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O76011

- KRT34_HUMAN

UniProt

O76011 - KRT34_HUMAN

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Protein

Keratin, type I cuticular Ha4

Gene
KRT34, HHA4, HKA4, KRTHA4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei347 – 3471Stutter

GO - Molecular functioni

  1. structural molecule activity Source: ProtInc

GO - Biological processi

  1. epidermis development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha4
Alternative name(s):
Hair keratin, type I Ha4
Keratin-34
Short name:
K34
Gene namesi
Name:KRT34
Synonyms:HHA4, HKA4, KRTHA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6452. KRT34.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. extracellular vesicular exosome Source: UniProt
  3. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Keratin, type I cuticular Ha4PRO_0000063691Add
BLAST

Proteomic databases

MaxQBiO76011.
PaxDbiO76011.
PRIDEiO76011.

PTM databases

PhosphoSiteiO76011.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiO76011.
CleanExiHS_KRT34.
GenevestigatoriO76011.

Interactioni

Protein-protein interaction databases

BioGridi110083. 5 interactions.
IntActiO76011. 1 interaction.
STRINGi9606.ENSP00000251648.

Structurei

3D structure databases

ProteinModelPortaliO76011.
SMRiO76011. Positions 148-246, 316-403.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9898HeadAdd
BLAST
Regioni99 – 405307RodAdd
BLAST
Regioni99 – 13335Coil 1AAdd
BLAST
Regioni134 – 14411Linker 1Add
BLAST
Regioni145 – 245101Coil 1BAdd
BLAST
Regioni246 – 26116Linker 12Add
BLAST
Regioni262 – 405144Coil 2Add
BLAST
Regioni406 – 43631TailAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG146780.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76011.
KOiK07604.
OMAiVEINRRE.
OrthoDBiEOG7FV3Q8.
PhylomeDBiO76011.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76011-1 [UniParc]FASTAAdd to Basket

« Hide

MLYAKPPPTI NGIKGLQRKE RLKPAHIHLQ QLTCFSITCS STMSYSCCLP    50
SLGCRTSCSS RPCVPPSCHG YTLPGACNIP ANVSNCNWFC EGSFNGSEKE 100
TMQFLNDRLA SYLEKVRQLE RDNAELEKLI QERSQQQEPL LCPSYQSYFK 150
TIEELQQKIL CAKAENARLV VNIDNAKLAS DDFRSKYQTE QSLRLLVESD 200
INSIRRILDE LTLCKSDLES QVESLREELI CLKKNHEEEV NTLRSQLGDR 250
LNVEVDTAPT VDLNQVLNET RSQYEALVEI NRREVEQWFA TQTEELNKQV 300
VSSSEQLQSC QAEIIELRRT VNALEIELQA QHNLRDSLEN TLTESEAHYS 350
SQLSQVQSLI TNVESQLAEI RCDLERQNQE YQVLLDVRAR LECEINTYRS 400
LLESEDCKLP CNPCATTNAS GNSCGPCGTS QKGCCN 436
Length:436
Mass (Da):49,424
Last modified:January 20, 2009 - v2
Checksum:iEE39CB9622A94CA8
GO

Sequence cautioni

The sequence CAA76386.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti280 – 2801I → T.1 Publication
Corresponds to variant rs2239710 [ dbSNP | Ensembl ].
VAR_056017
Natural varianti348 – 3481H → R.
Corresponds to variant rs2071599 [ dbSNP | Ensembl ].
VAR_056018

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461Q → P in CAA76386. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16790 Genomic DNA. Translation: CAA76386.1. Different initiation.
BC033252 mRNA. Translation: AAH33252.1.
BC041070 mRNA. Translation: AAH41070.1.
CCDSiCCDS11390.1.
RefSeqiNP_066293.2. NM_021013.3.
XP_003403930.1. XM_003403882.3.
UniGeneiHs.296942.

Genome annotation databases

EnsembliENST00000394001; ENSP00000377570; ENSG00000131737.
GeneIDi100653049.
3885.
KEGGihsa:100653049.
hsa:3885.
UCSCiuc002hwm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16790 Genomic DNA. Translation: CAA76386.1 . Different initiation.
BC033252 mRNA. Translation: AAH33252.1 .
BC041070 mRNA. Translation: AAH41070.1 .
CCDSi CCDS11390.1.
RefSeqi NP_066293.2. NM_021013.3.
XP_003403930.1. XM_003403882.3.
UniGenei Hs.296942.

3D structure databases

ProteinModelPortali O76011.
SMRi O76011. Positions 148-246, 316-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110083. 5 interactions.
IntActi O76011. 1 interaction.
STRINGi 9606.ENSP00000251648.

PTM databases

PhosphoSitei O76011.

Proteomic databases

MaxQBi O76011.
PaxDbi O76011.
PRIDEi O76011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000394001 ; ENSP00000377570 ; ENSG00000131737 .
GeneIDi 100653049.
3885.
KEGGi hsa:100653049.
hsa:3885.
UCSCi uc002hwm.3. human.

Organism-specific databases

CTDi 3885.
GeneCardsi GC17M039534.
H-InvDB HIX0027181.
HIX0135626.
HGNCi HGNC:6452. KRT34.
MIMi 602763. gene.
neXtProti NX_O76011.
PharmGKBi PA30241.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146780.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi O76011.
KOi K07604.
OMAi VEINRRE.
OrthoDBi EOG7FV3Q8.
PhylomeDBi O76011.

Miscellaneous databases

GeneWikii Keratin_34.
NextBioi 15251.
PROi O76011.
SOURCEi Search...

Gene expression databases

Bgeei O76011.
CleanExi HS_KRT34.
Genevestigatori O76011.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-280.
    Tissue: Skin.

Entry informationi

Entry nameiKRT34_HUMAN
AccessioniPrimary (citable) accession number: O76011
Secondary accession number(s): Q8IUT8, Q8N4W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2009
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Caution

It is uncertain whether Met-1 or Met-43 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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