O75970 (MPDZ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Multiple PDZ domain protein

Alternative name(s):
Multi-PDZ domain protein 1

Gene names

Name:	MPDZ
Synonyms:	MUPP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2070 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Interacts with HTR2C and provokes its clustering at the cell surface By similarity. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Ref.10 Ref.14
Subunit structure	Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 By similarity. Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with the adenovirus type 9 E4-ORF1 protein. Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14
Subcellular location	Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell projection › dendrite. Cell junction › tight junction. Cell junction › synapse. Cell junction › synapse › synaptosome. Note: Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells By similarity. In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. Ref.8 Ref.12 Ref.13
Tissue specificity	Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Ref.8
Domain	The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ domain 13 binds CXADR By similarity. The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1. Ref.10 Ref.11 Ref.14
Sequence similarities	Contains 1 L27 domain. Contains 13 PDZ (DHR) domains.
Sequence caution	The sequence AAC61870.1 differs from that shown. Reason: Aberrant splicing. The sequence BAC05409.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAE06123.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAH71900.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40490.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40491.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40492.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40494.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40495.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI41236.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI41237.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI41238.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI41240.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI56786.1 differs from that shown. Reason: Aberrant splicing.

Ontologies

Keywords
Biological process	Host-virus interaction
Cellular component	Cell junction Cell membrane Cell projection Membrane Postsynaptic cell membrane Synapse Synaptosome Tight junction
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: Compara myelination Inferred from electronic annotation. Source: Compara virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Schmidt-Lanterman incisure Inferred from electronic annotation. Source: Compara apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell apicolateral plasma membrane Inferred from direct assay Ref.12. Source: UniProtKB cytoplasm Inferred from direct assay Ref.12. Source: UniProtKB cytoplasmic vesicle Inferred from electronic annotation. Source: Compara postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW tight junction Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75970-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75970-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1794-1822: Missing.

Isoform 3 (identifier: O75970-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1248-1280: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2070

2070

Multiple PDZ domain protein

PRO_0000094594

Regions

Domain

1 – 63

63

L27

Domain

137 – 224

88

PDZ 1

Domain

257 – 337

81

PDZ 2

Domain

377 – 463

87

PDZ 3

Domain

553 – 634

82

PDZ 4

Domain

700 – 786

87

PDZ 5

Domain

1008 – 1089

82

PDZ 6

Domain

1151 – 1243

93

PDZ 7

Domain

1350 – 1433

84

PDZ 8

Domain

1483 – 1564

82

PDZ 9

Domain

1629 – 1712

84

PDZ 10

Domain

1725 – 1807

83

PDZ 11

Domain

1862 – 1948

87

PDZ 12

Domain

1987 – 2070

84

PDZ 13

Compositional bias

1818 – 1848

31

Ser-rich

Amino acid modifications

Modified residue

230

1

Phosphoserine Ref.15

Modified residue

483

1

Phosphoserine Ref.16

Natural variations

Alternative sequence

1248 – 1280

33

Missing in isoform 3.

VSP_040450

Alternative sequence

1794 – 1822

29

Missing in isoform 2.

VSP_040451

Natural variant

92

1

S → L.
Corresponds to variant rs17273542 [ dbSNP | Ensembl ].

VAR_056115

Natural variant

351

1

L → F.
Corresponds to variant rs3739757 [ dbSNP | Ensembl ].

VAR_056116

Natural variant

702

1

E → K.
Corresponds to variant rs4741289 [ dbSNP | Ensembl ].

VAR_056117

Natural variant

702

1

E → V.
Corresponds to variant rs4740548 [ dbSNP | Ensembl ].

VAR_056118

Natural variant

1604

1

T → A.
Corresponds to variant rs16930134 [ dbSNP | Ensembl ].

VAR_056119

Natural variant

1663

1

G → R.
Corresponds to variant rs2274648 [ dbSNP | Ensembl ].

VAR_056120

Experimental info

Mutagenesis

147 – 150

4

GLGF → PSES: Loss of interaction with CAMK2A. Ref.14

Sequence conflict

1950

1

V → M in CAI56786. Ref.6

Secondary structure

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2070

Helix Strand Turn

Details...

Helix

120 – 130

11

Beta strand

135 – 141

7

Beta strand

144 – 146

3

Beta strand

152 – 156

5

Beta strand

163 – 167

5

Helix

175 – 179

5

Beta strand

187 – 191

5

Helix

202 – 211

10

Beta strand

214 – 223

10

Beta strand

373 – 381

9

Beta strand

389 – 392

4

Beta strand

406 – 410

5

Helix

415 – 419

5

Beta strand

427 – 431

5

Helix

441 – 449

9

Beta strand

453 – 463

11

Beta strand

1150 – 1154

5

Beta strand

1164 – 1167

4

Beta strand

1185 – 1190

6

Beta strand

1192 – 1194

3

Helix

1195 – 1199

5

Beta strand

1207 – 1211

5

Helix

1221 – 1229

9

Beta strand

1233 – 1240

8

Beta strand

1626 – 1633

8

Beta strand

1641 – 1645

5

Beta strand

1653 – 1659

7

Helix

1664 – 1668

5

Beta strand

1676 – 1680

5

Helix

1690 – 1698

9

Beta strand

1702 – 1710

9

Beta strand

1723 – 1729

7

Beta strand

1737 – 1741

5

Beta strand

1744 – 1746

3

Beta strand

1750 – 1754

5

Helix

1759 – 1763

5

Beta strand

1771 – 1775

5

Helix

1785 – 1794

10

Beta strand

1797 – 1804

8

Beta strand

1861 – 1866

6

Beta strand

1875 – 1883

9

Beta strand

1886 – 1895

10

Helix

1900 – 1904

5

Beta strand

1912 – 1916

5

Helix

1926 – 1935

10

Beta strand

1938 – 1945

8

Beta strand

1984 – 1990

7

Beta strand

1998 – 2007

10

Beta strand

2010 – 2019

10

Helix

2024 – 2028

5

Beta strand

2036 – 2040

5

Helix

2050 – 2059

10

Beta strand

2062 – 2070

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: A4D304C20401FD45	FASTA	2,070	221,618
	10 20 30 40 50 60 MLEAIDKNRA LHAAERLQTK LRERGDVANE DKLSLLKSVL QSPLFSQILS LQTSVQQLKD 70 80 90 100 110 120 QVNIATSATS NIEYAHVPHL SPAVIPTLQN ESFLLSPNNG NLEALTGPGI PHINGKPACD 130 140 150 160 170 180 EFDQLIKNMA QGRHVEVFEL LKPPSGGLGF SVVGLRSENR GELGIFVQEI QEGSVAHRDG 190 200 210 220 230 240 RLKETDQILA INGQALDQTI THQQAISILQ KAKDTVQLVI ARGSLPQLVS PIVSRSPSAA 250 260 270 280 290 300 STISAHSNPV HWQHMETIEL VNDGSGLGFG IIGGKATGVI VKTILPGGVA DQHGRLCSGD 310 320 330 340 350 360 HILKIGDTDL AGMSSEQVAQ VLRQCGNRVK LMIARGAIEE RTAPTALGIT LSSSPTSTPE 370 380 390 400 410 420 LRVDASTQKG EESETFDVEL TKNVQGLGIT IAGYIGDKKL EPSGIFVKSI TKSSAVEHDG 430 440 450 460 470 480 RIQIGDQIIA VDGTNLQGFT NQQAVEVLRH TGQTVLLTLM RRGMKQEAEL MSREDVTKDA 490 500 510 520 530 540 DLSPVNASII KENYEKDEDF LSSTRNTNIL PTEEEGYPLL SAEIEEIEDA QKQEAALLTK 550 560 570 580 590 600 WQRIMGINYE IVVAHVSKFS ENSGLGISLE ATVGHHFIRS VLPEGPVGHS GKLFSGDELL 610 620 630 640 650 660 EVNGITLLGE NHQDVVNILK ELPIEVTMVC CRRTVPPTTQ SELDSLDLCD IELTEKPHVD 670 680 690 700 710 720 LGEFIGSSET EDPVLAMTDA GQSTEEVQAP LAMWEAGIQH IELEKGSKGL GFSILDYQDP 730 740 750 760 770 780 IDPASTVIII RSLVPGGIAE KDGRLLPGDR LMFVNDVNLE NSSLEEAVEA LKGAPSGTVR 790 800 810 820 830 840 IGVAKPLPLS PEEGYVSAKE DSFLYPPHSC EEAGLADKPL FRADLALVGT NDADLVDEST 850 860 870 880 890 900 FESPYSPEND SIYSTQASIL SLHGSSCGDG LNYGSSLPSS PPKDVIENSC DPVLDLHMSL 910 920 930 940 950 960 EELYTQNLLQ RQDENTPSVD ISMGPASGFT INDYTPANAI EQQYECENTI VWTESHLPSE 970 980 990 1000 1010 1020 VISSAELPSV LPDSAGKGSE YLLEQSSLAC NAECVMLQNV SKESFERTIN IAKGNSSLGM 1030 1040 1050 1060 1070 1080 TVSANKDGLG MIVRSIIHGG AISRDGRIAI GDCILSINEE STISVTNAQA RAMLRRHSLI 1090 1100 1110 1120 1130 1140 GPDIKITYVP AEHLEEFKIS LGQQSGRVMA LDIFSSYTGR DIPELPEREE GEGEESELQN 1150 1160 1170 1180 1190 1200 TAYSNWNQPR RVELWREPSK SLGISIVGGR GMGSRLSNGE VMRGIFIKHV LEDSPAGKNG 1210 1220 1230 1240 1250 1260 TLKPGDRIVE VDGMDLRDAS HEQAVEAIRK AGNPVVFMVQ SIINRPRKSP LPSLLHNLYP 1270 1280 1290 1300 1310 1320 KYNFSSTNPF ADSLQINADK APSQSESEPE KAPLCSVPPP PPSAFAEMGS DHTQSSASKI 1330 1340 1350 1360 1370 1380 SQDVDKEDEF GYSWKNIRER YGTLTGELHM IELEKGHSGL GLSLAGNKDR SRMSVFIVGI 1390 1400 1410 1420 1430 1440 DPNGAAGKDG RLQIADELLE INGQILYGRS HQNASSIIKC APSKVKIIFI RNKDAVNQMA 1450 1460 1470 1480 1490 1500 VCPGNAVEPL PSNSENLQNK ETEPTVTTSD AAVDLSSFKN VQHLELPKDQ GGLGIAISEE 1510 1520 1530 1540 1550 1560 DTLSGVIIKS LTEHGVAATD GRLKVGDQIL AVDDEIVVGY PIEKFISLLK TAKMTVKLTI 1570 1580 1590 1600 1610 1620 HAENPDSQAV PSAAGAASGE KKNSSQSLMV PQSGSPEPES IRNTSRSSTP AIFASDPATC 1630 1640 1650 1660 1670 1680 PIIPGCETTI EISKGRTGLG LSIVGGSDTL LGAIIIHEVY EEGAACKDGR LWAGDQILEV 1690 1700 1710 1720 1730 1740 NGIDLRKATH DEAINVLRQT PQRVRLTLYR DEAPYKEEEV CDTLTIELQK KPGKGLGLSI 1750 1760 1770 1780 1790 1800 VGKRNDTGVF VSDIVKGGIA DADGRLMQGD QILMVNGEDV RNATQEAVAA LLKCSLGTVT 1810 1820 1830 1840 1850 1860 LEVGRIKAGP FHSERRPSQS SQVSEGSLSS FTFPLSGSST SESLESSSKK NALASEIQGL 1870 1880 1890 1900 1910 1920 RTVEMKKGPT DSLGISIAGG VGSPLGDVPI FIAMMHPTGV AAQTQKLRVG DRIVTICGTS 1930 1940 1950 1960 1970 1980 TEGMTHTQAV NLLKNASGSI EMQVVAGGDV SVVTGHQQEP ASSSLSFTGL TSSSIFQDDL 1990 2000 2010 2020 2030 2040 GPPQCKSITL ERGPDGLGFS IVGGYGSPHG DLPIYVKTVF AKGAASEDGR LKRGDQIIAV 2050 2060 2070 NGQSLEGVTH EEAVAILKRT KGTVTLMVLS
	Isoform 2 [UniParc]. Checksum: 03736D2490F3E2C7	FASTA	2,041	218,507
	10 20 30 40 50 60 MLEAIDKNRA LHAAERLQTK LRERGDVANE DKLSLLKSVL QSPLFSQILS LQTSVQQLKD 70 80 90 100 110 120 QVNIATSATS NIEYAHVPHL SPAVIPTLQN ESFLLSPNNG NLEALTGPGI PHINGKPACD 130 140 150 160 170 180 EFDQLIKNMA QGRHVEVFEL LKPPSGGLGF SVVGLRSENR GELGIFVQEI QEGSVAHRDG 190 200 210 220 230 240 RLKETDQILA INGQALDQTI THQQAISILQ KAKDTVQLVI ARGSLPQLVS PIVSRSPSAA 250 260 270 280 290 300 STISAHSNPV HWQHMETIEL VNDGSGLGFG IIGGKATGVI VKTILPGGVA DQHGRLCSGD 310 320 330 340 350 360 HILKIGDTDL AGMSSEQVAQ VLRQCGNRVK LMIARGAIEE RTAPTALGIT LSSSPTSTPE 370 380 390 400 410 420 LRVDASTQKG EESETFDVEL TKNVQGLGIT IAGYIGDKKL EPSGIFVKSI TKSSAVEHDG 430 440 450 460 470 480 RIQIGDQIIA VDGTNLQGFT NQQAVEVLRH TGQTVLLTLM RRGMKQEAEL MSREDVTKDA 490 500 510 520 530 540 DLSPVNASII KENYEKDEDF LSSTRNTNIL PTEEEGYPLL SAEIEEIEDA QKQEAALLTK 550 560 570 580 590 600 WQRIMGINYE IVVAHVSKFS ENSGLGISLE ATVGHHFIRS VLPEGPVGHS GKLFSGDELL 610 620 630 640 650 660 EVNGITLLGE NHQDVVNILK ELPIEVTMVC CRRTVPPTTQ SELDSLDLCD IELTEKPHVD 670 680 690 700 710 720 LGEFIGSSET EDPVLAMTDA GQSTEEVQAP LAMWEAGIQH IELEKGSKGL GFSILDYQDP 730 740 750 760 770 780 IDPASTVIII RSLVPGGIAE KDGRLLPGDR LMFVNDVNLE NSSLEEAVEA LKGAPSGTVR 790 800 810 820 830 840 IGVAKPLPLS PEEGYVSAKE DSFLYPPHSC EEAGLADKPL FRADLALVGT NDADLVDEST 850 860 870 880 890 900 FESPYSPEND SIYSTQASIL SLHGSSCGDG LNYGSSLPSS PPKDVIENSC DPVLDLHMSL 910 920 930 940 950 960 EELYTQNLLQ RQDENTPSVD ISMGPASGFT INDYTPANAI EQQYECENTI VWTESHLPSE 970 980 990 1000 1010 1020 VISSAELPSV LPDSAGKGSE YLLEQSSLAC NAECVMLQNV SKESFERTIN IAKGNSSLGM 1030 1040 1050 1060 1070 1080 TVSANKDGLG MIVRSIIHGG AISRDGRIAI GDCILSINEE STISVTNAQA RAMLRRHSLI 1090 1100 1110 1120 1130 1140 GPDIKITYVP AEHLEEFKIS LGQQSGRVMA LDIFSSYTGR DIPELPEREE GEGEESELQN 1150 1160 1170 1180 1190 1200 TAYSNWNQPR RVELWREPSK SLGISIVGGR GMGSRLSNGE VMRGIFIKHV LEDSPAGKNG 1210 1220 1230 1240 1250 1260 TLKPGDRIVE VDGMDLRDAS HEQAVEAIRK AGNPVVFMVQ SIINRPRKSP LPSLLHNLYP 1270 1280 1290 1300 1310 1320 KYNFSSTNPF ADSLQINADK APSQSESEPE KAPLCSVPPP PPSAFAEMGS DHTQSSASKI 1330 1340 1350 1360 1370 1380 SQDVDKEDEF GYSWKNIRER YGTLTGELHM IELEKGHSGL GLSLAGNKDR SRMSVFIVGI 1390 1400 1410 1420 1430 1440 DPNGAAGKDG RLQIADELLE INGQILYGRS HQNASSIIKC APSKVKIIFI RNKDAVNQMA 1450 1460 1470 1480 1490 1500 VCPGNAVEPL PSNSENLQNK ETEPTVTTSD AAVDLSSFKN VQHLELPKDQ GGLGIAISEE 1510 1520 1530 1540 1550 1560 DTLSGVIIKS LTEHGVAATD GRLKVGDQIL AVDDEIVVGY PIEKFISLLK TAKMTVKLTI 1570 1580 1590 1600 1610 1620 HAENPDSQAV PSAAGAASGE KKNSSQSLMV PQSGSPEPES IRNTSRSSTP AIFASDPATC 1630 1640 1650 1660 1670 1680 PIIPGCETTI EISKGRTGLG LSIVGGSDTL LGAIIIHEVY EEGAACKDGR LWAGDQILEV 1690 1700 1710 1720 1730 1740 NGIDLRKATH DEAINVLRQT PQRVRLTLYR DEAPYKEEEV CDTLTIELQK KPGKGLGLSI 1750 1760 1770 1780 1790 1800 VGKRNDTGVF VSDIVKGGIA DADGRLMQGD QILMVNGEDV RNATQEAVAA LLKVSEGSLS 1810 1820 1830 1840 1850 1860 SFTFPLSGSS TSESLESSSK KNALASEIQG LRTVEMKKGP TDSLGISIAG GVGSPLGDVP 1870 1880 1890 1900 1910 1920 IFIAMMHPTG VAAQTQKLRV GDRIVTICGT STEGMTHTQA VNLLKNASGS IEMQVVAGGD 1930 1940 1950 1960 1970 1980 VSVVTGHQQE PASSSLSFTG LTSSSIFQDD LGPPQCKSIT LERGPDGLGF SIVGGYGSPH 1990 2000 2010 2020 2030 2040 GDLPIYVKTV FAKGAASEDG RLKRGDQIIA VNGQSLEGVT HEEAVAILKR TKGTVTLMVL S
	Isoform 3 [UniParc]. Checksum: 99D1557E87DECAE9	FASTA	2,037	217,915
	10 20 30 40 50 60 MLEAIDKNRA LHAAERLQTK LRERGDVANE DKLSLLKSVL QSPLFSQILS LQTSVQQLKD 70 80 90 100 110 120 QVNIATSATS NIEYAHVPHL SPAVIPTLQN ESFLLSPNNG NLEALTGPGI PHINGKPACD 130 140 150 160 170 180 EFDQLIKNMA QGRHVEVFEL LKPPSGGLGF SVVGLRSENR GELGIFVQEI QEGSVAHRDG 190 200 210 220 230 240 RLKETDQILA INGQALDQTI THQQAISILQ KAKDTVQLVI ARGSLPQLVS PIVSRSPSAA 250 260 270 280 290 300 STISAHSNPV HWQHMETIEL VNDGSGLGFG IIGGKATGVI VKTILPGGVA DQHGRLCSGD 310 320 330 340 350 360 HILKIGDTDL AGMSSEQVAQ VLRQCGNRVK LMIARGAIEE RTAPTALGIT LSSSPTSTPE 370 380 390 400 410 420 LRVDASTQKG EESETFDVEL TKNVQGLGIT IAGYIGDKKL EPSGIFVKSI TKSSAVEHDG 430 440 450 460 470 480 RIQIGDQIIA VDGTNLQGFT NQQAVEVLRH TGQTVLLTLM RRGMKQEAEL MSREDVTKDA 490 500 510 520 530 540 DLSPVNASII KENYEKDEDF LSSTRNTNIL PTEEEGYPLL SAEIEEIEDA QKQEAALLTK 550 560 570 580 590 600 WQRIMGINYE IVVAHVSKFS ENSGLGISLE ATVGHHFIRS VLPEGPVGHS GKLFSGDELL 610 620 630 640 650 660 EVNGITLLGE NHQDVVNILK ELPIEVTMVC CRRTVPPTTQ SELDSLDLCD IELTEKPHVD 670 680 690 700 710 720 LGEFIGSSET EDPVLAMTDA GQSTEEVQAP LAMWEAGIQH IELEKGSKGL GFSILDYQDP 730 740 750 760 770 780 IDPASTVIII RSLVPGGIAE KDGRLLPGDR LMFVNDVNLE NSSLEEAVEA LKGAPSGTVR 790 800 810 820 830 840 IGVAKPLPLS PEEGYVSAKE DSFLYPPHSC EEAGLADKPL FRADLALVGT NDADLVDEST 850 860 870 880 890 900 FESPYSPEND SIYSTQASIL SLHGSSCGDG LNYGSSLPSS PPKDVIENSC DPVLDLHMSL 910 920 930 940 950 960 EELYTQNLLQ RQDENTPSVD ISMGPASGFT INDYTPANAI EQQYECENTI VWTESHLPSE 970 980 990 1000 1010 1020 VISSAELPSV LPDSAGKGSE YLLEQSSLAC NAECVMLQNV SKESFERTIN IAKGNSSLGM 1030 1040 1050 1060 1070 1080 TVSANKDGLG MIVRSIIHGG AISRDGRIAI GDCILSINEE STISVTNAQA RAMLRRHSLI 1090 1100 1110 1120 1130 1140 GPDIKITYVP AEHLEEFKIS LGQQSGRVMA LDIFSSYTGR DIPELPEREE GEGEESELQN 1150 1160 1170 1180 1190 1200 TAYSNWNQPR RVELWREPSK SLGISIVGGR GMGSRLSNGE VMRGIFIKHV LEDSPAGKNG 1210 1220 1230 1240 1250 1260 TLKPGDRIVE VDGMDLRDAS HEQAVEAIRK AGNPVVFMVQ SIINRPRAPS QSESEPEKAP 1270 1280 1290 1300 1310 1320 LCSVPPPPPS AFAEMGSDHT QSSASKISQD VDKEDEFGYS WKNIRERYGT LTGELHMIEL 1330 1340 1350 1360 1370 1380 EKGHSGLGLS LAGNKDRSRM SVFIVGIDPN GAAGKDGRLQ IADELLEING QILYGRSHQN 1390 1400 1410 1420 1430 1440 ASSIIKCAPS KVKIIFIRNK DAVNQMAVCP GNAVEPLPSN SENLQNKETE PTVTTSDAAV 1450 1460 1470 1480 1490 1500 DLSSFKNVQH LELPKDQGGL GIAISEEDTL SGVIIKSLTE HGVAATDGRL KVGDQILAVD 1510 1520 1530 1540 1550 1560 DEIVVGYPIE KFISLLKTAK MTVKLTIHAE NPDSQAVPSA AGAASGEKKN SSQSLMVPQS 1570 1580 1590 1600 1610 1620 GSPEPESIRN TSRSSTPAIF ASDPATCPII PGCETTIEIS KGRTGLGLSI VGGSDTLLGA 1630 1640 1650 1660 1670 1680 IIIHEVYEEG AACKDGRLWA GDQILEVNGI DLRKATHDEA INVLRQTPQR VRLTLYRDEA 1690 1700 1710 1720 1730 1740 PYKEEEVCDT LTIELQKKPG KGLGLSIVGK RNDTGVFVSD IVKGGIADAD GRLMQGDQIL 1750 1760 1770 1780 1790 1800 MVNGEDVRNA TQEAVAALLK CSLGTVTLEV GRIKAGPFHS ERRPSQSSQV SEGSLSSFTF 1810 1820 1830 1840 1850 1860 PLSGSSTSES LESSSKKNAL ASEIQGLRTV EMKKGPTDSL GISIAGGVGS PLGDVPIFIA 1870 1880 1890 1900 1910 1920 MMHPTGVAAQ TQKLRVGDRI VTICGTSTEG MTHTQAVNLL KNASGSIEMQ VVAGGDVSVV 1930 1940 1950 1960 1970 1980 TGHQQEPASS SLSFTGLTSS SIFQDDLGPP QCKSITLERG PDGLGFSIVG GYGSPHGDLP 1990 2000 2010 2020 2030 IYVKTVFAKG AASEDGRLKR GDQIIAVNGQ SLEGVTHEEA VAILKRTKGT VTLMVLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human homolog of MUPP1 protein." Eng L., Krapivinsky G., Clapham D.E. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 573-2070 (ISOFORM 1). Tissue: Amygdala.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1535-2070 (ISOFORM 1). Tissue: Brain.
[8]	"Cloning and characterization of MUPP1, a novel PDZ domain protein." Ullmer C., Schmuck K., Figge A., Luebbert H. FEBS Lett. 424:63-68(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1618-2070 (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH HTR2C, SUBCELLULAR LOCATION. Tissue: Brain.
[9]	"Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins." Lee S.S., Glaunsinger B., Mantovani F., Banks L., Javier R.T. J. Virol. 74:9680-9693(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ADENOVIRUS TYPE 9 E4-ORF1 PROTEIN.
[10]	"Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1." Becamel C., Figge A., Poliak S., Dumuis A., Peles E., Bockaert J., Luebbert H., Ullmer C. J. Biol. Chem. 276:12974-12982(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HTR2A; HTR2B AND HTR2C, DOMAIN, FUNCTION.
[11]	"Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo." Kimber W.A., Trinkle-Mulcahy L., Cheung P.C.F., Deak M., Marsden L.J., Kieloch A., Watt S., Javier R.T., Gray A., Downes C.P., Lucocq J.M., Alessi D.R. Biochem. J. 361:525-536(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PLEKHA1 AND PLEKHA2, DOMAIN.
[12]	"The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction." Coyne C.B., Voelker T., Pichla S.L., Bergelson J.M. J. Biol. Chem. 279:48079-48084(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CXADR, SUBCELLULAR LOCATION.
[13]	"Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure." van de Pavert S.A., Kantardzhieva A., Malysheva A., Meuleman J., Versteeg I., Levelt C., Klooster J., Geiger S., Seeliger M.W., Rashbass P., Le Bivic A., Wijnholds J. J. Cell Sci. 117:4169-4177(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CRB1, SUBCELLULAR LOCATION.
[14]	"SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation." Krapivinsky G., Medina I., Krapivinsky L., Gapon S., Clapham D.E. Neuron 43:563-574(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SYNGAP1; CAMK2A AND CAMK2B, MUTAGENESIS OF 147-GLY--PHE-150, DOMAIN, FUNCTION.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, MASS SPECTROMETRY.
[17]	"Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions." Elkins J.M., Papagrigoriou E., Berridge G., Yang X., Phillips C., Gileadi C., Savitsky P., Doyle D.A. Protein Sci. 16:683-694(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 117-227, X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 373-463, X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 1148-1243, X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1625-1716, X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1722-1806, X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1859-1951, X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 1983-2070.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF093419 mRNA. Translation: AAC61870.1. Sequence problems.
AB210041 mRNA. Translation: BAE06123.1. Different initiation.
AL162386, AL161449, AL353639 Genomic DNA. Translation: CAH71899.1.
AL162386, AL161449, AL353639 Genomic DNA. Translation: CAH71900.1. Sequence problems.
AL353639, AL161449 Genomic DNA. Translation: CAI41236.1. Sequence problems.
AL353639, AL161449 Genomic DNA. Translation: CAI41237.1. Sequence problems.
AL353639, AL161449, AL162386 Genomic DNA. Translation: CAI41238.1. Sequence problems.
AL353639, AL161449, AL162386 Genomic DNA. Translation: CAI41239.1.
AL353639 Genomic DNA. Translation: CAI41240.1. Sequence problems.
AL161449, AL353639 Genomic DNA. Translation: CAI40490.1. Sequence problems.
AL161449, AL353639 Genomic DNA. Translation: CAI40491.1. Sequence problems.
AL161449, AL162386, AL353639 Genomic DNA. Translation: CAI40492.1. Sequence problems.
AL161449, AL162386, AL353639 Genomic DNA. Translation: CAI40493.1.
AL161449 Genomic DNA. Translation: CAI40494.1. Sequence problems.
AL161449 Genomic DNA. Translation: CAI40495.1. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58704.1.
BC140793 mRNA. Translation: AAI40794.1.
CR936648 mRNA. Translation: CAI56786.1. Sequence problems.
AK098775 mRNA. Translation: BAC05409.1. Different initiation.
AJ001319 mRNA. Translation: CAA04680.1.

IPI

IPI00552988.
IPI00553004.
IPI00973514.

RefSeq

NP_001248335.1. NM_001261406.1.
NP_003820.2. NM_003829.4.

UniGene

Hs.169378.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FCF	X-ray	1.76	A	1148-1243	[»]
2FNE	X-ray	1.83	A/B/C	1983-2070	[»]
2IWN	X-ray	1.35	A	373-463	[»]
2IWO	X-ray	1.70	A/B	1859-1951	[»]
2IWP	X-ray	2.15	A/B	1859-1951	[»]
2IWQ	X-ray	1.80	A	1148-1243	[»]
2O2T	X-ray	2.70	A/B	117-227	[»]
2OPG	X-ray	1.50	A/B	1625-1716	[»]
2QG1	X-ray	1.40	A	1722-1806	[»]

ProteinModelPortal

O75970.

SMR

O75970. Positions 119-227, 373-463, 1148-1244, 1331-1446, 1625-1716, 1722-1806, 1859-1951, 1983-2070.

ModBase

Search...

Protein-protein interaction databases

IntAct

O75970. 9 interactions.

MINT

MINT-275229.

PTM databases

PhosphoSite

O75970.

Proteomic databases

PaxDb

O75970.

PRIDE

O75970.

Protocols and materials databases

DNASU

8777.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000319217; ENSP00000320006; ENSG00000107186.
ENST00000381015; ENSP00000370403; ENSG00000107186.
ENST00000381022; ENSP00000370410; ENSG00000107186.
ENST00000438511; ENSP00000415964; ENSG00000107186.
ENST00000447879; ENSP00000415208; ENSG00000107186.
ENST00000541718; ENSP00000439807; ENSG00000107186.

GeneID

8777.

KEGG

hsa:8777.

UCSC

uc003zlb.4. human.
uc010mhz.3. human.
uc010mia.1. human.

Organism-specific databases

CTD

8777.

GeneCards

GC09M013095.

H-InvDB

HIX0007919.

HGNC

HGNC:7208. MPDZ.

HPA

CAB013512.
HPA020255.
HPA026686.

MIM

603785. gene.

neXtProt

NX_O75970.

Orphanet

269505. Congenital communicating hydrocephalus.

PharmGKB

PA30914.

GenAtlas

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Phylogenomic databases

eggNOG

NOG252837.

HOVERGEN

HBG080134.

KO

K06095.

Gene expression databases

ArrayExpress

O75970.

Bgee

O75970.

Genevestigator

O75970.

GermOnline

ENSG00000107186. Homo sapiens.

Family and domain databases

InterPro

IPR004172. L27.
IPR015132. L27_2.
IPR001478. PDZ.
[Graphical view]

Pfam

PF09045. L27_2. 1 hit.
PF00595. PDZ. 13 hits.
[Graphical view]

SMART

SM00569. L27. 1 hit.
SM00228. PDZ. 13 hits.
[Graphical view]

SUPFAM

SSF50156. PDZ. 13 hits.

PROSITE

PS51022. L27. 1 hit.
PS50106. PDZ. 13 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O75970.

GenomeRNAi

8777.

NextBio

32912.

SOURCE

Search...

Entry information

Entry name

MPDZ_HUMAN

Accession

Primary (citable) accession number: O75970
Secondary accession number(s): A6NLC2 , B2RTS3, O43798, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	January 11, 2011
Last modified:	May 29, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.