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Protein

Keratin, type I cuticular Ha3-I

Gene

KRT33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei305 – 3051Stutter

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-I
Alternative name(s):
Hair keratin, type I Ha3-I
Keratin-33A
Short name:
K33A
Gene namesi
Name:KRT33A
Synonyms:HHA3-I, HKA3A, KRTHA3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 17, Unplaced

Organism-specific databases

HGNCiHGNC:6450. KRT33A.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30239.

Polymorphism and mutation databases

BioMutaiKRT33A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Keratin, type I cuticular Ha3-IPRO_0000063688Add
BLAST

Proteomic databases

MaxQBiO76009.
PRIDEiO76009.

PTM databases

PhosphoSiteiO76009.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiO76009.
CleanExiHS_KRT33A.
GenevestigatoriO76009.

Organism-specific databases

HPAiHPA055194.

Interactioni

Protein-protein interaction databases

BioGridi110081. 2 interactions.
IntActiO76009. 2 interactions.
STRINGi9606.ENSP00000007735.

Structurei

3D structure databases

ProteinModelPortaliO76009.
SMRiO76009. Positions 106-204, 274-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656HeadAdd
BLAST
Regioni57 – 363307RodAdd
BLAST
Regioni57 – 9135Coil 1AAdd
BLAST
Regioni92 – 10211Linker 1Add
BLAST
Regioni103 – 203101Coil 1BAdd
BLAST
Regioni204 – 21916Linker 12Add
BLAST
Regioni220 – 363144Coil 2Add
BLAST
Regioni364 – 40441TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76009.
KOiK07604.
OMAiWCGPCNT.
OrthoDBiEOG7FV3Q8.
PhylomeDBiO76009.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC
110 120 130 140 150
ASYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLASDD FRTKYETELS
160 170 180 190 200
LRQLVESDIN GLRRILDELT LCRSDLEAQV ESLKEELLCL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR REVEQWFATQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN

TFGY
Length:404
Mass (Da):45,940
Last modified:February 10, 2009 - v2
Checksum:i14B0C556E64485B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821A → T in BAG36784 (PubMed:14702039).Curated
Sequence conflicti94 – 941Q → R in CAG17613 (PubMed:15617563).Curated
Sequence conflicti153 – 1542QL → HV in CAA76384 (PubMed:9756910).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti270 – 2701A → V.3 Publications
Corresponds to variant rs12937519 [ dbSNP | Ensembl ].
VAR_054432

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16788 Genomic DNA. Translation: CAA76384.1.
AJ633621 mRNA. Translation: CAG17613.2.
AK314088 mRNA. Translation: BAG36784.1.
AC003958 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60727.1.
BC069135 mRNA. Translation: AAH69135.1.
CCDSiCCDS11388.1.
RefSeqiNP_004129.2. NM_004138.3.
UniGeneiHs.512579.

Genome annotation databases

EnsembliENST00000007735; ENSP00000007735; ENSG00000006059.
ENST00000576236; ENSP00000461221; ENSG00000261986.
GeneIDi3883.
KEGGihsa:3883.
UCSCiuc002hwk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16788 Genomic DNA. Translation: CAA76384.1.
AJ633621 mRNA. Translation: CAG17613.2.
AK314088 mRNA. Translation: BAG36784.1.
AC003958 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60727.1.
BC069135 mRNA. Translation: AAH69135.1.
CCDSiCCDS11388.1.
RefSeqiNP_004129.2. NM_004138.3.
UniGeneiHs.512579.

3D structure databases

ProteinModelPortaliO76009.
SMRiO76009. Positions 106-204, 274-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110081. 2 interactions.
IntActiO76009. 2 interactions.
STRINGi9606.ENSP00000007735.

PTM databases

PhosphoSiteiO76009.

Polymorphism and mutation databases

BioMutaiKRT33A.

Proteomic databases

MaxQBiO76009.
PRIDEiO76009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000007735; ENSP00000007735; ENSG00000006059.
ENST00000576236; ENSP00000461221; ENSG00000261986.
GeneIDi3883.
KEGGihsa:3883.
UCSCiuc002hwk.2. human.

Organism-specific databases

CTDi3883.
GeneCardsiGC17M039502.
H-InvDBHIX0039114.
HGNCiHGNC:6450. KRT33A.
HPAiHPA055194.
MIMi602761. gene.
neXtProtiNX_O76009.
PharmGKBiPA30239.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76009.
KOiK07604.
OMAiWCGPCNT.
OrthoDBiEOG7FV3Q8.
PhylomeDBiO76009.
TreeFamiTF332742.

Miscellaneous databases

GeneWikiiKRT33A.
GenomeRNAii3883.
NextBioi15243.
PROiO76009.
SOURCEiSearch...

Gene expression databases

BgeeiO76009.
CleanExiHS_KRT33A.
GenevestigatoriO76009.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
    Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
    Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Scalp.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-270.
    Tissue: Testis.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-270.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-270.

Entry informationi

Entry nameiKT33A_HUMAN
AccessioniPrimary (citable) accession number: O76009
Secondary accession number(s): B2RA87, Q6NTB9, Q6ZZB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 10, 2009
Last modified: April 29, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.