O75976 (CBPD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carboxypeptidase D
EC=3.4.17.22

Alternative name(s):
Metallocarboxypeptidase D
gp180

Gene names

Name:

CPD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Releases C-terminal Arg and Lys from polypeptides.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
Domain	There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
Sequence similarities	Belongs to the peptidase M14 family.
Biophysicochemical properties	pH dependence: Optimum pH is 6.0-6.5.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Metal-binding Zinc
Molecular function	Carboxypeptidase Hydrolase Metalloprotease Protease
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Traceable author statement Ref.7. Source: ProtInc
Molecular_function	metallocarboxypeptidase activity Inferred from electronic annotation. Source: InterPro serine-type carboxypeptidase activity Traceable author statement Ref.7. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75976-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75976-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MA → MR
     3-249: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 1380	1349	Carboxypeptidase D		PRO_0000004401
Regions
	Topological domain	32 – 1299	1268	Extracellular Potential
	Transmembrane	1300 – 1320	21	Helical; Potential
	Topological domain	1321 – 1380	60	Cytoplasmic Potential
	Region	32 – 493	462	Carboxypeptidase-like 1
	Region	494 – 897	404	Carboxypeptidase-like 2
	Region	898 – 1299	402	Carboxypeptidase-like 3
	Motif	162 – 164	3	Cell attachment site Potential
Sites
	Active site	350	1	Nucleophile 1 By similarity
	Active site	762	1	Nucleophile 2 By similarity
	Metal binding	139	1	Zinc 1 By similarity
	Metal binding	142	1	Zinc 1 By similarity
	Metal binding	257	1	Zinc 1 By similarity
	Metal binding	564	1	Zinc 2 By similarity
	Metal binding	567	1	Zinc 2 By similarity
	Metal binding	671	1	Zinc 2 By similarity
Amino acid modifications
	Modified residue	1358	1	Phosphoserine Ref.12 Ref.14
	Modified residue	1361	1	Phosphoserine Ref.12 Ref.14
	Modified residue	1368	1	Phosphothreonine Ref.10 Ref.12 Ref.14
	Modified residue	1370	1	Phosphothreonine Ref.10 Ref.12 Ref.14
	Lipidation	1317	1	S-palmitoyl cysteine Ref.8
	Lipidation	1321	1	S-palmitoyl cysteine Ref.8
	Lipidation	1323	1	S-palmitoyl cysteine Ref.8
	Glycosylation	172	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	217	1	N-linked (GlcNAc...) Potential
	Glycosylation	399	1	N-linked (GlcNAc...) Potential
	Glycosylation	410	1	N-linked (GlcNAc...) Potential
	Glycosylation	429	1	N-linked (GlcNAc...) Potential
	Glycosylation	522	1	N-linked (GlcNAc...) Potential
	Glycosylation	626	1	N-linked (GlcNAc...) Potential
	Glycosylation	811	1	N-linked (GlcNAc...) Ref.9 Ref.11
	Glycosylation	855	1	N-linked (GlcNAc...) Potential
	Glycosylation	867	1	N-linked (GlcNAc...) Potential
	Glycosylation	879	1	N-linked (GlcNAc...) Potential
	Glycosylation	955	1	N-linked (GlcNAc...) Ref.9 Ref.11
	Glycosylation	978	1	N-linked (GlcNAc...) Potential
	Glycosylation	1070	1	N-linked (GlcNAc...) Ref.11
	Glycosylation	1142	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 2	2	MA → MR in isoform 2.		VSP_045833
	Alternative sequence	3 – 249	247	Missing in isoform 2.		VSP_045834
	Natural variant	36	1	K → E. Ref.6 Corresponds to variant rs17857300 [ dbSNP | Ensembl ].		VAR_027771
	Natural variant	454	1	E → G. Ref.6 Corresponds to variant rs17857301 [ dbSNP | Ensembl ].		VAR_027772
	Natural variant	505	1	H → N. Ref.6 Corresponds to variant rs17854355 [ dbSNP | Ensembl ].		VAR_027773
	Natural variant	899	1	T → I. Corresponds to variant rs1860543 [ dbSNP | Ensembl ].		VAR_027774
Experimental info
	Sequence conflict	863	1	A → V in BAH14780. Ref.3
	Sequence conflict	896	1	D → V Ref.1
	Sequence conflict	896	1	D → V Ref.2
	Sequence conflict	948	1	M → I in BAH14780. Ref.3
	Sequence conflict	1336	1	R → W in BAH13725. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: 567EC1F0B4B7A0C8	FASTA	1,380	152,931
	10 20 30 40 50 60 MASGRDERPP WRLGRLLLLM CLLLLGSSAR AAHIKKAEAT TTTTSAGAEA AEGQFDRYYH 70 80 90 100 110 120 EEELESALRE AAAAGLPGLA RLFSIGRSVE GRPLWVLRLT AGLGSLIPEG DAGPDAAGPD 130 140 150 160 170 180 AAGPLLPGRP QVKLVGNMHG DETVSRQVLI YLARELAAGY RRGDPRLVRL LNTTDVYLLP 190 200 210 220 230 240 SLNPDGFERA REGDCGFGDG GPSGASGRDN SRGRDLNRSF PDQFSTGEPP ALDEVPEVRA 250 260 270 280 290 300 LIEWIRRNKF VLSGNLHGGS VVASYPFDDS PEHKATGIYS KTSDDEVFKY LAKAYASNHP 310 320 330 340 350 360 IMKTGEPHCP GDEDETFKDG ITNGAHWYDV EGGMQDYNYV WANCFEITLE LSCCKYPPAS 370 380 390 400 410 420 QLRQEWENNR ESLITLIEKV HIGVKGFVKD SITGSGLENA TISVAGINHN ITTGRFGDFY 430 440 450 460 470 480 RLLVPGTYNL TVVLTGYMPL TVTNVVVKEG PATEVDFSLR PTVTSVIPDT TEAVSTASTV 490 500 510 520 530 540 AIPNILSGTS SSYQPIQPKD FHHHHFPDME IFLRRFANEY PNITRLYSLG KSVESRELYV 550 560 570 580 590 600 MEISDNPGVH EPGEPEFKYI GNMHGNEVVG RELLLNLIEY LCKNFGTDPE VTDLVHNTRI 610 620 630 640 650 660 HLMPSMNPDG YEKSQEGDSI SVIGRNNSNN FDLNRNFPDQ FVQITDPTQP ETIAVMSWMK 670 680 690 700 710 720 SYPFVLSANL HGGSLVVNYP FDDDEQGLAT YSKSPDDAVF QQIALSYSKE NSQMFQGRPC 730 740 750 760 770 780 KNMYPNEYFP HGITNGASWY NVPGGMQDWN YLQTNCFEVT IELGCVKYPL EKELPNFWEQ 790 800 810 820 830 840 NRRSLIQFMK QVHQGVRGFV LDATDGRGIL NATISVAEIN HPVTTYKTGD YWRLLVPGTY 850 860 870 880 890 900 KITASARGYN PVTKNVTVKS EGAIQVNFTL VRSSTDSNNE SKKGKGASSS TNDASDPTTK 910 920 930 940 950 960 EFETLIKDLS AENGLESLML RSSSNLALAL YRYHSYKDLS EFLRGLVMNY PHITNLTNLG 970 980 990 1000 1010 1020 QSTEYRHIWS LEISNKPNVS EPEEPKIRFV AGIHGNAPVG TELLLALAEF LCLNYKKNPA 1030 1040 1050 1060 1070 1080 VTQLVDRTRI VIVPSLNPDG RERAQEKDCT SKIGQTNARG KDLDTDFTNN ASQPETKAII 1090 1100 1110 1120 1130 1140 ENLIQKQDFS LSVALDGGSM LVTYPYDKPV QTVENKETLK HLASLYANNH PSMHMGQPSC 1150 1160 1170 1180 1190 1200 PNKSDENIPG GVMRGAEWHS HLGSMKDYSV TYGHCPEITV YTSCCYFPSA ARLPSLWADN 1210 1220 1230 1240 1250 1260 KRSLLSMLVE VHKGVHGFVK DKTGKPISKA VIVLNEGIKV QTKEGGYFHV LLAPGVHNII 1270 1280 1290 1300 1310 1320 AIADGYQQQH SQVFVHHDAA SSVVIVFDTD NRIFGLPREL VVTVSGATMS ALILTACIIW 1330 1340 1350 1360 1370 1380 CICSIKSNRH KDGFHRLRQH HDEYEDEIRM MSTGSKKSLL SHEFQDETDT EEETLYSSKH
	Isoform 2 [UniParc]. Checksum: D253BDC1BA9B56B6	FASTA	1,133	126,487
	10 20 30 40 50 60 MRFVLSGNLH GGSVVASYPF DDSPEHKATG IYSKTSDDEV FKYLAKAYAS NHPIMKTGEP 70 80 90 100 110 120 HCPGDEDETF KDGITNGAHW YDVEGGMQDY NYVWANCFEI TLELSCCKYP PASQLRQEWE 130 140 150 160 170 180 NNRESLITLI EKVHIGVKGF VKDSITGSGL ENATISVAGI NHNITTGRFG DFYRLLVPGT 190 200 210 220 230 240 YNLTVVLTGY MPLTVTNVVV KEGPATEVDF SLRPTVTSVI PDTTEAVSTA STVAIPNILS 250 260 270 280 290 300 GTSSSYQPIQ PKDFHHHHFP DMEIFLRRFA NEYPNITRLY SLGKSVESRE LYVMEISDNP 310 320 330 340 350 360 GVHEPGEPEF KYIGNMHGNE VVGRELLLNL IEYLCKNFGT DPEVTDLVHN TRIHLMPSMN 370 380 390 400 410 420 PDGYEKSQEG DSISVIGRNN SNNFDLNRNF PDQFVQITDP TQPETIAVMS WMKSYPFVLS 430 440 450 460 470 480 ANLHGGSLVV NYPFDDDEQG LATYSKSPDD AVFQQIALSY SKENSQMFQG RPCKNMYPNE 490 500 510 520 530 540 YFPHGITNGA SWYNVPGGMQ DWNYLQTNCF EVTIELGCVK YPLEKELPNF WEQNRRSLIQ 550 560 570 580 590 600 FMKQVHQGVR GFVLDATDGR GILNATISVA EINHPVTTYK TGDYWRLLVP GTYKITASAR 610 620 630 640 650 660 GYNPVTKNVT VKSEGAIQVN FTLVRSSTDS NNESKKGKGA SSSTNDASDP TTKEFETLIK 670 680 690 700 710 720 DLSAENGLES LMLRSSSNLA LALYRYHSYK DLSEFLRGLV MNYPHITNLT NLGQSTEYRH 730 740 750 760 770 780 IWSLEISNKP NVSEPEEPKI RFVAGIHGNA PVGTELLLAL AEFLCLNYKK NPAVTQLVDR 790 800 810 820 830 840 TRIVIVPSLN PDGRERAQEK DCTSKIGQTN ARGKDLDTDF TNNASQPETK AIIENLIQKQ 850 860 870 880 890 900 DFSLSVALDG GSMLVTYPYD KPVQTVENKE TLKHLASLYA NNHPSMHMGQ PSCPNKSDEN 910 920 930 940 950 960 IPGGVMRGAE WHSHLGSMKD YSVTYGHCPE ITVYTSCCYF PSAARLPSLW ADNKRSLLSM 970 980 990 1000 1010 1020 LVEVHKGVHG FVKDKTGKPI SKAVIVLNEG IKVQTKEGGY FHVLLAPGVH NIIAIADGYQ 1030 1040 1050 1060 1070 1080 QQHSQVFVHH DAASSVVIVF DTDNRIFGLP RELVVTVSGA TMSALILTAC IIWCICSIKS 1090 1100 1110 1120 1130 NRHKDGFHRL RQHHDEYEDE IRMMSTGSKK SLLSHEFQDE TDTEEETLYS SKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme." Ishikawa T., Murakami K., Kido Y., Ohnishi S., Yazaki Y., Harada F., Kuroki K. Gene 215:361-370(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal liver.
[2]	"Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains." Tan F., Rehli M., Krause S.W., Skidgel R.A. Biochem. J. 327:81-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain and Placenta.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Tan F., Rehli M., Skidgel R.A. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 11-13; 49-52; 159-162 AND 493.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-36; GLY-454 AND ASN-505. Tissue: Testis.
[7]	"Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein." McGwire G.B., Tan F., Michel B., Rehli M., Skidgel R.A. Life Sci. 60:715-724(1997) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[8]	"Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking." Kalinina E.V., Fricker L.D. J. Biol. Chem. 278:9244-9249(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PALMITOYLATION AT CYS-1317; CYS-1321 AND CYS-1323.
[9]	"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." Zhang H., Li X.-J., Martin D.B., Aebersold R. Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-172; ASN-811 AND ASN-955.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1368 AND THR-1370, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-811; ASN-955 AND ASN-1070, MASS SPECTROMETRY. Tissue: Liver.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1358; SER-1361; THR-1368 AND THR-1370, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1358; SER-1361; THR-1368 AND THR-1370, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D85390 mRNA. Translation: BAA33370.1. U65090 mRNA. Translation: AAC51775.2. AK302497 mRNA. Translation: BAH13725.1. AK316409 mRNA. Translation: BAH14780.1. AC006050 Genomic DNA. No translation available. AC090685 Genomic DNA. No translation available. BC045549 mRNA. Translation: AAH45549.1. BC045624 mRNA. Translation: AAH45624.1. BC051702 mRNA. Translation: AAH51702.1.
IPI	IPI00027078. IPI00979354.
RefSeq	NP_001186704.1. NM_001199775.1. NP_001295.2. NM_001304.4.
UniGene	Hs.446079.
3D structure databases
ProteinModelPortal	O75976.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75976. 1 interaction.
STRING	9606.ENSP00000225719.
Protein family/group databases
MEROPS	M14.950.
PTM databases
PhosphoSite	O75976.
Proteomic databases
PaxDb	O75976.
PRIDE	O75976.
Protocols and materials databases
DNASU	1362.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000225719; ENSP00000225719; ENSG00000108582. ENST00000543464; ENSP00000444443; ENSG00000108582.
GeneID	1362.
KEGG	hsa:1362.
UCSC	uc002hfb.2. human.
Organism-specific databases
CTD	1362.
GeneCards	GC17P028705.
HGNC	HGNC:2301. CPD.
HPA	HPA052796.
MIM	603102. gene.
neXtProt	NX_O75976.
PharmGKB	PA26823.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2866.
HOGENOM	HOG000046445.
HOVERGEN	HBG006932.
InParanoid	O75976.
KO	K07752.
OMA	RSFPDQF.
OrthoDB	EOG44J2H6.
Enzyme and pathway databases
BRENDA	3.4.17.22. 2681.
Reactome	REACT_11123. Membrane Trafficking.
Gene expression databases
ArrayExpress	O75976.
Bgee	O75976.
CleanEx	HS_CPD.
Genevestigator	O75976.
GermOnline	ENSG00000108582. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.1120. 3 hits.
InterPro	IPR008969. CarboxyPept-like_regulatory. IPR014766. CarboxyPept_regulatory_dom. IPR015567. Pept_M14B_carboxypept_D2. IPR000834. Peptidase_M14. [Graphical view]
PANTHER	PTHR11532:SF8. PTHR11532:SF8. 1 hit.
Pfam	PF00246. Peptidase_M14. 3 hits. [Graphical view]
PRINTS	PR00765. CRBOXYPTASEA.
SMART	SM00631. Zn_pept. 3 hits. [Graphical view]
SUPFAM	SSF49464. CarboxypepD_reg. 3 hits.
PROSITE	PS00132. CARBOXYPEPT_ZN_1. 2 hits. PS00133. CARBOXYPEPT_ZN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CPD. human.
GenomeRNAi	1362.
NextBio	35480310.
SOURCE	Search...

Entry information

Entry name

CBPD_HUMAN

Accession

Primary (citable) accession number: O75976
Secondary accession number(s): B7Z7T9 , B7ZAU4, F5GZH6, O15377, Q86SH9, Q86XE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 3, 2006
Last modified:	May 1, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.