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O75973

- C1QRF_HUMAN

UniProt

O75973 - C1QRF_HUMAN

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Protein
C1q-related factor
Gene
C1QL1, C1QRF, CRF, CTRP14
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity.

GO - Biological processi

  1. locomotory behavior Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
C1q-related factor
Alternative name(s):
C1q and tumor necrosis factor-related protein 14
Short name:
C1q/TNF-related protein 14
Complement component 1 Q subcomponent-like 1
Gene namesi
Name:C1QL1
Synonyms:C1QRF, CRF, CTRP14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:24182. C1QL1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. cytoplasm Source: Ensembl
  3. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 258242C1q-related factor
PRO_0000003527Add
BLAST

Proteomic databases

MaxQBiO75973.
PaxDbiO75973.
PRIDEiO75973.

Expressioni

Tissue specificityi

Expressed in brainstem.

Gene expression databases

BgeeiO75973.
CleanExiHS_C1QL1.
GenevestigatoriO75973.

Interactioni

Subunit structurei

Interacts with BAI3 By similarity. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion By similarity.

Protein-protein interaction databases

BioGridi116090. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO75973.
SMRiO75973. Positions 129-258.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 11549Collagen-like
Add
BLAST
Domaini125 – 258134C1q
Add
BLAST

Sequence similaritiesi

Contains 1 C1q domain.

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG134911.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiO75973.
OMAiLSDHSNV.
OrthoDBiEOG757CZJ.
PhylomeDBiO75973.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75973-1 [UniParc]FASTAAdd to Basket

« Hide

MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD    50
ALSEQSGAPP PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG 100
EPGKPGPPGL PGAGGSGAIS TATYTTVPRV AFYAGLKNPH EGYEVLKFDD 150
VVTNLGNNYD AASGKFTCNI PGTYFFTYHV LMRGGDGTSM WADLCKNGQV 200
RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH GGNSNKYSTF 250
SGFIIYSD 258
Length:258
Mass (Da):26,453
Last modified:November 1, 1998 - v1
Checksum:i52C51CDF59CAE2BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095154 mRNA. Translation: AAC64186.1.
AF410771 Genomic DNA. Translation: AAK95248.1.
BC008798 mRNA. Translation: AAH08798.1.
CCDSiCCDS11492.1.
RefSeqiNP_006679.1. NM_006688.3.
UniGeneiHs.134012.

Genome annotation databases

EnsembliENST00000253407; ENSP00000253407; ENSG00000131094.
GeneIDi10882.
KEGGihsa:10882.
UCSCiuc002ihv.3. human.

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095154 mRNA. Translation: AAC64186.1 .
AF410771 Genomic DNA. Translation: AAK95248.1 .
BC008798 mRNA. Translation: AAH08798.1 .
CCDSi CCDS11492.1.
RefSeqi NP_006679.1. NM_006688.3.
UniGenei Hs.134012.

3D structure databases

ProteinModelPortali O75973.
SMRi O75973. Positions 129-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116090. 1 interaction.

Proteomic databases

MaxQBi O75973.
PaxDbi O75973.
PRIDEi O75973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253407 ; ENSP00000253407 ; ENSG00000131094 .
GeneIDi 10882.
KEGGi hsa:10882.
UCSCi uc002ihv.3. human.

Organism-specific databases

CTDi 10882.
GeneCardsi GC17M043037.
HGNCi HGNC:24182. C1QL1.
MIMi 611586. gene.
neXtProti NX_O75973.
PharmGKBi PA134951551.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG134911.
HOGENOMi HOG000085653.
HOVERGENi HBG108220.
InParanoidi O75973.
OMAi LSDHSNV.
OrthoDBi EOG757CZJ.
PhylomeDBi O75973.
TreeFami TF329591.

Miscellaneous databases

GeneWikii C1QL1.
GenomeRNAii 10882.
NextBioi 41323.
PROi O75973.
SOURCEi Search...

Gene expression databases

Bgeei O75973.
CleanExi HS_C1QL1.
Genevestigatori O75973.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function."
    Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V., Baskin D.S., Smith J.R., Pereira-Smith O.M.
    Brain Res. Mol. Brain Res. 63:233-240(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. SeattleSNPs variation discovery resource
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiC1QRF_HUMAN
AccessioniPrimary (citable) accession number: O75973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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