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O76000

- OR2B3_HUMAN

UniProt

O76000 - OR2B3_HUMAN

Protein

Putative olfactory receptor 2B3

Gene

OR2B3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative olfactory receptor 2B3
    Alternative name(s):
    Hs6M1-1
    Olfactory receptor OR6-14
    Short name:
    OR6-4
    Short name:
    Olfactory receptor 6-4
    Gene namesi
    Name:OR2B3
    Synonyms:OR2B3P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8238. OR2B3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Putative olfactory receptor 2B3PRO_0000150461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO76000.
    PRIDEiO76000.

    PTM databases

    PhosphoSiteiO76000.

    Expressioni

    Gene expression databases

    GenevestigatoriO76000.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000366378.

    Structurei

    3D structure databases

    ProteinModelPortaliO76000.
    SMRiO76000. Positions 18-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31321CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272235.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiO76000.
    KOiK04257.
    OMAiWLQMPLF.
    OrthoDBiEOG751NFX.
    PhylomeDBiO76000.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O76000-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNWENESSPK EFILLGFSDR AWLQMPLFVV LLISYTITIF GNVSIMMVCI    50
    LDPKLHTPMY FFLTNLSILD LCYTTTTVPH MLVNIGCNKK TISYAGCVAH 100
    LIIFLALGAT ECLLLAVMSF DRYVAVCRPL HYVVIMNYWF CLRMAAFSWL 150
    IGFGNSVLQS SLTLNMPRCG HQEVDHFFCE VPALLKLSCA DTKPIEAELF 200
    FFSVLILLIP VTLILISYGF IAQAVLKIRS AEGRQKAFGT CGSHMIVVSL 250
    FYGTAIYMYL QPPSSTSKDW GKMVSLFYGI ITSMLNSLIY SLRNKDMKEA 300
    FKRLMPRIFF CKK 313
    Length:313
    Mass (Da):35,543
    Last modified:November 1, 1998 - v1
    Checksum:i786BF1EE7B624440
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302537 Genomic DNA. Translation: CAC20462.1.
    AJ302538 Genomic DNA. Translation: CAC20463.1.
    AJ302539 Genomic DNA. Translation: CAC20464.1.
    AJ302540 Genomic DNA. Translation: CAC20465.1.
    AJ302541 Genomic DNA. Translation: CAC20466.1.
    AJ302542 Genomic DNA. Translation: CAC20467.1.
    AJ302543 Genomic DNA. Translation: CAC20468.1.
    AJ302544 Genomic DNA. Translation: CAC20469.1.
    AJ302545 Genomic DNA. Translation: CAC20470.1.
    AJ302546 Genomic DNA. Translation: CAC20471.1.
    AL022727 Genomic DNA. Translation: CAA18782.1.
    AL662852 Genomic DNA. Translation: CAI17592.1.
    AL662791 Genomic DNA. Translation: CAI18246.1.
    AL929561 Genomic DNA. Translation: CAI41771.1.
    CR547123 Genomic DNA. Translation: CAQ06964.1.
    CR942175 Genomic DNA. Translation: CAQ07978.1.
    CR933783 Genomic DNA. Translation: CAQ08042.1.
    CH471081 Genomic DNA. Translation: EAX03182.1.
    AF399632 Genomic DNA. Translation: AAK95117.1.
    BK004436 Genomic DNA. Translation: DAA04834.1.
    CCDSiCCDS34358.1.
    RefSeqiNP_001005226.1. NM_001005226.2.
    UniGeneiHs.553835.

    Genome annotation databases

    EnsembliENST00000377173; ENSP00000366378; ENSG00000204703.
    ENST00000383653; ENSP00000373149; ENSG00000206524.
    ENST00000415976; ENSP00000394571; ENSG00000226832.
    ENST00000419873; ENSP00000394593; ENSG00000231319.
    ENST00000420178; ENSP00000388604; ENSG00000233054.
    ENST00000444830; ENSP00000393235; ENSG00000233180.
    ENST00000450817; ENSP00000399881; ENSG00000233687.
    ENST00000456140; ENSP00000403571; ENSG00000225736.
    GeneIDi442184.
    KEGGihsa:442184.
    UCSCiuc003nlx.3. human.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302537 Genomic DNA. Translation: CAC20462.1 .
    AJ302538 Genomic DNA. Translation: CAC20463.1 .
    AJ302539 Genomic DNA. Translation: CAC20464.1 .
    AJ302540 Genomic DNA. Translation: CAC20465.1 .
    AJ302541 Genomic DNA. Translation: CAC20466.1 .
    AJ302542 Genomic DNA. Translation: CAC20467.1 .
    AJ302543 Genomic DNA. Translation: CAC20468.1 .
    AJ302544 Genomic DNA. Translation: CAC20469.1 .
    AJ302545 Genomic DNA. Translation: CAC20470.1 .
    AJ302546 Genomic DNA. Translation: CAC20471.1 .
    AL022727 Genomic DNA. Translation: CAA18782.1 .
    AL662852 Genomic DNA. Translation: CAI17592.1 .
    AL662791 Genomic DNA. Translation: CAI18246.1 .
    AL929561 Genomic DNA. Translation: CAI41771.1 .
    CR547123 Genomic DNA. Translation: CAQ06964.1 .
    CR942175 Genomic DNA. Translation: CAQ07978.1 .
    CR933783 Genomic DNA. Translation: CAQ08042.1 .
    CH471081 Genomic DNA. Translation: EAX03182.1 .
    AF399632 Genomic DNA. Translation: AAK95117.1 .
    BK004436 Genomic DNA. Translation: DAA04834.1 .
    CCDSi CCDS34358.1.
    RefSeqi NP_001005226.1. NM_001005226.2.
    UniGenei Hs.553835.

    3D structure databases

    ProteinModelPortali O76000.
    SMRi O76000. Positions 18-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000366378.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O76000.

    Proteomic databases

    PaxDbi O76000.
    PRIDEi O76000.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377173 ; ENSP00000366378 ; ENSG00000204703 .
    ENST00000383653 ; ENSP00000373149 ; ENSG00000206524 .
    ENST00000415976 ; ENSP00000394571 ; ENSG00000226832 .
    ENST00000419873 ; ENSP00000394593 ; ENSG00000231319 .
    ENST00000420178 ; ENSP00000388604 ; ENSG00000233054 .
    ENST00000444830 ; ENSP00000393235 ; ENSG00000233180 .
    ENST00000450817 ; ENSP00000399881 ; ENSG00000233687 .
    ENST00000456140 ; ENSP00000403571 ; ENSG00000225736 .
    GeneIDi 442184.
    KEGGi hsa:442184.
    UCSCi uc003nlx.3. human.

    Organism-specific databases

    CTDi 442184.
    GeneCardsi GC06M029054.
    GC06Mi29054.
    GC06Mj29050.
    GC06Mk29053.
    GC06Ml29053.
    GC06Mm29054.
    GC06Mn29053.
    GC06Mo29054.
    HGNCi HGNC:8238. OR2B3.
    neXtProti NX_O76000.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272235.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi O76000.
    KOi K04257.
    OMAi WLQMPLF.
    OrthoDBi EOG751NFX.
    PhylomeDBi O76000.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2B3.
    GenomeRNAii 442184.
    NextBioi 110800.
    PROi O76000.

    Gene expression databases

    Genevestigatori O76000.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
      Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
      (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2B3_HUMAN
    AccessioniPrimary (citable) accession number: O76000
    Secondary accession number(s): B0UYQ1, Q5ST41, Q96R13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3