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Protein

Keratin, type I cuticular Ha7

Gene

KRT37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei353 – 3531Stutter

GO - Molecular functioni

  1. structural molecule activity Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha7
Alternative name(s):
Hair keratin, type I Ha7
Keratin-37
Short name:
K37
Gene namesi
Name:KRT37
Synonyms:HHA7, HKA7, KRTHA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:6455. KRT37.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Keratin, type I cuticular Ha7PRO_0000063694Add
BLAST

Proteomic databases

MaxQBiO76014.
PaxDbiO76014.
PRIDEiO76014.

PTM databases

PhosphoSiteiO76014.

Expressioni

Gene expression databases

BgeeiO76014.
CleanExiHS_KRT37.
GenevestigatoriO76014.

Organism-specific databases

HPAiHPA048646.

Interactioni

Protein-protein interaction databases

BioGridi114235. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO76014.
SMRiO76014. Positions 322-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 104104HeadAdd
BLAST
Regioni105 – 411307RodAdd
BLAST
Regioni105 – 13935Coil 1AAdd
BLAST
Regioni140 – 15011Linker 1Add
BLAST
Regioni151 – 251101Coil 1BAdd
BLAST
Regioni252 – 26716Linker 12Add
BLAST
Regioni268 – 411144Coil 2Add
BLAST
Regioni416 – 44934TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG145883.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76014.
KOiK07604.
OMAiANAASMC.
OrthoDBiEOG7S21XX.
PhylomeDBiO76014.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA
60 70 80 90 100
HANRVRVGST PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL
110 120 130 140 150
NGHEKETMKF LNDRLANYLE KVRQLEQENA ELETTLLERS KCHESTVCPD
160 170 180 190 200
YQSYFRTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLH
210 220 230 240 250
QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR
260 270 280 290 300
SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE
310 320 330 340 350
GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE
360 370 380 390 400
AEDRYGTELA QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE
410 420 430 440
IATYRNLLES EDCKLPCNPC STPASCTSCP SCGPVTGGSP SGHGASMGR
Length:449
Mass (Da):49,747
Last modified:April 13, 2004 - v3
Checksum:iE503974DFD8FCBAD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131G → C.
Corresponds to variant rs9910204 [ dbSNP | Ensembl ].
VAR_049795
Natural varianti39 – 391N → S.
Corresponds to variant rs9916724 [ dbSNP | Ensembl ].
VAR_049796
Natural varianti72 – 721T → A.
Corresponds to variant rs9916484 [ dbSNP | Ensembl ].
VAR_049797
Natural varianti73 – 731S → C.
Corresponds to variant rs9916475 [ dbSNP | Ensembl ].
VAR_049798
Natural varianti217 – 2171A → V.
Corresponds to variant rs16966811 [ dbSNP | Ensembl ].
VAR_049799
Natural varianti306 – 3061A → D.
Corresponds to variant rs2071607 [ dbSNP | Ensembl ].
VAR_049800
Natural varianti421 – 4211S → F.
Corresponds to variant rs35371972 [ dbSNP | Ensembl ].
VAR_049801
Natural varianti422 – 4221T → M.
Corresponds to variant rs8071814 [ dbSNP | Ensembl ].
VAR_049802
Natural varianti434 – 4341P → S.
Corresponds to variant rs17737019 [ dbSNP | Ensembl ].
VAR_049803

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16793 Genomic DNA. Translation: CAA76389.3.
CCDSiCCDS32653.1.
RefSeqiNP_003761.3. NM_003770.4.
UniGeneiHs.673852.

Genome annotation databases

EnsembliENST00000225550; ENSP00000225550; ENSG00000108417.
ENST00000574588; ENSP00000458693; ENSG00000263022.
GeneIDi8688.
KEGGihsa:8688.
UCSCiuc002hwp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16793 Genomic DNA. Translation: CAA76389.3.
CCDSiCCDS32653.1.
RefSeqiNP_003761.3. NM_003770.4.
UniGeneiHs.673852.

3D structure databases

ProteinModelPortaliO76014.
SMRiO76014. Positions 322-409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114235. 1 interaction.

PTM databases

PhosphoSiteiO76014.

Proteomic databases

MaxQBiO76014.
PaxDbiO76014.
PRIDEiO76014.

Protocols and materials databases

DNASUi8688.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225550; ENSP00000225550; ENSG00000108417.
ENST00000574588; ENSP00000458693; ENSG00000263022.
GeneIDi8688.
KEGGihsa:8688.
UCSCiuc002hwp.1. human.

Organism-specific databases

CTDi8688.
GeneCardsiGC17M039581.
HGNCiHGNC:6455. KRT37.
HPAiHPA048646.
MIMi604541. gene.
neXtProtiNX_O76014.
PharmGKBiPA30244.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG145883.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76014.
KOiK07604.
OMAiANAASMC.
OrthoDBiEOG7S21XX.
PhylomeDBiO76014.
TreeFamiTF332742.

Miscellaneous databases

GenomeRNAii8688.
NextBioi32583.
PROiO76014.
SOURCEiSearch...

Gene expression databases

BgeeiO76014.
CleanExiHS_KRT37.
GenevestigatoriO76014.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Schweizer J.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiKRT37_HUMAN
AccessioniPrimary (citable) accession number: O76014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: January 7, 2015
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.