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O75956 (CDKA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 2-associated protein 2

Short name=CDK2-associated protein 2
Alternative name(s):
DOC-1-related protein
Short name=DOC-1R
Gene names
Name:CDK2AP2
Synonyms:DOC1R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length126 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the CDK2AP family.

Ontologies

Keywords
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 126126Cyclin-dependent kinase 2-associated protein 2
PRO_0000079963

Secondary structure

......... 126
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O75956 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: D668D3FA8CE70CA5

FASTA12613,101
        10         20         30         40         50         60 
MSYKPIAPAP SSTPGSSTPG PGTPVPTGSV PSPSGSVPGA GAPFRPLFND FGPPSMGYVQ 

        70         80         90        100        110        120 
AMKPPGAQGS QSTYTDLLSV IEEMGKEIRP TYAGSKSAME RLKRGIIHAR ALVRECLAET 


ERNART 

« Hide

References

« Hide 'large scale' references
[1]"Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene."
Zhang X., Tsao H., Tsuji T., Minoshima S., McBride J., Majewski P., Todd R., Shimizu N., Wong D.T., Housman D.E., Haluska F.G.
Biochem. Biophys. Res. Commun. 255:59-63(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF089814 mRNA. Translation: AAC61745.1.
BT006909 mRNA. Translation: AAP35555.1.
BC002850 mRNA. Translation: AAH02850.1.
BC016704 mRNA. Translation: AAH16704.1.
RefSeqNP_005842.1. NM_005851.4.
UniGeneHs.523835.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2M1LNMR-A/B61-126[»]
ProteinModelPortalO75956.
SMRO75956. Positions 61-126.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115555. 16 interactions.
IntActO75956. 17 interactions.
MINTMINT-1408989.
STRING9606.ENSP00000301488.

Chemistry

BindingDBO75956.
ChEMBLCHEMBL6010.

PTM databases

PhosphoSiteO75956.

Proteomic databases

PaxDbO75956.
PRIDEO75956.

Protocols and materials databases

DNASU10263.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301488; ENSP00000301488; ENSG00000167797.
GeneID10263.
KEGGhsa:10263.
UCSCuc001oma.4. human.

Organism-specific databases

CTD10263.
GeneCardsGC11M067273.
HGNCHGNC:30833. CDK2AP2.
HPAHPA047599.
neXtProtNX_O75956.
PharmGKBPA128394572.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG235568.
HOGENOMHOG000035115.
HOVERGENHBG002074.
InParanoidO75956.
OMAMKPPGTQ.
OrthoDBEOG71RXN6.
PhylomeDBO75956.
TreeFamTF101037.

Gene expression databases

ArrayExpressO75956.
BgeeO75956.
CleanExHS_CDK2AP2.
GenevestigatorO75956.

Family and domain databases

InterProIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFPIRSF037709. CDK2-associated_p2. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCDK2AP2. human.
GenomeRNAi10263.
NextBio38884.
PROO75956.

Entry information

Entry nameCDKA2_HUMAN
AccessionPrimary (citable) accession number: O75956
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM