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O75969

- AKAP3_HUMAN

UniProt

O75969 - AKAP3_HUMAN

Protein

A-kinase anchor protein 3

Gene

AKAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein kinase A binding Source: ProtInc

    GO - Biological processi

    1. acrosome reaction Source: ProtInc
    2. cellular component movement Source: ProtInc
    3. protein localization Source: Ensembl
    4. single fertilization Source: ProtInc
    5. transmembrane receptor protein serine/threonine kinase signaling pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A-kinase anchor protein 3
    Short name:
    AKAP-3
    Alternative name(s):
    A-kinase anchor protein 110 kDa
    Short name:
    AKAP 110
    Cancer/testis antigen 82
    Short name:
    CT82
    Fibrous sheath protein of 95 kDa
    Short name:
    FSP95
    Fibrousheathin I
    Fibrousheathin-1
    Protein kinase A-anchoring protein 3
    Short name:
    PRKA3
    Sperm oocyte-binding protein
    Gene namesi
    Name:AKAP3
    Synonyms:AKAP110, SOB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:373. AKAP3.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicleacrosome By similarity
    Note: Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.

    GO - Cellular componenti

    1. acrosomal vesicle Source: UniProtKB-SubCell
    2. motile cilium Source: Ensembl
    3. nucleus Source: UniProt

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi131 – 1311L → P: Abolishes interaction with ROPN1. 1 Publication

    Organism-specific databases

    PharmGKBiPA24667.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 853853A-kinase anchor protein 3PRO_0000064526Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei205 – 2051Phosphoserine1 Publication
    Modified residuei208 – 2081Phosphoserine1 Publication
    Modified residuei403 – 4031Phosphoserine1 Publication
    Modified residuei404 – 4041Phosphotyrosine1 Publication
    Modified residuei635 – 6351Phosphoserine1 Publication
    Modified residuei636 – 6361Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated on tyrosine residues.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO75969.
    PRIDEiO75969.

    PTM databases

    PhosphoSiteiO75969.

    Expressioni

    Tissue specificityi

    Testis specific; only expressed in spermatids.

    Gene expression databases

    ArrayExpressiO75969.
    BgeeiO75969.
    CleanExiHS_AKAP3.
    GenevestigatoriO75969.

    Organism-specific databases

    HPAiHPA039765.

    Interactioni

    Subunit structurei

    Interacts with ROPN1 AND ROPN1L.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRKAR2AP138612EBI-9033101,EBI-2556122
    ROPN1BQ9BZX42EBI-9033101,EBI-9033148

    Protein-protein interaction databases

    BioGridi115817. 7 interactions.
    IntActiO75969. 3 interactions.
    STRINGi9606.ENSP00000228850.

    Structurei

    3D structure databases

    ProteinModelPortaliO75969.
    SMRiO75969. Positions 769-851.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni124 – 13714PKA-RII subunit binding domainAdd
    BLAST

    Domaini

    RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

    Sequence similaritiesi

    Belongs to the AKAP110 family.Curated

    Phylogenomic databases

    eggNOGiNOG42108.
    HOGENOMiHOG000220883.
    HOVERGENiHBG050478.
    InParanoidiO75969.
    KOiK16520.
    OMAiQYHLAQG.
    OrthoDBiEOG7327N3.
    PhylomeDBiO75969.
    TreeFamiTF105403.

    Family and domain databases

    InterProiIPR020799. AKAP_110.
    IPR018292. AKAP_110_C.
    IPR018459. RII_binding_1.
    IPR008382. SPHK1-interactor_AKAP_110.
    [Graphical view]
    PANTHERiPTHR10226. PTHR10226. 1 hit.
    PfamiPF05716. AKAP_110. 1 hit.
    PF10522. RII_binding_1. 1 hit.
    [Graphical view]
    SMARTiSM00807. AKAP_110. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75969-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKVDWLQS QNGVCKVDVY SPGDNQAQDW KMDTSTDPVR VLSWLRRDLE    50
    KSTAEFQDVR FKPGESFGGE TSNSGDPHKG FSVDYYNTTT KGTPERLHFE 100
    MTHKEIPCQG PRAQLGNGSS VDEVSFYANR LTNLVIAMAR KEINEKIDGS 150
    ENKCVYQSLY MGNEPTPTKS LSKIASELVN ETVSACSRNA APDKAPGSGD 200
    RVSGSSQSPP NLKYKSTLKI KESTKERQGP DDKPPSKKSF FYKEVFESRN 250
    GDYAREGGRF FPRERKRFRG QERPDDFTAS VSEGIMTYAN SVVSDMMVSI 300
    MKTLKIQVKD TTIATILLKK VLLKHAKEVV SDLIDSFLRN LHSVTGTLMT 350
    DTQFVSAVKR TVFSHGSQKA TDIMDAMLRK LYNVMFAKKV PEHVRKAQDK 400
    AESYSLISMK GMGDPKNRNV NFAMKSETKL REKMYSEPKS EEETCAKTLG 450
    EHIIKEGLTL WHKTQQKECK SLGFQHAAFE APNTQRKPAS DISFEYPEDI 500
    GNLSLPPYPP EKPENFMYDS DSWAEDLIVS ALLLIQYHLA QGGRRDARSF 550
    VEAAGTTNFP ANEPPVAPDE SCLKSAPIVG DQEQAEKKDL RSVFFNFIRN 600
    LLSETIFKRD QSPEPKVPEQ PVKEDRKLCE RPLASSPPRL YEDDETPGAL 650
    SGLTKMAVSQ IDGHMSGQMV EHLMNSVMKL CVIIAKSCDA SLAELGDDKS 700
    GDASRLTSAF PDSLYECLPA KGTGSAEAVL QNAYQAIHNE MRGTSGQPPE 750
    GCAAPTVIVS NHNLTDTVQN KQLQAVLQWV AASELNVPIL YFAGDDEGIQ 800
    EKLLQLSAAA VDKGCSVGEV LQSVLRYEKE RQLNEAVGNV TPLQLLDWLM 850
    VNL 853
    Length:853
    Mass (Da):94,751
    Last modified:December 15, 2009 - v2
    Checksum:iCFDEA26922B5A86E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti272 – 2721E → D in AAD21218. (PubMed:10334916)Curated
    Sequence conflicti282 – 2821S → G in AAC35854. (PubMed:10529264)Curated
    Sequence conflicti402 – 4021E → V in AAC35854. (PubMed:10529264)Curated
    Sequence conflicti467 – 4671K → N in AAC35854. (PubMed:10529264)Curated
    Sequence conflicti597 – 5971F → S AA sequence (PubMed:10529264)Curated
    Sequence conflicti700 – 7001S → L in AAC35854. (PubMed:10529264)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti118 – 1181G → E.4 Publications
    Corresponds to variant rs2072355 [ dbSNP | Ensembl ].
    VAR_055488
    Natural varianti464 – 4641T → S.3 Publications
    Corresponds to variant rs11063266 [ dbSNP | Ensembl ].
    VAR_060730
    Natural varianti500 – 5001I → T.1 Publication
    Corresponds to variant rs12366671 [ dbSNP | Ensembl ].
    VAR_055489
    Natural varianti525 – 5251E → K.3 Publications
    Corresponds to variant rs1990312 [ dbSNP | Ensembl ].
    VAR_061000
    Natural varianti661 – 6611I → T.
    Corresponds to variant rs1990313 [ dbSNP | Ensembl ].
    VAR_055490
    Natural varianti700 – 7001S → F.
    Corresponds to variant rs2041291 [ dbSNP | Ensembl ].
    VAR_055491
    Natural varianti700 – 7001S → P.
    Corresponds to variant rs2041290 [ dbSNP | Ensembl ].
    VAR_059112
    Natural varianti725 – 7251S → L.
    Corresponds to variant rs2072357 [ dbSNP | Ensembl ].
    VAR_055492
    Natural varianti831 – 8311R → C in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036428

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85715 mRNA. Translation: AAD21218.1.
    AF087003 mRNA. Translation: AAC35854.1.
    AF093408 mRNA. Translation: AAC63371.1.
    AK292451 mRNA. Translation: BAF85140.1.
    AC005832 Genomic DNA. No translation available.
    BC047535 mRNA. Translation: AAH47535.1.
    CCDSiCCDS8531.1.
    RefSeqiNP_001265238.1. NM_001278309.1.
    NP_006413.3. NM_006422.3.
    XP_005253721.1. XM_005253664.1.
    XP_005253722.1. XM_005253665.2.
    XP_006719014.1. XM_006718951.1.
    UniGeneiHs.98397.

    Genome annotation databases

    EnsembliENST00000228850; ENSP00000228850; ENSG00000111254.
    ENST00000545990; ENSP00000440994; ENSG00000111254.
    GeneIDi10566.
    KEGGihsa:10566.
    UCSCiuc001qnb.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85715 mRNA. Translation: AAD21218.1 .
    AF087003 mRNA. Translation: AAC35854.1 .
    AF093408 mRNA. Translation: AAC63371.1 .
    AK292451 mRNA. Translation: BAF85140.1 .
    AC005832 Genomic DNA. No translation available.
    BC047535 mRNA. Translation: AAH47535.1 .
    CCDSi CCDS8531.1.
    RefSeqi NP_001265238.1. NM_001278309.1.
    NP_006413.3. NM_006422.3.
    XP_005253721.1. XM_005253664.1.
    XP_005253722.1. XM_005253665.2.
    XP_006719014.1. XM_006718951.1.
    UniGenei Hs.98397.

    3D structure databases

    ProteinModelPortali O75969.
    SMRi O75969. Positions 769-851.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115817. 7 interactions.
    IntActi O75969. 3 interactions.
    STRINGi 9606.ENSP00000228850.

    PTM databases

    PhosphoSitei O75969.

    Proteomic databases

    PaxDbi O75969.
    PRIDEi O75969.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228850 ; ENSP00000228850 ; ENSG00000111254 .
    ENST00000545990 ; ENSP00000440994 ; ENSG00000111254 .
    GeneIDi 10566.
    KEGGi hsa:10566.
    UCSCi uc001qnb.4. human.

    Organism-specific databases

    CTDi 10566.
    GeneCardsi GC12M004724.
    H-InvDB HIX0026339.
    HGNCi HGNC:373. AKAP3.
    HPAi HPA039765.
    MIMi 604689. gene.
    neXtProti NX_O75969.
    PharmGKBi PA24667.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42108.
    HOGENOMi HOG000220883.
    HOVERGENi HBG050478.
    InParanoidi O75969.
    KOi K16520.
    OMAi QYHLAQG.
    OrthoDBi EOG7327N3.
    PhylomeDBi O75969.
    TreeFami TF105403.

    Miscellaneous databases

    GeneWikii AKAP3.
    GenomeRNAii 10566.
    NextBioi 40101.
    PROi O75969.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75969.
    Bgeei O75969.
    CleanExi HS_AKAP3.
    Genevestigatori O75969.

    Family and domain databases

    InterProi IPR020799. AKAP_110.
    IPR018292. AKAP_110_C.
    IPR018459. RII_binding_1.
    IPR008382. SPHK1-interactor_AKAP_110.
    [Graphical view ]
    PANTHERi PTHR10226. PTHR10226. 1 hit.
    Pfami PF05716. AKAP_110. 1 hit.
    PF10522. RII_binding_1. 1 hit.
    [Graphical view ]
    SMARTi SM00807. AKAP_110. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition."
      Lefevre A., Duquenne C., Rousseau-Merck M.-F., Rogier E., Finaz C.
      Biochem. Biophys. Res. Commun. 259:60-66(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS GLU-118; SER-464 AND LYS-525.
      Tissue: Testis.
    2. "FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa."
      Mandal A., Naaby-Hansen S., Wolkowicz M.J., Klotz K., Shetty J., Retief J.D., Coonrod S.A., Kinter M., Sherman N., Cesar F., Flickinger C.J., Herr J.C.
      Biol. Reprod. 61:1184-1197(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANTS GLU-118; SER-464; THR-500 AND LYS-525.
      Tissue: Testis.
    3. "Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein."
      Vijayaraghavan S., Liberty G.A., Mohan J., Winfrey V.P., Olson G.E., Carr D.W.
      Mol. Endocrinol. 13:705-717(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-464 AND LYS-525.
      Tissue: Testis.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-118.
      Tissue: Testis.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-118.
      Tissue: Testis.
    7. "Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA."
      Carr D.W., Fujita A., Stentz C.L., Liberty G.A., Olson G.E., Narumiya S.
      J. Biol. Chem. 276:17332-17338(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ROPN1 AND ROPN1L, MUTAGENESIS OF LEU-131.
    8. "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation."
      Ficarro S., Chertihin O., Westbrook V.A., White F., Jayes F., Kalab P., Marto J.A., Shabanowitz J., Herr J.C., Hunt D.F., Visconti P.E.
      J. Biol. Chem. 278:11579-11589(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; SER-208; SER-403; TYR-404; SER-635 AND SER-636, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Sperm.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-831.

    Entry informationi

    Entry nameiAKAP3_HUMAN
    AccessioniPrimary (citable) accession number: O75969
    Secondary accession number(s): O75945, Q86X01, Q9UM61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3