. 1 interaction.
STRING9606.ENSP00000246646.

Proteomic databases

PaxDbO76015.
PRIDEO76015.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000246646; ENSP00000246646; ENSG00000171360.
GeneID8687.
KEGGhsa:8687.
UCSCuc002hwq.1. human.

Organism-specific databases

CTD8687.
GeneCardsGC17M039592.
H-InvDBHIX0039116.
HGNCHGNC:6456. KRT38.
HPAHPA049150.
MIM604542. gene.
neXtProtNX_O76015.
PharmGKBPA30245.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145883.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidO76015.
KOK07604.
OMAMVEADMC.
OrthoDBEOG7S21XX.
PhylomeDBO76015.
TreeFamTF332742.

Gene expression databases

BgeeO76015.
CleanExHS_KRT38.
GenevestigatorO76015.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8687.
NextBio32579.
PROO76015.
SOURCESearch...

Entry information

Entry nameKRT38_HUMAN
AccessionPrimary (citable) accession number: O76015
Secondary accession number(s): A2RRM5, Q6A164
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: March 19, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM