ID   KRT36_HUMAN             Reviewed;         467 AA.
AC   O76013; Q86XG4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   24-JAN-2024, entry version 179.
DE   RecName: Full=Keratin, type I cuticular Ha6;
DE   AltName: Full=Hair keratin, type I Ha6;
DE   AltName: Full=Keratin-36;
DE            Short=K36;
GN   Name=KRT36; Synonyms=HHA6, HKA6, KRTHA6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), AND
RP   TISSUE SPECIFICITY.
RX   PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
RA   Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
RT   "Characterization of a 190-kilobase pair domain of human type I hair
RT   keratin genes.";
RL   J. Biol. Chem. 273:26683-26691(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       O76013-2; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-11958506, EBI-11096309;
CC       O76013-2; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-11958506, EBI-742038;
CC       O76013-2; Q13155: AIMP2; NbExp=3; IntAct=EBI-11958506, EBI-745226;
CC       O76013-2; A2BDD9: AMOT; NbExp=3; IntAct=EBI-11958506, EBI-17286414;
CC       O76013-2; O75934: BCAS2; NbExp=3; IntAct=EBI-11958506, EBI-1050106;
CC       O76013-2; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-11958506, EBI-747505;
CC       O76013-2; Q6UXH8-3: CCBE1; NbExp=3; IntAct=EBI-11958506, EBI-12013534;
CC       O76013-2; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-11958506, EBI-10175300;
CC       O76013-2; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-11958506, EBI-396137;
CC       O76013-2; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11958506, EBI-9679045;
CC       O76013-2; Q8IYI6: EXOC8; NbExp=4; IntAct=EBI-11958506, EBI-742102;
CC       O76013-2; P55040: GEM; NbExp=3; IntAct=EBI-11958506, EBI-744104;
CC       O76013-2; Q13227: GPS2; NbExp=3; IntAct=EBI-11958506, EBI-713355;
CC       O76013-2; P08631-2: HCK; NbExp=3; IntAct=EBI-11958506, EBI-9834454;
CC       O76013-2; O14964: HGS; NbExp=3; IntAct=EBI-11958506, EBI-740220;
CC       O76013-2; P31273: HOXC8; NbExp=3; IntAct=EBI-11958506, EBI-1752118;
CC       O76013-2; P04264: KRT1; NbExp=3; IntAct=EBI-11958506, EBI-298429;
CC       O76013-2; P35908: KRT2; NbExp=3; IntAct=EBI-11958506, EBI-1247312;
CC       O76013-2; P12035: KRT3; NbExp=5; IntAct=EBI-11958506, EBI-2430095;
CC       O76013-2; P19013: KRT4; NbExp=5; IntAct=EBI-11958506, EBI-2371606;
CC       O76013-2; P02538: KRT6A; NbExp=3; IntAct=EBI-11958506, EBI-702198;
CC       O76013-2; P48668: KRT6C; NbExp=3; IntAct=EBI-11958506, EBI-2564105;
CC       O76013-2; Q86Y46-2: KRT73; NbExp=3; IntAct=EBI-11958506, EBI-12039441;
CC       O76013-2; O95678: KRT75; NbExp=5; IntAct=EBI-11958506, EBI-2949715;
CC       O76013-2; Q01546: KRT76; NbExp=3; IntAct=EBI-11958506, EBI-2952745;
CC       O76013-2; Q7Z794: KRT77; NbExp=3; IntAct=EBI-11958506, EBI-3045529;
CC       O76013-2; Q8N1N4: KRT78; NbExp=3; IntAct=EBI-11958506, EBI-1056564;
CC       O76013-2; Q5XKE5: KRT79; NbExp=3; IntAct=EBI-11958506, EBI-2514135;
CC       O76013-2; P05787: KRT8; NbExp=3; IntAct=EBI-11958506, EBI-297852;
CC       O76013-2; Q6KB66-2: KRT80; NbExp=3; IntAct=EBI-11958506, EBI-11999246;
CC       O76013-2; P78386: KRT85; NbExp=3; IntAct=EBI-11958506, EBI-1049371;
CC       O76013-2; O43790: KRT86; NbExp=5; IntAct=EBI-11958506, EBI-9996498;
CC       O76013-2; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-11958506, EBI-744402;
CC       O76013-2; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-11958506, EBI-5662487;
CC       O76013-2; Q16512: PKN1; NbExp=3; IntAct=EBI-11958506, EBI-602382;
CC       O76013-2; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-11958506, EBI-12014286;
CC       O76013-2; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-11958506, EBI-2557469;
CC       O76013-2; P20618: PSMB1; NbExp=3; IntAct=EBI-11958506, EBI-372273;
CC       O76013-2; P47897: QARS1; NbExp=3; IntAct=EBI-11958506, EBI-347462;
CC       O76013-2; Q9HCM1: RESF1; NbExp=3; IntAct=EBI-11958506, EBI-308368;
CC       O76013-2; Q8N443: RIBC1; NbExp=3; IntAct=EBI-11958506, EBI-10265323;
CC       O76013-2; P62328: TMSB4X; NbExp=3; IntAct=EBI-11958506, EBI-712598;
CC       O76013-2; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-11958506, EBI-3650647;
CC       O76013-2; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11958506, EBI-10241197;
CC       O76013-2; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-11958506, EBI-9090990;
CC       O76013-2; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-11958506, EBI-11979997;
CC       O76013-2; P40222: TXLNA; NbExp=3; IntAct=EBI-11958506, EBI-359793;
CC       O76013-2; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-11958506, EBI-744257;
CC       O76013-2; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-11958506, EBI-3925400;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O76013-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O76013-2; Sequence=VSP_036403;
CC   -!- TISSUE SPECIFICITY: Expressed in the hair follicles.
CC       {ECO:0000269|PubMed:9756910}.
CC   -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC       (acidic) and II (neutral to basic).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; Y16792; CAA76388.1; -; Genomic_DNA.
DR   EMBL; CH471152; EAW60738.1; -; Genomic_DNA.
DR   EMBL; BC043581; AAH43581.1; -; mRNA.
DR   CCDS; CCDS11395.1; -. [O76013-1]
DR   RefSeq; NP_003762.1; NM_003771.4. [O76013-1]
DR   AlphaFoldDB; O76013; -.
DR   SMR; O76013; -.
DR   BioGRID; 114236; 61.
DR   ComplexPortal; CPX-5663; Keratin-36 - Keratin-86 dimer complex.
DR   IntAct; O76013; 63.
DR   STRING; 9606.ENSP00000329165; -.
DR   CarbonylDB; O76013; -.
DR   GlyGen; O76013; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; O76013; -.
DR   PhosphoSitePlus; O76013; -.
DR   BioMuta; KRT36; -.
DR   jPOST; O76013; -.
DR   MassIVE; O76013; -.
DR   PaxDb; 9606-ENSP00000329165; -.
DR   PeptideAtlas; O76013; -.
DR   PRIDE; O76013; -.
DR   ProteomicsDB; 50344; -. [O76013-1]
DR   ProteomicsDB; 50345; -. [O76013-2]
DR   Antibodypedia; 16678; 162 antibodies from 26 providers.
DR   DNASU; 8689; -.
DR   Ensembl; ENST00000328119.11; ENSP00000329165.6; ENSG00000126337.14. [O76013-1]
DR   Ensembl; ENST00000393986.2; ENSP00000377555.2; ENSG00000126337.14. [O76013-2]
DR   GeneID; 8689; -.
DR   KEGG; hsa:8689; -.
DR   MANE-Select; ENST00000328119.11; ENSP00000329165.6; NM_003771.5; NP_003762.1.
DR   UCSC; uc002hwt.3; human. [O76013-1]
DR   AGR; HGNC:6454; -.
DR   CTD; 8689; -.
DR   DisGeNET; 8689; -.
DR   GeneCards; KRT36; -.
DR   HGNC; HGNC:6454; KRT36.
DR   HPA; ENSG00000126337; Tissue enhanced (lymphoid tissue, skin).
DR   MIM; 604540; gene.
DR   neXtProt; NX_O76013; -.
DR   OpenTargets; ENSG00000126337; -.
DR   PharmGKB; PA30243; -.
DR   VEuPathDB; HostDB:ENSG00000126337; -.
DR   eggNOG; ENOG502QQY9; Eukaryota.
DR   GeneTree; ENSGT00940000161311; -.
DR   HOGENOM; CLU_012560_8_0_1; -.
DR   InParanoid; O76013; -.
DR   OMA; AVRVPYI; -.
DR   OrthoDB; 4640531at2759; -.
DR   PhylomeDB; O76013; -.
DR   TreeFam; TF332742; -.
DR   PathwayCommons; O76013; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR   SignaLink; O76013; -.
DR   SIGNOR; O76013; -.
DR   BioGRID-ORCS; 8689; 9 hits in 1142 CRISPR screens.
DR   GeneWiki; KRT36; -.
DR   GenomeRNAi; 8689; -.
DR   Pharos; O76013; Tdark.
DR   PRO; PR:O76013; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; O76013; Protein.
DR   Bgee; ENSG00000126337; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 38 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0045111; C:intermediate filament cytoskeleton; IBA:GO_Central.
DR   GO; GO:0045095; C:keratin filament; IPI:ComplexPortal.
DR   GO; GO:0030280; F:structural constituent of skin epidermis; IBA:GO_Central.
DR   GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:0045616; P:regulation of keratinocyte differentiation; IEA:Ensembl.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF204; KERATIN, TYPE I CUTICULAR HA6; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   SUPFAM; SSF46579; Prefoldin; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   Genevisible; O76013; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Intermediate filament; Keratin;
KW   Reference proteome.
FT   CHAIN           1..467
FT                   /note="Keratin, type I cuticular Ha6"
FT                   /id="PRO_0000063693"
FT   DOMAIN          93..404
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..93
FT                   /note="Head"
FT   REGION          94..128
FT                   /note="Coil 1A"
FT   REGION          129..139
FT                   /note="Linker 1"
FT   REGION          140..240
FT                   /note="Coil 1B"
FT   REGION          241..256
FT                   /note="Linker 12"
FT   REGION          257..400
FT                   /note="Coil 2"
FT   REGION          401..467
FT                   /note="Tail"
FT   SITE            342
FT                   /note="Stutter"
FT   VAR_SEQ         1..52
FT                   /note="MATQTCTPTFSTGSIKGLCGTAGGISRVSSIRSVGSCRVPSLAGAAGYISSA
FT                   -> ML (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_036403"
FT   VARIANT         119
FT                   /note="A -> V (in dbSNP:rs8082683)"
FT                   /id="VAR_024490"
FT   VARIANT         126
FT                   /note="Q -> R (in dbSNP:rs8069943)"
FT                   /id="VAR_024491"
FT   VARIANT         179
FT                   /note="R -> Q (in dbSNP:rs9675246)"
FT                   /id="VAR_049792"
FT   VARIANT         277
FT                   /note="R -> C (in dbSNP:rs9904102)"
FT                   /id="VAR_049793"
FT   VARIANT         315
FT                   /note="T -> M (in dbSNP:rs2301354)"
FT                   /id="VAR_020306"
FT   VARIANT         357
FT                   /note="N -> T (in dbSNP:rs11657323)"
FT                   /id="VAR_049794"
SQ   SEQUENCE   467 AA;  52247 MW;  492B3B2DE3BCAECD CRC64;
     MATQTCTPTF STGSIKGLCG TAGGISRVSS IRSVGSCRVP SLAGAAGYIS SARSGLSGLG
     SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL NDRLANYLEK VRQLERENAE
     LESRIQEWYE FQIPYICPDY QSYFKTIEDF QQKILLTKSE NARLVLQIDN AKLAADDFRT
     KYETELSLRQ LVEADINGLR RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC
     QLGDRLNVEV DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE
     QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ MQCLISNVEA
     QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE DCKLPPQPCA TACKPVIRVP
     SVPPVPCVPS VPCTPAPQVG TQIRTITEEI RDGKVISSRE HVQSRPL
//