ID OR2J3_HUMAN Reviewed; 311 AA. AC O76001; B0UY52; B9EH11; Q5SUJ7; Q6IF25; Q96R15; Q9GZK5; Q9GZL4; Q9GZL5; DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 27-MAR-2024, entry version 190. DE RecName: Full=Olfactory receptor 2J3; DE AltName: Full=Hs6M1-3; DE AltName: Full=Olfactory receptor OR6-16; DE Short=OR6-6; DE Short=Olfactory receptor 6-6; GN Name=OR2J3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-113; GLN-226; ILE-228 RP AND MET-261. RA Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., RA Volz A., Younger R., Beck S.; RT "Polymorphic olfactory receptor genes and HLA loci constitute extended RT haplotypes."; RL (In) Kasahara M. (eds.); RL Major histocompatibility complex-evolution, structure, and function, RL pp.110-130, Springer-Verlag, Tokyo (2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT MET-261. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-261. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286. RX PubMed=12213199; DOI=10.1006/geno.2002.6830; RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., RA Lehrach H., Lancet D., Shamir R.; RT "DEFOG: a practical scheme for deciphering families of genes."; RL Genomics 80:295-302(2002). RN [5] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [6] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). RN [7] RP FUNCTION, POLYMORPHISM, VARIANTS ALA-113 AND GLN-226, AND CHARACTERIZATION RP OF VARIANTS ALA-113 AND GLN-226. RX PubMed=22714804; DOI=10.1093/chemse/bjs049; RA McRae J.F., Mainland J.D., Jaeger S.R., Adipietro K.A., Matsunami H., RA Newcomb R.D.; RT "Genetic variation in the odorant receptor OR2J3 is associated with the RT ability to detect the 'grassy' smelling odor, cis-3-hexen-1-ol."; RL Chem. Senses 37:585-593(2012). CC -!- FUNCTION: Odorant receptor involved in the detection of the flavor CC compound cis-3-hexen-1-ol (C3HEX), a compound typically described as CC 'green grassy' or the smell of 'cut grass'. CC {ECO:0000269|PubMed:22714804}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- POLYMORPHISM: Variants Ala-113 and Gln-226 exhibit a reduced ability to CC smell C3HEX [MIM:615082]. When both variants are present in the same CC haplotype (allele 6M1-3*02), the response to C3HEX is abolished. CC African populations have a higher proportion of the C3HEX-nonresponsive CC haplotype than other populations. All haplotypes containing Gln-226 CC show low levels of surface expression. {ECO:0000269|PubMed:22714804}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2J3"; CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=The intricacy of a smell CC - Issue 150 of July 2013; CC URL="https://web.expasy.org/spotlight/back_issues/150"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ302547; CAC20472.1; -; Genomic_DNA. DR EMBL; AJ302548; CAC20473.1; -; Genomic_DNA. DR EMBL; AJ302549; CAC20474.1; -; Genomic_DNA. DR EMBL; AJ302550; CAC20475.1; -; Genomic_DNA. DR EMBL; AJ302551; CAC20476.1; -; Genomic_DNA. DR EMBL; AJ302552; CAC21440.1; -; Genomic_DNA. DR EMBL; AJ302553; CAC21441.1; -; Genomic_DNA. DR EMBL; AJ302554; CAC21442.1; -; Genomic_DNA. DR EMBL; AJ302555; CAC21443.1; -; Genomic_DNA. DR EMBL; AJ302556; CAC21444.1; -; Genomic_DNA. DR EMBL; AJ302557; CAC20477.1; -; Genomic_DNA. DR EMBL; AJ302558; CAC20478.1; -; Genomic_DNA. DR EMBL; AL645937; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL022727; CAA18783.1; -; Genomic_DNA. DR EMBL; AL662852; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL929561; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX248093; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR547123; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR388415; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR942175; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC136973; AAI36974.1; -; mRNA. DR EMBL; BC136975; AAI36976.1; -; mRNA. DR EMBL; AF399630; AAK95115.1; -; Genomic_DNA. DR EMBL; BK004437; DAA04835.1; -; Genomic_DNA. DR CCDS; CCDS43433.1; -. DR RefSeq; NP_001005216.2; NM_001005216.3. DR AlphaFoldDB; O76001; -. DR SMR; O76001; -. DR STRING; 9606.ENSP00000493439; -. DR GlyCosmos; O76001; 1 site, No reported glycans. DR GlyGen; O76001; 1 site. DR BioMuta; OR2J3; -. DR PaxDb; 9606-ENSP00000366374; -. DR PeptideAtlas; O76001; -. DR ProteomicsDB; 50339; -. DR Antibodypedia; 62681; 89 antibodies from 17 providers. DR DNASU; 442186; -. DR Ensembl; ENST00000377169.2; ENSP00000366374.1; ENSG00000204701.3. DR Ensembl; ENST00000383651.1; ENSP00000373147.1; ENSG00000206522.1. DR Ensembl; ENST00000414140.1; ENSP00000390144.1; ENSG00000232178.1. DR Ensembl; ENST00000418630.1; ENSP00000400546.1; ENSG00000233618.1. DR Ensembl; ENST00000419260.1; ENSP00000408783.1; ENSG00000229866.1. DR Ensembl; ENST00000428081.1; ENSP00000388392.1; ENSG00000226271.1. DR Ensembl; ENST00000430478.1; ENSP00000388205.1; ENSG00000233636.1. DR GeneID; 442186; -. DR KEGG; hsa:442186; -. DR UCSC; uc011dll.4; human. DR AGR; HGNC:8261; -. DR CTD; 442186; -. DR DisGeNET; 442186; -. DR GeneCards; OR2J3; -. DR HGNC; HGNC:8261; OR2J3. DR HPA; ENSG00000204701; Not detected. DR MalaCards; OR2J3; -. DR MIM; 615016; gene. DR MIM; 615082; phenotype. DR neXtProt; NX_O76001; -. DR PharmGKB; PA32178; -. DR VEuPathDB; HostDB:ENSG00000204701; -. DR eggNOG; ENOG502RU1S; Eukaryota. DR HOGENOM; CLU_012526_1_2_1; -. DR InParanoid; O76001; -. DR OrthoDB; 4790557at2759; -. DR PhylomeDB; O76001; -. DR TreeFam; TF336512; -. DR PathwayCommons; O76001; -. DR Reactome; R-HSA-381753; Olfactory Signaling Pathway. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 442186; 13 hits in 710 CRISPR screens. DR GeneWiki; OR2J3; -. DR GenomeRNAi; 442186; -. DR Pharos; O76001; Tbio. DR PRO; PR:O76001; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; O76001; Protein. DR Bgee; ENSG00000204701; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 3 other cell types or tissues. DR ExpressionAtlas; O76001; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central. DR CDD; cd15947; 7tmA_OR2B-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR26453:SF184; OLFACTORY RECEPTOR 2J3; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; O76001; HS. PE 1: Evidence at protein level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..311 FT /note="Olfactory receptor 2J3" FT /id="PRO_0000150484" FT TOPO_DOM 1..28 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 29..52 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 53..60 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 61..82 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 83..103 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 104..123 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 124..142 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 143..161 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 162..198 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 199..222 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 223..239 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 240..262 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 263..275 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 276..295 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 296..311 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 8 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 100..192 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 113 FT /note="T -> A (in allele 6M1-3*02; decreased response to FT C3HEX; dbSNP:rs28757581)" FT /evidence="ECO:0000269|PubMed:22714804, ECO:0000269|Ref.1" FT /id="VAR_010949" FT VARIANT 226 FT /note="R -> Q (in allele 6M1-3*02; decreased response to FT C3HEX; dbSNP:rs3749977)" FT /evidence="ECO:0000269|PubMed:22714804, ECO:0000269|Ref.1" FT /id="VAR_010950" FT VARIANT 228 FT /note="V -> I (in allele 6M1-3*03; dbSNP:rs3130764)" FT /evidence="ECO:0000269|Ref.1" FT /id="VAR_010951" FT VARIANT 261 FT /note="I -> M (in allele 6M1-3*03 and allele 6M1-3*04; FT dbSNP:rs3130765)" FT /evidence="ECO:0000269|PubMed:14574404, FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1" FT /id="VAR_010952" SQ SEQUENCE 311 AA; 34950 MW; 84201145B9D5AA68 CRC64; MNDDGKVNAS SEGYFILVGF SNWPHLEVVI FVVVLIFYLM TLIGNLFIII LSYLDSHLHT PMYFFLSNLS FLDLCYTTSS IPQLLVNLWG PEKTISYAGC MIQLYFVLAL GTTECVLLVV MSYDRYAAVC RPLHYTVLMH PRFCHLLAVA SWVSGFTNSA LHSSFTFWVP LCGHRQVDHF FCEVPALLRL SCVDTHVNEL TLMITSSIFV LIPLILILTS YGAIVRAVLR MQSTTGLQKV FGTCGAHLMA VSLFFIPAMC IYLQPPSGNS QDQGKFIALF YTVVTPSLNP LIYTLRNKVV RGAVKRLMGW E //