SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O76014

- KRT37_HUMAN

UniProt

O76014 - KRT37_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Keratin, type I cuticular Ha7
Gene
KRT37, HHA7, HKA7, KRTHA7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei353 – 3531Stutter

GO - Molecular functioni

  1. structural molecule activity Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha7
Alternative name(s):
Hair keratin, type I Ha7
Keratin-37
Short name:
K37
Gene namesi
Name:KRT37
Synonyms:HHA7, HKA7, KRTHA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6455. KRT37.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Keratin, type I cuticular Ha7
PRO_0000063694Add
BLAST

Proteomic databases

MaxQBiO76014.
PaxDbiO76014.
PRIDEiO76014.

PTM databases

PhosphoSiteiO76014.

Expressioni

Gene expression databases

BgeeiO76014.
CleanExiHS_KRT37.
GenevestigatoriO76014.

Organism-specific databases

HPAiHPA048646.

Interactioni

Protein-protein interaction databases

BioGridi114235. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO76014.
SMRiO76014. Positions 322-409.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 104104Head
Add
BLAST
Regioni105 – 411307Rod
Add
BLAST
Regioni105 – 13935Coil 1A
Add
BLAST
Regioni140 – 15011Linker 1
Add
BLAST
Regioni151 – 251101Coil 1B
Add
BLAST
Regioni252 – 26716Linker 12
Add
BLAST
Regioni268 – 411144Coil 2
Add
BLAST
Regioni416 – 44934Tail
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG145883.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76014.
KOiK07604.
OMAiANAASMC.
OrthoDBiEOG7S21XX.
PhylomeDBiO76014.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76014-1 [UniParc]FASTAAdd to Basket

« Hide

MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA    50
HANRVRVGST PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL 100
NGHEKETMKF LNDRLANYLE KVRQLEQENA ELETTLLERS KCHESTVCPD 150
YQSYFRTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLH 200
QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR 250
SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE 300
GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE 350
AEDRYGTELA QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE 400
IATYRNLLES EDCKLPCNPC STPASCTSCP SCGPVTGGSP SGHGASMGR 449
Length:449
Mass (Da):49,747
Last modified:April 13, 2004 - v3
Checksum:iE503974DFD8FCBAD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131G → C.
Corresponds to variant rs9910204 [ dbSNP | Ensembl ].
VAR_049795
Natural varianti39 – 391N → S.
Corresponds to variant rs9916724 [ dbSNP | Ensembl ].
VAR_049796
Natural varianti72 – 721T → A.
Corresponds to variant rs9916484 [ dbSNP | Ensembl ].
VAR_049797
Natural varianti73 – 731S → C.
Corresponds to variant rs9916475 [ dbSNP | Ensembl ].
VAR_049798
Natural varianti217 – 2171A → V.
Corresponds to variant rs16966811 [ dbSNP | Ensembl ].
VAR_049799
Natural varianti306 – 3061A → D.
Corresponds to variant rs2071607 [ dbSNP | Ensembl ].
VAR_049800
Natural varianti421 – 4211S → F.
Corresponds to variant rs35371972 [ dbSNP | Ensembl ].
VAR_049801
Natural varianti422 – 4221T → M.
Corresponds to variant rs8071814 [ dbSNP | Ensembl ].
VAR_049802
Natural varianti434 – 4341P → S.
Corresponds to variant rs17737019 [ dbSNP | Ensembl ].
VAR_049803

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16793 Genomic DNA. Translation: CAA76389.3.
CCDSiCCDS32653.1.
RefSeqiNP_003761.3. NM_003770.4.
UniGeneiHs.673852.

Genome annotation databases

EnsembliENST00000225550; ENSP00000225550; ENSG00000108417.
ENST00000574588; ENSP00000458693; ENSG00000263022.
GeneIDi8688.
KEGGihsa:8688.
UCSCiuc002hwp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16793 Genomic DNA. Translation: CAA76389.3 .
CCDSi CCDS32653.1.
RefSeqi NP_003761.3. NM_003770.4.
UniGenei Hs.673852.

3D structure databases

ProteinModelPortali O76014.
SMRi O76014. Positions 322-409.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114235. 1 interaction.

PTM databases

PhosphoSitei O76014.

Proteomic databases

MaxQBi O76014.
PaxDbi O76014.
PRIDEi O76014.

Protocols and materials databases

DNASUi 8688.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225550 ; ENSP00000225550 ; ENSG00000108417 .
ENST00000574588 ; ENSP00000458693 ; ENSG00000263022 .
GeneIDi 8688.
KEGGi hsa:8688.
UCSCi uc002hwp.1. human.

Organism-specific databases

CTDi 8688.
GeneCardsi GC17M039581.
HGNCi HGNC:6455. KRT37.
HPAi HPA048646.
MIMi 604541. gene.
neXtProti NX_O76014.
PharmGKBi PA30244.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145883.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi O76014.
KOi K07604.
OMAi ANAASMC.
OrthoDBi EOG7S21XX.
PhylomeDBi O76014.
TreeFami TF332742.

Miscellaneous databases

GenomeRNAii 8688.
NextBioi 32583.
PROi O76014.
SOURCEi Search...

Gene expression databases

Bgeei O76014.
CleanExi HS_KRT37.
Genevestigatori O76014.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Schweizer J.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiKRT37_HUMAN
AccessioniPrimary (citable) accession number: O76014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi