SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O76009

- KT33A_HUMAN

UniProt

O76009 - KT33A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Keratin, type I cuticular Ha3-I
Gene
KRT33A, HHA3-I, HKA3A, KRTHA3A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei305 – 3051Stutter

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-I
Alternative name(s):
Hair keratin, type I Ha3-I
Keratin-33A
Short name:
K33A
Gene namesi
Name:KRT33A
Synonyms:HHA3-I, HKA3A, KRTHA3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6450. KRT33A.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30239.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Keratin, type I cuticular Ha3-I
PRO_0000063688Add
BLAST

Proteomic databases

MaxQBiO76009.
PRIDEiO76009.

PTM databases

PhosphoSiteiO76009.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiO76009.
CleanExiHS_KRT33A.
GenevestigatoriO76009.

Organism-specific databases

HPAiHPA055194.

Interactioni

Protein-protein interaction databases

BioGridi110081. 2 interactions.
IntActiO76009. 2 interactions.
STRINGi9606.ENSP00000007735.

Structurei

3D structure databases

ProteinModelPortaliO76009.
SMRiO76009. Positions 54-204, 220-361.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656Head
Add
BLAST
Regioni57 – 363307Rod
Add
BLAST
Regioni57 – 9135Coil 1A
Add
BLAST
Regioni92 – 10211Linker 1
Add
BLAST
Regioni103 – 203101Coil 1B
Add
BLAST
Regioni204 – 21916Linker 12
Add
BLAST
Regioni220 – 363144Coil 2
Add
BLAST
Regioni364 – 40441Tail
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76009.
KOiK07604.
OMAiWCGPCNT.
OrthoDBiEOG7FV3Q8.
PhylomeDBiO76009.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76009-1 [UniParc]FASTAAdd to Basket

« Hide

MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG    50
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC 100
ASYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLASDD FRTKYETELS 150
LRQLVESDIN GLRRILDELT LCRSDLEAQV ESLKEELLCL KQNHEQEVNT 200
LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR REVEQWFATQ 250
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL 300
TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE 350
CEINTYRSLL ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN 400
TFGY 404
Length:404
Mass (Da):45,940
Last modified:February 10, 2009 - v2
Checksum:i14B0C556E64485B0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti270 – 2701A → V.3 Publications
Corresponds to variant rs12937519 [ dbSNP | Ensembl ].
VAR_054432

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821A → T in BAG36784. 1 Publication
Sequence conflicti94 – 941Q → R in CAG17613. 1 Publication
Sequence conflicti153 – 1542QL → HV in CAA76384. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16788 Genomic DNA. Translation: CAA76384.1.
AJ633621 mRNA. Translation: CAG17613.2.
AK314088 mRNA. Translation: BAG36784.1.
AC003958 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60727.1.
BC069135 mRNA. Translation: AAH69135.1.
CCDSiCCDS11388.1.
RefSeqiNP_004129.2. NM_004138.3.
UniGeneiHs.512579.

Genome annotation databases

EnsembliENST00000007735; ENSP00000007735; ENSG00000006059.
ENST00000576236; ENSP00000461221; ENSG00000261986.
GeneIDi3883.
KEGGihsa:3883.
UCSCiuc002hwk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16788 Genomic DNA. Translation: CAA76384.1 .
AJ633621 mRNA. Translation: CAG17613.2 .
AK314088 mRNA. Translation: BAG36784.1 .
AC003958 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60727.1 .
BC069135 mRNA. Translation: AAH69135.1 .
CCDSi CCDS11388.1.
RefSeqi NP_004129.2. NM_004138.3.
UniGenei Hs.512579.

3D structure databases

ProteinModelPortali O76009.
SMRi O76009. Positions 54-204, 220-361.
ModBasei Search...

Protein-protein interaction databases

BioGridi 110081. 2 interactions.
IntActi O76009. 2 interactions.
STRINGi 9606.ENSP00000007735.

PTM databases

PhosphoSitei O76009.

Proteomic databases

MaxQBi O76009.
PRIDEi O76009.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000007735 ; ENSP00000007735 ; ENSG00000006059 .
ENST00000576236 ; ENSP00000461221 ; ENSG00000261986 .
GeneIDi 3883.
KEGGi hsa:3883.
UCSCi uc002hwk.2. human.

Organism-specific databases

CTDi 3883.
GeneCardsi GC17M039502.
H-InvDB HIX0039114.
HGNCi HGNC:6450. KRT33A.
HPAi HPA055194.
MIMi 602761. gene.
neXtProti NX_O76009.
PharmGKBi PA30239.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi O76009.
KOi K07604.
OMAi WCGPCNT.
OrthoDBi EOG7FV3Q8.
PhylomeDBi O76009.
TreeFami TF332742.

Miscellaneous databases

GeneWikii KRT33A.
GenomeRNAii 3883.
NextBioi 15243.
PROi O76009.
SOURCEi Search...

Gene expression databases

Bgeei O76009.
CleanExi HS_KRT33A.
Genevestigatori O76009.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
    Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
    Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Scalp.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-270.
    Tissue: Testis.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-270.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-270.

Entry informationi

Entry nameiKT33A_HUMAN
AccessioniPrimary (citable) accession number: O76009
Secondary accession number(s): B2RA87, Q6NTB9, Q6ZZB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi