ID   KT33A_HUMAN             Reviewed;         404 AA.
AC   O76009; B2RA87; Q6NTB9; Q6ZZB9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   24-JAN-2024, entry version 169.
DE   RecName: Full=Keratin, type I cuticular Ha3-I;
DE   AltName: Full=Hair keratin, type I Ha3-I;
DE   AltName: Full=Keratin-33A;
DE            Short=K33A;
GN   Name=KRT33A; Synonyms=HHA3-I, HKA3A, KRTHA3A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
RA   Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
RT   "Characterization of a 190-kilobase pair domain of human type I hair
RT   keratin genes.";
RL   J. Biol. Chem. 273:26683-26691(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Scalp;
RX   PubMed=15617563; DOI=10.1111/j.1432-0436.2004.07209006.x;
RA   Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.;
RT   "The human type I keratin gene family: characterization of new hair
RT   follicle specific members and evaluation of the chromosome 17q21.2 gene
RT   domain.";
RL   Differentiation 72:527-540(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-270.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-270.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-270.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- TISSUE SPECIFICITY: Expressed in the hair follicles.
CC       {ECO:0000269|PubMed:9756910}.
CC   -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC       (acidic) and II (neutral to basic).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; Y16788; CAA76384.1; -; Genomic_DNA.
DR   EMBL; AJ633621; CAG17613.2; -; mRNA.
DR   EMBL; AK314088; BAG36784.1; -; mRNA.
DR   EMBL; AC003958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471152; EAW60727.1; -; Genomic_DNA.
DR   EMBL; BC069135; AAH69135.1; -; mRNA.
DR   CCDS; CCDS11388.1; -.
DR   RefSeq; NP_004129.2; NM_004138.3.
DR   AlphaFoldDB; O76009; -.
DR   SMR; O76009; -.
DR   BioGRID; 110081; 7.
DR   IntAct; O76009; 4.
DR   STRING; 9606.ENSP00000007735; -.
DR   iPTMnet; O76009; -.
DR   PhosphoSitePlus; O76009; -.
DR   SwissPalm; O76009; -.
DR   BioMuta; KRT33A; -.
DR   jPOST; O76009; -.
DR   MassIVE; O76009; -.
DR   PaxDb; 9606-ENSP00000007735; -.
DR   PeptideAtlas; O76009; -.
DR   ProteomicsDB; 50342; -.
DR   Antibodypedia; 66112; 112 antibodies from 19 providers.
DR   DNASU; 3883; -.
DR   Ensembl; ENST00000007735.4; ENSP00000007735.3; ENSG00000006059.4.
DR   Ensembl; ENST00000576236.1; ENSP00000461221.1; ENSG00000261986.1.
DR   Ensembl; ENST00000709590.1; ENSP00000517782.1; ENSG00000292027.1.
DR   GeneID; 3883; -.
DR   KEGG; hsa:3883; -.
DR   MANE-Select; ENST00000007735.4; ENSP00000007735.3; NM_004138.4; NP_004129.2.
DR   UCSC; uc002hwk.3; human.
DR   AGR; HGNC:6450; -.
DR   CTD; 3883; -.
DR   GeneCards; KRT33A; -.
DR   HGNC; HGNC:6450; KRT33A.
DR   HPA; ENSG00000006059; Tissue enriched (skin).
DR   MIM; 602761; gene.
DR   neXtProt; NX_O76009; -.
DR   OpenTargets; ENSG00000006059; -.
DR   PharmGKB; PA30239; -.
DR   VEuPathDB; HostDB:ENSG00000006059; -.
DR   eggNOG; ENOG502SNBF; Eukaryota.
DR   GeneTree; ENSGT00940000153980; -.
DR   HOGENOM; CLU_012560_8_0_1; -.
DR   InParanoid; O76009; -.
DR   OMA; ACNISAN; -.
DR   OrthoDB; 4640531at2759; -.
DR   PhylomeDB; O76009; -.
DR   TreeFam; TF332742; -.
DR   PathwayCommons; O76009; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR   SignaLink; O76009; -.
DR   BioGRID-ORCS; 3883; 17 hits in 1135 CRISPR screens.
DR   GeneWiki; KRT33A; -.
DR   GenomeRNAi; 3883; -.
DR   Pharos; O76009; Tdark.
DR   PRO; PR:O76009; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; O76009; Protein.
DR   Bgee; ENSG00000006059; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 35 other cell types or tissues.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF98; KERATIN, TYPE I CUTICULAR HA3-I; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   Genevisible; O76009; HS.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..404
FT                   /note="Keratin, type I cuticular Ha3-I"
FT                   /id="PRO_0000063688"
FT   DOMAIN          56..367
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..56
FT                   /note="Head"
FT   REGION          57..91
FT                   /note="Coil 1A"
FT   REGION          92..102
FT                   /note="Linker 1"
FT   REGION          103..203
FT                   /note="Coil 1B"
FT   REGION          204..219
FT                   /note="Linker 12"
FT   REGION          220..363
FT                   /note="Coil 2"
FT   REGION          364..404
FT                   /note="Tail"
FT   SITE            305
FT                   /note="Stutter"
FT   VARIANT         270
FT                   /note="A -> V (in dbSNP:rs12937519)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|Ref.5"
FT                   /id="VAR_054432"
FT   CONFLICT        82
FT                   /note="A -> T (in Ref. 3; BAG36784)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        94
FT                   /note="Q -> R (in Ref. 2; CAG17613)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        153..154
FT                   /note="QL -> HV (in Ref. 1; CAA76384)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   404 AA;  45940 MW;  14B0C556E64485B0 CRC64;
     MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM
     QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC ASYQSYFKTI EELQQKILCS
     KSENARLVVQ IDNAKLASDD FRTKYETELS LRQLVESDIN GLRRILDELT LCRSDLEAQV
     ESLKEELLCL KQNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR
     REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
     TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL
     ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN TFGY
//