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O76001

- OR2J3_HUMAN

UniProt

O76001 - OR2J3_HUMAN

Protein

Olfactory receptor 2J3

Gene

OR2J3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2J3
    Alternative name(s):
    Hs6M1-3
    Olfactory receptor OR6-16
    Short name:
    OR6-6
    Short name:
    Olfactory receptor 6-6
    Gene namesi
    Name:OR2J3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8261. OR2J3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi615082. phenotype.
    PharmGKBiPA32178.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 2J3PRO_0000150484Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO76001.
    PRIDEiO76001.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2J3.
    GenevestigatoriO76001.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000408783.

    Structurei

    3D structure databases

    ProteinModelPortaliO76001.
    SMRiO76001. Positions 29-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 608CytoplasmicSequence Analysis
    Topological domaini83 – 10321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini124 – 14219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 23917CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 31116CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 5224Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8222Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12320Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16119Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 22224Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26223Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29520Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146261.
    HOVERGENiHBG017625.
    InParanoidiO76001.
    KOiK04257.
    OMAiILMHPRF.
    OrthoDBiEOG751NFX.
    PhylomeDBiO76001.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76001-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNDDGKVNAS SEGYFILVGF SNWPHLEVVI FVVVLIFYLM TLIGNLFIII    50
    LSYLDSHLHT PMYFFLSNLS FLDLCYTTSS IPQLLVNLWG PEKTISYAGC 100
    MIQLYFVLAL GTTECVLLVV MSYDRYAAVC RPLHYTVLMH PRFCHLLAVA 150
    SWVSGFTNSA LHSSFTFWVP LCGHRQVDHF FCEVPALLRL SCVDTHVNEL 200
    TLMITSSIFV LIPLILILTS YGAIVRAVLR MQSTTGLQKV FGTCGAHLMA 250
    VSLFFIPAMC IYLQPPSGNS QDQGKFIALF YTVVTPSLNP LIYTLRNKVV 300
    RGAVKRLMGW E 311
    Length:311
    Mass (Da):34,950
    Last modified:November 1, 1998 - v1
    Checksum:i84201145B9D5AA68
    GO

    Polymorphismi

    Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIMi:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti113 – 1131T → A in allele 6M1-3*02; decreased response to C3HEX. 2 Publications
    Corresponds to variant rs28757581 [ dbSNP | Ensembl ].
    VAR_010949
    Natural varianti226 – 2261R → Q in allele 6M1-3*02; decreased response to C3HEX. 2 Publications
    Corresponds to variant rs3749977 [ dbSNP | Ensembl ].
    VAR_010950
    Natural varianti228 – 2281V → I in allele 6M1-3*03. 1 Publication
    Corresponds to variant rs3130764 [ dbSNP | Ensembl ].
    VAR_010951
    Natural varianti261 – 2611I → M in allele 6M1-3*03 and allele 6M1-3*04. 3 Publications
    Corresponds to variant rs3130765 [ dbSNP | Ensembl ].
    VAR_010952

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302547 Genomic DNA. Translation: CAC20472.1.
    AJ302548 Genomic DNA. Translation: CAC20473.1.
    AJ302549 Genomic DNA. Translation: CAC20474.1.
    AJ302550 Genomic DNA. Translation: CAC20475.1.
    AJ302551 Genomic DNA. Translation: CAC20476.1.
    AJ302552 Genomic DNA. Translation: CAC21440.1.
    AJ302553 Genomic DNA. Translation: CAC21441.1.
    AJ302554 Genomic DNA. Translation: CAC21442.1.
    AJ302555 Genomic DNA. Translation: CAC21443.1.
    AJ302556 Genomic DNA. Translation: CAC21444.1.
    AJ302557 Genomic DNA. Translation: CAC20477.1.
    AJ302558 Genomic DNA. Translation: CAC20478.1.
    AL645937 Genomic DNA. Translation: CAI18102.1.
    AL022727 Genomic DNA. Translation: CAA18783.1.
    AL662852 Genomic DNA. Translation: CAI17594.1.
    AL929561 Genomic DNA. Translation: CAI41773.1.
    BX248093 Genomic DNA. Translation: CAM26133.1.
    CR547123 Genomic DNA. Translation: CAQ06966.1.
    CR388415 Genomic DNA. Translation: CAQ07703.1.
    CR942175 Genomic DNA. Translation: CAQ07980.1.
    BC136973 mRNA. Translation: AAI36974.1.
    BC136975 mRNA. Translation: AAI36976.1.
    AF399630 Genomic DNA. Translation: AAK95115.1.
    BK004437 Genomic DNA. Translation: DAA04835.1.
    CCDSiCCDS43433.1.
    RefSeqiNP_001005216.2. NM_001005216.3.
    UniGeneiHs.738947.

    Genome annotation databases

    EnsembliENST00000377169; ENSP00000366374; ENSG00000204701.
    ENST00000383651; ENSP00000373147; ENSG00000206522.
    ENST00000414140; ENSP00000390144; ENSG00000232178.
    ENST00000418630; ENSP00000400546; ENSG00000233618.
    ENST00000419260; ENSP00000408783; ENSG00000229866.
    ENST00000428081; ENSP00000388392; ENSG00000226271.
    ENST00000430478; ENSP00000388205; ENSG00000233636.
    GeneIDi442186.
    KEGGihsa:442186.
    UCSCiuc011dll.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)
    Protein Spotlight

    The intricacy of a smell - Issue 150 of July 2013

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302547 Genomic DNA. Translation: CAC20472.1 .
    AJ302548 Genomic DNA. Translation: CAC20473.1 .
    AJ302549 Genomic DNA. Translation: CAC20474.1 .
    AJ302550 Genomic DNA. Translation: CAC20475.1 .
    AJ302551 Genomic DNA. Translation: CAC20476.1 .
    AJ302552 Genomic DNA. Translation: CAC21440.1 .
    AJ302553 Genomic DNA. Translation: CAC21441.1 .
    AJ302554 Genomic DNA. Translation: CAC21442.1 .
    AJ302555 Genomic DNA. Translation: CAC21443.1 .
    AJ302556 Genomic DNA. Translation: CAC21444.1 .
    AJ302557 Genomic DNA. Translation: CAC20477.1 .
    AJ302558 Genomic DNA. Translation: CAC20478.1 .
    AL645937 Genomic DNA. Translation: CAI18102.1 .
    AL022727 Genomic DNA. Translation: CAA18783.1 .
    AL662852 Genomic DNA. Translation: CAI17594.1 .
    AL929561 Genomic DNA. Translation: CAI41773.1 .
    BX248093 Genomic DNA. Translation: CAM26133.1 .
    CR547123 Genomic DNA. Translation: CAQ06966.1 .
    CR388415 Genomic DNA. Translation: CAQ07703.1 .
    CR942175 Genomic DNA. Translation: CAQ07980.1 .
    BC136973 mRNA. Translation: AAI36974.1 .
    BC136975 mRNA. Translation: AAI36976.1 .
    AF399630 Genomic DNA. Translation: AAK95115.1 .
    BK004437 Genomic DNA. Translation: DAA04835.1 .
    CCDSi CCDS43433.1.
    RefSeqi NP_001005216.2. NM_001005216.3.
    UniGenei Hs.738947.

    3D structure databases

    ProteinModelPortali O76001.
    SMRi O76001. Positions 29-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000408783.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O76001.
    PRIDEi O76001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377169 ; ENSP00000366374 ; ENSG00000204701 .
    ENST00000383651 ; ENSP00000373147 ; ENSG00000206522 .
    ENST00000414140 ; ENSP00000390144 ; ENSG00000232178 .
    ENST00000418630 ; ENSP00000400546 ; ENSG00000233618 .
    ENST00000419260 ; ENSP00000408783 ; ENSG00000229866 .
    ENST00000428081 ; ENSP00000388392 ; ENSG00000226271 .
    ENST00000430478 ; ENSP00000388205 ; ENSG00000233636 .
    GeneIDi 442186.
    KEGGi hsa:442186.
    UCSCi uc011dll.2. human.

    Organism-specific databases

    CTDi 442186.
    GeneCardsi GC06P029079.
    GC06Pi29079.
    GC06Pj29076.
    GC06Pk29079.
    GC06Pl29079.
    GC06Pn29079.
    GC06Po29079.
    H-InvDB HIX0165965.
    HIX0166175.
    HIX0201061.
    HIX0201063.
    HIX0201071.
    HIX0201073.
    HIX0201086.
    HIX0201090.
    HIX0201106.
    HIX0201108.
    HGNCi HGNC:8261. OR2J3.
    MIMi 615016. gene.
    615082. phenotype.
    neXtProti NX_O76001.
    PharmGKBi PA32178.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146261.
    HOVERGENi HBG017625.
    InParanoidi O76001.
    KOi K04257.
    OMAi ILMHPRF.
    OrthoDBi EOG751NFX.
    PhylomeDBi O76001.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2J3.
    GenomeRNAii 442186.
    NextBioi 110806.
    PROi O76001.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_OR2J3.
    Genevestigatori O76001.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
      Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
      (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-113; GLN-226; ILE-228 AND MET-261.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-261.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-261.
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
    7. "Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the 'grassy' smelling odor, cis-3-hexen-1-ol."
      McRae J.F., Mainland J.D., Jaeger S.R., Adipietro K.A., Matsunami H., Newcomb R.D.
      Chem. Senses 37:585-593(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, POLYMORPHISM, VARIANTS ALA-113 AND GLN-226.

    Entry informationi

    Entry nameiOR2J3_HUMAN
    AccessioniPrimary (citable) accession number: O76001
    Secondary accession number(s): B0UY52
    , B9EH11, Q5SUJ7, Q6IF25, Q96R15, Q9GZK5, Q9GZL4, Q9GZL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3