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O76002

- OR2J2_HUMAN

UniProt

O76002 - OR2J2_HUMAN

Protein

Olfactory receptor 2J2

Gene

OR2J2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2J2
    Alternative name(s):
    Hs6M1-6
    Olfactory receptor 6-8
    Short name:
    OR6-8
    Olfactory receptor OR6-19
    Gene namesi
    Name:OR2J2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8260. OR2J2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32177.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 2J2PRO_0000150483Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO76002.
    PRIDEiO76002.

    Expressioni

    Gene expression databases

    BgeeiO76002.
    CleanExiHS_OR2J2.
    GenevestigatoriO76002.

    Structurei

    3D structure databases

    ProteinModelPortaliO76002.
    SMRiO76002. Positions 24-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 588CytoplasmicSequence Analysis
    Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 31219CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29320Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146261.
    HOVERGENiHBG017625.
    InParanoidiO76002.
    KOiK04257.
    OMAiVCELLVI.
    OrthoDBiEOG751NFX.
    PhylomeDBiO76002.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76002-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMIKKNASSE DFFILLGFSN WPQLEVVLFV VILIFYLMTL TGNLFIIILS    50
    YVDSHLHTPM YFFLSNLSFL DLCHTTSSIP QLLVNLRGPE KTISYAGCMV 100
    QLYFVLALGI AECVLLVVMS YDRYVAVCRP LHYTVLMHPR FCHLLAAASW 150
    VIGFTISALH SSFTFWVPLC GHRLVDHFFC EVPALLRLSC VDTHANELTL 200
    MVMSSIFVLI PLILILTAYG AIARAVLSMQ STTGLQKVFR TCGAHLMVVS 250
    LFFIPVMCMY LQPPSENSPD QGKFIALFYT VVTPSLNPLI YTLRNKHVKG 300
    AAKRLLGWEW GK 312
    Length:312
    Mass (Da):35,204
    Last modified:November 1, 1998 - v1
    Checksum:iFB7D20BB2379C43E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261V → A in AAI08897. (PubMed:15489334)Curated

    Polymorphismi

    Three OR2J2 alleles are known: 6M1-6*01, 6M1-6*02 and 6M1-6*03. The sequence shown is that of allele 6M1-6*01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti74 – 741H → Y in allele 6M1-6*02 and allele 6M1-6*03. 3 Publications
    Corresponds to variant rs3116855 [ dbSNP | Ensembl ].
    VAR_010945
    Natural varianti111 – 1111A → T in allele 6M1-6*03. 2 Publications
    Corresponds to variant rs3129157 [ dbSNP | Ensembl ].
    VAR_010946
    Natural varianti146 – 1461A → V in allele 6M1-6*02 and allele 6M1-6*03. 3 Publications
    Corresponds to variant rs3116856 [ dbSNP | Ensembl ].
    VAR_010947
    Natural varianti218 – 2181A → T in allele 6M1-6*02 and allele 6M1-6*03. 3 Publications
    Corresponds to variant rs3130743 [ dbSNP | Ensembl ].
    VAR_010948

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302571 Genomic DNA. Translation: CAC20491.1.
    AJ302572 Genomic DNA. Translation: CAC20492.1.
    AJ302573 Genomic DNA. Translation: CAC20493.1.
    AJ302574 Genomic DNA. Translation: CAC20494.1.
    AJ302575 Genomic DNA. Translation: CAC20495.1.
    AJ302576 Genomic DNA. Translation: CAC20496.1.
    AJ302577 Genomic DNA. Translation: CAC20497.1.
    AJ302578 Genomic DNA. Translation: CAC20498.1.
    AJ302579 Genomic DNA. Translation: CAC20499.1.
    AJ302580 Genomic DNA. Translation: CAC20500.1.
    AJ302581 Genomic DNA. Translation: CAC20501.1.
    AJ302582 Genomic DNA. Translation: CAC20502.1.
    AJ302583 Genomic DNA. Translation: CAC20503.1.
    CR388415 Genomic DNA. Translation: CAQ07705.1.
    AL662852 Genomic DNA. Translation: CAI17596.1.
    AL645937 Genomic DNA. Translation: CAI18104.1.
    CR759834 Genomic DNA. No translation available.
    AL022727 Genomic DNA. Translation: CAA18784.1.
    BX248093 Genomic DNA. Translation: CAM26135.1.
    BC069121 mRNA. Translation: AAH69121.1.
    BC108896 mRNA. Translation: AAI08897.1.
    BC108897 mRNA. Translation: AAI08898.1.
    BC108898 mRNA. Translation: AAI08899.1.
    BC108899 mRNA. Translation: AAI08900.1.
    BK004438 Genomic DNA. Translation: DAA04836.1.
    CCDSiCCDS43434.1.
    RefSeqiNP_112167.2. NM_030905.2.
    UniGeneiHs.163518.

    Genome annotation databases

    EnsembliENST00000358688; ENSP00000351519; ENSG00000196231.
    ENST00000377167; ENSP00000366372; ENSG00000204700.
    ENST00000411588; ENSP00000396524; ENSG00000231676.
    ENST00000415857; ENSP00000392497; ENSG00000226000.
    ENST00000419605; ENSP00000408988; ENSG00000232945.
    ENST00000427744; ENSP00000403186; ENSG00000234746.
    ENST00000440124; ENSP00000398238; ENSG00000225550.
    ENST00000457762; ENSP00000416299; ENSG00000226347.
    GeneIDi26707.
    KEGGihsa:26707.
    UCSCiuc011dlm.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302571 Genomic DNA. Translation: CAC20491.1 .
    AJ302572 Genomic DNA. Translation: CAC20492.1 .
    AJ302573 Genomic DNA. Translation: CAC20493.1 .
    AJ302574 Genomic DNA. Translation: CAC20494.1 .
    AJ302575 Genomic DNA. Translation: CAC20495.1 .
    AJ302576 Genomic DNA. Translation: CAC20496.1 .
    AJ302577 Genomic DNA. Translation: CAC20497.1 .
    AJ302578 Genomic DNA. Translation: CAC20498.1 .
    AJ302579 Genomic DNA. Translation: CAC20499.1 .
    AJ302580 Genomic DNA. Translation: CAC20500.1 .
    AJ302581 Genomic DNA. Translation: CAC20501.1 .
    AJ302582 Genomic DNA. Translation: CAC20502.1 .
    AJ302583 Genomic DNA. Translation: CAC20503.1 .
    CR388415 Genomic DNA. Translation: CAQ07705.1 .
    AL662852 Genomic DNA. Translation: CAI17596.1 .
    AL645937 Genomic DNA. Translation: CAI18104.1 .
    CR759834 Genomic DNA. No translation available.
    AL022727 Genomic DNA. Translation: CAA18784.1 .
    BX248093 Genomic DNA. Translation: CAM26135.1 .
    BC069121 mRNA. Translation: AAH69121.1 .
    BC108896 mRNA. Translation: AAI08897.1 .
    BC108897 mRNA. Translation: AAI08898.1 .
    BC108898 mRNA. Translation: AAI08899.1 .
    BC108899 mRNA. Translation: AAI08900.1 .
    BK004438 Genomic DNA. Translation: DAA04836.1 .
    CCDSi CCDS43434.1.
    RefSeqi NP_112167.2. NM_030905.2.
    UniGenei Hs.163518.

    3D structure databases

    ProteinModelPortali O76002.
    SMRi O76002. Positions 24-299.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O76002.
    PRIDEi O76002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358688 ; ENSP00000351519 ; ENSG00000196231 .
    ENST00000377167 ; ENSP00000366372 ; ENSG00000204700 .
    ENST00000411588 ; ENSP00000396524 ; ENSG00000231676 .
    ENST00000415857 ; ENSP00000392497 ; ENSG00000226000 .
    ENST00000419605 ; ENSP00000408988 ; ENSG00000232945 .
    ENST00000427744 ; ENSP00000403186 ; ENSG00000234746 .
    ENST00000440124 ; ENSP00000398238 ; ENSG00000225550 .
    ENST00000457762 ; ENSP00000416299 ; ENSG00000226347 .
    GeneIDi 26707.
    KEGGi hsa:26707.
    UCSCi uc011dlm.2. human.

    Organism-specific databases

    CTDi 26707.
    GeneCardsi GC06P029141.
    GC06Pi29141.
    GC06Pj29137.
    GC06Pk29141.
    GC06Pl29141.
    GC06Pm29141.
    GC06Pn29141.
    GC06Po29141.
    H-InvDB HIX0165964.
    HIX0166461.
    HIX0167456.
    HIX0201070.
    HIX0201087.
    HGNCi HGNC:8260. OR2J2.
    neXtProti NX_O76002.
    PharmGKBi PA32177.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146261.
    HOVERGENi HBG017625.
    InParanoidi O76002.
    KOi K04257.
    OMAi VCELLVI.
    OrthoDBi EOG751NFX.
    PhylomeDBi O76002.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2J2.
    GenomeRNAii 26707.
    NextBioi 49075.
    PROi O76002.

    Gene expression databases

    Bgeei O76002.
    CleanExi HS_OR2J2.
    Genevestigatori O76002.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
      Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
      (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-74; THR-111; VAL-146 AND THR-218.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS TYR-74; THR-111; VAL-146 AND THR-218.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TYR-74; VAL-146 AND THR-218.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2J2_HUMAN
    AccessioniPrimary (citable) accession number: O76002
    Secondary accession number(s): A6NCU9
    , A6NLD0, B0UY53, Q32N09, Q5ST39, Q5SUJ6, Q6IF24, Q9GZK2, Q9GZL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3