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Protein

Olfactory receptor 2J3

Gene

OR2J3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2J3
Alternative name(s):
Hs6M1-3
Olfactory receptor OR6-16
Short name:
OR6-6
Short name:
Olfactory receptor 6-6
Gene namesi
Name:OR2J3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204701.1.
HGNCiHGNC:8261. OR2J3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 52Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 82Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini83 – 103ExtracellularSequence analysisAdd BLAST21
Transmembranei104 – 123Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 161Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 222Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini223 – 239CytoplasmicSequence analysisAdd BLAST17
Transmembranei240 – 262Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 295Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini296 – 311CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi442186.
MIMi615082. phenotype.
PharmGKBiPA32178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504841 – 311Olfactory receptor 2J3Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76001.
PRIDEiO76001.

Expressioni

Gene expression databases

BgeeiENSG00000204701.
CleanExiHS_OR2J3.
ExpressionAtlasiO76001. baseline and differential.
GenevisibleiO76001. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366374.

Structurei

3D structure databases

ProteinModelPortaliO76001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAWR. Eukaryota.
ENOG4111DPD. LUCA.
HOVERGENiHBG017625.
InParanoidiO76001.
KOiK04257.
OrthoDBiEOG09370HYW.
PhylomeDBiO76001.
TreeFamiTF336512.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O76001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDDGKVNAS SEGYFILVGF SNWPHLEVVI FVVVLIFYLM TLIGNLFIII
60 70 80 90 100
LSYLDSHLHT PMYFFLSNLS FLDLCYTTSS IPQLLVNLWG PEKTISYAGC
110 120 130 140 150
MIQLYFVLAL GTTECVLLVV MSYDRYAAVC RPLHYTVLMH PRFCHLLAVA
160 170 180 190 200
SWVSGFTNSA LHSSFTFWVP LCGHRQVDHF FCEVPALLRL SCVDTHVNEL
210 220 230 240 250
TLMITSSIFV LIPLILILTS YGAIVRAVLR MQSTTGLQKV FGTCGAHLMA
260 270 280 290 300
VSLFFIPAMC IYLQPPSGNS QDQGKFIALF YTVVTPSLNP LIYTLRNKVV
310
RGAVKRLMGW E
Length:311
Mass (Da):34,950
Last modified:November 1, 1998 - v1
Checksum:i84201145B9D5AA68
GO

Polymorphismi

Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIMi:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010949113T → A in allele 6M1-3*02; decreased response to C3HEX. 2 PublicationsCorresponds to variant dbSNP:rs28757581Ensembl.1
Natural variantiVAR_010950226R → Q in allele 6M1-3*02; decreased response to C3HEX. 2 PublicationsCorresponds to variant dbSNP:rs3749977Ensembl.1
Natural variantiVAR_010951228V → I in allele 6M1-3*03. 1 PublicationCorresponds to variant dbSNP:rs3130764Ensembl.1
Natural variantiVAR_010952261I → M in allele 6M1-3*03 and allele 6M1-3*04. 3 PublicationsCorresponds to variant dbSNP:rs3130765Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302547 Genomic DNA. Translation: CAC20472.1.
AJ302548 Genomic DNA. Translation: CAC20473.1.
AJ302549 Genomic DNA. Translation: CAC20474.1.
AJ302550 Genomic DNA. Translation: CAC20475.1.
AJ302551 Genomic DNA. Translation: CAC20476.1.
AJ302552 Genomic DNA. Translation: CAC21440.1.
AJ302553 Genomic DNA. Translation: CAC21441.1.
AJ302554 Genomic DNA. Translation: CAC21442.1.
AJ302555 Genomic DNA. Translation: CAC21443.1.
AJ302556 Genomic DNA. Translation: CAC21444.1.
AJ302557 Genomic DNA. Translation: CAC20477.1.
AJ302558 Genomic DNA. Translation: CAC20478.1.
AL645937 Genomic DNA. No translation available.
AL022727 Genomic DNA. Translation: CAA18783.1.
AL662852 Genomic DNA. No translation available.
AL929561 Genomic DNA. No translation available.
BX248093 Genomic DNA. No translation available.
CR547123 Genomic DNA. No translation available.
CR388415 Genomic DNA. No translation available.
CR942175 Genomic DNA. No translation available.
BC136973 mRNA. Translation: AAI36974.1.
BC136975 mRNA. Translation: AAI36976.1.
AF399630 Genomic DNA. Translation: AAK95115.1.
BK004437 Genomic DNA. Translation: DAA04835.1.
CCDSiCCDS43433.1.
RefSeqiNP_001005216.2. NM_001005216.3.
UniGeneiHs.738947.

Genome annotation databases

EnsembliENST00000377169; ENSP00000366374; ENSG00000204701.
ENST00000383651; ENSP00000373147; ENSG00000206522.
ENST00000414140; ENSP00000390144; ENSG00000232178.
ENST00000418630; ENSP00000400546; ENSG00000233618.
ENST00000419260; ENSP00000408783; ENSG00000229866.
ENST00000428081; ENSP00000388392; ENSG00000226271.
ENST00000430478; ENSP00000388205; ENSG00000233636.
GeneIDi442186.
KEGGihsa:442186.
UCSCiuc011dll.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2J3_HUMAN
AccessioniPrimary (citable) accession number: O76001
Secondary accession number(s): B0UY52
, B9EH11, Q5SUJ7, Q6IF25, Q96R15, Q9GZK5, Q9GZL4, Q9GZL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families