Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

snRNA-activating protein complex subunit 5

Gene

SNAPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • snRNA transcription from RNA polymerase II promoter Source: Reactome
  • transcription from RNA polymerase II promoter Source: ProtInc
  • transcription initiation from RNA polymerase III promoter Source: ProtInc

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 5
Short name:
SNAPc subunit 5
Alternative name(s):
Small nuclear RNA-activating complex polypeptide 5
snRNA-activating protein complex 19 kDa subunit
Short name:
SNAPc 19 kDa subunit
Gene namesi
Name:SNAPC5
Synonyms:SNAP19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:15484. SNAPC5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi8L → A: Reduced SNAPC4 binding in both the presence or absence of SNAPC1. 1 Publication1
Mutagenesisi18L → A: Minimal effect on SNAPC4 binding in the absence of SNAPC1. Reduced SNAPC4 binding in the presence of SNAPC1. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000174446.
PharmGKBiPA37967.

Polymorphism and mutation databases

BioMutaiSNAPC5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720281 – 98snRNA-activating protein complex subunit 5Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75971.
MaxQBiO75971.
PaxDbiO75971.
PeptideAtlasiO75971.
PRIDEiO75971.

PTM databases

iPTMnetiO75971.
PhosphoSitePlusiO75971.

Expressioni

Gene expression databases

BgeeiENSG00000174446.
CleanExiHS_SNAPC5.
ExpressionAtlasiO75971. baseline and differential.
GenevisibleiO75971. HS.

Organism-specific databases

HPAiHPA024379.

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115590. 13 interactors.
IntActiO75971. 24 interactors.
MINTiMINT-1440780.
STRINGi9606.ENSP00000319597.

Structurei

3D structure databases

ProteinModelPortaliO75971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 95Poly-Glu10

Phylogenomic databases

eggNOGiENOG410J33C. Eukaryota.
ENOG4112ANI. LUCA.
GeneTreeiENSGT00390000010331.
HOGENOMiHOG000013144.
HOVERGENiHBG055993.
InParanoidiO75971.
KOiK15211.
OMAiSMINSRG.
OrthoDBiEOG091G10TP.
PhylomeDBiO75971.
TreeFamiTF328823.

Family and domain databases

InterProiView protein in InterPro
IPR029138. SNAPC5.
PfamiView protein in Pfam
PF15497. SNAPc19. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75971-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRLQELRK EEETLLRLKA ALHDQLNRLK VEELALQSMI SSRRGDEMLS
60 70 80 90
SHTVPEQSHD MLVHVDNEAS INQTTLELST KSHVTEEEEE EEEEESDS
Length:98
Mass (Da):11,328
Last modified:November 1, 1998 - v1
Checksum:i4D797E35AF2D1485
GO
Isoform 2 (identifier: O75971-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-60: Missing.

Show »
Length:68
Mass (Da):7,977
Checksum:iE1098AFF04F7E6EF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01278531 – 60Missing in isoform 2. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093593 mRNA. Translation: AAC61873.1.
AK292051 mRNA. Translation: BAF84740.1.
CH471082 Genomic DNA. Translation: EAW77771.1.
BC014315 mRNA. Translation: AAH14315.1.
CCDSiCCDS10217.1. [O75971-1]
RefSeqiNP_001316542.1. NM_001329613.1. [O75971-2]
NP_001316544.1. NM_001329615.1. [O75971-1]
NP_006040.1. NM_006049.3. [O75971-1]
UniGeneiHs.30174.

Genome annotation databases

EnsembliENST00000307979; ENSP00000308439; ENSG00000174446. [O75971-2]
ENST00000316634; ENSP00000319597; ENSG00000174446. [O75971-1]
ENST00000395589; ENSP00000378954; ENSG00000174446. [O75971-1]
ENST00000562411; ENSP00000454421; ENSG00000174446. [O75971-1]
ENST00000563480; ENSP00000457892; ENSG00000174446. [O75971-1]
GeneIDi10302.
KEGGihsa:10302.
UCSCiuc002apu.2. human. [O75971-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093593 mRNA. Translation: AAC61873.1.
AK292051 mRNA. Translation: BAF84740.1.
CH471082 Genomic DNA. Translation: EAW77771.1.
BC014315 mRNA. Translation: AAH14315.1.
CCDSiCCDS10217.1. [O75971-1]
RefSeqiNP_001316542.1. NM_001329613.1. [O75971-2]
NP_001316544.1. NM_001329615.1. [O75971-1]
NP_006040.1. NM_006049.3. [O75971-1]
UniGeneiHs.30174.

3D structure databases

ProteinModelPortaliO75971.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115590. 13 interactors.
IntActiO75971. 24 interactors.
MINTiMINT-1440780.
STRINGi9606.ENSP00000319597.

PTM databases

iPTMnetiO75971.
PhosphoSitePlusiO75971.

Polymorphism and mutation databases

BioMutaiSNAPC5.

Proteomic databases

EPDiO75971.
MaxQBiO75971.
PaxDbiO75971.
PeptideAtlasiO75971.
PRIDEiO75971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307979; ENSP00000308439; ENSG00000174446. [O75971-2]
ENST00000316634; ENSP00000319597; ENSG00000174446. [O75971-1]
ENST00000395589; ENSP00000378954; ENSG00000174446. [O75971-1]
ENST00000562411; ENSP00000454421; ENSG00000174446. [O75971-1]
ENST00000563480; ENSP00000457892; ENSG00000174446. [O75971-1]
GeneIDi10302.
KEGGihsa:10302.
UCSCiuc002apu.2. human. [O75971-1]

Organism-specific databases

CTDi10302.
GeneCardsiSNAPC5.
HGNCiHGNC:15484. SNAPC5.
HPAiHPA024379.
MIMi605979. gene.
neXtProtiNX_O75971.
OpenTargetsiENSG00000174446.
PharmGKBiPA37967.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J33C. Eukaryota.
ENOG4112ANI. LUCA.
GeneTreeiENSGT00390000010331.
HOGENOMiHOG000013144.
HOVERGENiHBG055993.
InParanoidiO75971.
KOiK15211.
OMAiSMINSRG.
OrthoDBiEOG091G10TP.
PhylomeDBiO75971.
TreeFamiTF328823.

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

ChiTaRSiSNAPC5. human.
GeneWikiiSNAPC5.
GenomeRNAii10302.
PROiPR:O75971.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174446.
CleanExiHS_SNAPC5.
ExpressionAtlasiO75971. baseline and differential.
GenevisibleiO75971. HS.

Family and domain databases

InterProiView protein in InterPro
IPR029138. SNAPC5.
PfamiView protein in Pfam
PF15497. SNAPc19. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSNPC5_HUMAN
AccessioniPrimary (citable) accession number: O75971
Secondary accession number(s): A8K7N6, Q96CF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 15, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.