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Protein

Putative olfactory receptor 2B3

Gene

OR2B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181311-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 2B3
Alternative name(s):
Hs6M1-1
Olfactory receptor OR6-14
Short name:
OR6-4
Short name:
Olfactory receptor 6-4
Gene namesi
Name:OR2B3
Synonyms:OR2B3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8238. OR2B3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi442184.
OpenTargetsiENSG00000204703.
ENSG00000206524.
ENSG00000225736.
ENSG00000226832.
ENSG00000231319.
ENSG00000233054.
ENSG00000233180.
ENSG00000233687.

Polymorphism and mutation databases

BioMutaiOR2B3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504611 – 313Putative olfactory receptor 2B3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76000.
PRIDEiO76000.

PTM databases

iPTMnetiO76000.
PhosphoSitePlusiO76000.

Expressioni

Gene expression databases

ExpressionAtlasiO76000. baseline and differential.
GenevisibleiO76000. HS.

Structurei

3D structure databases

ProteinModelPortaliO76000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAXK. Eukaryota.
ENOG4111A74. LUCA.
GeneTreeiENSGT00740000115013.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO76000.
KOiK04257.
OMAiWLQMPLF.
OrthoDBiEOG091G0CU6.
PhylomeDBiO76000.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWENESSPK EFILLGFSDR AWLQMPLFVV LLISYTITIF GNVSIMMVCI
60 70 80 90 100
LDPKLHTPMY FFLTNLSILD LCYTTTTVPH MLVNIGCNKK TISYAGCVAH
110 120 130 140 150
LIIFLALGAT ECLLLAVMSF DRYVAVCRPL HYVVIMNYWF CLRMAAFSWL
160 170 180 190 200
IGFGNSVLQS SLTLNMPRCG HQEVDHFFCE VPALLKLSCA DTKPIEAELF
210 220 230 240 250
FFSVLILLIP VTLILISYGF IAQAVLKIRS AEGRQKAFGT CGSHMIVVSL
260 270 280 290 300
FYGTAIYMYL QPPSSTSKDW GKMVSLFYGI ITSMLNSLIY SLRNKDMKEA
310
FKRLMPRIFF CKK
Length:313
Mass (Da):35,543
Last modified:November 1, 1998 - v1
Checksum:i786BF1EE7B624440
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302537 Genomic DNA. Translation: CAC20462.1.
AJ302538 Genomic DNA. Translation: CAC20463.1.
AJ302539 Genomic DNA. Translation: CAC20464.1.
AJ302540 Genomic DNA. Translation: CAC20465.1.
AJ302541 Genomic DNA. Translation: CAC20466.1.
AJ302542 Genomic DNA. Translation: CAC20467.1.
AJ302543 Genomic DNA. Translation: CAC20468.1.
AJ302544 Genomic DNA. Translation: CAC20469.1.
AJ302545 Genomic DNA. Translation: CAC20470.1.
AJ302546 Genomic DNA. Translation: CAC20471.1.
AL022727 Genomic DNA. Translation: CAA18782.1.
AL662852 Genomic DNA. Translation: CAI17592.1.
AL662791 Genomic DNA. Translation: CAI18246.1.
AL929561 Genomic DNA. Translation: CAI41771.1.
CR547123 Genomic DNA. Translation: CAQ06964.1.
CR942175 Genomic DNA. Translation: CAQ07978.1.
CR933783 Genomic DNA. Translation: CAQ08042.1.
CH471081 Genomic DNA. Translation: EAX03182.1.
AF399632 Genomic DNA. Translation: AAK95117.1.
BK004436 Genomic DNA. Translation: DAA04834.1.
CCDSiCCDS34358.1.
RefSeqiNP_001005226.1. NM_001005226.2.
UniGeneiHs.553835.

Genome annotation databases

EnsembliENST00000377173; ENSP00000366378; ENSG00000204703.
ENST00000383653; ENSP00000373149; ENSG00000206524.
ENST00000415976; ENSP00000394571; ENSG00000226832.
ENST00000419873; ENSP00000394593; ENSG00000231319.
ENST00000420178; ENSP00000388604; ENSG00000233054.
ENST00000444830; ENSP00000393235; ENSG00000233180.
ENST00000450817; ENSP00000399881; ENSG00000233687.
ENST00000456140; ENSP00000403571; ENSG00000225736.
GeneIDi442184.
KEGGihsa:442184.
UCSCiuc003nlx.4. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302537 Genomic DNA. Translation: CAC20462.1.
AJ302538 Genomic DNA. Translation: CAC20463.1.
AJ302539 Genomic DNA. Translation: CAC20464.1.
AJ302540 Genomic DNA. Translation: CAC20465.1.
AJ302541 Genomic DNA. Translation: CAC20466.1.
AJ302542 Genomic DNA. Translation: CAC20467.1.
AJ302543 Genomic DNA. Translation: CAC20468.1.
AJ302544 Genomic DNA. Translation: CAC20469.1.
AJ302545 Genomic DNA. Translation: CAC20470.1.
AJ302546 Genomic DNA. Translation: CAC20471.1.
AL022727 Genomic DNA. Translation: CAA18782.1.
AL662852 Genomic DNA. Translation: CAI17592.1.
AL662791 Genomic DNA. Translation: CAI18246.1.
AL929561 Genomic DNA. Translation: CAI41771.1.
CR547123 Genomic DNA. Translation: CAQ06964.1.
CR942175 Genomic DNA. Translation: CAQ07978.1.
CR933783 Genomic DNA. Translation: CAQ08042.1.
CH471081 Genomic DNA. Translation: EAX03182.1.
AF399632 Genomic DNA. Translation: AAK95117.1.
BK004436 Genomic DNA. Translation: DAA04834.1.
CCDSiCCDS34358.1.
RefSeqiNP_001005226.1. NM_001005226.2.
UniGeneiHs.553835.

3D structure databases

ProteinModelPortaliO76000.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO76000.
PhosphoSitePlusiO76000.

Polymorphism and mutation databases

BioMutaiOR2B3.

Proteomic databases

PaxDbiO76000.
PRIDEiO76000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377173; ENSP00000366378; ENSG00000204703.
ENST00000383653; ENSP00000373149; ENSG00000206524.
ENST00000415976; ENSP00000394571; ENSG00000226832.
ENST00000419873; ENSP00000394593; ENSG00000231319.
ENST00000420178; ENSP00000388604; ENSG00000233054.
ENST00000444830; ENSP00000393235; ENSG00000233180.
ENST00000450817; ENSP00000399881; ENSG00000233687.
ENST00000456140; ENSP00000403571; ENSG00000225736.
GeneIDi442184.
KEGGihsa:442184.
UCSCiuc003nlx.4. human.

Organism-specific databases

CTDi442184.
DisGeNETi442184.
GeneCardsiOR2B3.
HGNCiHGNC:8238. OR2B3.
neXtProtiNX_O76000.
OpenTargetsiENSG00000204703.
ENSG00000206524.
ENSG00000225736.
ENSG00000226832.
ENSG00000231319.
ENSG00000233054.
ENSG00000233180.
ENSG00000233687.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAXK. Eukaryota.
ENOG4111A74. LUCA.
GeneTreeiENSGT00740000115013.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO76000.
KOiK04257.
OMAiWLQMPLF.
OrthoDBiEOG091G0CU6.
PhylomeDBiO76000.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181311-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2B3.
GenomeRNAii442184.
PROiO76000.

Gene expression databases

ExpressionAtlasiO76000. baseline and differential.
GenevisibleiO76000. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2B3_HUMAN
AccessioniPrimary (citable) accession number: O76000
Secondary accession number(s): B0UYQ1, Q5ST41, Q96R13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.