ID   C1QRF_HUMAN             Reviewed;         258 AA.
AC   O75973;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   24-JAN-2024, entry version 171.
DE   RecName: Full=C1q-related factor;
DE   AltName: Full=C1q and tumor necrosis factor-related protein 14;
DE            Short=C1q/TNF-related protein 14;
DE   AltName: Full=Complement component 1 Q subcomponent-like 1;
DE   Flags: Precursor;
GN   Name=C1QL1; Synonyms=C1QRF, CRF, CTRP14;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9878755; DOI=10.1016/s0169-328x(98)00278-2;
RA   Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V.,
RA   Baskin D.S., Smith J.R., Pereira-Smith O.M.;
RT   "Cloning and characterization of CRF, a novel C1q-related factor, expressed
RT   in areas of the brain involved in motor function.";
RL   Brain Res. Mol. Brain Res. 63:233-240(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   SeattleSNPs variation discovery resource;
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May regulate the number of excitatory synapses that are
CC       formed on hippocampus neurons. Has no effect on inhibitory synapses (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ADGRB3. Forms heterooligomers with C1QL4, when
CC       proteins are coexpressed; this interaction does not occur after
CC       secretion. {ECO:0000250|UniProtKB:O88992}.
CC   -!- INTERACTION:
CC       O75973; P60827: C1QTNF8; NbExp=2; IntAct=EBI-10826419, EBI-10826404;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in brainstem.
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/crf/";
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DR   EMBL; AF095154; AAC64186.1; -; mRNA.
DR   EMBL; AF410771; AAK95248.1; -; Genomic_DNA.
DR   EMBL; BC008798; AAH08798.1; -; mRNA.
DR   CCDS; CCDS11492.1; -.
DR   RefSeq; NP_006679.1; NM_006688.4.
DR   AlphaFoldDB; O75973; -.
DR   SMR; O75973; -.
DR   BioGRID; 116090; 39.
DR   IntAct; O75973; 23.
DR   STRING; 9606.ENSP00000253407; -.
DR   iPTMnet; O75973; -.
DR   PhosphoSitePlus; O75973; -.
DR   BioMuta; C1QL1; -.
DR   MassIVE; O75973; -.
DR   MaxQB; O75973; -.
DR   PaxDb; 9606-ENSP00000253407; -.
DR   PeptideAtlas; O75973; -.
DR   ProteomicsDB; 50335; -.
DR   Antibodypedia; 29941; 75 antibodies from 17 providers.
DR   DNASU; 10882; -.
DR   Ensembl; ENST00000253407.4; ENSP00000253407.2; ENSG00000131094.4.
DR   GeneID; 10882; -.
DR   KEGG; hsa:10882; -.
DR   MANE-Select; ENST00000253407.4; ENSP00000253407.2; NM_006688.5; NP_006679.1.
DR   UCSC; uc002ihv.4; human.
DR   AGR; HGNC:24182; -.
DR   CTD; 10882; -.
DR   DisGeNET; 10882; -.
DR   GeneCards; C1QL1; -.
DR   HGNC; HGNC:24182; C1QL1.
DR   HPA; ENSG00000131094; Tissue enhanced (brain, kidney).
DR   MIM; 611586; gene.
DR   neXtProt; NX_O75973; -.
DR   OpenTargets; ENSG00000131094; -.
DR   PharmGKB; PA134951551; -.
DR   VEuPathDB; HostDB:ENSG00000131094; -.
DR   eggNOG; ENOG502QSKV; Eukaryota.
DR   GeneTree; ENSGT00940000162478; -.
DR   HOGENOM; CLU_001074_3_1_1; -.
DR   InParanoid; O75973; -.
DR   OMA; GIDGHYE; -.
DR   OrthoDB; 4210331at2759; -.
DR   PhylomeDB; O75973; -.
DR   TreeFam; TF329591; -.
DR   PathwayCommons; O75973; -.
DR   SignaLink; O75973; -.
DR   BioGRID-ORCS; 10882; 8 hits in 1144 CRISPR screens.
DR   GeneWiki; C1QL1; -.
DR   GenomeRNAi; 10882; -.
DR   Pharos; O75973; Tdark.
DR   PRO; PR:O75973; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; O75973; Protein.
DR   Bgee; ENSG00000131094; Expressed in amygdala and 133 other cell types or tissues.
DR   GO; GO:0150053; C:cerebellar climbing fiber to Purkinje cell synapse; IEA:Ensembl.
DR   GO; GO:0044301; C:climbing fiber; IEA:Ensembl.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:Ensembl.
DR   GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; NAS:UniProtKB.
DR   GO; GO:0099558; P:maintenance of synapse structure; IEA:Ensembl.
DR   GO; GO:0061743; P:motor learning; IEA:Ensembl.
DR   GO; GO:0016322; P:neuron remodeling; IEA:Ensembl.
DR   GO; GO:1905806; P:regulation of synapse pruning; IEA:Ensembl.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   PANTHER; PTHR22923:SF64; C1Q-RELATED FACTOR; 1.
DR   PANTHER; PTHR22923; CEREBELLIN-RELATED; 1.
DR   Pfam; PF00386; C1q; 1.
DR   Pfam; PF01391; Collagen; 1.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; TNF-like; 1.
DR   PROSITE; PS50871; C1Q; 1.
DR   Genevisible; O75973; HS.
PE   1: Evidence at protein level;
KW   Collagen; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..258
FT                   /note="C1q-related factor"
FT                   /id="PRO_0000003527"
FT   DOMAIN          67..115
FT                   /note="Collagen-like"
FT   DOMAIN          125..258
FT                   /note="C1q"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT   REGION          39..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..109
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   258 AA;  26453 MW;  52C51CDF59CAE2BF CRC64;
     MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD ALSEQSGAPP
     PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG EPGKPGPPGL PGAGGSGAIS
     TATYTTVPRV AFYAGLKNPH EGYEVLKFDD VVTNLGNNYD AASGKFTCNI PGTYFFTYHV
     LMRGGDGTSM WADLCKNGQV RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH
     GGNSNKYSTF SGFIIYSD
//