Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O75976

- CBPD_HUMAN

UniProt

O75976 - CBPD_HUMAN

Protein

Carboxypeptidase D

Gene

CPD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Releases C-terminal Arg and Lys from polypeptides.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    pH dependencei

    Optimum pH is 6.0-6.5.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi139 – 1391Zinc 1By similarity
    Metal bindingi142 – 1421Zinc 1By similarity
    Metal bindingi257 – 2571Zinc 1By similarity
    Active sitei350 – 3501Nucleophile 1By similarity
    Metal bindingi564 – 5641Zinc 2By similarity
    Metal bindingi567 – 5671Zinc 2By similarity
    Metal bindingi671 – 6711Zinc 2By similarity
    Active sitei762 – 7621Nucleophile 2By similarity

    GO - Molecular functioni

    1. metallocarboxypeptidase activity Source: InterPro
    2. serine-type carboxypeptidase activity Source: ProtInc
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi3.4.17.22. 2681.
    ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.

    Protein family/group databases

    MEROPSiM14.011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase D (EC:3.4.17.22)
    Alternative name(s):
    Metallocarboxypeptidase D
    gp180
    Gene namesi
    Name:CPD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:2301. CPD.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26823.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 13801349Carboxypeptidase DPRO_0000004401Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi172 – 1721N-linked (GlcNAc...)1 Publication
    Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi399 – 3991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi626 – 6261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi811 – 8111N-linked (GlcNAc...)2 Publications
    Glycosylationi855 – 8551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi867 – 8671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi879 – 8791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi955 – 9551N-linked (GlcNAc...)2 Publications
    Glycosylationi978 – 9781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1070 – 10701N-linked (GlcNAc...)1 Publication
    Glycosylationi1142 – 11421N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1317 – 13171S-palmitoyl cysteine1 Publication
    Lipidationi1321 – 13211S-palmitoyl cysteine1 Publication
    Lipidationi1323 – 13231S-palmitoyl cysteine1 Publication
    Modified residuei1358 – 13581Phosphoserine2 Publications
    Modified residuei1361 – 13611Phosphoserine2 Publications
    Modified residuei1368 – 13681Phosphothreonine3 Publications
    Modified residuei1370 – 13701Phosphothreonine3 Publications

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiO75976.
    PaxDbiO75976.
    PRIDEiO75976.

    PTM databases

    PhosphoSiteiO75976.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.

    Gene expression databases

    ArrayExpressiO75976.
    BgeeiO75976.
    CleanExiHS_CPD.
    GenevestigatoriO75976.

    Organism-specific databases

    HPAiHPA052796.

    Interactioni

    Protein-protein interaction databases

    BioGridi107754. 11 interactions.
    IntActiO75976. 1 interaction.
    MINTiMINT-5003925.
    STRINGi9606.ENSP00000225719.

    Structurei

    3D structure databases

    ProteinModelPortaliO75976.
    SMRiO75976. Positions 47-460, 494-873, 898-1266.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 12991268ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1321 – 138060CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1300 – 132021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni32 – 493462Carboxypeptidase-like 1Add
    BLAST
    Regioni494 – 897404Carboxypeptidase-like 2Add
    BLAST
    Regioni898 – 1299402Carboxypeptidase-like 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi162 – 1643Cell attachment siteSequence Analysis

    Domaini

    There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.

    Sequence similaritiesi

    Belongs to the peptidase M14 family.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2866.
    HOGENOMiHOG000046445.
    HOVERGENiHBG006932.
    InParanoidiO75976.
    KOiK07752.
    OMAiEKVHIGV.
    OrthoDBiEOG7B8S32.
    PhylomeDBiO75976.
    TreeFamiTF315592.

    Family and domain databases

    Gene3Di2.60.40.1120. 3 hits.
    InterProiIPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR015567. Pept_M14B_carboxypept_D2.
    IPR000834. Peptidase_M14.
    [Graphical view]
    PANTHERiPTHR11532:SF40. PTHR11532:SF40. 1 hit.
    PfamiPF00246. Peptidase_M14. 3 hits.
    [Graphical view]
    PRINTSiPR00765. CRBOXYPTASEA.
    SMARTiSM00631. Zn_pept. 3 hits.
    [Graphical view]
    SUPFAMiSSF49464. SSF49464. 3 hits.
    PROSITEiPS00132. CARBOXYPEPT_ZN_1. 2 hits.
    PS00133. CARBOXYPEPT_ZN_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75976-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASGRDERPP WRLGRLLLLM CLLLLGSSAR AAHIKKAEAT TTTTSAGAEA     50
    AEGQFDRYYH EEELESALRE AAAAGLPGLA RLFSIGRSVE GRPLWVLRLT 100
    AGLGSLIPEG DAGPDAAGPD AAGPLLPGRP QVKLVGNMHG DETVSRQVLI 150
    YLARELAAGY RRGDPRLVRL LNTTDVYLLP SLNPDGFERA REGDCGFGDG 200
    GPSGASGRDN SRGRDLNRSF PDQFSTGEPP ALDEVPEVRA LIEWIRRNKF 250
    VLSGNLHGGS VVASYPFDDS PEHKATGIYS KTSDDEVFKY LAKAYASNHP 300
    IMKTGEPHCP GDEDETFKDG ITNGAHWYDV EGGMQDYNYV WANCFEITLE 350
    LSCCKYPPAS QLRQEWENNR ESLITLIEKV HIGVKGFVKD SITGSGLENA 400
    TISVAGINHN ITTGRFGDFY RLLVPGTYNL TVVLTGYMPL TVTNVVVKEG 450
    PATEVDFSLR PTVTSVIPDT TEAVSTASTV AIPNILSGTS SSYQPIQPKD 500
    FHHHHFPDME IFLRRFANEY PNITRLYSLG KSVESRELYV MEISDNPGVH 550
    EPGEPEFKYI GNMHGNEVVG RELLLNLIEY LCKNFGTDPE VTDLVHNTRI 600
    HLMPSMNPDG YEKSQEGDSI SVIGRNNSNN FDLNRNFPDQ FVQITDPTQP 650
    ETIAVMSWMK SYPFVLSANL HGGSLVVNYP FDDDEQGLAT YSKSPDDAVF 700
    QQIALSYSKE NSQMFQGRPC KNMYPNEYFP HGITNGASWY NVPGGMQDWN 750
    YLQTNCFEVT IELGCVKYPL EKELPNFWEQ NRRSLIQFMK QVHQGVRGFV 800
    LDATDGRGIL NATISVAEIN HPVTTYKTGD YWRLLVPGTY KITASARGYN 850
    PVTKNVTVKS EGAIQVNFTL VRSSTDSNNE SKKGKGASSS TNDASDPTTK 900
    EFETLIKDLS AENGLESLML RSSSNLALAL YRYHSYKDLS EFLRGLVMNY 950
    PHITNLTNLG QSTEYRHIWS LEISNKPNVS EPEEPKIRFV AGIHGNAPVG 1000
    TELLLALAEF LCLNYKKNPA VTQLVDRTRI VIVPSLNPDG RERAQEKDCT 1050
    SKIGQTNARG KDLDTDFTNN ASQPETKAII ENLIQKQDFS LSVALDGGSM 1100
    LVTYPYDKPV QTVENKETLK HLASLYANNH PSMHMGQPSC PNKSDENIPG 1150
    GVMRGAEWHS HLGSMKDYSV TYGHCPEITV YTSCCYFPSA ARLPSLWADN 1200
    KRSLLSMLVE VHKGVHGFVK DKTGKPISKA VIVLNEGIKV QTKEGGYFHV 1250
    LLAPGVHNII AIADGYQQQH SQVFVHHDAA SSVVIVFDTD NRIFGLPREL 1300
    VVTVSGATMS ALILTACIIW CICSIKSNRH KDGFHRLRQH HDEYEDEIRM 1350
    MSTGSKKSLL SHEFQDETDT EEETLYSSKH 1380
    Length:1,380
    Mass (Da):152,931
    Last modified:October 3, 2006 - v2
    Checksum:i567EC1F0B4B7A0C8
    GO
    Isoform 2 (identifier: O75976-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2: MA → MR
         3-249: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,133
    Mass (Da):126,487
    Checksum:iD253BDC1BA9B56B6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti863 – 8631A → V in BAH14780. (PubMed:14702039)Curated
    Sequence conflicti896 – 8961D → V(PubMed:9714835)Curated
    Sequence conflicti896 – 8961D → V(PubMed:9355738)Curated
    Sequence conflicti948 – 9481M → I in BAH14780. (PubMed:14702039)Curated
    Sequence conflicti1336 – 13361R → W in BAH13725. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361K → E.1 Publication
    Corresponds to variant rs17857300 [ dbSNP | Ensembl ].
    VAR_027771
    Natural varianti454 – 4541E → G.1 Publication
    Corresponds to variant rs17857301 [ dbSNP | Ensembl ].
    VAR_027772
    Natural varianti505 – 5051H → N.1 Publication
    Corresponds to variant rs17854355 [ dbSNP | Ensembl ].
    VAR_027773
    Natural varianti899 – 8991T → I.
    Corresponds to variant rs1860543 [ dbSNP | Ensembl ].
    VAR_027774

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 22MA → MR in isoform 2. 1 PublicationVSP_045833
    Alternative sequencei3 – 249247Missing in isoform 2. 1 PublicationVSP_045834Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85390 mRNA. Translation: BAA33370.1.
    U65090 mRNA. Translation: AAC51775.2.
    AK302497 mRNA. Translation: BAH13725.1.
    AK316409 mRNA. Translation: BAH14780.1.
    AC006050 Genomic DNA. No translation available.
    AC090685 Genomic DNA. No translation available.
    BC045549 mRNA. Translation: AAH45549.1.
    BC045624 mRNA. Translation: AAH45624.1.
    BC051702 mRNA. Translation: AAH51702.1.
    CCDSiCCDS11257.1. [O75976-1]
    CCDS56025.1. [O75976-2]
    RefSeqiNP_001186704.1. NM_001199775.1. [O75976-2]
    NP_001295.2. NM_001304.4. [O75976-1]
    UniGeneiHs.446079.

    Genome annotation databases

    EnsembliENST00000225719; ENSP00000225719; ENSG00000108582. [O75976-1]
    ENST00000543464; ENSP00000444443; ENSG00000108582. [O75976-2]
    GeneIDi1362.
    KEGGihsa:1362.
    UCSCiuc002hfb.2. human. [O75976-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85390 mRNA. Translation: BAA33370.1 .
    U65090 mRNA. Translation: AAC51775.2 .
    AK302497 mRNA. Translation: BAH13725.1 .
    AK316409 mRNA. Translation: BAH14780.1 .
    AC006050 Genomic DNA. No translation available.
    AC090685 Genomic DNA. No translation available.
    BC045549 mRNA. Translation: AAH45549.1 .
    BC045624 mRNA. Translation: AAH45624.1 .
    BC051702 mRNA. Translation: AAH51702.1 .
    CCDSi CCDS11257.1. [O75976-1 ]
    CCDS56025.1. [O75976-2 ]
    RefSeqi NP_001186704.1. NM_001199775.1. [O75976-2 ]
    NP_001295.2. NM_001304.4. [O75976-1 ]
    UniGenei Hs.446079.

    3D structure databases

    ProteinModelPortali O75976.
    SMRi O75976. Positions 47-460, 494-873, 898-1266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107754. 11 interactions.
    IntActi O75976. 1 interaction.
    MINTi MINT-5003925.
    STRINGi 9606.ENSP00000225719.

    Protein family/group databases

    MEROPSi M14.011.

    PTM databases

    PhosphoSitei O75976.

    Proteomic databases

    MaxQBi O75976.
    PaxDbi O75976.
    PRIDEi O75976.

    Protocols and materials databases

    DNASUi 1362.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225719 ; ENSP00000225719 ; ENSG00000108582 . [O75976-1 ]
    ENST00000543464 ; ENSP00000444443 ; ENSG00000108582 . [O75976-2 ]
    GeneIDi 1362.
    KEGGi hsa:1362.
    UCSCi uc002hfb.2. human. [O75976-1 ]

    Organism-specific databases

    CTDi 1362.
    GeneCardsi GC17P028705.
    HGNCi HGNC:2301. CPD.
    HPAi HPA052796.
    MIMi 603102. gene.
    neXtProti NX_O75976.
    PharmGKBi PA26823.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2866.
    HOGENOMi HOG000046445.
    HOVERGENi HBG006932.
    InParanoidi O75976.
    KOi K07752.
    OMAi EKVHIGV.
    OrthoDBi EOG7B8S32.
    PhylomeDBi O75976.
    TreeFami TF315592.

    Enzyme and pathway databases

    BRENDAi 3.4.17.22. 2681.
    Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.

    Miscellaneous databases

    ChiTaRSi CPD. human.
    GeneWikii CPD_(gene).
    GenomeRNAii 1362.
    NextBioi 35480310.
    PROi O75976.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75976.
    Bgeei O75976.
    CleanExi HS_CPD.
    Genevestigatori O75976.

    Family and domain databases

    Gene3Di 2.60.40.1120. 3 hits.
    InterProi IPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR015567. Pept_M14B_carboxypept_D2.
    IPR000834. Peptidase_M14.
    [Graphical view ]
    PANTHERi PTHR11532:SF40. PTHR11532:SF40. 1 hit.
    Pfami PF00246. Peptidase_M14. 3 hits.
    [Graphical view ]
    PRINTSi PR00765. CRBOXYPTASEA.
    SMARTi SM00631. Zn_pept. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49464. SSF49464. 3 hits.
    PROSITEi PS00132. CARBOXYPEPT_ZN_1. 2 hits.
    PS00133. CARBOXYPEPT_ZN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme."
      Ishikawa T., Murakami K., Kido Y., Ohnishi S., Yazaki Y., Harada F., Kuroki K.
      Gene 215:361-370(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal liver.
    2. "Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains."
      Tan F., Rehli M., Krause S.W., Skidgel R.A.
      Biochem. J. 327:81-87(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain and Placenta.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Tan F., Rehli M., Skidgel R.A.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 11-13; 49-52; 159-162 AND 493.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-36; GLY-454 AND ASN-505.
      Tissue: Testis.
    7. "Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein."
      McGwire G.B., Tan F., Michel B., Rehli M., Skidgel R.A.
      Life Sci. 60:715-724(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking."
      Kalinina E.V., Fricker L.D.
      J. Biol. Chem. 278:9244-9249(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-1317; CYS-1321 AND CYS-1323.
    9. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-172; ASN-811 AND ASN-955.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1368 AND THR-1370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-811; ASN-955 AND ASN-1070.
      Tissue: Liver.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1358; SER-1361; THR-1368 AND THR-1370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1358; SER-1361; THR-1368 AND THR-1370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCBPD_HUMAN
    AccessioniPrimary (citable) accession number: O75976
    Secondary accession number(s): B7Z7T9
    , B7ZAU4, F5GZH6, O15377, Q86SH9, Q86XE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3