Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cuticular Ha3-I

Gene

KRT33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-I
Alternative name(s):
Hair keratin, type I Ha3-I
Keratin-33A
Short name:
K33A
Gene namesi
Name:KRT33A
Synonyms:HHA3-I, HKA3A, KRTHA3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000006059.3.
HGNCiHGNC:6450. KRT33A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000006059.
PharmGKBiPA30239.

Polymorphism and mutation databases

BioMutaiKRT33A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636881 – 404Keratin, type I cuticular Ha3-IAdd BLAST404

Proteomic databases

PaxDbiO76009.
PeptideAtlasiO76009.
PRIDEiO76009.

PTM databases

iPTMnetiO76009.
PhosphoSitePlusiO76009.
SwissPalmiO76009.

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiENSG00000006059.
CleanExiHS_KRT33A.
GenevisibleiO76009. HS.

Organism-specific databases

HPAiHPA055194.

Interactioni

Protein-protein interaction databases

BioGridi110081. 3 interactors.
IntActiO76009. 2 interactors.
STRINGi9606.ENSP00000007735.

Structurei

3D structure databases

ProteinModelPortaliO76009.
SMRiO76009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 367IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadAdd BLAST56
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 404TailAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00900000140814.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO76009.
KOiK07604.
OMAiSYSCGLP.
OrthoDBiEOG091G087I.
PhylomeDBiO76009.
TreeFamiTF332742.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PRINTSiPR01248. TYPE1KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF_ROD_1. 1 hit.
PS51842. IF_ROD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O76009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC
110 120 130 140 150
ASYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLASDD FRTKYETELS
160 170 180 190 200
LRQLVESDIN GLRRILDELT LCRSDLEAQV ESLKEELLCL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR REVEQWFATQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN

TFGY
Length:404
Mass (Da):45,940
Last modified:February 10, 2009 - v2
Checksum:i14B0C556E64485B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82A → T in BAG36784 (PubMed:14702039).Curated1
Sequence conflicti94Q → R in CAG17613 (PubMed:15617563).Curated1
Sequence conflicti153 – 154QL → HV in CAA76384 (PubMed:9756910).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054432270A → V3 PublicationsCorresponds to variant dbSNP:rs12937519Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16788 Genomic DNA. Translation: CAA76384.1.
AJ633621 mRNA. Translation: CAG17613.2.
AK314088 mRNA. Translation: BAG36784.1.
AC003958 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60727.1.
BC069135 mRNA. Translation: AAH69135.1.
CCDSiCCDS11388.1.
RefSeqiNP_004129.2. NM_004138.3.
UniGeneiHs.512579.

Genome annotation databases

EnsembliENST00000007735; ENSP00000007735; ENSG00000006059.
ENST00000576236; ENSP00000461221; ENSG00000261986.
GeneIDi3883.
KEGGihsa:3883.
UCSCiuc002hwk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKT33A_HUMAN
AccessioniPrimary (citable) accession number: O76009
Secondary accession number(s): B2RA87, Q6NTB9, Q6ZZB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families