Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O76011 (KRT34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cuticular Ha4
Alternative name(s):
Hair keratin, type I Ha4
Keratin-34
Short name=K34
Gene names
Name:KRT34
Synonyms:HHA4, HKA4, KRTHA4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Expressed in the hair follicles. Ref.1

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Caution

It is uncertain whether Met-1 or Met-43 is the initiator.

Sequence caution

The sequence CAA76386.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processepidermis development

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular space

Inferred from direct assay PubMed 23580065. Source: UniProt

intermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Non-traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Keratin, type I cuticular Ha4
PRO_0000063691

Regions

Region1 – 9898Head
Region99 – 405307Rod
Region99 – 13335Coil 1A
Region134 – 14411Linker 1
Region145 – 245101Coil 1B
Region246 – 26116Linker 12
Region262 – 405144Coil 2
Region406 – 43631Tail

Sites

Site3471Stutter

Natural variations

Natural variant2801I → T. Ref.2
Corresponds to variant rs2239710 [ dbSNP | Ensembl ].
VAR_056017
Natural variant3481H → R.
Corresponds to variant rs2071599 [ dbSNP | Ensembl ].
VAR_056018

Experimental info

Sequence conflict2461Q → P in CAA76386. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O76011 [UniParc].

Last modified January 20, 2009. Version 2.
Checksum: EE39CB9622A94CA8

FASTA43649,424
        10         20         30         40         50         60 
MLYAKPPPTI NGIKGLQRKE RLKPAHIHLQ QLTCFSITCS STMSYSCCLP SLGCRTSCSS 

        70         80         90        100        110        120 
RPCVPPSCHG YTLPGACNIP ANVSNCNWFC EGSFNGSEKE TMQFLNDRLA SYLEKVRQLE 

       130        140        150        160        170        180 
RDNAELEKLI QERSQQQEPL LCPSYQSYFK TIEELQQKIL CAKAENARLV VNIDNAKLAS 

       190        200        210        220        230        240 
DDFRSKYQTE QSLRLLVESD INSIRRILDE LTLCKSDLES QVESLREELI CLKKNHEEEV 

       250        260        270        280        290        300 
NTLRSQLGDR LNVEVDTAPT VDLNQVLNET RSQYEALVEI NRREVEQWFA TQTEELNKQV 

       310        320        330        340        350        360 
VSSSEQLQSC QAEIIELRRT VNALEIELQA QHNLRDSLEN TLTESEAHYS SQLSQVQSLI 

       370        380        390        400        410        420 
TNVESQLAEI RCDLERQNQE YQVLLDVRAR LECEINTYRS LLESEDCKLP CNPCATTNAS 

       430 
GNSCGPCGTS QKGCCN 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-280.
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y16790 Genomic DNA. Translation: CAA76386.1. Different initiation.
BC033252 mRNA. Translation: AAH33252.1.
BC041070 mRNA. Translation: AAH41070.1.
CCDSCCDS11390.1.
RefSeqNP_066293.2. NM_021013.3.
XP_003403930.1. XM_003403882.3.
UniGeneHs.296942.

3D structure databases

ProteinModelPortalO76011.
SMRO76011. Positions 148-246, 316-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110083. 5 interactions.
IntActO76011. 1 interaction.
STRING9606.ENSP00000251648.

PTM databases

PhosphoSiteO76011.

Proteomic databases

MaxQBO76011.
PaxDbO76011.
PRIDEO76011.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000394001; ENSP00000377570; ENSG00000131737.
GeneID100653049.
3885.
KEGGhsa:100653049.
hsa:3885.
UCSCuc002hwm.3. human.

Organism-specific databases

CTD3885.
GeneCardsGC17M039534.
H-InvDBHIX0027181.
HIX0135626.
HGNCHGNC:6452. KRT34.
MIM602763. gene.
neXtProtNX_O76011.
PharmGKBPA30241.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146780.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidO76011.
KOK07604.
OMAVEINRRE.
OrthoDBEOG7FV3Q8.
PhylomeDBO76011.

Gene expression databases

BgeeO76011.
CleanExHS_KRT34.
GenevestigatorO76011.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKeratin_34.
NextBio15251.
PROO76011.
SOURCESearch...

Entry information

Entry nameKRT34_HUMAN
AccessionPrimary (citable) accession number: O76011
Secondary accession number(s): Q8IUT8, Q8N4W2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2009
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM