Reviewed, UniProtKB/Swiss-Prot O76013 (KRT36_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratin, type I cuticular Ha6
Alternative name(s):
    Hair keratin, type I Ha6
    Keratin-36
      Short name=K36

Gene names

Name:	KRT36
Synonyms:	HHA6, HKA6, KRTHA6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Heterotetramer of two type I and two type II keratins By similarity.
Tissue specificity	Expressed in the hair follicle. Ref.1
Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct structural constituent of epidermis Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DNPEP	Q9ULA0	1	EBI-1054946,EBI-748356
TWF2	Q6IBS0	1	EBI-1054946,EBI-722204

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O76013-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O76013-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MATQTCTPTFSTGSIKGLCGTAGGISRVSSIRSVGSCRVPSLAGAAGYISSA → ML

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Keratin, type I cuticular Ha6		PRO_0000063693
Regions
	Region	1 – 93	93	Head
	Region	94 – 400	307	Rod
	Region	94 – 128	35	Coil 1A
	Region	129 – 139	11	Linker 1
	Region	140 – 240	101	Coil 1B
	Region	241 – 256	16	Linker 12
	Region	257 – 400	144	Coil 2
	Region	401 – 467	67	Tail
Sites
	Site	342	1	Stutter
Amino acid modifications
	Modified residue	315	1	Phosphothreonine Ref.4
	Modified residue	328	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	1 – 52	52	MATQT…YISSA → ML in isoform 2.		VSP_036403
	Natural variant	119	1	A → V: dbSNP rs8082683.		VAR_024490
	Natural variant	126	1	Q → R: dbSNP rs8069943.		VAR_024491
	Natural variant	179	1	R → Q: dbSNP rs9675246.		VAR_049792
	Natural variant	277	1	R → C: dbSNP rs9904102.		VAR_049793
	Natural variant	315	1	T → M: dbSNP rs2301354.		VAR_020306
	Natural variant	357	1	N → T: dbSNP rs11657323.		VAR_049794

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 492B3B2DE3BCAECD	FASTA	467	52,247
	10 20 30 40 50 60 MATQTCTPTF STGSIKGLCG TAGGISRVSS IRSVGSCRVP SLAGAAGYIS SARSGLSGLG 70 80 90 100 110 120 SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL NDRLANYLEK VRQLERENAE 130 140 150 160 170 180 LESRIQEWYE FQIPYICPDY QSYFKTIEDF QQKILLTKSE NARLVLQIDN AKLAADDFRT 190 200 210 220 230 240 KYETELSLRQ LVEADINGLR RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC 250 260 270 280 290 300 QLGDRLNVEV DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE 310 320 330 340 350 360 QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ MQCLISNVEA 370 380 390 400 410 420 QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE DCKLPPQPCA TACKPVIRVP 430 440 450 460 SVPPVPCVPS VPCTPAPQVG TQIRTITEEI RDGKVISSRE HVQSRPL
	Isoform 2. Checksum: D27B5052EDC12A3B	FASTA	417	47,485
	10 20 30 40 50 60 MLRSGLSGLG SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL NDRLANYLEK 70 80 90 100 110 120 VRQLERENAE LESRIQEWYE FQIPYICPDY QSYFKTIEDF QQKILLTKSE NARLVLQIDN 130 140 150 160 170 180 AKLAADDFRT KYETELSLRQ LVEADINGLR RILDELTLCK ADLEAQVESL KEELMCLKKN 190 200 210 220 230 240 HEEEVSVLRC QLGDRLNVEV DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE 250 260 270 280 290 300 LNQQVVSSSE QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ 310 320 330 340 350 360 MQCLISNVEA QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE DCKLPPQPCA 370 380 390 400 410 TACKPVIRVP SVPPVPCVPS VPCTPAPQVG TQIRTITEEI RDGKVISSRE HVQSRPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), TISSUE SPECIFICITY.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-315 AND SER-328, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y16792 Genomic DNA. Translation: CAA76388.1. CH471152 Genomic DNA. Translation: EAW60738.1. BC043581 mRNA. Translation: AAH43581.1.
IPI	IPI00008692. IPI00795958.
RefSeq	NP_003762.1.
UniGene	Hs.248189
3D structure databases
HSSP	HSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBase	Search...
Protein-protein interaction databases
IntAct	O76013. 5 interactions.
PTM databases
PhosphoSite	O76013.
Proteomic databases
PeptideAtlas	O76013.
PRIDE	O76013.
Genome annotation databases
Ensembl	ENSG00000126337. Homo sapiens. [Contig view]
GeneID	8689.
KEGG	hsa:8689.
Organism-specific databases
GeneCards	GC17M036896.
H-InvDB	HIX0027332.
HGNC	HGNC:6454. KRT36.
MIM	604540. gene.
PharmGKB	PA30243.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O76013.
HOVERGEN	O76013.
OMA	O76013. ILDDMRC.
Gene expression databases
ArrayExpress	O76013.
Bgee	O76013.
CleanEx	HS_KRT36.
GermOnline	ENSG00000126337. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. IF. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	32587.
SOURCE	Search...

Entry information

Entry name

KRT36_HUMAN

Accession

Primary (citable) accession number: O76013
Secondary accession number(s): Q86XG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)