Reviewed, UniProtKB/Swiss-Prot O76011 (KRT34_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratin, type I cuticular Ha4
Alternative name(s):
    Hair keratin, type I Ha4
    Keratin-34
      Short name=K34

Gene names

Name:	KRT34
Synonyms:	HHA4, HKA4, KRTHA4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Expressed in the hair follicle. Ref.1
Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.
Caution	It is uncertain whether Met-1 or Met-43 is the initiator.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	epidermis development Ref.1 Traceable author statement. Source: ProtInc
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct structural molecule activity Ref.1 Non-traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DLG3	Q92796	1	EBI-1047093,EBI-80440
PLEKHB2	Q96CS7	1	EBI-1047093,EBI-373552

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Keratin, type I cuticular Ha4		PRO_0000063691
Regions
	Region	1 – 98	98	Head
	Region	99 – 405	307	Rod
	Region	99 – 133	35	Coil 1A
	Region	134 – 144	11	Linker 1
	Region	145 – 245	101	Coil 1B
	Region	246 – 261	16	Linker 12
	Region	262 – 405	144	Coil 2
	Region	406 – 436	31	Tail
Sites
	Site	347	1	Stutter
Natural variations
	Natural variant	280	1	I → T: dbSNP rs2239710.		VAR_056017
	Natural variant	348	1	H → R: dbSNP rs2071599.		VAR_056018
Experimental info
	Sequence conflict	246	1	Q → P in CAA76386. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O76011-1 [UniParc]. Last modified January 20, 2009. Version 2. Checksum: EE39CB9622A94CA8	FASTA	436	49,424
	10 20 30 40 50 60 MLYAKPPPTI NGIKGLQRKE RLKPAHIHLQ QLTCFSITCS STMSYSCCLP SLGCRTSCSS 70 80 90 100 110 120 RPCVPPSCHG YTLPGACNIP ANVSNCNWFC EGSFNGSEKE TMQFLNDRLA SYLEKVRQLE 130 140 150 160 170 180 RDNAELEKLI QERSQQQEPL LCPSYQSYFK TIEELQQKIL CAKAENARLV VNIDNAKLAS 190 200 210 220 230 240 DDFRSKYQTE QSLRLLVESD INSIRRILDE LTLCKSDLES QVESLREELI CLKKNHEEEV 250 260 270 280 290 300 NTLRSQLGDR LNVEVDTAPT VDLNQVLNET RSQYEALVEI NRREVEQWFA TQTEELNKQV 310 320 330 340 350 360 VSSSEQLQSC QAEIIELRRT VNALEIELQA QHNLRDSLEN TLTESEAHYS SQLSQVQSLI 370 380 390 400 410 420 TNVESQLAEI RCDLERQNQE YQVLLDVRAR LECEINTYRS LLESEDCKLP CNPCATTNAS 430 GNSCGPCGTS QKGCCN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-280. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y16790 Genomic DNA. Translation: CAA76386.1. Different initiation. BC033252 mRNA. Translation: AAH33252.1. BC041070 mRNA. Translation: AAH41070.1.
IPI	IPI00796822.
RefSeq	NP_066293.2.
UniGene	Hs.296942
3D structure databases
HSSP	HSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBase	Search...
Protein-protein interaction databases
IntAct	O76011. 4 interactions.
Proteomic databases
PRIDE	O76011.
Genome annotation databases
Ensembl	ENSG00000131737. Homo sapiens. [Contig view]
GeneID	3885.
UCSC	uc002hwm.1. human.
Organism-specific databases
GeneCards	GC17M036788.
HGNC	HGNC:6452. KRT34.
MIM	602763. gene.
PharmGKB	PA30241.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O76011.
OMA	O76011. CGPCGTS.
Gene expression databases
ArrayExpress	O76011.
Bgee	O76011.
CleanEx	HS_KRT34.
GermOnline	ENSG00000131737. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. IF. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

KRT34_HUMAN

Accession

Primary (citable) accession number: O76011
Secondary accession number(s): Q8IUT8, Q8N4W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 20, 2009
Last modified:	July 7, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)