Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O75973 (C1QRF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C1q-related factor
Alternative name(s):
C1q and tumor necrosis factor-related protein 14
Short name=C1q/TNF-related protein 14
Complement component 1 Q subcomponent-like 1
Gene names
Name:C1QL1
Synonyms:C1QRF, CRF, CTRP14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity.

Subunit structure

Interacts with BAI3 By similarity. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed in brainstem.

Sequence similarities

Contains 1 C1q domain.

Contains 1 collagen-like domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainCollagen
Signal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlocomotory behavior

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentcollagen trimer

Inferred from electronic annotation. Source: UniProtKB-KW

cytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 258242C1q-related factor
PRO_0000003527

Regions

Domain67 – 11549Collagen-like
Domain125 – 258134C1q

Sequences

Sequence LengthMass (Da)Tools
O75973 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 52C51CDF59CAE2BF

FASTA25826,453
        10         20         30         40         50         60 
MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD ALSEQSGAPP 

        70         80         90        100        110        120 
PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG EPGKPGPPGL PGAGGSGAIS 

       130        140        150        160        170        180 
TATYTTVPRV AFYAGLKNPH EGYEVLKFDD VVTNLGNNYD AASGKFTCNI PGTYFFTYHV 

       190        200        210        220        230        240 
LMRGGDGTSM WADLCKNGQV RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH 

       250 
GGNSNKYSTF SGFIIYSD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function."
Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V., Baskin D.S., Smith J.R., Pereira-Smith O.M.
Brain Res. Mol. Brain Res. 63:233-240(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]SeattleSNPs variation discovery resource
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF095154 mRNA. Translation: AAC64186.1.
AF410771 Genomic DNA. Translation: AAK95248.1.
BC008798 mRNA. Translation: AAH08798.1.
CCDSCCDS11492.1.
RefSeqNP_006679.1. NM_006688.3.
UniGeneHs.134012.

3D structure databases

ProteinModelPortalO75973.
SMRO75973. Positions 129-258.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116090. 1 interaction.

Proteomic databases

MaxQBO75973.
PaxDbO75973.
PRIDEO75973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253407; ENSP00000253407; ENSG00000131094.
GeneID10882.
KEGGhsa:10882.
UCSCuc002ihv.3. human.

Organism-specific databases

CTD10882.
GeneCardsGC17M043037.
HGNCHGNC:24182. C1QL1.
MIM611586. gene.
neXtProtNX_O75973.
PharmGKBPA134951551.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG134911.
HOGENOMHOG000085653.
HOVERGENHBG108220.
InParanoidO75973.
OMALSDHSNV.
OrthoDBEOG757CZJ.
PhylomeDBO75973.
TreeFamTF329591.

Gene expression databases

BgeeO75973.
CleanExHS_C1QL1.
GenevestigatorO75973.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiC1QL1.
GenomeRNAi10882.
NextBio41323.
PROO75973.
SOURCESearch...

Entry information

Entry nameC1QRF_HUMAN
AccessionPrimary (citable) accession number: O75973
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM