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O76009

- KT33A_HUMAN

UniProt

O76009 - KT33A_HUMAN

Protein

Keratin, type I cuticular Ha3-I

Gene

KRT33A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei305 – 3051Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cuticular Ha3-I
    Alternative name(s):
    Hair keratin, type I Ha3-I
    Keratin-33A
    Short name:
    K33A
    Gene namesi
    Name:KRT33A
    Synonyms:HHA3-I, HKA3A, KRTHA3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6450. KRT33A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30239.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Keratin, type I cuticular Ha3-IPRO_0000063688Add
    BLAST

    Proteomic databases

    MaxQBiO76009.
    PRIDEiO76009.

    PTM databases

    PhosphoSiteiO76009.

    Expressioni

    Tissue specificityi

    Expressed in the hair follicles.1 Publication

    Gene expression databases

    BgeeiO76009.
    CleanExiHS_KRT33A.
    GenevestigatoriO76009.

    Organism-specific databases

    HPAiHPA055194.

    Interactioni

    Protein-protein interaction databases

    BioGridi110081. 2 interactions.
    IntActiO76009. 2 interactions.
    STRINGi9606.ENSP00000007735.

    Structurei

    3D structure databases

    ProteinModelPortaliO76009.
    SMRiO76009. Positions 54-204, 220-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5656HeadAdd
    BLAST
    Regioni57 – 363307RodAdd
    BLAST
    Regioni57 – 9135Coil 1AAdd
    BLAST
    Regioni92 – 10211Linker 1Add
    BLAST
    Regioni103 – 203101Coil 1BAdd
    BLAST
    Regioni204 – 21916Linker 12Add
    BLAST
    Regioni220 – 363144Coil 2Add
    BLAST
    Regioni364 – 40441TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiO76009.
    KOiK07604.
    OMAiWCGPCNT.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiO76009.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76009-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG    50
    SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC 100
    ASYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLASDD FRTKYETELS 150
    LRQLVESDIN GLRRILDELT LCRSDLEAQV ESLKEELLCL KQNHEQEVNT 200
    LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR REVEQWFATQ 250
    TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL 300
    TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE 350
    CEINTYRSLL ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN 400
    TFGY 404
    Length:404
    Mass (Da):45,940
    Last modified:February 10, 2009 - v2
    Checksum:i14B0C556E64485B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821A → T in BAG36784. (PubMed:14702039)Curated
    Sequence conflicti94 – 941Q → R in CAG17613. (PubMed:15617563)Curated
    Sequence conflicti153 – 1542QL → HV in CAA76384. (PubMed:9756910)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti270 – 2701A → V.3 Publications
    Corresponds to variant rs12937519 [ dbSNP | Ensembl ].
    VAR_054432

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16788 Genomic DNA. Translation: CAA76384.1.
    AJ633621 mRNA. Translation: CAG17613.2.
    AK314088 mRNA. Translation: BAG36784.1.
    AC003958 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60727.1.
    BC069135 mRNA. Translation: AAH69135.1.
    CCDSiCCDS11388.1.
    RefSeqiNP_004129.2. NM_004138.3.
    UniGeneiHs.512579.

    Genome annotation databases

    EnsembliENST00000007735; ENSP00000007735; ENSG00000006059.
    ENST00000576236; ENSP00000461221; ENSG00000261986.
    GeneIDi3883.
    KEGGihsa:3883.
    UCSCiuc002hwk.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16788 Genomic DNA. Translation: CAA76384.1 .
    AJ633621 mRNA. Translation: CAG17613.2 .
    AK314088 mRNA. Translation: BAG36784.1 .
    AC003958 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60727.1 .
    BC069135 mRNA. Translation: AAH69135.1 .
    CCDSi CCDS11388.1.
    RefSeqi NP_004129.2. NM_004138.3.
    UniGenei Hs.512579.

    3D structure databases

    ProteinModelPortali O76009.
    SMRi O76009. Positions 54-204, 220-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110081. 2 interactions.
    IntActi O76009. 2 interactions.
    STRINGi 9606.ENSP00000007735.

    PTM databases

    PhosphoSitei O76009.

    Proteomic databases

    MaxQBi O76009.
    PRIDEi O76009.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000007735 ; ENSP00000007735 ; ENSG00000006059 .
    ENST00000576236 ; ENSP00000461221 ; ENSG00000261986 .
    GeneIDi 3883.
    KEGGi hsa:3883.
    UCSCi uc002hwk.2. human.

    Organism-specific databases

    CTDi 3883.
    GeneCardsi GC17M039502.
    H-InvDB HIX0039114.
    HGNCi HGNC:6450. KRT33A.
    HPAi HPA055194.
    MIMi 602761. gene.
    neXtProti NX_O76009.
    PharmGKBi PA30239.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi O76009.
    KOi K07604.
    OMAi WCGPCNT.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi O76009.
    TreeFami TF332742.

    Miscellaneous databases

    GeneWikii KRT33A.
    GenomeRNAii 3883.
    NextBioi 15243.
    PROi O76009.
    SOURCEi Search...

    Gene expression databases

    Bgeei O76009.
    CleanExi HS_KRT33A.
    Genevestigatori O76009.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
      Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
      J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    2. "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
      Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
      Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Scalp.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-270.
      Tissue: Testis.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-270.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-270.

    Entry informationi

    Entry nameiKT33A_HUMAN
    AccessioniPrimary (citable) accession number: O76009
    Secondary accession number(s): B2RA87, Q6NTB9, Q6ZZB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3