Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O76014

- KRT37_HUMAN

UniProt

O76014 - KRT37_HUMAN

Protein

Keratin, type I cuticular Ha7

Gene

KRT37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (13 Apr 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei353 – 3531Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cuticular Ha7
    Alternative name(s):
    Hair keratin, type I Ha7
    Keratin-37
    Short name:
    K37
    Gene namesi
    Name:KRT37
    Synonyms:HHA7, HKA7, KRTHA7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6455. KRT37.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30244.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Keratin, type I cuticular Ha7PRO_0000063694Add
    BLAST

    Proteomic databases

    MaxQBiO76014.
    PaxDbiO76014.
    PRIDEiO76014.

    PTM databases

    PhosphoSiteiO76014.

    Expressioni

    Gene expression databases

    BgeeiO76014.
    CleanExiHS_KRT37.
    GenevestigatoriO76014.

    Organism-specific databases

    HPAiHPA048646.

    Interactioni

    Protein-protein interaction databases

    BioGridi114235. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO76014.
    SMRiO76014. Positions 322-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 104104HeadAdd
    BLAST
    Regioni105 – 411307RodAdd
    BLAST
    Regioni105 – 13935Coil 1AAdd
    BLAST
    Regioni140 – 15011Linker 1Add
    BLAST
    Regioni151 – 251101Coil 1BAdd
    BLAST
    Regioni252 – 26716Linker 12Add
    BLAST
    Regioni268 – 411144Coil 2Add
    BLAST
    Regioni416 – 44934TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG145883.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiO76014.
    KOiK07604.
    OMAiANAASMC.
    OrthoDBiEOG7S21XX.
    PhylomeDBiO76014.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76014-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA    50
    HANRVRVGST PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL 100
    NGHEKETMKF LNDRLANYLE KVRQLEQENA ELETTLLERS KCHESTVCPD 150
    YQSYFRTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLH 200
    QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR 250
    SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE 300
    GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE 350
    AEDRYGTELA QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE 400
    IATYRNLLES EDCKLPCNPC STPASCTSCP SCGPVTGGSP SGHGASMGR 449
    Length:449
    Mass (Da):49,747
    Last modified:April 13, 2004 - v3
    Checksum:iE503974DFD8FCBAD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131G → C.
    Corresponds to variant rs9910204 [ dbSNP | Ensembl ].
    VAR_049795
    Natural varianti39 – 391N → S.
    Corresponds to variant rs9916724 [ dbSNP | Ensembl ].
    VAR_049796
    Natural varianti72 – 721T → A.
    Corresponds to variant rs9916484 [ dbSNP | Ensembl ].
    VAR_049797
    Natural varianti73 – 731S → C.
    Corresponds to variant rs9916475 [ dbSNP | Ensembl ].
    VAR_049798
    Natural varianti217 – 2171A → V.
    Corresponds to variant rs16966811 [ dbSNP | Ensembl ].
    VAR_049799
    Natural varianti306 – 3061A → D.
    Corresponds to variant rs2071607 [ dbSNP | Ensembl ].
    VAR_049800
    Natural varianti421 – 4211S → F.
    Corresponds to variant rs35371972 [ dbSNP | Ensembl ].
    VAR_049801
    Natural varianti422 – 4221T → M.
    Corresponds to variant rs8071814 [ dbSNP | Ensembl ].
    VAR_049802
    Natural varianti434 – 4341P → S.
    Corresponds to variant rs17737019 [ dbSNP | Ensembl ].
    VAR_049803

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16793 Genomic DNA. Translation: CAA76389.3.
    CCDSiCCDS32653.1.
    RefSeqiNP_003761.3. NM_003770.4.
    UniGeneiHs.673852.

    Genome annotation databases

    EnsembliENST00000225550; ENSP00000225550; ENSG00000108417.
    ENST00000574588; ENSP00000458693; ENSG00000263022.
    GeneIDi8688.
    KEGGihsa:8688.
    UCSCiuc002hwp.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16793 Genomic DNA. Translation: CAA76389.3 .
    CCDSi CCDS32653.1.
    RefSeqi NP_003761.3. NM_003770.4.
    UniGenei Hs.673852.

    3D structure databases

    ProteinModelPortali O76014.
    SMRi O76014. Positions 322-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114235. 1 interaction.

    PTM databases

    PhosphoSitei O76014.

    Proteomic databases

    MaxQBi O76014.
    PaxDbi O76014.
    PRIDEi O76014.

    Protocols and materials databases

    DNASUi 8688.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225550 ; ENSP00000225550 ; ENSG00000108417 .
    ENST00000574588 ; ENSP00000458693 ; ENSG00000263022 .
    GeneIDi 8688.
    KEGGi hsa:8688.
    UCSCi uc002hwp.1. human.

    Organism-specific databases

    CTDi 8688.
    GeneCardsi GC17M039581.
    HGNCi HGNC:6455. KRT37.
    HPAi HPA048646.
    MIMi 604541. gene.
    neXtProti NX_O76014.
    PharmGKBi PA30244.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145883.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi O76014.
    KOi K07604.
    OMAi ANAASMC.
    OrthoDBi EOG7S21XX.
    PhylomeDBi O76014.
    TreeFami TF332742.

    Miscellaneous databases

    GenomeRNAii 8688.
    NextBioi 32583.
    PROi O76014.
    SOURCEi Search...

    Gene expression databases

    Bgeei O76014.
    CleanExi HS_KRT37.
    Genevestigatori O76014.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
      Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
      J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Schweizer J.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiKRT37_HUMAN
    AccessioniPrimary (citable) accession number: O76014
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3