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Protein

Multiple PDZ domain protein

Gene

MPDZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.By similarity2 Publications

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107186-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple PDZ domain protein
Alternative name(s):
Multi-PDZ domain protein 1
Gene namesi
Name:MPDZ
Synonyms:MUPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:7208. MPDZ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

Pathology & Biotechi

Involvement in diseasei

Hydrocephalus, non-syndromic, autosomal recessive 2 (HYC2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by a disturbance of cerebrospinal fluid circulation causing accumulation of ventricular cerebrospinal fluid, which results in progressive ventricular dilatation with onset in utero. Affected individuals may have neurologic impairment.
See also OMIM:615219

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi147 – 150GLGF → PSES: Loss of interaction with CAMK2A. 1 Publication4

Organism-specific databases

DisGeNETi8777.
MalaCardsiMPDZ.
MIMi615219. phenotype.
OpenTargetsiENSG00000107186.
Orphaneti269505. Congenital communicating hydrocephalus.
PharmGKBiPA30914.

Polymorphism and mutation databases

BioMutaiMPDZ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945941 – 2070Multiple PDZ domain proteinAdd BLAST2070

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1
Modified residuei1078PhosphoserineCombined sources1
Modified residuei1170Omega-N-methylarginineBy similarity1
Modified residuei1818PhosphoserineCombined sources1
Modified residuei1824PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiO75970.
PaxDbiO75970.
PeptideAtlasiO75970.
PRIDEiO75970.

PTM databases

iPTMnetiO75970.
PhosphoSitePlusiO75970.

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000107186.
ExpressionAtlasiO75970. baseline and differential.
GenevisibleiO75970. HS.

Organism-specific databases

HPAiCAB013512.
HPA020255.
HPA026686.

Interactioni

Subunit structurei

Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 (By similarity). Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with FAT4 (via cytoplasmic domain) (By similarity). Interacts with the adenovirus type 9 E4-ORF1 protein. Interacts with DLL1 (By similarity).By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
OR2AG1Q9H2058EBI-821405,EBI-7590304
PLEKHA1Q9HB216EBI-821405,EBI-2652984
Plekha2Q9ERS55EBI-821405,EBI-8079166From a different organism.
SSTR3P327455EBI-821405,EBI-6266935
TP53P046373EBI-821405,EBI-366083

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114307. 31 interactors.
IntActiO75970. 37 interactors.
MINTiMINT-275229.
STRINGi9606.ENSP00000370410.

Structurei

Secondary structure

12070
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi120 – 130Combined sources11
Beta strandi135 – 141Combined sources7
Beta strandi144 – 146Combined sources3
Beta strandi152 – 156Combined sources5
Beta strandi163 – 167Combined sources5
Helixi175 – 179Combined sources5
Beta strandi187 – 191Combined sources5
Helixi202 – 211Combined sources10
Beta strandi214 – 223Combined sources10
Beta strandi373 – 381Combined sources9
Beta strandi389 – 392Combined sources4
Beta strandi406 – 410Combined sources5
Helixi415 – 419Combined sources5
Beta strandi427 – 431Combined sources5
Helixi441 – 449Combined sources9
Beta strandi453 – 463Combined sources11
Beta strandi1150 – 1154Combined sources5
Beta strandi1164 – 1167Combined sources4
Beta strandi1185 – 1190Combined sources6
Beta strandi1192 – 1194Combined sources3
Helixi1195 – 1199Combined sources5
Beta strandi1207 – 1211Combined sources5
Helixi1221 – 1229Combined sources9
Beta strandi1233 – 1240Combined sources8
Beta strandi1626 – 1633Combined sources8
Beta strandi1641 – 1645Combined sources5
Beta strandi1653 – 1659Combined sources7
Helixi1664 – 1668Combined sources5
Beta strandi1676 – 1680Combined sources5
Helixi1690 – 1698Combined sources9
Beta strandi1702 – 1710Combined sources9
Beta strandi1723 – 1729Combined sources7
Beta strandi1737 – 1741Combined sources5
Beta strandi1744 – 1746Combined sources3
Beta strandi1750 – 1754Combined sources5
Helixi1759 – 1763Combined sources5
Beta strandi1771 – 1775Combined sources5
Helixi1785 – 1794Combined sources10
Beta strandi1797 – 1804Combined sources8
Beta strandi1861 – 1866Combined sources6
Turni1869 – 1871Combined sources3
Beta strandi1875 – 1883Combined sources9
Beta strandi1886 – 1895Combined sources10
Helixi1900 – 1904Combined sources5
Beta strandi1912 – 1916Combined sources5
Helixi1926 – 1935Combined sources10
Beta strandi1938 – 1945Combined sources8
Beta strandi1984 – 1990Combined sources7
Beta strandi1998 – 2007Combined sources10
Beta strandi2010 – 2019Combined sources10
Helixi2024 – 2028Combined sources5
Beta strandi2036 – 2040Combined sources5
Helixi2050 – 2059Combined sources10
Beta strandi2062 – 2070Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FCFX-ray1.76A1148-1243[»]
2FNEX-ray1.83A/B/C1983-2070[»]
2IWNX-ray1.35A373-463[»]
2IWOX-ray1.70A/B1859-1951[»]
2IWPX-ray2.15A/B1859-1951[»]
2IWQX-ray1.80A1148-1243[»]
2O2TX-ray2.70A/B117-227[»]
2OPGX-ray1.50A/B1625-1716[»]
2QG1X-ray1.40A1722-1806[»]
ProteinModelPortaliO75970.
SMRiO75970.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75970.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 63L27PROSITE-ProRule annotationAdd BLAST63
Domaini137 – 224PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini257 – 337PDZ 2PROSITE-ProRule annotationAdd BLAST81
Domaini377 – 463PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini553 – 634PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini700 – 786PDZ 5PROSITE-ProRule annotationAdd BLAST87
Domaini1008 – 1089PDZ 6PROSITE-ProRule annotationAdd BLAST82
Domaini1151 – 1243PDZ 7PROSITE-ProRule annotationAdd BLAST93
Domaini1350 – 1433PDZ 8PROSITE-ProRule annotationAdd BLAST84
Domaini1483 – 1564PDZ 9PROSITE-ProRule annotationAdd BLAST82
Domaini1629 – 1712PDZ 10PROSITE-ProRule annotationAdd BLAST84
Domaini1725 – 1807PDZ 11PROSITE-ProRule annotationAdd BLAST83
Domaini1862 – 1948PDZ 12PROSITE-ProRule annotationAdd BLAST87
Domaini1987 – 2070PDZ 13PROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1818 – 1848Ser-richAdd BLAST31

Domaini

The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ domain 13 binds CXADR (By similarity). The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1.By similarity3 Publications

Sequence similaritiesi

Contains 1 L27 domain.PROSITE-ProRule annotation
Contains 13 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
GeneTreeiENSGT00760000119017.
HOVERGENiHBG080134.
InParanoidiO75970.
KOiK06095.
PhylomeDBiO75970.
TreeFamiTF330709.

Family and domain databases

Gene3Di2.30.42.10. 13 hits.
InterProiIPR015132. L27_2.
IPR004172. L27_dom.
IPR032078. MPDZ.
IPR001478. PDZ.
[Graphical view]
PfamiPF09045. L27_2. 1 hit.
PF16667. MPDZ_u10. 1 hit.
PF00595. PDZ. 12 hits.
[Graphical view]
SMARTiSM00228. PDZ. 13 hits.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 13 hits.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 13 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75970-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEAIDKNRA LHAAERLQTK LRERGDVANE DKLSLLKSVL QSPLFSQILS
60 70 80 90 100
LQTSVQQLKD QVNIATSATS NIEYAHVPHL SPAVIPTLQN ESFLLSPNNG
110 120 130 140 150
NLEALTGPGI PHINGKPACD EFDQLIKNMA QGRHVEVFEL LKPPSGGLGF
160 170 180 190 200
SVVGLRSENR GELGIFVQEI QEGSVAHRDG RLKETDQILA INGQALDQTI
210 220 230 240 250
THQQAISILQ KAKDTVQLVI ARGSLPQLVS PIVSRSPSAA STISAHSNPV
260 270 280 290 300
HWQHMETIEL VNDGSGLGFG IIGGKATGVI VKTILPGGVA DQHGRLCSGD
310 320 330 340 350
HILKIGDTDL AGMSSEQVAQ VLRQCGNRVK LMIARGAIEE RTAPTALGIT
360 370 380 390 400
LSSSPTSTPE LRVDASTQKG EESETFDVEL TKNVQGLGIT IAGYIGDKKL
410 420 430 440 450
EPSGIFVKSI TKSSAVEHDG RIQIGDQIIA VDGTNLQGFT NQQAVEVLRH
460 470 480 490 500
TGQTVLLTLM RRGMKQEAEL MSREDVTKDA DLSPVNASII KENYEKDEDF
510 520 530 540 550
LSSTRNTNIL PTEEEGYPLL SAEIEEIEDA QKQEAALLTK WQRIMGINYE
560 570 580 590 600
IVVAHVSKFS ENSGLGISLE ATVGHHFIRS VLPEGPVGHS GKLFSGDELL
610 620 630 640 650
EVNGITLLGE NHQDVVNILK ELPIEVTMVC CRRTVPPTTQ SELDSLDLCD
660 670 680 690 700
IELTEKPHVD LGEFIGSSET EDPVLAMTDA GQSTEEVQAP LAMWEAGIQH
710 720 730 740 750
IELEKGSKGL GFSILDYQDP IDPASTVIII RSLVPGGIAE KDGRLLPGDR
760 770 780 790 800
LMFVNDVNLE NSSLEEAVEA LKGAPSGTVR IGVAKPLPLS PEEGYVSAKE
810 820 830 840 850
DSFLYPPHSC EEAGLADKPL FRADLALVGT NDADLVDEST FESPYSPEND
860 870 880 890 900
SIYSTQASIL SLHGSSCGDG LNYGSSLPSS PPKDVIENSC DPVLDLHMSL
910 920 930 940 950
EELYTQNLLQ RQDENTPSVD ISMGPASGFT INDYTPANAI EQQYECENTI
960 970 980 990 1000
VWTESHLPSE VISSAELPSV LPDSAGKGSE YLLEQSSLAC NAECVMLQNV
1010 1020 1030 1040 1050
SKESFERTIN IAKGNSSLGM TVSANKDGLG MIVRSIIHGG AISRDGRIAI
1060 1070 1080 1090 1100
GDCILSINEE STISVTNAQA RAMLRRHSLI GPDIKITYVP AEHLEEFKIS
1110 1120 1130 1140 1150
LGQQSGRVMA LDIFSSYTGR DIPELPEREE GEGEESELQN TAYSNWNQPR
1160 1170 1180 1190 1200
RVELWREPSK SLGISIVGGR GMGSRLSNGE VMRGIFIKHV LEDSPAGKNG
1210 1220 1230 1240 1250
TLKPGDRIVE VDGMDLRDAS HEQAVEAIRK AGNPVVFMVQ SIINRPRKSP
1260 1270 1280 1290 1300
LPSLLHNLYP KYNFSSTNPF ADSLQINADK APSQSESEPE KAPLCSVPPP
1310 1320 1330 1340 1350
PPSAFAEMGS DHTQSSASKI SQDVDKEDEF GYSWKNIRER YGTLTGELHM
1360 1370 1380 1390 1400
IELEKGHSGL GLSLAGNKDR SRMSVFIVGI DPNGAAGKDG RLQIADELLE
1410 1420 1430 1440 1450
INGQILYGRS HQNASSIIKC APSKVKIIFI RNKDAVNQMA VCPGNAVEPL
1460 1470 1480 1490 1500
PSNSENLQNK ETEPTVTTSD AAVDLSSFKN VQHLELPKDQ GGLGIAISEE
1510 1520 1530 1540 1550
DTLSGVIIKS LTEHGVAATD GRLKVGDQIL AVDDEIVVGY PIEKFISLLK
1560 1570 1580 1590 1600
TAKMTVKLTI HAENPDSQAV PSAAGAASGE KKNSSQSLMV PQSGSPEPES
1610 1620 1630 1640 1650
IRNTSRSSTP AIFASDPATC PIIPGCETTI EISKGRTGLG LSIVGGSDTL
1660 1670 1680 1690 1700
LGAIIIHEVY EEGAACKDGR LWAGDQILEV NGIDLRKATH DEAINVLRQT
1710 1720 1730 1740 1750
PQRVRLTLYR DEAPYKEEEV CDTLTIELQK KPGKGLGLSI VGKRNDTGVF
1760 1770 1780 1790 1800
VSDIVKGGIA DADGRLMQGD QILMVNGEDV RNATQEAVAA LLKCSLGTVT
1810 1820 1830 1840 1850
LEVGRIKAGP FHSERRPSQS SQVSEGSLSS FTFPLSGSST SESLESSSKK
1860 1870 1880 1890 1900
NALASEIQGL RTVEMKKGPT DSLGISIAGG VGSPLGDVPI FIAMMHPTGV
1910 1920 1930 1940 1950
AAQTQKLRVG DRIVTICGTS TEGMTHTQAV NLLKNASGSI EMQVVAGGDV
1960 1970 1980 1990 2000
SVVTGHQQEP ASSSLSFTGL TSSSIFQDDL GPPQCKSITL ERGPDGLGFS
2010 2020 2030 2040 2050
IVGGYGSPHG DLPIYVKTVF AKGAASEDGR LKRGDQIIAV NGQSLEGVTH
2060 2070
EEAVAILKRT KGTVTLMVLS
Length:2,070
Mass (Da):221,618
Last modified:January 11, 2011 - v2
Checksum:iA4D304C20401FD45
GO
Isoform 2 (identifier: O75970-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1794-1822: Missing.

Show »
Length:2,041
Mass (Da):218,507
Checksum:i03736D2490F3E2C7
GO
Isoform 3 (identifier: O75970-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1248-1280: Missing.

Show »
Length:2,037
Mass (Da):217,915
Checksum:i99D1557E87DECAE9
GO
Isoform 4 (identifier: O75970-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1248-1280: Missing.
     1794-1822: Missing.

Show »
Length:2,008
Mass (Da):214,804
Checksum:iC0EBEA38A7020807
GO

Sequence cautioni

The sequence AAC61870 differs from that shown. Aberrant splicing.Curated
The sequence BAC05409 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE06123 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH71900 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40490 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40491 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40492 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40494 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40495 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41236 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41237 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41238 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41240 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI56786 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1950V → M in CAI56786 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05611592S → L.Corresponds to variant rs17273542dbSNPEnsembl.1
Natural variantiVAR_056116351L → F.Corresponds to variant rs3739757dbSNPEnsembl.1
Natural variantiVAR_056117702E → K.Corresponds to variant rs4741289dbSNPEnsembl.1
Natural variantiVAR_056118702E → V.Corresponds to variant rs4740548dbSNPEnsembl.1
Natural variantiVAR_0561191604T → A.Corresponds to variant rs16930134dbSNPEnsembl.1
Natural variantiVAR_0561201663G → R.Corresponds to variant rs2274648dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0404501248 – 1280Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0404511794 – 1822Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093419 mRNA. Translation: AAC61870.1. Sequence problems.
AB210041 mRNA. Translation: BAE06123.1. Different initiation.
AL162386, AL161449, AL353639 Genomic DNA. Translation: CAH71899.1.
AL162386, AL161449, AL353639 Genomic DNA. Translation: CAH71900.1. Sequence problems.
AL353639, AL161449 Genomic DNA. Translation: CAI41236.1. Sequence problems.
AL353639, AL161449 Genomic DNA. Translation: CAI41237.1. Sequence problems.
AL353639, AL161449, AL162386 Genomic DNA. Translation: CAI41238.1. Sequence problems.
AL353639, AL161449, AL162386 Genomic DNA. Translation: CAI41239.1.
AL353639 Genomic DNA. Translation: CAI41240.1. Sequence problems.
AL161449, AL353639 Genomic DNA. Translation: CAI40490.1. Sequence problems.
AL161449, AL353639 Genomic DNA. Translation: CAI40491.1. Sequence problems.
AL161449, AL162386, AL353639 Genomic DNA. Translation: CAI40492.1. Sequence problems.
AL161449, AL162386, AL353639 Genomic DNA. Translation: CAI40493.1.
AL161449 Genomic DNA. Translation: CAI40494.1. Sequence problems.
AL161449 Genomic DNA. Translation: CAI40495.1. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58704.1.
BC140793 mRNA. Translation: AAI40794.1.
BC144564 mRNA. Translation: AAI44565.1.
CR936648 mRNA. Translation: CAI56786.1. Sequence problems.
AK098775 mRNA. Translation: BAC05409.1. Different initiation.
AJ001319 mRNA. Translation: CAA04680.1.
CCDSiCCDS47951.1. [O75970-2]
CCDS59119.1. [O75970-5]
CCDS59120.1. [O75970-3]
CCDS83342.1. [O75970-1]
RefSeqiNP_001248335.1. NM_001261406.1. [O75970-3]
NP_001248336.1. NM_001261407.1. [O75970-5]
NP_001317566.1. NM_001330637.1.
NP_003820.2. NM_003829.4. [O75970-2]
XP_006716948.1. XM_006716885.3. [O75970-1]
XP_006716949.1. XM_006716886.3. [O75970-1]
XP_006716950.1. XM_006716887.3. [O75970-1]
XP_006716951.1. XM_006716888.3. [O75970-2]
XP_006716952.1. XM_006716889.3. [O75970-3]
XP_006716954.1. XM_006716891.3. [O75970-5]
XP_016870742.1. XM_017015253.1. [O75970-5]
UniGeneiHs.169378.

Genome annotation databases

EnsembliENST00000319217; ENSP00000320006; ENSG00000107186. [O75970-1]
ENST00000381022; ENSP00000370410; ENSG00000107186. [O75970-3]
ENST00000447879; ENSP00000415208; ENSG00000107186. [O75970-3]
ENST00000536827; ENSP00000444151; ENSG00000107186. [O75970-5]
ENST00000541718; ENSP00000439807; ENSG00000107186. [O75970-2]
GeneIDi8777.
KEGGihsa:8777.
UCSCiuc003zlb.5. human. [O75970-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093419 mRNA. Translation: AAC61870.1. Sequence problems.
AB210041 mRNA. Translation: BAE06123.1. Different initiation.
AL162386, AL161449, AL353639 Genomic DNA. Translation: CAH71899.1.
AL162386, AL161449, AL353639 Genomic DNA. Translation: CAH71900.1. Sequence problems.
AL353639, AL161449 Genomic DNA. Translation: CAI41236.1. Sequence problems.
AL353639, AL161449 Genomic DNA. Translation: CAI41237.1. Sequence problems.
AL353639, AL161449, AL162386 Genomic DNA. Translation: CAI41238.1. Sequence problems.
AL353639, AL161449, AL162386 Genomic DNA. Translation: CAI41239.1.
AL353639 Genomic DNA. Translation: CAI41240.1. Sequence problems.
AL161449, AL353639 Genomic DNA. Translation: CAI40490.1. Sequence problems.
AL161449, AL353639 Genomic DNA. Translation: CAI40491.1. Sequence problems.
AL161449, AL162386, AL353639 Genomic DNA. Translation: CAI40492.1. Sequence problems.
AL161449, AL162386, AL353639 Genomic DNA. Translation: CAI40493.1.
AL161449 Genomic DNA. Translation: CAI40494.1. Sequence problems.
AL161449 Genomic DNA. Translation: CAI40495.1. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58704.1.
BC140793 mRNA. Translation: AAI40794.1.
BC144564 mRNA. Translation: AAI44565.1.
CR936648 mRNA. Translation: CAI56786.1. Sequence problems.
AK098775 mRNA. Translation: BAC05409.1. Different initiation.
AJ001319 mRNA. Translation: CAA04680.1.
CCDSiCCDS47951.1. [O75970-2]
CCDS59119.1. [O75970-5]
CCDS59120.1. [O75970-3]
CCDS83342.1. [O75970-1]
RefSeqiNP_001248335.1. NM_001261406.1. [O75970-3]
NP_001248336.1. NM_001261407.1. [O75970-5]
NP_001317566.1. NM_001330637.1.
NP_003820.2. NM_003829.4. [O75970-2]
XP_006716948.1. XM_006716885.3. [O75970-1]
XP_006716949.1. XM_006716886.3. [O75970-1]
XP_006716950.1. XM_006716887.3. [O75970-1]
XP_006716951.1. XM_006716888.3. [O75970-2]
XP_006716952.1. XM_006716889.3. [O75970-3]
XP_006716954.1. XM_006716891.3. [O75970-5]
XP_016870742.1. XM_017015253.1. [O75970-5]
UniGeneiHs.169378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FCFX-ray1.76A1148-1243[»]
2FNEX-ray1.83A/B/C1983-2070[»]
2IWNX-ray1.35A373-463[»]
2IWOX-ray1.70A/B1859-1951[»]
2IWPX-ray2.15A/B1859-1951[»]
2IWQX-ray1.80A1148-1243[»]
2O2TX-ray2.70A/B117-227[»]
2OPGX-ray1.50A/B1625-1716[»]
2QG1X-ray1.40A1722-1806[»]
ProteinModelPortaliO75970.
SMRiO75970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114307. 31 interactors.
IntActiO75970. 37 interactors.
MINTiMINT-275229.
STRINGi9606.ENSP00000370410.

PTM databases

iPTMnetiO75970.
PhosphoSitePlusiO75970.

Polymorphism and mutation databases

BioMutaiMPDZ.

Proteomic databases

MaxQBiO75970.
PaxDbiO75970.
PeptideAtlasiO75970.
PRIDEiO75970.

Protocols and materials databases

DNASUi8777.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319217; ENSP00000320006; ENSG00000107186. [O75970-1]
ENST00000381022; ENSP00000370410; ENSG00000107186. [O75970-3]
ENST00000447879; ENSP00000415208; ENSG00000107186. [O75970-3]
ENST00000536827; ENSP00000444151; ENSG00000107186. [O75970-5]
ENST00000541718; ENSP00000439807; ENSG00000107186. [O75970-2]
GeneIDi8777.
KEGGihsa:8777.
UCSCiuc003zlb.5. human. [O75970-1]

Organism-specific databases

CTDi8777.
DisGeNETi8777.
GeneCardsiMPDZ.
H-InvDBHIX0007919.
HGNCiHGNC:7208. MPDZ.
HPAiCAB013512.
HPA020255.
HPA026686.
MalaCardsiMPDZ.
MIMi603785. gene.
615219. phenotype.
neXtProtiNX_O75970.
OpenTargetsiENSG00000107186.
Orphaneti269505. Congenital communicating hydrocephalus.
PharmGKBiPA30914.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3528. Eukaryota.
ENOG4110362. LUCA.
GeneTreeiENSGT00760000119017.
HOVERGENiHBG080134.
InParanoidiO75970.
KOiK06095.
PhylomeDBiO75970.
TreeFamiTF330709.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107186-MONOMER.

Miscellaneous databases

ChiTaRSiMPDZ. human.
EvolutionaryTraceiO75970.
GeneWikiiMPDZ.
GenomeRNAii8777.
PROiO75970.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107186.
ExpressionAtlasiO75970. baseline and differential.
GenevisibleiO75970. HS.

Family and domain databases

Gene3Di2.30.42.10. 13 hits.
InterProiIPR015132. L27_2.
IPR004172. L27_dom.
IPR032078. MPDZ.
IPR001478. PDZ.
[Graphical view]
PfamiPF09045. L27_2. 1 hit.
PF16667. MPDZ_u10. 1 hit.
PF00595. PDZ. 12 hits.
[Graphical view]
SMARTiSM00228. PDZ. 13 hits.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 13 hits.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPDZ_HUMAN
AccessioniPrimary (citable) accession number: O75970
Secondary accession number(s): A6NLC2
, B2RTS3, B7ZMI4, O43798, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.