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Protein

Putative olfactory receptor 2B3

Gene

OR2B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 2B3
Alternative name(s):
Hs6M1-1
Olfactory receptor OR6-14
Short name:
OR6-4
Short name:
Olfactory receptor 6-4
Gene namesi
Name:OR2B3
Synonyms:OR2B3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204703.4
HGNCiHGNC:8238 OR2B3
neXtProtiNX_O76000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi442184

Polymorphism and mutation databases

BioMutaiOR2B3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504611 – 313Putative olfactory receptor 2B3Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76000
PRIDEiO76000

PTM databases

iPTMnetiO76000
PhosphoSitePlusiO76000

Expressioni

Gene expression databases

ExpressionAtlasiO76000 differential
GenevisibleiO76000 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366378

Structurei

3D structure databases

ProteinModelPortaliO76000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAXK Eukaryota
ENOG4111A74 LUCA
GeneTreeiENSGT00740000115013
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiO76000
KOiK04257
OMAiMPRIFFC
OrthoDBiEOG093700HZ
PhylomeDBiO76000
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O76000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWENESSPK EFILLGFSDR AWLQMPLFVV LLISYTITIF GNVSIMMVCI
60 70 80 90 100
LDPKLHTPMY FFLTNLSILD LCYTTTTVPH MLVNIGCNKK TISYAGCVAH
110 120 130 140 150
LIIFLALGAT ECLLLAVMSF DRYVAVCRPL HYVVIMNYWF CLRMAAFSWL
160 170 180 190 200
IGFGNSVLQS SLTLNMPRCG HQEVDHFFCE VPALLKLSCA DTKPIEAELF
210 220 230 240 250
FFSVLILLIP VTLILISYGF IAQAVLKIRS AEGRQKAFGT CGSHMIVVSL
260 270 280 290 300
FYGTAIYMYL QPPSSTSKDW GKMVSLFYGI ITSMLNSLIY SLRNKDMKEA
310
FKRLMPRIFF CKK
Length:313
Mass (Da):35,543
Last modified:November 1, 1998 - v1
Checksum:i786BF1EE7B624440
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302537 Genomic DNA Translation: CAC20462.1
AJ302538 Genomic DNA Translation: CAC20463.1
AJ302539 Genomic DNA Translation: CAC20464.1
AJ302540 Genomic DNA Translation: CAC20465.1
AJ302541 Genomic DNA Translation: CAC20466.1
AJ302542 Genomic DNA Translation: CAC20467.1
AJ302543 Genomic DNA Translation: CAC20468.1
AJ302544 Genomic DNA Translation: CAC20469.1
AJ302545 Genomic DNA Translation: CAC20470.1
AJ302546 Genomic DNA Translation: CAC20471.1
AL022727 Genomic DNA Translation: CAA18782.1
AL662852 Genomic DNA No translation available.
AL662791 Genomic DNA No translation available.
AL929561 Genomic DNA No translation available.
CR547123 Genomic DNA No translation available.
CR942175 Genomic DNA No translation available.
CR933783 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03182.1
AF399632 Genomic DNA Translation: AAK95117.1
BK004436 Genomic DNA Translation: DAA04834.1
CCDSiCCDS34358.1
RefSeqiNP_001005226.1, NM_001005226.2
UniGeneiHs.553835

Genome annotation databases

EnsembliENST00000377173; ENSP00000366378; ENSG00000204703
ENST00000383653; ENSP00000373149; ENSG00000206524
ENST00000415976; ENSP00000394571; ENSG00000226832
ENST00000419873; ENSP00000394593; ENSG00000231319
ENST00000420178; ENSP00000388604; ENSG00000233054
ENST00000444830; ENSP00000393235; ENSG00000233180
ENST00000450817; ENSP00000399881; ENSG00000233687
ENST00000456140; ENSP00000403571; ENSG00000225736
GeneIDi442184
KEGGihsa:442184
UCSCiuc003nlx.4 human

Similar proteinsi

Entry informationi

Entry nameiOR2B3_HUMAN
AccessioniPrimary (citable) accession number: O76000
Secondary accession number(s): B0UYQ1, Q5ST41, Q96R13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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