Reviewed,
UniProtKB/Swiss-Prot O76011 (KRT34_HUMAN)
Last modified
July 7, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Keratin, type I cuticular Ha4 Alternative name(s): Hair keratin, type I Ha4 Keratin-34 Short name=K34 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 436 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Tissue specificity | Expressed in the hair follicle. Ref.1 |
| Miscellaneous | There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). |
| Sequence similarities | Belongs to the intermediate filament family. |
| Caution | It is uncertain whether Met-1 or Met-43 is the initiator. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Intermediate filament Keratin |
| Coding sequence diversity | Polymorphism |
| Domain | Coiled coil |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | epidermis development Ref.1 Traceable author statement. Source: ProtInc |
| Cellular component | intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct structural molecule activity Ref.1Non-traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| DLG3 | Q92796 | 1 | EBI-1047093,EBI-80440 | |
| PLEKHB2 | Q96CS7 | 1 | EBI-1047093,EBI-373552 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 436 | 436 | Keratin, type I cuticular Ha4 | PRO_0000063691 | |||||
Regions | |||||||||
| Region | 1 – 98 | 98 | Head | ||||||
| Region | 99 – 405 | 307 | Rod | ||||||
| Region | 99 – 133 | 35 | Coil 1A | ||||||
| Region | 134 – 144 | 11 | Linker 1 | ||||||
| Region | 145 – 245 | 101 | Coil 1B | ||||||
| Region | 246 – 261 | 16 | Linker 12 | ||||||
| Region | 262 – 405 | 144 | Coil 2 | ||||||
| Region | 406 – 436 | 31 | Tail | ||||||
Sites | |||||||||
| Site | 347 | 1 | Stutter | ||||||
Natural variations | |||||||||
| Natural variant | 280 | 1 | I → T: dbSNP rs2239710. | VAR_056017 | |||||
| Natural variant | 348 | 1 | H → R: dbSNP rs2071599. | VAR_056018 | |||||
Experimental info | |||||||||
| Sequence conflict | 246 | 1 | Q → P in CAA76386. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-280. Tissue: Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Y16790 Genomic DNA. Translation: CAA76386.1. Different initiation. BC033252 mRNA. Translation: AAH33252.1. BC041070 mRNA. Translation: AAH41070.1. | |
| IPI | IPI00796822. |
| RefSeq | NP_066293.2. |
| UniGene | Hs.296942 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GK7 based on UniProtKB P08670. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O76011. 4 interactions. |
Proteomic databases | |
| PRIDE | O76011. |
Genome annotation databases | |
| Ensembl | ENSG00000131737. Homo sapiens. [Contig view] |
| GeneID | 3885. |
| UCSC | uc002hwm.1. human. |
Organism-specific databases | |
| GeneCards | GC17M036788. |
| HGNC | HGNC:6452. KRT34. |
| MIM | 602763. gene. |
| PharmGKB | PA30241. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | O76011. |
| OMA | O76011. CGPCGTS. |
Gene expression databases | |
| ArrayExpress | O76011. |
| Bgee | O76011. |
| CleanEx | HS_KRT34. |
| GermOnline | ENSG00000131737. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view] |
| PANTHER | PTHR23239. IF. 1 hit. |
| Pfam | PF00038. Filament. 1 hit. [Graphical view] |
| PRINTS | PR01248. TYPE1KERATIN. |
| PROSITE | PS00226. IF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | KRT34_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O76011 Secondary accession number(s): Q8IUT8, Q8N4W2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


