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O76011

- KRT34_HUMAN

UniProt

O76011 - KRT34_HUMAN

Protein

Keratin, type I cuticular Ha4

Gene

KRT34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei347 – 3471Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: ProtInc

    GO - Biological processi

    1. epidermis development Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cuticular Ha4
    Alternative name(s):
    Hair keratin, type I Ha4
    Keratin-34
    Short name:
    K34
    Gene namesi
    Name:KRT34
    Synonyms:HHA4, HKA4, KRTHA4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6452. KRT34.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. extracellular vesicular exosome Source: UniProt
    3. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30241.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Keratin, type I cuticular Ha4PRO_0000063691Add
    BLAST

    Proteomic databases

    MaxQBiO76011.
    PaxDbiO76011.
    PRIDEiO76011.

    PTM databases

    PhosphoSiteiO76011.

    Expressioni

    Tissue specificityi

    Expressed in the hair follicles.1 Publication

    Gene expression databases

    BgeeiO76011.
    CleanExiHS_KRT34.
    GenevestigatoriO76011.

    Interactioni

    Protein-protein interaction databases

    BioGridi110083. 5 interactions.
    IntActiO76011. 1 interaction.
    STRINGi9606.ENSP00000251648.

    Structurei

    3D structure databases

    ProteinModelPortaliO76011.
    SMRiO76011. Positions 148-246, 316-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9898HeadAdd
    BLAST
    Regioni99 – 405307RodAdd
    BLAST
    Regioni99 – 13335Coil 1AAdd
    BLAST
    Regioni134 – 14411Linker 1Add
    BLAST
    Regioni145 – 245101Coil 1BAdd
    BLAST
    Regioni246 – 26116Linker 12Add
    BLAST
    Regioni262 – 405144Coil 2Add
    BLAST
    Regioni406 – 43631TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG146780.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiO76011.
    KOiK07604.
    OMAiVEINRRE.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiO76011.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76011-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLYAKPPPTI NGIKGLQRKE RLKPAHIHLQ QLTCFSITCS STMSYSCCLP    50
    SLGCRTSCSS RPCVPPSCHG YTLPGACNIP ANVSNCNWFC EGSFNGSEKE 100
    TMQFLNDRLA SYLEKVRQLE RDNAELEKLI QERSQQQEPL LCPSYQSYFK 150
    TIEELQQKIL CAKAENARLV VNIDNAKLAS DDFRSKYQTE QSLRLLVESD 200
    INSIRRILDE LTLCKSDLES QVESLREELI CLKKNHEEEV NTLRSQLGDR 250
    LNVEVDTAPT VDLNQVLNET RSQYEALVEI NRREVEQWFA TQTEELNKQV 300
    VSSSEQLQSC QAEIIELRRT VNALEIELQA QHNLRDSLEN TLTESEAHYS 350
    SQLSQVQSLI TNVESQLAEI RCDLERQNQE YQVLLDVRAR LECEINTYRS 400
    LLESEDCKLP CNPCATTNAS GNSCGPCGTS QKGCCN 436
    Length:436
    Mass (Da):49,424
    Last modified:January 20, 2009 - v2
    Checksum:iEE39CB9622A94CA8
    GO

    Sequence cautioni

    The sequence CAA76386.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti246 – 2461Q → P in CAA76386. (PubMed:9756910)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti280 – 2801I → T.1 Publication
    Corresponds to variant rs2239710 [ dbSNP | Ensembl ].
    VAR_056017
    Natural varianti348 – 3481H → R.
    Corresponds to variant rs2071599 [ dbSNP | Ensembl ].
    VAR_056018

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16790 Genomic DNA. Translation: CAA76386.1. Different initiation.
    BC033252 mRNA. Translation: AAH33252.1.
    BC041070 mRNA. Translation: AAH41070.1.
    CCDSiCCDS11390.1.
    RefSeqiNP_066293.2. NM_021013.3.
    XP_003403930.1. XM_003403882.3.
    UniGeneiHs.296942.

    Genome annotation databases

    EnsembliENST00000394001; ENSP00000377570; ENSG00000131737.
    GeneIDi100653049.
    3885.
    KEGGihsa:100653049.
    hsa:3885.
    UCSCiuc002hwm.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16790 Genomic DNA. Translation: CAA76386.1 . Different initiation.
    BC033252 mRNA. Translation: AAH33252.1 .
    BC041070 mRNA. Translation: AAH41070.1 .
    CCDSi CCDS11390.1.
    RefSeqi NP_066293.2. NM_021013.3.
    XP_003403930.1. XM_003403882.3.
    UniGenei Hs.296942.

    3D structure databases

    ProteinModelPortali O76011.
    SMRi O76011. Positions 148-246, 316-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110083. 5 interactions.
    IntActi O76011. 1 interaction.
    STRINGi 9606.ENSP00000251648.

    PTM databases

    PhosphoSitei O76011.

    Proteomic databases

    MaxQBi O76011.
    PaxDbi O76011.
    PRIDEi O76011.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394001 ; ENSP00000377570 ; ENSG00000131737 .
    GeneIDi 100653049.
    3885.
    KEGGi hsa:100653049.
    hsa:3885.
    UCSCi uc002hwm.3. human.

    Organism-specific databases

    CTDi 3885.
    GeneCardsi GC17M039534.
    H-InvDB HIX0027181.
    HIX0135626.
    HGNCi HGNC:6452. KRT34.
    MIMi 602763. gene.
    neXtProti NX_O76011.
    PharmGKBi PA30241.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146780.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi O76011.
    KOi K07604.
    OMAi VEINRRE.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi O76011.

    Miscellaneous databases

    GeneWikii Keratin_34.
    NextBioi 15251.
    PROi O76011.
    SOURCEi Search...

    Gene expression databases

    Bgeei O76011.
    CleanExi HS_KRT34.
    Genevestigatori O76011.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
      Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
      J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-280.
      Tissue: Skin.

    Entry informationi

    Entry nameiKRT34_HUMAN
    AccessioniPrimary (citable) accession number: O76011
    Secondary accession number(s): Q8IUT8, Q8N4W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Caution

    It is uncertain whether Met-1 or Met-43 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3