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Protein

Keratin, type I cuticular Ha3-I

Gene

KRT33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-I
Alternative name(s):
Hair keratin, type I Ha3-I
Keratin-33A
Short name:
K33A
Gene namesi
Name:KRT33A
Synonyms:HHA3-I, HKA3A, KRTHA3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000006059.3
HGNCiHGNC:6450 KRT33A
MIMi602761 gene
neXtProtiNX_O76009

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000006059
PharmGKBiPA30239

Polymorphism and mutation databases

BioMutaiKRT33A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636881 – 404Keratin, type I cuticular Ha3-IAdd BLAST404

Proteomic databases

PaxDbiO76009
PeptideAtlasiO76009
PRIDEiO76009

PTM databases

iPTMnetiO76009
PhosphoSitePlusiO76009
SwissPalmiO76009

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiENSG00000006059
CleanExiHS_KRT33A
GenevisibleiO76009 HS

Organism-specific databases

HPAiHPA055194

Interactioni

Protein-protein interaction databases

BioGridi1100813 interactors.
IntActiO76009 4 interactors.
STRINGi9606.ENSP00000007735

Structurei

3D structure databases

ProteinModelPortaliO76009
SMRiO76009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 367IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadAdd BLAST56
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 404TailAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiO76009
KOiK07604
OMAiSYSCGLP
OrthoDBiEOG091G087I
PhylomeDBiO76009
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 Intermediate_filament_CS
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O76009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC
110 120 130 140 150
ASYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLASDD FRTKYETELS
160 170 180 190 200
LRQLVESDIN GLRRILDELT LCRSDLEAQV ESLKEELLCL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR REVEQWFATQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN

TFGY
Length:404
Mass (Da):45,940
Last modified:February 10, 2009 - v2
Checksum:i14B0C556E64485B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82A → T in BAG36784 (PubMed:14702039).Curated1
Sequence conflicti94Q → R in CAG17613 (PubMed:15617563).Curated1
Sequence conflicti153 – 154QL → HV in CAA76384 (PubMed:9756910).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054432270A → V3 PublicationsCorresponds to variant dbSNP:rs12937519Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16788 Genomic DNA Translation: CAA76384.1
AJ633621 mRNA Translation: CAG17613.2
AK314088 mRNA Translation: BAG36784.1
AC003958 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60727.1
BC069135 mRNA Translation: AAH69135.1
CCDSiCCDS11388.1
RefSeqiNP_004129.2, NM_004138.3
UniGeneiHs.512579

Genome annotation databases

EnsembliENST00000007735; ENSP00000007735; ENSG00000006059
ENST00000576236; ENSP00000461221; ENSG00000261986
GeneIDi3883
KEGGihsa:3883
UCSCiuc002hwk.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKT33A_HUMAN
AccessioniPrimary (citable) accession number: O76009
Secondary accession number(s): B2RA87, Q6NTB9, Q6ZZB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome