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Protein

snRNA-activating protein complex subunit 5

Gene

SNAPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

GO - Molecular functioni

  • DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  • snRNA transcription by RNA polymerase II Source: Reactome
  • transcription by RNA polymerase II Source: ProtInc
  • transcription initiation from RNA polymerase III promoter Source: ProtInc

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 5
Short name:
SNAPc subunit 5
Alternative name(s):
Small nuclear RNA-activating complex polypeptide 5
snRNA-activating protein complex 19 kDa subunit
Short name:
SNAPc 19 kDa subunit
Gene namesi
Name:SNAPC5
Synonyms:SNAP19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000174446.12
HGNCiHGNC:15484 SNAPC5
MIMi605979 gene
neXtProtiNX_O75971

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi8L → A: Reduced SNAPC4 binding in both the presence or absence of SNAPC1. 1 Publication1
Mutagenesisi18L → A: Minimal effect on SNAPC4 binding in the absence of SNAPC1. Reduced SNAPC4 binding in the presence of SNAPC1. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000174446
PharmGKBiPA37967

Polymorphism and mutation databases

BioMutaiSNAPC5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720281 – 98snRNA-activating protein complex subunit 5Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75971
MaxQBiO75971
PaxDbiO75971
PeptideAtlasiO75971
PRIDEiO75971

PTM databases

iPTMnetiO75971
PhosphoSitePlusiO75971

Expressioni

Gene expression databases

BgeeiENSG00000174446
CleanExiHS_SNAPC5
ExpressionAtlasiO75971 baseline and differential
GenevisibleiO75971 HS

Organism-specific databases

HPAiHPA024379

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115590, 14 interactors
CORUMiO75971
IntActiO75971, 22 interactors
MINTiO75971
STRINGi9606.ENSP00000319597

Structurei

3D structure databases

ProteinModelPortaliO75971
SMRiO75971
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 95Poly-Glu10

Phylogenomic databases

eggNOGiENOG410J33C Eukaryota
ENOG4112ANI LUCA
GeneTreeiENSGT00390000010331
HOGENOMiHOG000013144
HOVERGENiHBG055993
InParanoidiO75971
KOiK15211
OMAiSMINSRG
OrthoDBiEOG091G10TP
PhylomeDBiO75971
TreeFamiTF328823

Family and domain databases

InterProiView protein in InterPro
IPR029138 SNAPC5
PfamiView protein in Pfam
PF15497 SNAPc19, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75971-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRLQELRK EEETLLRLKA ALHDQLNRLK VEELALQSMI SSRRGDEMLS
60 70 80 90
SHTVPEQSHD MLVHVDNEAS INQTTLELST KSHVTEEEEE EEEEESDS
Length:98
Mass (Da):11,328
Last modified:November 1, 1998 - v1
Checksum:i4D797E35AF2D1485
GO
Isoform 2 (identifier: O75971-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-60: Missing.

Show »
Length:68
Mass (Da):7,977
Checksum:iE1098AFF04F7E6EF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01278531 – 60Missing in isoform 2. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093593 mRNA Translation: AAC61873.1
AK292051 mRNA Translation: BAF84740.1
CH471082 Genomic DNA Translation: EAW77771.1
BC014315 mRNA Translation: AAH14315.1
CCDSiCCDS10217.1 [O75971-1]
RefSeqiNP_001316542.1, NM_001329613.1 [O75971-2]
NP_001316544.1, NM_001329615.1 [O75971-1]
NP_006040.1, NM_006049.3 [O75971-1]
UniGeneiHs.30174

Genome annotation databases

EnsembliENST00000307979; ENSP00000308439; ENSG00000174446 [O75971-2]
ENST00000316634; ENSP00000319597; ENSG00000174446 [O75971-1]
ENST00000395589; ENSP00000378954; ENSG00000174446 [O75971-1]
ENST00000562411; ENSP00000454421; ENSG00000174446 [O75971-1]
ENST00000563480; ENSP00000457892; ENSG00000174446 [O75971-1]
GeneIDi10302
KEGGihsa:10302
UCSCiuc002apu.2 human [O75971-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNPC5_HUMAN
AccessioniPrimary (citable) accession number: O75971
Secondary accession number(s): A8K7N6, Q96CF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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