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Protein

Keratin, type I cuticular Ha7

Gene

KRT37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei353Stutter1

GO - Molecular functioni

  • structural molecule activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha7
Alternative name(s):
Hair keratin, type I Ha7
Keratin-37
Short name:
K37
Gene namesi
Name:KRT37
Synonyms:HHA7, HKA7, KRTHA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108417.3
HGNCiHGNC:6455 KRT37
MIMi604541 gene
neXtProtiNX_O76014

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108417
PharmGKBiPA30244

Polymorphism and mutation databases

BioMutaiKRT37

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636941 – 449Keratin, type I cuticular Ha7Add BLAST449

Proteomic databases

PaxDbiO76014
PeptideAtlasiO76014
PRIDEiO76014

PTM databases

iPTMnetiO76014
PhosphoSitePlusiO76014

Expressioni

Gene expression databases

BgeeiENSG00000108417
CleanExiHS_KRT37
GenevisibleiO76014 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114235, 1 interactor
IntActiO76014, 46 interactors

Structurei

3D structure databases

ProteinModelPortaliO76014
SMRiO76014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 415IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 104HeadAdd BLAST104
Regioni105 – 139Coil 1AAdd BLAST35
Regioni140 – 150Linker 1Add BLAST11
Regioni151 – 251Coil 1BAdd BLAST101
Regioni252 – 267Linker 12Add BLAST16
Regioni268 – 411Coil 2Add BLAST144
Regioni416 – 449TailAdd BLAST34

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J94T Eukaryota
ENOG4111D61 LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiO76014
KOiK07604
OMAiANAASMC
OrthoDBiEOG091G05GB
PhylomeDBiO76014
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O76014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA
60 70 80 90 100
HANRVRVGST PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL
110 120 130 140 150
NGHEKETMKF LNDRLANYLE KVRQLEQENA ELETTLLERS KCHESTVCPD
160 170 180 190 200
YQSYFRTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLH
210 220 230 240 250
QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR
260 270 280 290 300
SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE
310 320 330 340 350
GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE
360 370 380 390 400
AEDRYGTELA QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE
410 420 430 440
IATYRNLLES EDCKLPCNPC STPASCTSCP SCGPVTGGSP SGHGASMGR
Length:449
Mass (Da):49,747
Last modified:April 13, 2004 - v3
Checksum:iE503974DFD8FCBAD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04979513G → C. Corresponds to variant dbSNP:rs9910204Ensembl.1
Natural variantiVAR_04979639N → S. Corresponds to variant dbSNP:rs9916724Ensembl.1
Natural variantiVAR_04979772T → A. Corresponds to variant dbSNP:rs9916484Ensembl.1
Natural variantiVAR_04979873S → C. Corresponds to variant dbSNP:rs9916475Ensembl.1
Natural variantiVAR_049799217A → V. Corresponds to variant dbSNP:rs16966811Ensembl.1
Natural variantiVAR_049800306A → D. Corresponds to variant dbSNP:rs2071607Ensembl.1
Natural variantiVAR_049801421S → F. Corresponds to variant dbSNP:rs35371972Ensembl.1
Natural variantiVAR_049802422T → M. Corresponds to variant dbSNP:rs8071814Ensembl.1
Natural variantiVAR_049803434P → S. Corresponds to variant dbSNP:rs17737019Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16793 Genomic DNA Translation: CAA76389.3
CCDSiCCDS32653.1
RefSeqiNP_003761.3, NM_003770.4
UniGeneiHs.673852

Genome annotation databases

EnsembliENST00000225550; ENSP00000225550; ENSG00000108417
ENST00000574588; ENSP00000458693; ENSG00000263022
GeneIDi8688
KEGGihsa:8688
UCSCiuc002hwp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKRT37_HUMAN
AccessioniPrimary (citable) accession number: O76014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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