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O75973

- C1QRF_HUMAN

UniProt

O75973 - C1QRF_HUMAN

Protein

C1q-related factor

Gene

C1QL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses By similarity.By similarity

    GO - Biological processi

    1. locomotory behavior Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C1q-related factor
    Alternative name(s):
    C1q and tumor necrosis factor-related protein 14
    Short name:
    C1q/TNF-related protein 14
    Complement component 1 Q subcomponent-like 1
    Gene namesi
    Name:C1QL1
    Synonyms:C1QRF, CRF, CTRP14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:24182. C1QL1.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. cytoplasm Source: Ensembl
    3. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134951551.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 258242C1q-related factorPRO_0000003527Add
    BLAST

    Proteomic databases

    MaxQBiO75973.
    PaxDbiO75973.
    PRIDEiO75973.

    Expressioni

    Tissue specificityi

    Expressed in brainstem.

    Gene expression databases

    BgeeiO75973.
    CleanExiHS_C1QL1.
    GenevestigatoriO75973.

    Interactioni

    Subunit structurei

    Interacts with BAI3. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.By similarity

    Protein-protein interaction databases

    BioGridi116090. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO75973.
    SMRiO75973. Positions 129-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 11549Collagen-likeAdd
    BLAST
    Domaini125 – 258134C1qPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Signal

    Phylogenomic databases

    eggNOGiNOG134911.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiO75973.
    OMAiLSDHSNV.
    OrthoDBiEOG757CZJ.
    PhylomeDBiO75973.
    TreeFamiTF329591.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75973-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD    50
    ALSEQSGAPP PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG 100
    EPGKPGPPGL PGAGGSGAIS TATYTTVPRV AFYAGLKNPH EGYEVLKFDD 150
    VVTNLGNNYD AASGKFTCNI PGTYFFTYHV LMRGGDGTSM WADLCKNGQV 200
    RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH GGNSNKYSTF 250
    SGFIIYSD 258
    Length:258
    Mass (Da):26,453
    Last modified:November 1, 1998 - v1
    Checksum:i52C51CDF59CAE2BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095154 mRNA. Translation: AAC64186.1.
    AF410771 Genomic DNA. Translation: AAK95248.1.
    BC008798 mRNA. Translation: AAH08798.1.
    CCDSiCCDS11492.1.
    RefSeqiNP_006679.1. NM_006688.3.
    UniGeneiHs.134012.

    Genome annotation databases

    EnsembliENST00000253407; ENSP00000253407; ENSG00000131094.
    GeneIDi10882.
    KEGGihsa:10882.
    UCSCiuc002ihv.3. human.

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095154 mRNA. Translation: AAC64186.1 .
    AF410771 Genomic DNA. Translation: AAK95248.1 .
    BC008798 mRNA. Translation: AAH08798.1 .
    CCDSi CCDS11492.1.
    RefSeqi NP_006679.1. NM_006688.3.
    UniGenei Hs.134012.

    3D structure databases

    ProteinModelPortali O75973.
    SMRi O75973. Positions 129-258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116090. 1 interaction.

    Proteomic databases

    MaxQBi O75973.
    PaxDbi O75973.
    PRIDEi O75973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253407 ; ENSP00000253407 ; ENSG00000131094 .
    GeneIDi 10882.
    KEGGi hsa:10882.
    UCSCi uc002ihv.3. human.

    Organism-specific databases

    CTDi 10882.
    GeneCardsi GC17M043037.
    HGNCi HGNC:24182. C1QL1.
    MIMi 611586. gene.
    neXtProti NX_O75973.
    PharmGKBi PA134951551.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG134911.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi O75973.
    OMAi LSDHSNV.
    OrthoDBi EOG757CZJ.
    PhylomeDBi O75973.
    TreeFami TF329591.

    Miscellaneous databases

    GeneWikii C1QL1.
    GenomeRNAii 10882.
    NextBioi 41323.
    PROi O75973.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75973.
    CleanExi HS_C1QL1.
    Genevestigatori O75973.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function."
      Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V., Baskin D.S., Smith J.R., Pereira-Smith O.M.
      Brain Res. Mol. Brain Res. 63:233-240(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. SeattleSNPs variation discovery resource
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiC1QRF_HUMAN
    AccessioniPrimary (citable) accession number: O75973
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3