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O76014 (KRT37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cuticular Ha7
Alternative name(s):
Hair keratin, type I Ha7
Keratin-37
Short name=K37
Gene names
Name:KRT37
Synonyms:HHA7, HKA7, KRTHA7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Keratin, type I cuticular Ha7
PRO_0000063694

Regions

Region1 – 104104Head
Region105 – 411307Rod
Region105 – 13935Coil 1A
Region140 – 15011Linker 1
Region151 – 251101Coil 1B
Region252 – 26716Linker 12
Region268 – 411144Coil 2
Region416 – 44934Tail

Sites

Site3531Stutter

Natural variations

Natural variant131G → C.
Corresponds to variant rs9910204 [ dbSNP | Ensembl ].
VAR_049795
Natural variant391N → S.
Corresponds to variant rs9916724 [ dbSNP | Ensembl ].
VAR_049796
Natural variant721T → A.
Corresponds to variant rs9916484 [ dbSNP | Ensembl ].
VAR_049797
Natural variant731S → C.
Corresponds to variant rs9916475 [ dbSNP | Ensembl ].
VAR_049798
Natural variant2171A → V.
Corresponds to variant rs16966811 [ dbSNP | Ensembl ].
VAR_049799
Natural variant3061A → D.
Corresponds to variant rs2071607 [ dbSNP | Ensembl ].
VAR_049800
Natural variant4211S → F.
Corresponds to variant rs35371972 [ dbSNP | Ensembl ].
VAR_049801
Natural variant4221T → M.
Corresponds to variant rs8071814 [ dbSNP | Ensembl ].
VAR_049802
Natural variant4341P → S.
Corresponds to variant rs17737019 [ dbSNP | Ensembl ].
VAR_049803

Sequences

Sequence LengthMass (Da)Tools
O76014 [UniParc].

Last modified April 13, 2004. Version 3.
Checksum: E503974DFD8FCBAD

FASTA44949,747
        10         20         30         40         50         60 
MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA HANRVRVGST 

        70         80         90        100        110        120 
PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL NGHEKETMKF LNDRLANYLE 

       130        140        150        160        170        180 
KVRQLEQENA ELETTLLERS KCHESTVCPD YQSYFRTIEE LQQKILCSKA ENARLIVQID 

       190        200        210        220        230        240 
NAKLAADDFR IKLESERSLH QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS 

       250        260        270        280        290        300 
NHEQEVKILR SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE 

       310        320        330        340        350        360 
GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRYGTELA 

       370        380        390        400        410        420 
QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE IATYRNLLES EDCKLPCNPC 

       430        440 
STPASCTSCP SCGPVTGGSP SGHGASMGR 

« Hide

References

[1]"Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Schweizer J.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y16793 Genomic DNA. Translation: CAA76389.3.
RefSeqNP_003761.3. NM_003770.4.
UniGeneHs.673852.

3D structure databases

ProteinModelPortalO76014.
SMRO76014. Positions 102-253, 268-409.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114235. 1 interaction.

PTM databases

PhosphoSiteO76014.

Proteomic databases

PaxDbO76014.
PRIDEO76014.

Protocols and materials databases

DNASU8688.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225550; ENSP00000225550; ENSG00000108417.
ENST00000574588; ENSP00000458693; ENSG00000263022.
GeneID8688.
KEGGhsa:8688.
UCSCuc002hwp.1. human.

Organism-specific databases

CTD8688.
GeneCardsGC17M039581.
HGNCHGNC:6455. KRT37.
HPAHPA048646.
MIM604541. gene.
neXtProtNX_O76014.
PharmGKBPA30244.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145883.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidO76014.
KOK07604.
OMAANAASMC.
OrthoDBEOG7S21XX.
PhylomeDBO76014.
TreeFamTF332742.

Gene expression databases

BgeeO76014.
CleanExHS_KRT37.
GenevestigatorO76014.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8688.
NextBio32583.
PROO76014.
SOURCESearch...

Entry information

Entry nameKRT37_HUMAN
AccessionPrimary (citable) accession number: O76014
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: April 16, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM