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O76000

- OR2B3_HUMAN

UniProt

O76000 - OR2B3_HUMAN

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Protein

Putative olfactory receptor 2B3

Gene
OR2B3, OR2B3P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 2B3
Alternative name(s):
Hs6M1-1
Olfactory receptor OR6-14
Short name:
OR6-4
Short name:
Olfactory receptor 6-4
Gene namesi
Name:OR2B3
Synonyms:OR2B3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:8238. OR2B3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4924Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7922Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini80 – 10021Extracellular Reviewed predictionAdd
BLAST
Transmembranei101 – 12020Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 15819Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini159 – 19537Extracellular Reviewed predictionAdd
BLAST
Transmembranei196 – 21924Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini220 – 23617Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25923Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini260 – 27213Extracellular Reviewed predictionAdd
BLAST
Transmembranei273 – 29220Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 31321Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Putative olfactory receptor 2B3PRO_0000150461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76000.
PRIDEiO76000.

PTM databases

PhosphoSiteiO76000.

Expressioni

Gene expression databases

GenevestigatoriO76000.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366378.

Structurei

3D structure databases

ProteinModelPortaliO76000.
SMRiO76000. Positions 18-305.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272235.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiO76000.
KOiK04257.
OMAiWLQMPLF.
OrthoDBiEOG751NFX.
PhylomeDBiO76000.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O76000-1 [UniParc]FASTAAdd to Basket

« Hide

MNWENESSPK EFILLGFSDR AWLQMPLFVV LLISYTITIF GNVSIMMVCI    50
LDPKLHTPMY FFLTNLSILD LCYTTTTVPH MLVNIGCNKK TISYAGCVAH 100
LIIFLALGAT ECLLLAVMSF DRYVAVCRPL HYVVIMNYWF CLRMAAFSWL 150
IGFGNSVLQS SLTLNMPRCG HQEVDHFFCE VPALLKLSCA DTKPIEAELF 200
FFSVLILLIP VTLILISYGF IAQAVLKIRS AEGRQKAFGT CGSHMIVVSL 250
FYGTAIYMYL QPPSSTSKDW GKMVSLFYGI ITSMLNSLIY SLRNKDMKEA 300
FKRLMPRIFF CKK 313
Length:313
Mass (Da):35,543
Last modified:November 1, 1998 - v1
Checksum:i786BF1EE7B624440
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302537 Genomic DNA. Translation: CAC20462.1.
AJ302538 Genomic DNA. Translation: CAC20463.1.
AJ302539 Genomic DNA. Translation: CAC20464.1.
AJ302540 Genomic DNA. Translation: CAC20465.1.
AJ302541 Genomic DNA. Translation: CAC20466.1.
AJ302542 Genomic DNA. Translation: CAC20467.1.
AJ302543 Genomic DNA. Translation: CAC20468.1.
AJ302544 Genomic DNA. Translation: CAC20469.1.
AJ302545 Genomic DNA. Translation: CAC20470.1.
AJ302546 Genomic DNA. Translation: CAC20471.1.
AL022727 Genomic DNA. Translation: CAA18782.1.
AL662852 Genomic DNA. Translation: CAI17592.1.
AL662791 Genomic DNA. Translation: CAI18246.1.
AL929561 Genomic DNA. Translation: CAI41771.1.
CR547123 Genomic DNA. Translation: CAQ06964.1.
CR942175 Genomic DNA. Translation: CAQ07978.1.
CR933783 Genomic DNA. Translation: CAQ08042.1.
CH471081 Genomic DNA. Translation: EAX03182.1.
AF399632 Genomic DNA. Translation: AAK95117.1.
BK004436 Genomic DNA. Translation: DAA04834.1.
CCDSiCCDS34358.1.
RefSeqiNP_001005226.1. NM_001005226.2.
UniGeneiHs.553835.

Genome annotation databases

EnsembliENST00000377173; ENSP00000366378; ENSG00000204703.
ENST00000383653; ENSP00000373149; ENSG00000206524.
ENST00000415976; ENSP00000394571; ENSG00000226832.
ENST00000419873; ENSP00000394593; ENSG00000231319.
ENST00000420178; ENSP00000388604; ENSG00000233054.
ENST00000444830; ENSP00000393235; ENSG00000233180.
ENST00000450817; ENSP00000399881; ENSG00000233687.
ENST00000456140; ENSP00000403571; ENSG00000225736.
GeneIDi442184.
KEGGihsa:442184.
UCSCiuc003nlx.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302537 Genomic DNA. Translation: CAC20462.1 .
AJ302538 Genomic DNA. Translation: CAC20463.1 .
AJ302539 Genomic DNA. Translation: CAC20464.1 .
AJ302540 Genomic DNA. Translation: CAC20465.1 .
AJ302541 Genomic DNA. Translation: CAC20466.1 .
AJ302542 Genomic DNA. Translation: CAC20467.1 .
AJ302543 Genomic DNA. Translation: CAC20468.1 .
AJ302544 Genomic DNA. Translation: CAC20469.1 .
AJ302545 Genomic DNA. Translation: CAC20470.1 .
AJ302546 Genomic DNA. Translation: CAC20471.1 .
AL022727 Genomic DNA. Translation: CAA18782.1 .
AL662852 Genomic DNA. Translation: CAI17592.1 .
AL662791 Genomic DNA. Translation: CAI18246.1 .
AL929561 Genomic DNA. Translation: CAI41771.1 .
CR547123 Genomic DNA. Translation: CAQ06964.1 .
CR942175 Genomic DNA. Translation: CAQ07978.1 .
CR933783 Genomic DNA. Translation: CAQ08042.1 .
CH471081 Genomic DNA. Translation: EAX03182.1 .
AF399632 Genomic DNA. Translation: AAK95117.1 .
BK004436 Genomic DNA. Translation: DAA04834.1 .
CCDSi CCDS34358.1.
RefSeqi NP_001005226.1. NM_001005226.2.
UniGenei Hs.553835.

3D structure databases

ProteinModelPortali O76000.
SMRi O76000. Positions 18-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000366378.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O76000.

Proteomic databases

PaxDbi O76000.
PRIDEi O76000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377173 ; ENSP00000366378 ; ENSG00000204703 .
ENST00000383653 ; ENSP00000373149 ; ENSG00000206524 .
ENST00000415976 ; ENSP00000394571 ; ENSG00000226832 .
ENST00000419873 ; ENSP00000394593 ; ENSG00000231319 .
ENST00000420178 ; ENSP00000388604 ; ENSG00000233054 .
ENST00000444830 ; ENSP00000393235 ; ENSG00000233180 .
ENST00000450817 ; ENSP00000399881 ; ENSG00000233687 .
ENST00000456140 ; ENSP00000403571 ; ENSG00000225736 .
GeneIDi 442184.
KEGGi hsa:442184.
UCSCi uc003nlx.3. human.

Organism-specific databases

CTDi 442184.
GeneCardsi GC06M029054.
GC06Mi29054.
GC06Mj29050.
GC06Mk29053.
GC06Ml29053.
GC06Mm29054.
GC06Mn29053.
GC06Mo29054.
HGNCi HGNC:8238. OR2B3.
neXtProti NX_O76000.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272235.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi O76000.
KOi K04257.
OMAi WLQMPLF.
OrthoDBi EOG751NFX.
PhylomeDBi O76000.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2B3.
GenomeRNAii 442184.
NextBioi 110800.
PROi O76000.

Gene expression databases

Genevestigatori O76000.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
    Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
    (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2B3_HUMAN
AccessioniPrimary (citable) accession number: O76000
Secondary accession number(s): B0UYQ1, Q5ST41, Q96R13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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