O75971 (SNPC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
snRNA-activating protein complex subunit 5
Short name=SNAPc subunit 5

Alternative name(s):
Small nuclear RNA-activating complex polypeptide 5
snRNA-activating protein complex 19 kDa subunit
Short name=SNAPc 19 kDa subunit

Gene names

Name:	SNAPC5
Synonyms:	SNAP19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subunit structure	Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4. Ref.5
Subcellular location	Nucleus.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc transcription initiation from RNA polymerase III promoter Traceable author statement Ref.1. Source: ProtInc
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75971-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75971-2)

The sequence of this isoform differs from the canonical sequence as follows:
     31-60: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	snRNA-activating protein complex subunit 5		PRO_0000072028
Regions
	Compositional bias	86 – 95	10	Poly-Glu
Amino acid modifications
	Modified residue	85	1	Phosphothreonine Ref.7
Natural variations
	Alternative sequence	31 – 60	30	Missing in isoform 2.		VSP_012785
Experimental info
	Mutagenesis	8	1	L → A: Reduced SNAPC4 binding in both the presence or absence of SNAPC1. Ref.5
	Mutagenesis	18	1	L → A: Minimal effect on SNAPC4 binding in the absence of SNAPC1. Reduced SNAPC4 binding in the presence of SNAPC1. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 4D797E35AF2D1485	FASTA	98	11,328
	10 20 30 40 50 60 MLSRLQELRK EEETLLRLKA ALHDQLNRLK VEELALQSMI SSRRGDEMLS SHTVPEQSHD 70 80 90 MLVHVDNEAS INQTTLELST KSHVTEEEEE EEEEESDS
	Isoform 2 [UniParc]. Checksum: E1098AFF04F7E6EF	FASTA	68	7,977
	10 20 30 40 50 60 MLSRLQELRK EEETLLRLKA ALHDQLNRLK MLVHVDNEAS INQTTLELST KSHVTEEEEE EEEEESDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III." Henry R.W., Mittal V., Ma B., Kobayashi R., Hernandez N. Genes Dev. 12:2664-2672(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Spleen.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Urinary bladder.
[5]	"A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc." Ma B., Hernandez N. J. Biol. Chem. 276:5027-5035(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SNAPC4, MUTAGENESIS OF LEU-8 AND LEU-18.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-85, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF093593 mRNA. Translation: AAC61873.1. AK292051 mRNA. Translation: BAF84740.1. CH471082 Genomic DNA. Translation: EAW77771.1. BC014315 mRNA. Translation: AAH14315.1.
IPI	IPI00027456. IPI00060415.
RefSeq	NP_006040.1. NM_006049.2.
UniGene	Hs.30174.
3D structure databases
ProteinModelPortal	O75971.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75971. 4 interactions.
MINT	MINT-1440780.
STRING	9606.ENSP00000319597.
PTM databases
PhosphoSite	O75971.
Proteomic databases
PaxDb	O75971.
PRIDE	O75971.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307979; ENSP00000308439; ENSG00000174446. ENST00000316634; ENSP00000319597; ENSG00000174446. ENST00000395589; ENSP00000378954; ENSG00000174446. ENST00000562411; ENSP00000454421; ENSG00000174446. ENST00000563480; ENSP00000457892; ENSG00000174446.
GeneID	10302.
KEGG	hsa:10302.
UCSC	uc002apu.1. human.
Organism-specific databases
CTD	10302.
GeneCards	GC15M066782.
HGNC	HGNC:15484. SNAPC5.
HPA	HPA024379.
MIM	605979. gene.
neXtProt	NX_O75971.
PharmGKB	PA37967.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG28007.
HOGENOM	HOG000013144.
HOVERGEN	HBG055993.
InParanoid	O75971.
KO	K15211.
OMA	TRSHVPE.
OrthoDB	EOG4SXNF8.
PhylomeDB	O75971.
Enzyme and pathway databases
Reactome	REACT_1788. Transcription. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	O75971.
Bgee	O75971.
CleanEx	HS_SNAPC5.
Genevestigator	O75971.
GermOnline	ENSG00000174446. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	SNAPC5. human.
GenomeRNAi	10302.
NextBio	39051.
SOURCE	Search...

Entry information

Entry name

SNPC5_HUMAN

Accession

Primary (citable) accession number: O75971
Secondary accession number(s): A8K7N6, Q96CF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.