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O76001

- OR2J3_HUMAN

UniProt

O76001 - OR2J3_HUMAN

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Protein
Olfactory receptor 2J3
Gene
OR2J3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2J3
Alternative name(s):
Hs6M1-3
Olfactory receptor OR6-16
Short name:
OR6-6
Short name:
Olfactory receptor 6-6
Gene namesi
Name:OR2J3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:8261. OR2J3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Extracellular Reviewed prediction
Add
BLAST
Transmembranei29 – 5224Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini53 – 608Cytoplasmic Reviewed prediction
Transmembranei61 – 8222Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini83 – 10321Extracellular Reviewed prediction
Add
BLAST
Transmembranei104 – 12320Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini124 – 14219Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei143 – 16119Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini162 – 19837Extracellular Reviewed prediction
Add
BLAST
Transmembranei199 – 22224Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini223 – 23917Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei240 – 26223Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini263 – 27513Extracellular Reviewed prediction
Add
BLAST
Transmembranei276 – 29520Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini296 – 31116Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi615082. phenotype.
PharmGKBiPA32178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 2J3
PRO_0000150484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi100 ↔ 192 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76001.
PRIDEiO76001.

Expressioni

Gene expression databases

CleanExiHS_OR2J3.
GenevestigatoriO76001.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000408783.

Structurei

3D structure databases

ProteinModelPortaliO76001.
SMRiO76001. Positions 29-308.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146261.
HOVERGENiHBG017625.
InParanoidiO76001.
KOiK04257.
OMAiILMHPRF.
OrthoDBiEOG751NFX.
PhylomeDBiO76001.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76001-1 [UniParc]FASTAAdd to Basket

« Hide

MNDDGKVNAS SEGYFILVGF SNWPHLEVVI FVVVLIFYLM TLIGNLFIII    50
LSYLDSHLHT PMYFFLSNLS FLDLCYTTSS IPQLLVNLWG PEKTISYAGC 100
MIQLYFVLAL GTTECVLLVV MSYDRYAAVC RPLHYTVLMH PRFCHLLAVA 150
SWVSGFTNSA LHSSFTFWVP LCGHRQVDHF FCEVPALLRL SCVDTHVNEL 200
TLMITSSIFV LIPLILILTS YGAIVRAVLR MQSTTGLQKV FGTCGAHLMA 250
VSLFFIPAMC IYLQPPSGNS QDQGKFIALF YTVVTPSLNP LIYTLRNKVV 300
RGAVKRLMGW E 311
Length:311
Mass (Da):34,950
Last modified:November 1, 1998 - v1
Checksum:i84201145B9D5AA68
GO

Polymorphismi

Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIMi:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131T → A in allele 6M1-3*02; decreased response to C3HEX. 2 Publications
Corresponds to variant rs28757581 [ dbSNP | Ensembl ].
VAR_010949
Natural varianti226 – 2261R → Q in allele 6M1-3*02; decreased response to C3HEX. 2 Publications
Corresponds to variant rs3749977 [ dbSNP | Ensembl ].
VAR_010950
Natural varianti228 – 2281V → I in allele 6M1-3*03. 1 Publication
Corresponds to variant rs3130764 [ dbSNP | Ensembl ].
VAR_010951
Natural varianti261 – 2611I → M in allele 6M1-3*03 and allele 6M1-3*04. 3 Publications
Corresponds to variant rs3130765 [ dbSNP | Ensembl ].
VAR_010952

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302547 Genomic DNA. Translation: CAC20472.1.
AJ302548 Genomic DNA. Translation: CAC20473.1.
AJ302549 Genomic DNA. Translation: CAC20474.1.
AJ302550 Genomic DNA. Translation: CAC20475.1.
AJ302551 Genomic DNA. Translation: CAC20476.1.
AJ302552 Genomic DNA. Translation: CAC21440.1.
AJ302553 Genomic DNA. Translation: CAC21441.1.
AJ302554 Genomic DNA. Translation: CAC21442.1.
AJ302555 Genomic DNA. Translation: CAC21443.1.
AJ302556 Genomic DNA. Translation: CAC21444.1.
AJ302557 Genomic DNA. Translation: CAC20477.1.
AJ302558 Genomic DNA. Translation: CAC20478.1.
AL645937 Genomic DNA. Translation: CAI18102.1.
AL022727 Genomic DNA. Translation: CAA18783.1.
AL662852 Genomic DNA. Translation: CAI17594.1.
AL929561 Genomic DNA. Translation: CAI41773.1.
BX248093 Genomic DNA. Translation: CAM26133.1.
CR547123 Genomic DNA. Translation: CAQ06966.1.
CR388415 Genomic DNA. Translation: CAQ07703.1.
CR942175 Genomic DNA. Translation: CAQ07980.1.
BC136973 mRNA. Translation: AAI36974.1.
BC136975 mRNA. Translation: AAI36976.1.
AF399630 Genomic DNA. Translation: AAK95115.1.
BK004437 Genomic DNA. Translation: DAA04835.1.
CCDSiCCDS43433.1.
RefSeqiNP_001005216.2. NM_001005216.3.
UniGeneiHs.738947.

Genome annotation databases

EnsembliENST00000377169; ENSP00000366374; ENSG00000204701.
ENST00000383651; ENSP00000373147; ENSG00000206522.
ENST00000414140; ENSP00000390144; ENSG00000232178.
ENST00000418630; ENSP00000400546; ENSG00000233618.
ENST00000419260; ENSP00000408783; ENSG00000229866.
ENST00000428081; ENSP00000388392; ENSG00000226271.
ENST00000430478; ENSP00000388205; ENSG00000233636.
GeneIDi442186.
KEGGihsa:442186.
UCSCiuc011dll.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)
Protein Spotlight

The intricacy of a smell - Issue 150 of July 2013

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302547 Genomic DNA. Translation: CAC20472.1 .
AJ302548 Genomic DNA. Translation: CAC20473.1 .
AJ302549 Genomic DNA. Translation: CAC20474.1 .
AJ302550 Genomic DNA. Translation: CAC20475.1 .
AJ302551 Genomic DNA. Translation: CAC20476.1 .
AJ302552 Genomic DNA. Translation: CAC21440.1 .
AJ302553 Genomic DNA. Translation: CAC21441.1 .
AJ302554 Genomic DNA. Translation: CAC21442.1 .
AJ302555 Genomic DNA. Translation: CAC21443.1 .
AJ302556 Genomic DNA. Translation: CAC21444.1 .
AJ302557 Genomic DNA. Translation: CAC20477.1 .
AJ302558 Genomic DNA. Translation: CAC20478.1 .
AL645937 Genomic DNA. Translation: CAI18102.1 .
AL022727 Genomic DNA. Translation: CAA18783.1 .
AL662852 Genomic DNA. Translation: CAI17594.1 .
AL929561 Genomic DNA. Translation: CAI41773.1 .
BX248093 Genomic DNA. Translation: CAM26133.1 .
CR547123 Genomic DNA. Translation: CAQ06966.1 .
CR388415 Genomic DNA. Translation: CAQ07703.1 .
CR942175 Genomic DNA. Translation: CAQ07980.1 .
BC136973 mRNA. Translation: AAI36974.1 .
BC136975 mRNA. Translation: AAI36976.1 .
AF399630 Genomic DNA. Translation: AAK95115.1 .
BK004437 Genomic DNA. Translation: DAA04835.1 .
CCDSi CCDS43433.1.
RefSeqi NP_001005216.2. NM_001005216.3.
UniGenei Hs.738947.

3D structure databases

ProteinModelPortali O76001.
SMRi O76001. Positions 29-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000408783.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O76001.
PRIDEi O76001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377169 ; ENSP00000366374 ; ENSG00000204701 .
ENST00000383651 ; ENSP00000373147 ; ENSG00000206522 .
ENST00000414140 ; ENSP00000390144 ; ENSG00000232178 .
ENST00000418630 ; ENSP00000400546 ; ENSG00000233618 .
ENST00000419260 ; ENSP00000408783 ; ENSG00000229866 .
ENST00000428081 ; ENSP00000388392 ; ENSG00000226271 .
ENST00000430478 ; ENSP00000388205 ; ENSG00000233636 .
GeneIDi 442186.
KEGGi hsa:442186.
UCSCi uc011dll.2. human.

Organism-specific databases

CTDi 442186.
GeneCardsi GC06P029079.
GC06Pi29079.
GC06Pj29076.
GC06Pk29079.
GC06Pl29079.
GC06Pn29079.
GC06Po29079.
H-InvDB HIX0165965.
HIX0166175.
HIX0201061.
HIX0201063.
HIX0201071.
HIX0201073.
HIX0201086.
HIX0201090.
HIX0201106.
HIX0201108.
HGNCi HGNC:8261. OR2J3.
MIMi 615016. gene.
615082. phenotype.
neXtProti NX_O76001.
PharmGKBi PA32178.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146261.
HOVERGENi HBG017625.
InParanoidi O76001.
KOi K04257.
OMAi ILMHPRF.
OrthoDBi EOG751NFX.
PhylomeDBi O76001.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2J3.
GenomeRNAii 442186.
NextBioi 110806.
PROi O76001.
SOURCEi Search...

Gene expression databases

CleanExi HS_OR2J3.
Genevestigatori O76001.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
    Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
    (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-113; GLN-226; ILE-228 AND MET-261.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-261.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-261.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  7. "Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the 'grassy' smelling odor, cis-3-hexen-1-ol."
    McRae J.F., Mainland J.D., Jaeger S.R., Adipietro K.A., Matsunami H., Newcomb R.D.
    Chem. Senses 37:585-593(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, POLYMORPHISM, VARIANTS ALA-113 AND GLN-226.

Entry informationi

Entry nameiOR2J3_HUMAN
AccessioniPrimary (citable) accession number: O76001
Secondary accession number(s): B0UY52
, B9EH11, Q5SUJ7, Q6IF25, Q96R15, Q9GZK5, Q9GZL4, Q9GZL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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