Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C1q-related factor

Gene

C1QL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).By similarity

GO - Biological processi

  • locomotory behavior Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
C1q-related factor
Alternative name(s):
C1q and tumor necrosis factor-related protein 14
Short name:
C1q/TNF-related protein 14
Complement component 1 Q subcomponent-like 1
Gene namesi
Name:C1QL1
Synonyms:C1QRF, CRF, CTRP14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24182. C1QL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951551.

Polymorphism and mutation databases

BioMutaiC1QL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 258242C1q-related factorPRO_0000003527Add
BLAST

Proteomic databases

MaxQBiO75973.
PaxDbiO75973.
PRIDEiO75973.

Expressioni

Tissue specificityi

Expressed in brainstem.

Gene expression databases

BgeeiO75973.
CleanExiHS_C1QL1.
GenevisibleiO75973. HS.

Interactioni

Subunit structurei

Interacts with BAI3. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.By similarity

Protein-protein interaction databases

BioGridi116090. 8 interactions.
STRINGi9606.ENSP00000253407.

Structurei

3D structure databases

ProteinModelPortaliO75973.
SMRiO75973. Positions 128-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 11549Collagen-likeAdd
BLAST
Domaini125 – 258134C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG134911.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiO75973.
OMAiLSDHSNV.
OrthoDBiEOG757CZJ.
PhylomeDBiO75973.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD
60 70 80 90 100
ALSEQSGAPP PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG
110 120 130 140 150
EPGKPGPPGL PGAGGSGAIS TATYTTVPRV AFYAGLKNPH EGYEVLKFDD
160 170 180 190 200
VVTNLGNNYD AASGKFTCNI PGTYFFTYHV LMRGGDGTSM WADLCKNGQV
210 220 230 240 250
RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH GGNSNKYSTF

SGFIIYSD
Length:258
Mass (Da):26,453
Last modified:November 1, 1998 - v1
Checksum:i52C51CDF59CAE2BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095154 mRNA. Translation: AAC64186.1.
AF410771 Genomic DNA. Translation: AAK95248.1.
BC008798 mRNA. Translation: AAH08798.1.
CCDSiCCDS11492.1.
RefSeqiNP_006679.1. NM_006688.4.
UniGeneiHs.134012.

Genome annotation databases

EnsembliENST00000253407; ENSP00000253407; ENSG00000131094.
GeneIDi10882.
KEGGihsa:10882.
UCSCiuc002ihv.3. human.

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095154 mRNA. Translation: AAC64186.1.
AF410771 Genomic DNA. Translation: AAK95248.1.
BC008798 mRNA. Translation: AAH08798.1.
CCDSiCCDS11492.1.
RefSeqiNP_006679.1. NM_006688.4.
UniGeneiHs.134012.

3D structure databases

ProteinModelPortaliO75973.
SMRiO75973. Positions 128-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116090. 8 interactions.
STRINGi9606.ENSP00000253407.

Polymorphism and mutation databases

BioMutaiC1QL1.

Proteomic databases

MaxQBiO75973.
PaxDbiO75973.
PRIDEiO75973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253407; ENSP00000253407; ENSG00000131094.
GeneIDi10882.
KEGGihsa:10882.
UCSCiuc002ihv.3. human.

Organism-specific databases

CTDi10882.
GeneCardsiGC17M043037.
HGNCiHGNC:24182. C1QL1.
MIMi611586. gene.
neXtProtiNX_O75973.
PharmGKBiPA134951551.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG134911.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiO75973.
OMAiLSDHSNV.
OrthoDBiEOG757CZJ.
PhylomeDBiO75973.
TreeFamiTF329591.

Miscellaneous databases

GeneWikiiC1QL1.
GenomeRNAii10882.
NextBioi41323.
PROiO75973.
SOURCEiSearch...

Gene expression databases

BgeeiO75973.
CleanExiHS_C1QL1.
GenevisibleiO75973. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function."
    Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V., Baskin D.S., Smith J.R., Pereira-Smith O.M.
    Brain Res. Mol. Brain Res. 63:233-240(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. SeattleSNPs variation discovery resource
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiC1QRF_HUMAN
AccessioniPrimary (citable) accession number: O75973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: July 22, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.