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O76002

- OR2J2_HUMAN

UniProt

O76002 - OR2J2_HUMAN

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Protein

Olfactory receptor 2J2

Gene

OR2J2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2J2
Alternative name(s):
Hs6M1-6
Olfactory receptor 6-8
Short name:
OR6-8
Olfactory receptor OR6-19
Gene namesi
Name:OR2J2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:8260. OR2J2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence Analysis
Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei274 – 29320Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31219CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2J2PRO_0000150483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76002.
PRIDEiO76002.

Expressioni

Gene expression databases

BgeeiO76002.
CleanExiHS_OR2J2.
GenevestigatoriO76002.

Structurei

3D structure databases

ProteinModelPortaliO76002.
SMRiO76002. Positions 24-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146261.
GeneTreeiENSGT00760000118914.
HOVERGENiHBG017625.
InParanoidiO76002.
KOiK04257.
OMAiVCELLVI.
OrthoDBiEOG751NFX.
PhylomeDBiO76002.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76002-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMIKKNASSE DFFILLGFSN WPQLEVVLFV VILIFYLMTL TGNLFIIILS
60 70 80 90 100
YVDSHLHTPM YFFLSNLSFL DLCHTTSSIP QLLVNLRGPE KTISYAGCMV
110 120 130 140 150
QLYFVLALGI AECVLLVVMS YDRYVAVCRP LHYTVLMHPR FCHLLAAASW
160 170 180 190 200
VIGFTISALH SSFTFWVPLC GHRLVDHFFC EVPALLRLSC VDTHANELTL
210 220 230 240 250
MVMSSIFVLI PLILILTAYG AIARAVLSMQ STTGLQKVFR TCGAHLMVVS
260 270 280 290 300
LFFIPVMCMY LQPPSENSPD QGKFIALFYT VVTPSLNPLI YTLRNKHVKG
310
AAKRLLGWEW GK
Length:312
Mass (Da):35,204
Last modified:November 1, 1998 - v1
Checksum:iFB7D20BB2379C43E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261V → A in AAI08897. (PubMed:15489334)Curated

Polymorphismi

Three OR2J2 alleles are known: 6M1-6*01, 6M1-6*02 and 6M1-6*03. The sequence shown is that of allele 6M1-6*01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti74 – 741H → Y in allele 6M1-6*02 and allele 6M1-6*03. 3 Publications
Corresponds to variant rs3116855 [ dbSNP | Ensembl ].
VAR_010945
Natural varianti111 – 1111A → T in allele 6M1-6*03. 2 Publications
Corresponds to variant rs3129157 [ dbSNP | Ensembl ].
VAR_010946
Natural varianti146 – 1461A → V in allele 6M1-6*02 and allele 6M1-6*03. 3 Publications
Corresponds to variant rs3116856 [ dbSNP | Ensembl ].
VAR_010947
Natural varianti218 – 2181A → T in allele 6M1-6*02 and allele 6M1-6*03. 3 Publications
Corresponds to variant rs3130743 [ dbSNP | Ensembl ].
VAR_010948

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302571 Genomic DNA. Translation: CAC20491.1.
AJ302572 Genomic DNA. Translation: CAC20492.1.
AJ302573 Genomic DNA. Translation: CAC20493.1.
AJ302574 Genomic DNA. Translation: CAC20494.1.
AJ302575 Genomic DNA. Translation: CAC20495.1.
AJ302576 Genomic DNA. Translation: CAC20496.1.
AJ302577 Genomic DNA. Translation: CAC20497.1.
AJ302578 Genomic DNA. Translation: CAC20498.1.
AJ302579 Genomic DNA. Translation: CAC20499.1.
AJ302580 Genomic DNA. Translation: CAC20500.1.
AJ302581 Genomic DNA. Translation: CAC20501.1.
AJ302582 Genomic DNA. Translation: CAC20502.1.
AJ302583 Genomic DNA. Translation: CAC20503.1.
CR388415 Genomic DNA. Translation: CAQ07705.1.
AL662852 Genomic DNA. Translation: CAI17596.1.
AL645937 Genomic DNA. Translation: CAI18104.1.
CR759834 Genomic DNA. No translation available.
AL022727 Genomic DNA. Translation: CAA18784.1.
BX248093 Genomic DNA. Translation: CAM26135.1.
BC069121 mRNA. Translation: AAH69121.1.
BC108896 mRNA. Translation: AAI08897.1.
BC108897 mRNA. Translation: AAI08898.1.
BC108898 mRNA. Translation: AAI08899.1.
BC108899 mRNA. Translation: AAI08900.1.
BK004438 Genomic DNA. Translation: DAA04836.1.
CCDSiCCDS43434.1.
RefSeqiNP_112167.2. NM_030905.2.
UniGeneiHs.163518.

Genome annotation databases

EnsembliENST00000358688; ENSP00000351519; ENSG00000196231.
ENST00000377167; ENSP00000366372; ENSG00000204700.
ENST00000411588; ENSP00000396524; ENSG00000231676.
ENST00000415857; ENSP00000392497; ENSG00000226000.
ENST00000419605; ENSP00000408988; ENSG00000232945.
ENST00000427744; ENSP00000403186; ENSG00000234746.
ENST00000440124; ENSP00000398238; ENSG00000225550.
ENST00000457762; ENSP00000416299; ENSG00000226347.
GeneIDi26707.
KEGGihsa:26707.
UCSCiuc011dlm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302571 Genomic DNA. Translation: CAC20491.1 .
AJ302572 Genomic DNA. Translation: CAC20492.1 .
AJ302573 Genomic DNA. Translation: CAC20493.1 .
AJ302574 Genomic DNA. Translation: CAC20494.1 .
AJ302575 Genomic DNA. Translation: CAC20495.1 .
AJ302576 Genomic DNA. Translation: CAC20496.1 .
AJ302577 Genomic DNA. Translation: CAC20497.1 .
AJ302578 Genomic DNA. Translation: CAC20498.1 .
AJ302579 Genomic DNA. Translation: CAC20499.1 .
AJ302580 Genomic DNA. Translation: CAC20500.1 .
AJ302581 Genomic DNA. Translation: CAC20501.1 .
AJ302582 Genomic DNA. Translation: CAC20502.1 .
AJ302583 Genomic DNA. Translation: CAC20503.1 .
CR388415 Genomic DNA. Translation: CAQ07705.1 .
AL662852 Genomic DNA. Translation: CAI17596.1 .
AL645937 Genomic DNA. Translation: CAI18104.1 .
CR759834 Genomic DNA. No translation available.
AL022727 Genomic DNA. Translation: CAA18784.1 .
BX248093 Genomic DNA. Translation: CAM26135.1 .
BC069121 mRNA. Translation: AAH69121.1 .
BC108896 mRNA. Translation: AAI08897.1 .
BC108897 mRNA. Translation: AAI08898.1 .
BC108898 mRNA. Translation: AAI08899.1 .
BC108899 mRNA. Translation: AAI08900.1 .
BK004438 Genomic DNA. Translation: DAA04836.1 .
CCDSi CCDS43434.1.
RefSeqi NP_112167.2. NM_030905.2.
UniGenei Hs.163518.

3D structure databases

ProteinModelPortali O76002.
SMRi O76002. Positions 24-299.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O76002.
PRIDEi O76002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358688 ; ENSP00000351519 ; ENSG00000196231 .
ENST00000377167 ; ENSP00000366372 ; ENSG00000204700 .
ENST00000411588 ; ENSP00000396524 ; ENSG00000231676 .
ENST00000415857 ; ENSP00000392497 ; ENSG00000226000 .
ENST00000419605 ; ENSP00000408988 ; ENSG00000232945 .
ENST00000427744 ; ENSP00000403186 ; ENSG00000234746 .
ENST00000440124 ; ENSP00000398238 ; ENSG00000225550 .
ENST00000457762 ; ENSP00000416299 ; ENSG00000226347 .
GeneIDi 26707.
KEGGi hsa:26707.
UCSCi uc011dlm.2. human.

Organism-specific databases

CTDi 26707.
GeneCardsi GC06P029141.
GC06Pi29141.
GC06Pj29137.
GC06Pk29141.
GC06Pl29141.
GC06Pm29141.
GC06Pn29141.
GC06Po29141.
H-InvDB HIX0165964.
HIX0166461.
HIX0167456.
HIX0201070.
HIX0201087.
HGNCi HGNC:8260. OR2J2.
neXtProti NX_O76002.
PharmGKBi PA32177.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146261.
GeneTreei ENSGT00760000118914.
HOVERGENi HBG017625.
InParanoidi O76002.
KOi K04257.
OMAi VCELLVI.
OrthoDBi EOG751NFX.
PhylomeDBi O76002.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2J2.
GenomeRNAii 26707.
NextBioi 49075.
PROi O76002.

Gene expression databases

Bgeei O76002.
CleanExi HS_OR2J2.
Genevestigatori O76002.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
    Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
    (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-74; THR-111; VAL-146 AND THR-218.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS TYR-74; THR-111; VAL-146 AND THR-218.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TYR-74; VAL-146 AND THR-218.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2J2_HUMAN
AccessioniPrimary (citable) accession number: O76002
Secondary accession number(s): A6NCU9
, A6NLD0, B0UY53, Q32N09, Q5ST39, Q5SUJ6, Q6IF24, Q9GZK2, Q9GZL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3