O75973 (C1QRF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C1q-related factor

Alternative name(s):
Complement component 1 Q subcomponent-like 1

Gene names

Name:	C1QL1
Synonyms:	C1QRF, CRF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity.
Subunit structure	Interacts with BAI3 By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed in brainstem.
Sequence similarities	Contains 1 C1q domain. Contains 1 collagen-like domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Collagen Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	locomotory behavior Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 258	242	C1q-related factor		PRO_0000003527
Regions
	Domain	67 – 115	49	Collagen-like
	Domain	125 – 258	134	C1q

Sequences

	Sequence		Length	Mass (Da)
	O75973 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 52C51CDF59CAE2BF	FASTA	258	26,453
	10 20 30 40 50 60 MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD ALSEQSGAPP 70 80 90 100 110 120 PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG EPGKPGPPGL PGAGGSGAIS 130 140 150 160 170 180 TATYTTVPRV AFYAGLKNPH EGYEVLKFDD VVTNLGNNYD AASGKFTCNI PGTYFFTYHV 190 200 210 220 230 240 LMRGGDGTSM WADLCKNGQV RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH 250 GGNSNKYSTF SGFIIYSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function." Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V., Baskin D.S., Smith J.R., Pereira-Smith O.M. Brain Res. Mol. Brain Res. 63:233-240(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	SeattleSNPs variation discovery resource Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF095154 mRNA. Translation: AAC64186.1. AF410771 Genomic DNA. Translation: AAK95248.1. BC008798 mRNA. Translation: AAH08798.1.
IPI	IPI00027457.
RefSeq	NP_006679.1. NM_006688.3.
UniGene	Hs.134012.
3D structure databases
ProteinModelPortal	O75973.
ModBase	Search...
Proteomic databases
PaxDb	O75973.
PRIDE	O75973.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253407; ENSP00000253407; ENSG00000131094.
GeneID	10882.
KEGG	hsa:10882.
UCSC	uc002ihv.3. human.
Organism-specific databases
CTD	10882.
GeneCards	GC17M043037.
HGNC	HGNC:24182. C1QL1.
MIM	611586. gene.
neXtProt	NX_O75973.
PharmGKB	PA134951551.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG134911.
HOGENOM	HOG000085653.
HOVERGEN	HBG108220.
InParanoid	O75973.
OMA	MVCDPYL.
OrthoDB	EOG4R23VZ.
PhylomeDB	O75973.
Gene expression databases
Bgee	O75973.
CleanEx	HS_C1QL1.
Genevestigator	O75973.
GermOnline	ENSG00000131094. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10882.
NextBio	41323.
SOURCE	Search...

Entry information

Entry name

C1QRF_HUMAN

Accession

Primary (citable) accession number: O75973

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.