O76014 (KRT37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cuticular Ha7

Alternative name(s):
Hair keratin, type I Ha7
Keratin-37
Short name=K37

Gene names

Name:	KRT37
Synonyms:	HHA7, HKA7, KRTHA7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural molecule activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Keratin, type I cuticular Ha7		PRO_0000063694
Regions
	Region	1 – 104	104	Head
	Region	105 – 411	307	Rod
	Region	105 – 139	35	Coil 1A
	Region	140 – 150	11	Linker 1
	Region	151 – 251	101	Coil 1B
	Region	252 – 267	16	Linker 12
	Region	268 – 411	144	Coil 2
	Region	416 – 449	34	Tail
Sites
	Site	353	1	Stutter
Natural variations
	Natural variant	13	1	G → C. Corresponds to variant rs9910204 [ dbSNP | Ensembl ].		VAR_049795
	Natural variant	39	1	N → S. Corresponds to variant rs9916724 [ dbSNP | Ensembl ].		VAR_049796
	Natural variant	72	1	T → A. Corresponds to variant rs9916484 [ dbSNP | Ensembl ].		VAR_049797
	Natural variant	73	1	S → C. Corresponds to variant rs9916475 [ dbSNP | Ensembl ].		VAR_049798
	Natural variant	217	1	A → V. Corresponds to variant rs16966811 [ dbSNP | Ensembl ].		VAR_049799
	Natural variant	306	1	A → D. Corresponds to variant rs2071607 [ dbSNP | Ensembl ].		VAR_049800
	Natural variant	421	1	S → F. Corresponds to variant rs35371972 [ dbSNP | Ensembl ].		VAR_049801
	Natural variant	422	1	T → M. Corresponds to variant rs8071814 [ dbSNP | Ensembl ].		VAR_049802
	Natural variant	434	1	P → S. Corresponds to variant rs17737019 [ dbSNP | Ensembl ].		VAR_049803

Sequences

	Sequence		Length	Mass (Da)
	O76014 [UniParc]. Last modified April 13, 2004. Version 3. Checksum: E503974DFD8FCBAD	FASTA	449	49,747
	10 20 30 40 50 60 MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA HANRVRVGST 70 80 90 100 110 120 PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL NGHEKETMKF LNDRLANYLE 130 140 150 160 170 180 KVRQLEQENA ELETTLLERS KCHESTVCPD YQSYFRTIEE LQQKILCSKA ENARLIVQID 190 200 210 220 230 240 NAKLAADDFR IKLESERSLH QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS 250 260 270 280 290 300 NHEQEVKILR SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE 310 320 330 340 350 360 GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRYGTELA 370 380 390 400 410 420 QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE IATYRNLLES EDCKLPCNPC 430 440 STPASCTSCP SCGPVTGGSP SGHGASMGR

References

[1]	"Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Schweizer J. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y16793 Genomic DNA. Translation: CAA76389.3.
IPI	IPI00329240.
RefSeq	NP_003761.3. NM_003770.4.
UniGene	Hs.673852.
3D structure databases
ProteinModelPortal	O76014.
SMR	O76014. Positions 102-139, 148-252, 267-410.
ModBase	Search...
Protein-protein interaction databases
STRING	O76014.
PTM databases
PhosphoSite	O76014.
Proteomic databases
PRIDE	O76014.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000225550; ENSP00000225550; ENSG00000108417.
GeneID	8688.
KEGG	hsa:8688.
UCSC	uc002hwp.1. human.
Organism-specific databases
CTD	8688.
GeneCards	GC17M039581.
HGNC	HGNC:6455. KRT37.
MIM	604541. gene.
neXtProt	NX_O76014.
PharmGKB	PA30244.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG715391.
HOVERGEN	HBG013015.
InParanoid	O76014.
OMA	FRIELDI.
OrthoDB	EOG4DNF4J.
PhylomeDB	O76014.
Gene expression databases
ArrayExpress	O76014.
Bgee	O76014.
CleanEx	HS_KRT37.
Genevestigator	O76014.
GermOnline	ENSG00000108417. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
KO	K07604.
PANTHER	PTHR23239. IF. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	32583.
SOURCE	Search...

Entry information

Entry name

KRT37_HUMAN

Accession

Primary (citable) accession number: O76014

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	April 13, 2004
Last modified:	January 25, 2012
This is version 82 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.