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Protein

Cyclin-dependent kinase 2-associated protein 2

Gene

CDK2AP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 2
Short name:
CDK2-associated protein 2
Alternative name(s):
DOC-1-related protein
Short name:
DOC-1R
Gene namesi
Name:CDK2AP2
Synonyms:DOC1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30833. CDK2AP2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10263.
OpenTargetsiENSG00000167797.
PharmGKBiPA128394572.

Chemistry databases

ChEMBLiCHEMBL6010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799631 – 126Cyclin-dependent kinase 2-associated protein 2Add BLAST126

Post-translational modificationi

Phosphorylated by MAPK1 and CDK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75956.
PaxDbiO75956.
PeptideAtlasiO75956.
PRIDEiO75956.

PTM databases

iPTMnetiO75956.
PhosphoSitePlusiO75956.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000167797.
CleanExiHS_CDK2AP2.
ExpressionAtlasiO75956. baseline and differential.
GenevisibleiO75956. HS.

Organism-specific databases

HPAiHPA047599.

Interactioni

Subunit structurei

Interacts with CDK2AP1 (PubMed:14985111). Interacts with CDK2 (PubMed:23781148). Interacts with MAPK1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi115555. 16 interactors.
IntActiO75956. 19 interactors.
MINTiMINT-1408989.
STRINGi9606.ENSP00000301488.

Chemistry databases

BindingDBiO75956.

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi67 – 70Combined sources4
Helixi72 – 85Combined sources14
Helixi88 – 92Combined sources5
Helixi96 – 120Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M1LNMR-A/B61-126[»]
ProteinModelPortaliO75956.
SMRiO75956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 106Interaction with CDK21 PublicationAdd BLAST43

Sequence similaritiesi

Belongs to the CDK2AP family.Curated

Phylogenomic databases

eggNOGiKOG4713. Eukaryota.
ENOG41126TJ. LUCA.
GeneTreeiENSGT00390000006964.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiO75956.
OMAiMKPPGTQ.
OrthoDBiEOG091G1364.
PhylomeDBiO75956.
TreeFamiTF101037.

Family and domain databases

InterProiView protein in InterPro
IPR017266. DOC_1/2.
PANTHERiPTHR22607. PTHR22607. 1 hit.
PfamiView protein in Pfam
PF09806. CDK2AP. 1 hit.
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

O75956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKPIAPAP SSTPGSSTPG PGTPVPTGSV PSPSGSVPGA GAPFRPLFND
60 70 80 90 100
FGPPSMGYVQ AMKPPGAQGS QSTYTDLLSV IEEMGKEIRP TYAGSKSAME
110 120
RLKRGIIHAR ALVRECLAET ERNART
Length:126
Mass (Da):13,101
Last modified:November 1, 1998 - v1
Checksum:iD668D3FA8CE70CA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089814 mRNA. Translation: AAC61745.1.
BT006909 mRNA. Translation: AAP35555.1.
BC002850 mRNA. Translation: AAH02850.1.
BC016704 mRNA. Translation: AAH16704.1.
CCDSiCCDS8169.1.
RefSeqiNP_005842.1. NM_005851.4.
UniGeneiHs.523835.

Genome annotation databases

EnsembliENST00000301488; ENSP00000301488; ENSG00000167797.
GeneIDi10263.
KEGGihsa:10263.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCDKA2_HUMAN
AccessioniPrimary (citable) accession number: O75956
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 10, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families