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Protein

Keratin, type I cuticular Ha4

Gene

KRT34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei347Stutter1

GO - Molecular functioni

  • structural molecule activity Source: ProtInc

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: ProtInc
  • keratinization Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha4
Alternative name(s):
Hair keratin, type I Ha4
Keratin-34
Short name:
K34
Gene namesi
Name:KRT34
Synonyms:HHA4, HKA4, KRTHA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131737.5.
HGNCiHGNC:6452. KRT34.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131737.
PharmGKBiPA30241.

Polymorphism and mutation databases

BioMutaiKRT34.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636911 – 436Keratin, type I cuticular Ha4Add BLAST436

Proteomic databases

EPDiO76011.
PaxDbiO76011.
PeptideAtlasiO76011.
PRIDEiO76011.

PTM databases

iPTMnetiO76011.
PhosphoSitePlusiO76011.
SwissPalmiO76011.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiENSG00000131737.
CleanExiHS_KRT34.
GenevisibleiO76011. HS.

Organism-specific databases

HPAiHPA055194.
HPA072208.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110083. 6 interactors.
IntActiO76011. 257 interactors.
STRINGi9606.ENSP00000377570.

Structurei

3D structure databases

ProteinModelPortaliO76011.
SMRiO76011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 409IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98HeadAdd BLAST98
Regioni99 – 133Coil 1AAdd BLAST35
Regioni134 – 144Linker 1Add BLAST11
Regioni145 – 245Coil 1BAdd BLAST101
Regioni246 – 261Linker 12Add BLAST16
Regioni262 – 405Coil 2Add BLAST144
Regioni406 – 436TailAdd BLAST31

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00900000140814.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76011.
KOiK07604.
OMAiTITPCIS.
OrthoDBiEOG091G087I.
PhylomeDBiO76011.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PRINTSiPR01248. TYPE1KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF_ROD_1. 1 hit.
PS51842. IF_ROD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O76011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYAKPPPTI NGIKGLQRKE RLKPAHIHLQ QLTCFSITCS STMSYSCCLP
60 70 80 90 100
SLGCRTSCSS RPCVPPSCHG YTLPGACNIP ANVSNCNWFC EGSFNGSEKE
110 120 130 140 150
TMQFLNDRLA SYLEKVRQLE RDNAELEKLI QERSQQQEPL LCPSYQSYFK
160 170 180 190 200
TIEELQQKIL CAKAENARLV VNIDNAKLAS DDFRSKYQTE QSLRLLVESD
210 220 230 240 250
INSIRRILDE LTLCKSDLES QVESLREELI CLKKNHEEEV NTLRSQLGDR
260 270 280 290 300
LNVEVDTAPT VDLNQVLNET RSQYEALVEI NRREVEQWFA TQTEELNKQV
310 320 330 340 350
VSSSEQLQSC QAEIIELRRT VNALEIELQA QHNLRDSLEN TLTESEAHYS
360 370 380 390 400
SQLSQVQSLI TNVESQLAEI RCDLERQNQE YQVLLDVRAR LECEINTYRS
410 420 430
LLESEDCKLP CNPCATTNAS GNSCGPCGTS QKGCCN
Length:436
Mass (Da):49,424
Last modified:January 20, 2009 - v2
Checksum:iEE39CB9622A94CA8
GO

Sequence cautioni

The sequence CAA76386 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246Q → P in CAA76386 (PubMed:9756910).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056017280I → T1 PublicationCorresponds to variant dbSNP:rs2239710Ensembl.1
Natural variantiVAR_056018348H → R. Corresponds to variant dbSNP:rs2071599Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16790 Genomic DNA. Translation: CAA76386.1. Different initiation.
BC033252 mRNA. Translation: AAH33252.1.
BC041070 mRNA. Translation: AAH41070.1.
CCDSiCCDS11390.1.
RefSeqiNP_066293.2. NM_021013.3.
XP_003403930.1. XM_003403882.4.
UniGeneiHs.296942.

Genome annotation databases

EnsembliENST00000394001; ENSP00000377570; ENSG00000131737.
GeneIDi100653049.
3885.
KEGGihsa:100653049.
hsa:3885.
UCSCiuc002hwm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKRT34_HUMAN
AccessioniPrimary (citable) accession number: O76011
Secondary accession number(s): Q8IUT8, Q8N4W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2009
Last modified: October 25, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-43 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families