Reviewed,
UniProtKB/Swiss-Prot O76014 (KRT37_HUMAN)
Last modified
July 7, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Keratin, type I cuticular Ha7 Alternative name(s): Hair keratin, type I Ha7 Keratin-37 Short name=K37 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 449 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Miscellaneous | There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). |
| Sequence similarities | Belongs to the intermediate filament family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Intermediate filament Keratin |
| Coding sequence diversity | Polymorphism |
| Domain | Coiled coil |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | structural molecule activity Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 449 | 449 | Keratin, type I cuticular Ha7 | PRO_0000063694 | |||||
Regions | |||||||||
| Region | 1 – 104 | 104 | Head | ||||||
| Region | 105 – 411 | 307 | Rod | ||||||
| Region | 105 – 139 | 35 | Coil 1A | ||||||
| Region | 140 – 150 | 11 | Linker 1 | ||||||
| Region | 151 – 251 | 101 | Coil 1B | ||||||
| Region | 252 – 267 | 16 | Linker 12 | ||||||
| Region | 268 – 411 | 144 | Coil 2 | ||||||
| Region | 416 – 449 | 34 | Tail | ||||||
Sites | |||||||||
| Site | 353 | 1 | Stutter | ||||||
Natural variations | |||||||||
| Natural variant | 13 | 1 | G → C: dbSNP rs9910204. | VAR_049795 | |||||
| Natural variant | 39 | 1 | N → S: dbSNP rs9916724. | VAR_049796 | |||||
| Natural variant | 72 | 1 | T → A: dbSNP rs9916484. | VAR_049797 | |||||
| Natural variant | 73 | 1 | S → C: dbSNP rs9916475. | VAR_049798 | |||||
| Natural variant | 217 | 1 | A → V: dbSNP rs16966811. | VAR_049799 | |||||
| Natural variant | 306 | 1 | A → D: dbSNP rs2071607. | VAR_049800 | |||||
| Natural variant | 421 | 1 | S → F: dbSNP rs35371972. | VAR_049801 | |||||
| Natural variant | 422 | 1 | T → M: dbSNP rs8071814. | VAR_049802 | |||||
| Natural variant | 434 | 1 | P → S: dbSNP rs17737019. | VAR_049803 | |||||
Sequences
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References
| [1] | "Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | Schweizer J. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
Cross-references
Sequence databases | |
|---|---|
| Y16793 Genomic DNA. Translation: CAA76389.3. | |
| IPI | IPI00329240. |
| RefSeq | NP_003761.3. |
| UniGene | Hs.463024 Hs.673852 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GK7 based on UniProtKB P08670. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O76014. 3 interactions. |
PTM databases | |
| PhosphoSite | O76014. |
Proteomic databases | |
| PRIDE | O76014. |
Genome annotation databases | |
| Ensembl | ENSG00000108417. Homo sapiens. [Contig view] |
| GeneID | 8688. |
| KEGG | hsa:8688. |
| UCSC | uc002hwp.1. human. |
Organism-specific databases | |
| GeneCards | GC17M036831. |
| H-InvDB | HIX0027154. HIX0039115. |
| HGNC | HGNC:6455. KRT37. |
| MIM | 604541. gene. |
| PharmGKB | PA30244. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O76014. |
| HOVERGEN | O76014. |
| OMA | O76014. FRIELDI. |
Gene expression databases | |
| ArrayExpress | O76014. |
| Bgee | O76014. |
| CleanEx | HS_KRT37. |
| GermOnline | ENSG00000108417. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view] |
| PANTHER | PTHR23239. IF. 1 hit. |
| Pfam | PF00038. Filament. 1 hit. [Graphical view] |
| PRINTS | PR01248. TYPE1KERATIN. |
| PROSITE | PS00226. IF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 32583. |
| SOURCE | Search... |
Entry information
| Entry name | KRT37_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O76014 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


