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O75970

- MPDZ_HUMAN

UniProt

O75970 - MPDZ_HUMAN

Protein

Multiple PDZ domain protein

Gene

MPDZ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Interacts with HTR2C and provokes its clustering at the cell surface By similarity. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.By similarity2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein C-terminus binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: Ensembl
    2. myelination Source: Ensembl
    3. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multiple PDZ domain protein
    Alternative name(s):
    Multi-PDZ domain protein 1
    Gene namesi
    Name:MPDZ
    Synonyms:MUPP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:7208. MPDZ.

    Subcellular locationi

    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density. Cell projectiondendrite. Cell junctiontight junction. Cell junctionsynapse. Cell junctionsynapsesynaptosome
    Note: Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells By similarity. In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. apicolateral plasma membrane Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. cytoplasmic vesicle Source: Ensembl
    5. dendrite Source: UniProtKB-SubCell
    6. postsynaptic density Source: UniProtKB-SubCell
    7. postsynaptic membrane Source: UniProtKB-KW
    8. Schmidt-Lanterman incisure Source: Ensembl
    9. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

    Pathology & Biotechi

    Involvement in diseasei

    Hydrocephalus, non-syndromic, autosomal recessive 2 (HYC2) [MIM:615219]: A disease characterized by a disturbance of cerebrospinal fluid circulation causing accumulation of ventricular cerebrospinal fluid, which results in progressive ventricular dilatation with onset in utero. Affected individuals may have neurologic impairment.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi147 – 1504GLGF → PSES: Loss of interaction with CAMK2A. 1 Publication

    Organism-specific databases

    MIMi615219. phenotype.
    Orphaneti269505. Congenital communicating hydrocephalus.
    PharmGKBiPA30914.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20702070Multiple PDZ domain proteinPRO_0000094594Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei230 – 2301Phosphoserine1 Publication
    Modified residuei483 – 4831Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO75970.
    PaxDbiO75970.
    PRIDEiO75970.

    PTM databases

    PhosphoSiteiO75970.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiO75970.
    BgeeiO75970.
    GenevestigatoriO75970.

    Organism-specific databases

    HPAiCAB013512.
    HPA020255.
    HPA026686.

    Interactioni

    Subunit structurei

    Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 By similarity. Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with FAT4 (via cytoplasmic domain) By similarity. Interacts with the adenovirus type 9 E4-ORF1 protein.By similarity7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    OR2AG1Q9H2058EBI-821405,EBI-7590304
    PLEKHA1Q9HB216EBI-821405,EBI-2652984
    Plekha2Q9ERS55EBI-821405,EBI-8079166From a different organism.
    SSTR3P327455EBI-821405,EBI-6266935
    TP53P046373EBI-821405,EBI-366083

    Protein-protein interaction databases

    BioGridi114307. 14 interactions.
    IntActiO75970. 25 interactions.
    MINTiMINT-275229.

    Structurei

    Secondary structure

    1
    2070
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi120 – 13011
    Beta strandi135 – 1417
    Beta strandi144 – 1463
    Beta strandi152 – 1565
    Beta strandi163 – 1675
    Helixi175 – 1795
    Beta strandi187 – 1915
    Helixi202 – 21110
    Beta strandi214 – 22310
    Beta strandi373 – 3819
    Beta strandi389 – 3924
    Beta strandi406 – 4105
    Helixi415 – 4195
    Beta strandi427 – 4315
    Helixi441 – 4499
    Beta strandi453 – 46311
    Beta strandi1150 – 11545
    Beta strandi1164 – 11674
    Beta strandi1185 – 11906
    Beta strandi1192 – 11943
    Helixi1195 – 11995
    Beta strandi1207 – 12115
    Helixi1221 – 12299
    Beta strandi1233 – 12408
    Beta strandi1626 – 16338
    Beta strandi1641 – 16455
    Beta strandi1653 – 16597
    Helixi1664 – 16685
    Beta strandi1676 – 16805
    Helixi1690 – 16989
    Beta strandi1702 – 17109
    Beta strandi1723 – 17297
    Beta strandi1737 – 17415
    Beta strandi1744 – 17463
    Beta strandi1750 – 17545
    Helixi1759 – 17635
    Beta strandi1771 – 17755
    Helixi1785 – 179410
    Beta strandi1797 – 18048
    Beta strandi1861 – 18666
    Beta strandi1875 – 18839
    Beta strandi1886 – 189510
    Helixi1900 – 19045
    Beta strandi1912 – 19165
    Helixi1926 – 193510
    Beta strandi1938 – 19458
    Beta strandi1984 – 19907
    Beta strandi1998 – 200710
    Beta strandi2010 – 201910
    Helixi2024 – 20285
    Beta strandi2036 – 20405
    Helixi2050 – 205910
    Beta strandi2062 – 20709

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FCFX-ray1.76A1148-1243[»]
    2FNEX-ray1.83A/B/C1983-2070[»]
    2IWNX-ray1.35A373-463[»]
    2IWOX-ray1.70A/B1859-1951[»]
    2IWPX-ray2.15A/B1859-1951[»]
    2IWQX-ray1.80A1148-1243[»]
    2O2TX-ray2.70A/B117-227[»]
    2OPGX-ray1.50A/B1625-1716[»]
    2QG1X-ray1.40A1722-1806[»]
    ProteinModelPortaliO75970.
    SMRiO75970. Positions 119-227, 373-463, 1148-1244, 1331-1446, 1625-1716, 1722-1806, 1859-1951, 1983-2070.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75970.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6363L27PROSITE-ProRule annotationAdd
    BLAST
    Domaini137 – 22488PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini257 – 33781PDZ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini377 – 46387PDZ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini553 – 63482PDZ 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini700 – 78687PDZ 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1008 – 108982PDZ 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1151 – 124393PDZ 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1350 – 143384PDZ 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1483 – 156482PDZ 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1629 – 171284PDZ 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1725 – 180783PDZ 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1862 – 194887PDZ 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1987 – 207084PDZ 13PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1818 – 184831Ser-richAdd
    BLAST

    Domaini

    The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ domain 13 binds CXADR By similarity. The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1.By similarity3 Publications

    Sequence similaritiesi

    Contains 1 L27 domain.PROSITE-ProRule annotation
    Contains 13 PDZ (DHR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG252837.
    HOVERGENiHBG080134.
    KOiK06095.
    OrthoDBiEOG72ZCD0.
    PhylomeDBiO75970.
    TreeFamiTF330709.

    Family and domain databases

    Gene3Di2.30.42.10. 13 hits.
    InterProiIPR004172. L27.
    IPR015132. L27_2.
    IPR001478. PDZ.
    [Graphical view]
    PfamiPF09045. L27_2. 1 hit.
    PF00595. PDZ. 13 hits.
    [Graphical view]
    SMARTiSM00569. L27. 1 hit.
    SM00228. PDZ. 13 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 13 hits.
    PROSITEiPS51022. L27. 1 hit.
    PS50106. PDZ. 13 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75970-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLEAIDKNRA LHAAERLQTK LRERGDVANE DKLSLLKSVL QSPLFSQILS     50
    LQTSVQQLKD QVNIATSATS NIEYAHVPHL SPAVIPTLQN ESFLLSPNNG 100
    NLEALTGPGI PHINGKPACD EFDQLIKNMA QGRHVEVFEL LKPPSGGLGF 150
    SVVGLRSENR GELGIFVQEI QEGSVAHRDG RLKETDQILA INGQALDQTI 200
    THQQAISILQ KAKDTVQLVI ARGSLPQLVS PIVSRSPSAA STISAHSNPV 250
    HWQHMETIEL VNDGSGLGFG IIGGKATGVI VKTILPGGVA DQHGRLCSGD 300
    HILKIGDTDL AGMSSEQVAQ VLRQCGNRVK LMIARGAIEE RTAPTALGIT 350
    LSSSPTSTPE LRVDASTQKG EESETFDVEL TKNVQGLGIT IAGYIGDKKL 400
    EPSGIFVKSI TKSSAVEHDG RIQIGDQIIA VDGTNLQGFT NQQAVEVLRH 450
    TGQTVLLTLM RRGMKQEAEL MSREDVTKDA DLSPVNASII KENYEKDEDF 500
    LSSTRNTNIL PTEEEGYPLL SAEIEEIEDA QKQEAALLTK WQRIMGINYE 550
    IVVAHVSKFS ENSGLGISLE ATVGHHFIRS VLPEGPVGHS GKLFSGDELL 600
    EVNGITLLGE NHQDVVNILK ELPIEVTMVC CRRTVPPTTQ SELDSLDLCD 650
    IELTEKPHVD LGEFIGSSET EDPVLAMTDA GQSTEEVQAP LAMWEAGIQH 700
    IELEKGSKGL GFSILDYQDP IDPASTVIII RSLVPGGIAE KDGRLLPGDR 750
    LMFVNDVNLE NSSLEEAVEA LKGAPSGTVR IGVAKPLPLS PEEGYVSAKE 800
    DSFLYPPHSC EEAGLADKPL FRADLALVGT NDADLVDEST FESPYSPEND 850
    SIYSTQASIL SLHGSSCGDG LNYGSSLPSS PPKDVIENSC DPVLDLHMSL 900
    EELYTQNLLQ RQDENTPSVD ISMGPASGFT INDYTPANAI EQQYECENTI 950
    VWTESHLPSE VISSAELPSV LPDSAGKGSE YLLEQSSLAC NAECVMLQNV 1000
    SKESFERTIN IAKGNSSLGM TVSANKDGLG MIVRSIIHGG AISRDGRIAI 1050
    GDCILSINEE STISVTNAQA RAMLRRHSLI GPDIKITYVP AEHLEEFKIS 1100
    LGQQSGRVMA LDIFSSYTGR DIPELPEREE GEGEESELQN TAYSNWNQPR 1150
    RVELWREPSK SLGISIVGGR GMGSRLSNGE VMRGIFIKHV LEDSPAGKNG 1200
    TLKPGDRIVE VDGMDLRDAS HEQAVEAIRK AGNPVVFMVQ SIINRPRKSP 1250
    LPSLLHNLYP KYNFSSTNPF ADSLQINADK APSQSESEPE KAPLCSVPPP 1300
    PPSAFAEMGS DHTQSSASKI SQDVDKEDEF GYSWKNIRER YGTLTGELHM 1350
    IELEKGHSGL GLSLAGNKDR SRMSVFIVGI DPNGAAGKDG RLQIADELLE 1400
    INGQILYGRS HQNASSIIKC APSKVKIIFI RNKDAVNQMA VCPGNAVEPL 1450
    PSNSENLQNK ETEPTVTTSD AAVDLSSFKN VQHLELPKDQ GGLGIAISEE 1500
    DTLSGVIIKS LTEHGVAATD GRLKVGDQIL AVDDEIVVGY PIEKFISLLK 1550
    TAKMTVKLTI HAENPDSQAV PSAAGAASGE KKNSSQSLMV PQSGSPEPES 1600
    IRNTSRSSTP AIFASDPATC PIIPGCETTI EISKGRTGLG LSIVGGSDTL 1650
    LGAIIIHEVY EEGAACKDGR LWAGDQILEV NGIDLRKATH DEAINVLRQT 1700
    PQRVRLTLYR DEAPYKEEEV CDTLTIELQK KPGKGLGLSI VGKRNDTGVF 1750
    VSDIVKGGIA DADGRLMQGD QILMVNGEDV RNATQEAVAA LLKCSLGTVT 1800
    LEVGRIKAGP FHSERRPSQS SQVSEGSLSS FTFPLSGSST SESLESSSKK 1850
    NALASEIQGL RTVEMKKGPT DSLGISIAGG VGSPLGDVPI FIAMMHPTGV 1900
    AAQTQKLRVG DRIVTICGTS TEGMTHTQAV NLLKNASGSI EMQVVAGGDV 1950
    SVVTGHQQEP ASSSLSFTGL TSSSIFQDDL GPPQCKSITL ERGPDGLGFS 2000
    IVGGYGSPHG DLPIYVKTVF AKGAASEDGR LKRGDQIIAV NGQSLEGVTH 2050
    EEAVAILKRT KGTVTLMVLS 2070
    Length:2,070
    Mass (Da):221,618
    Last modified:January 11, 2011 - v2
    Checksum:iA4D304C20401FD45
    GO
    Isoform 2 (identifier: O75970-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1794-1822: Missing.

    Show »
    Length:2,041
    Mass (Da):218,507
    Checksum:i03736D2490F3E2C7
    GO
    Isoform 3 (identifier: O75970-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1248-1280: Missing.

    Show »
    Length:2,037
    Mass (Da):217,915
    Checksum:i99D1557E87DECAE9
    GO
    Isoform 4 (identifier: O75970-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1248-1280: Missing.
         1794-1822: Missing.

    Show »
    Length:2,008
    Mass (Da):214,804
    Checksum:iC0EBEA38A7020807
    GO

    Sequence cautioni

    The sequence AAC61870.1 differs from that shown. Reason: Aberrant splicing.
    The sequence CAI56786.1 differs from that shown. Reason: Aberrant splicing.
    The sequence BAC05409.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAE06123.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAH71900.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI40490.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI40491.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI40492.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI40494.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI40495.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI41236.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI41237.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI41238.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI41240.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1950 – 19501V → M in CAI56786. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921S → L.
    Corresponds to variant rs17273542 [ dbSNP | Ensembl ].
    VAR_056115
    Natural varianti351 – 3511L → F.
    Corresponds to variant rs3739757 [ dbSNP | Ensembl ].
    VAR_056116
    Natural varianti702 – 7021E → K.
    Corresponds to variant rs4741289 [ dbSNP | Ensembl ].
    VAR_056117
    Natural varianti702 – 7021E → V.
    Corresponds to variant rs4740548 [ dbSNP | Ensembl ].
    VAR_056118
    Natural varianti1604 – 16041T → A.
    Corresponds to variant rs16930134 [ dbSNP | Ensembl ].
    VAR_056119
    Natural varianti1663 – 16631G → R.
    Corresponds to variant rs2274648 [ dbSNP | Ensembl ].
    VAR_056120

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1248 – 128033Missing in isoform 3 and isoform 4. 1 PublicationVSP_040450Add
    BLAST
    Alternative sequencei1794 – 182229Missing in isoform 2 and isoform 4. 2 PublicationsVSP_040451Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093419 mRNA. Translation: AAC61870.1. Sequence problems.
    AB210041 mRNA. Translation: BAE06123.1. Different initiation.
    AL162386, AL161449, AL353639 Genomic DNA. Translation: CAH71899.1.
    AL162386, AL161449, AL353639 Genomic DNA. Translation: CAH71900.1. Sequence problems.
    AL353639, AL161449 Genomic DNA. Translation: CAI41236.1. Sequence problems.
    AL353639, AL161449 Genomic DNA. Translation: CAI41237.1. Sequence problems.
    AL353639, AL161449, AL162386 Genomic DNA. Translation: CAI41238.1. Sequence problems.
    AL353639, AL161449, AL162386 Genomic DNA. Translation: CAI41239.1.
    AL353639 Genomic DNA. Translation: CAI41240.1. Sequence problems.
    AL161449, AL353639 Genomic DNA. Translation: CAI40490.1. Sequence problems.
    AL161449, AL353639 Genomic DNA. Translation: CAI40491.1. Sequence problems.
    AL161449, AL162386, AL353639 Genomic DNA. Translation: CAI40492.1. Sequence problems.
    AL161449, AL162386, AL353639 Genomic DNA. Translation: CAI40493.1.
    AL161449 Genomic DNA. Translation: CAI40494.1. Sequence problems.
    AL161449 Genomic DNA. Translation: CAI40495.1. Sequence problems.
    CH471071 Genomic DNA. Translation: EAW58704.1.
    BC140793 mRNA. Translation: AAI40794.1.
    BC144564 mRNA. Translation: AAI44565.1.
    CR936648 mRNA. Translation: CAI56786.1. Sequence problems.
    AK098775 mRNA. Translation: BAC05409.1. Different initiation.
    AJ001319 mRNA. Translation: CAA04680.1.
    CCDSiCCDS47951.1. [O75970-2]
    CCDS59119.1. [O75970-5]
    CCDS59120.1. [O75970-3]
    RefSeqiNP_001248335.1. NM_001261406.1. [O75970-3]
    NP_001248336.1. NM_001261407.1. [O75970-5]
    NP_003820.2. NM_003829.4. [O75970-2]
    XP_005251679.1. XM_005251622.2. [O75970-1]
    XP_006716948.1. XM_006716885.1. [O75970-1]
    XP_006716949.1. XM_006716886.1. [O75970-1]
    XP_006716950.1. XM_006716887.1. [O75970-1]
    XP_006716951.1. XM_006716888.1. [O75970-2]
    XP_006716952.1. XM_006716889.1. [O75970-3]
    XP_006716954.1. XM_006716891.1. [O75970-5]
    UniGeneiHs.169378.

    Genome annotation databases

    EnsembliENST00000319217; ENSP00000320006; ENSG00000107186. [O75970-1]
    ENST00000381022; ENSP00000370410; ENSG00000107186. [O75970-2]
    ENST00000447879; ENSP00000415208; ENSG00000107186. [O75970-3]
    ENST00000536827; ENSP00000444151; ENSG00000107186. [O75970-5]
    ENST00000541718; ENSP00000439807; ENSG00000107186. [O75970-2]
    GeneIDi8777.
    KEGGihsa:8777.
    UCSCiuc003zlb.4. human. [O75970-2]
    uc010mhz.4. human. [O75970-3]
    uc010mia.1. human. [O75970-1]
    uc011lmn.3. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093419 mRNA. Translation: AAC61870.1 . Sequence problems.
    AB210041 mRNA. Translation: BAE06123.1 . Different initiation.
    AL162386 , AL161449 , AL353639 Genomic DNA. Translation: CAH71899.1 .
    AL162386 , AL161449 , AL353639 Genomic DNA. Translation: CAH71900.1 . Sequence problems.
    AL353639 , AL161449 Genomic DNA. Translation: CAI41236.1 . Sequence problems.
    AL353639 , AL161449 Genomic DNA. Translation: CAI41237.1 . Sequence problems.
    AL353639 , AL161449 , AL162386 Genomic DNA. Translation: CAI41238.1 . Sequence problems.
    AL353639 , AL161449 , AL162386 Genomic DNA. Translation: CAI41239.1 .
    AL353639 Genomic DNA. Translation: CAI41240.1 . Sequence problems.
    AL161449 , AL353639 Genomic DNA. Translation: CAI40490.1 . Sequence problems.
    AL161449 , AL353639 Genomic DNA. Translation: CAI40491.1 . Sequence problems.
    AL161449 , AL162386 , AL353639 Genomic DNA. Translation: CAI40492.1 . Sequence problems.
    AL161449 , AL162386 , AL353639 Genomic DNA. Translation: CAI40493.1 .
    AL161449 Genomic DNA. Translation: CAI40494.1 . Sequence problems.
    AL161449 Genomic DNA. Translation: CAI40495.1 . Sequence problems.
    CH471071 Genomic DNA. Translation: EAW58704.1 .
    BC140793 mRNA. Translation: AAI40794.1 .
    BC144564 mRNA. Translation: AAI44565.1 .
    CR936648 mRNA. Translation: CAI56786.1 . Sequence problems.
    AK098775 mRNA. Translation: BAC05409.1 . Different initiation.
    AJ001319 mRNA. Translation: CAA04680.1 .
    CCDSi CCDS47951.1. [O75970-2 ]
    CCDS59119.1. [O75970-5 ]
    CCDS59120.1. [O75970-3 ]
    RefSeqi NP_001248335.1. NM_001261406.1. [O75970-3 ]
    NP_001248336.1. NM_001261407.1. [O75970-5 ]
    NP_003820.2. NM_003829.4. [O75970-2 ]
    XP_005251679.1. XM_005251622.2. [O75970-1 ]
    XP_006716948.1. XM_006716885.1. [O75970-1 ]
    XP_006716949.1. XM_006716886.1. [O75970-1 ]
    XP_006716950.1. XM_006716887.1. [O75970-1 ]
    XP_006716951.1. XM_006716888.1. [O75970-2 ]
    XP_006716952.1. XM_006716889.1. [O75970-3 ]
    XP_006716954.1. XM_006716891.1. [O75970-5 ]
    UniGenei Hs.169378.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FCF X-ray 1.76 A 1148-1243 [» ]
    2FNE X-ray 1.83 A/B/C 1983-2070 [» ]
    2IWN X-ray 1.35 A 373-463 [» ]
    2IWO X-ray 1.70 A/B 1859-1951 [» ]
    2IWP X-ray 2.15 A/B 1859-1951 [» ]
    2IWQ X-ray 1.80 A 1148-1243 [» ]
    2O2T X-ray 2.70 A/B 117-227 [» ]
    2OPG X-ray 1.50 A/B 1625-1716 [» ]
    2QG1 X-ray 1.40 A 1722-1806 [» ]
    ProteinModelPortali O75970.
    SMRi O75970. Positions 119-227, 373-463, 1148-1244, 1331-1446, 1625-1716, 1722-1806, 1859-1951, 1983-2070.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114307. 14 interactions.
    IntActi O75970. 25 interactions.
    MINTi MINT-275229.

    PTM databases

    PhosphoSitei O75970.

    Proteomic databases

    MaxQBi O75970.
    PaxDbi O75970.
    PRIDEi O75970.

    Protocols and materials databases

    DNASUi 8777.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319217 ; ENSP00000320006 ; ENSG00000107186 . [O75970-1 ]
    ENST00000381022 ; ENSP00000370410 ; ENSG00000107186 . [O75970-2 ]
    ENST00000447879 ; ENSP00000415208 ; ENSG00000107186 . [O75970-3 ]
    ENST00000536827 ; ENSP00000444151 ; ENSG00000107186 . [O75970-5 ]
    ENST00000541718 ; ENSP00000439807 ; ENSG00000107186 . [O75970-2 ]
    GeneIDi 8777.
    KEGGi hsa:8777.
    UCSCi uc003zlb.4. human. [O75970-2 ]
    uc010mhz.4. human. [O75970-3 ]
    uc010mia.1. human. [O75970-1 ]
    uc011lmn.3. human.

    Organism-specific databases

    CTDi 8777.
    GeneCardsi GC09M013095.
    H-InvDB HIX0007919.
    HGNCi HGNC:7208. MPDZ.
    HPAi CAB013512.
    HPA020255.
    HPA026686.
    MIMi 603785. gene.
    615219. phenotype.
    neXtProti NX_O75970.
    Orphaneti 269505. Congenital communicating hydrocephalus.
    PharmGKBi PA30914.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252837.
    HOVERGENi HBG080134.
    KOi K06095.
    OrthoDBi EOG72ZCD0.
    PhylomeDBi O75970.
    TreeFami TF330709.

    Miscellaneous databases

    EvolutionaryTracei O75970.
    GeneWikii MPDZ.
    GenomeRNAii 8777.
    NextBioi 32912.
    PROi O75970.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75970.
    Bgeei O75970.
    Genevestigatori O75970.

    Family and domain databases

    Gene3Di 2.30.42.10. 13 hits.
    InterProi IPR004172. L27.
    IPR015132. L27_2.
    IPR001478. PDZ.
    [Graphical view ]
    Pfami PF09045. L27_2. 1 hit.
    PF00595. PDZ. 13 hits.
    [Graphical view ]
    SMARTi SM00569. L27. 1 hit.
    SM00228. PDZ. 13 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 13 hits.
    PROSITEi PS51022. L27. 1 hit.
    PS50106. PDZ. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human homolog of MUPP1 protein."
      Eng L., Krapivinsky G., Clapham D.E.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
      Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 573-2070 (ISOFORM 1).
      Tissue: Amygdala.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1535-2070 (ISOFORM 1).
      Tissue: Brain.
    8. "Cloning and characterization of MUPP1, a novel PDZ domain protein."
      Ullmer C., Schmuck K., Figge A., Luebbert H.
      FEBS Lett. 424:63-68(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1618-2070 (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH HTR2C, SUBCELLULAR LOCATION.
      Tissue: Brain.
    9. "Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins."
      Lee S.S., Glaunsinger B., Mantovani F., Banks L., Javier R.T.
      J. Virol. 74:9680-9693(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ADENOVIRUS TYPE 9 E4-ORF1 PROTEIN.
    10. "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1."
      Becamel C., Figge A., Poliak S., Dumuis A., Peles E., Bockaert J., Luebbert H., Ullmer C.
      J. Biol. Chem. 276:12974-12982(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTR2A; HTR2B AND HTR2C, DOMAIN, FUNCTION.
    11. "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo."
      Kimber W.A., Trinkle-Mulcahy L., Cheung P.C.F., Deak M., Marsden L.J., Kieloch A., Watt S., Javier R.T., Gray A., Downes C.P., Lucocq J.M., Alessi D.R.
      Biochem. J. 361:525-536(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLEKHA1 AND PLEKHA2, DOMAIN.
    12. "The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction."
      Coyne C.B., Voelker T., Pichla S.L., Bergelson J.M.
      J. Biol. Chem. 279:48079-48084(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CXADR, SUBCELLULAR LOCATION.
    13. "Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure."
      van de Pavert S.A., Kantardzhieva A., Malysheva A., Meuleman J., Versteeg I., Levelt C., Klooster J., Geiger S., Seeliger M.W., Rashbass P., Le Bivic A., Wijnholds J.
      J. Cell Sci. 117:4169-4177(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRB1, SUBCELLULAR LOCATION.
    14. "SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation."
      Krapivinsky G., Medina I., Krapivinsky L., Gapon S., Clapham D.E.
      Neuron 43:563-574(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYNGAP1; CAMK2A AND CAMK2B, MUTAGENESIS OF 147-GLY--PHE-150, DOMAIN, FUNCTION.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: INVOLVEMENT IN HYC2.
    20. "Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions."
      Elkins J.M., Papagrigoriou E., Berridge G., Yang X., Phillips C., Gileadi C., Savitsky P., Doyle D.A.
      Protein Sci. 16:683-694(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 117-227, X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 373-463, X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 1148-1243, X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1625-1716, X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1722-1806, X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1859-1951, X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 1983-2070.

    Entry informationi

    Entry nameiMPDZ_HUMAN
    AccessioniPrimary (citable) accession number: O75970
    Secondary accession number(s): A6NLC2
    , B2RTS3, B7ZMI4, O43798, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3