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Protein

Olfactory receptor 2J3

Gene

OR2J3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2J3
Alternative name(s):
Hs6M1-3
Olfactory receptor OR6-16
Short name:
OR6-6
Short name:
Olfactory receptor 6-6
Gene namesi
Name:OR2J3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204701.1
HGNCiHGNC:8261 OR2J3
MIMi615016 gene
neXtProtiNX_O76001

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 52Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 82Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini83 – 103ExtracellularSequence analysisAdd BLAST21
Transmembranei104 – 123Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 161Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 222Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini223 – 239CytoplasmicSequence analysisAdd BLAST17
Transmembranei240 – 262Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 295Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini296 – 311CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi442186
MalaCardsiOR2J3
MIMi615082 phenotype
PharmGKBiPA32178

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504841 – 311Olfactory receptor 2J3Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO76001
PaxDbiO76001
PeptideAtlasiO76001
PRIDEiO76001

Expressioni

Gene expression databases

BgeeiENSG00000204701
CleanExiHS_OR2J3
ExpressionAtlasiO76001 baseline and differential
GenevisibleiO76001 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366374

Structurei

3D structure databases

ProteinModelPortaliO76001
SMRiO76001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAWR Eukaryota
ENOG4111DPD LUCA
HOVERGENiHBG017625
InParanoidiO76001
KOiK04257
OrthoDBiEOG09370HYW
PhylomeDBiO76001
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O76001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDDGKVNAS SEGYFILVGF SNWPHLEVVI FVVVLIFYLM TLIGNLFIII
60 70 80 90 100
LSYLDSHLHT PMYFFLSNLS FLDLCYTTSS IPQLLVNLWG PEKTISYAGC
110 120 130 140 150
MIQLYFVLAL GTTECVLLVV MSYDRYAAVC RPLHYTVLMH PRFCHLLAVA
160 170 180 190 200
SWVSGFTNSA LHSSFTFWVP LCGHRQVDHF FCEVPALLRL SCVDTHVNEL
210 220 230 240 250
TLMITSSIFV LIPLILILTS YGAIVRAVLR MQSTTGLQKV FGTCGAHLMA
260 270 280 290 300
VSLFFIPAMC IYLQPPSGNS QDQGKFIALF YTVVTPSLNP LIYTLRNKVV
310
RGAVKRLMGW E
Length:311
Mass (Da):34,950
Last modified:November 1, 1998 - v1
Checksum:i84201145B9D5AA68
GO

Polymorphismi

Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIMi:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010949113T → A in allele 6M1-3*02; decreased response to C3HEX. 2 PublicationsCorresponds to variant dbSNP:rs28757581EnsemblClinVar.1
Natural variantiVAR_010950226R → Q in allele 6M1-3*02; decreased response to C3HEX. 2 PublicationsCorresponds to variant dbSNP:rs3749977EnsemblClinVar.1
Natural variantiVAR_010951228V → I in allele 6M1-3*03. 1 PublicationCorresponds to variant dbSNP:rs3130764Ensembl.1
Natural variantiVAR_010952261I → M in allele 6M1-3*03 and allele 6M1-3*04. 3 PublicationsCorresponds to variant dbSNP:rs3130765Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302547 Genomic DNA Translation: CAC20472.1
AJ302548 Genomic DNA Translation: CAC20473.1
AJ302549 Genomic DNA Translation: CAC20474.1
AJ302550 Genomic DNA Translation: CAC20475.1
AJ302551 Genomic DNA Translation: CAC20476.1
AJ302552 Genomic DNA Translation: CAC21440.1
AJ302553 Genomic DNA Translation: CAC21441.1
AJ302554 Genomic DNA Translation: CAC21442.1
AJ302555 Genomic DNA Translation: CAC21443.1
AJ302556 Genomic DNA Translation: CAC21444.1
AJ302557 Genomic DNA Translation: CAC20477.1
AJ302558 Genomic DNA Translation: CAC20478.1
AL645937 Genomic DNA No translation available.
AL022727 Genomic DNA Translation: CAA18783.1
AL662852 Genomic DNA No translation available.
AL929561 Genomic DNA No translation available.
BX248093 Genomic DNA No translation available.
CR547123 Genomic DNA No translation available.
CR388415 Genomic DNA No translation available.
CR942175 Genomic DNA No translation available.
BC136973 mRNA Translation: AAI36974.1
BC136975 mRNA Translation: AAI36976.1
AF399630 Genomic DNA Translation: AAK95115.1
BK004437 Genomic DNA Translation: DAA04835.1
CCDSiCCDS43433.1
RefSeqiNP_001005216.2, NM_001005216.3
UniGeneiHs.738947

Genome annotation databases

EnsembliENST00000377169; ENSP00000366374; ENSG00000204701
ENST00000383651; ENSP00000373147; ENSG00000206522
ENST00000414140; ENSP00000390144; ENSG00000232178
ENST00000418630; ENSP00000400546; ENSG00000233618
ENST00000419260; ENSP00000408783; ENSG00000229866
ENST00000428081; ENSP00000388392; ENSG00000226271
ENST00000430478; ENSP00000388205; ENSG00000233636
GeneIDi442186
KEGGihsa:442186
UCSCiuc011dll.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2J3_HUMAN
AccessioniPrimary (citable) accession number: O76001
Secondary accession number(s): B0UY52
, B9EH11, Q5SUJ7, Q6IF25, Q96R15, Q9GZK5, Q9GZL4, Q9GZL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

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