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O75956

- CDKA2_HUMAN

UniProt

O75956 - CDKA2_HUMAN

Protein

Cyclin-dependent kinase 2-associated protein 2

Gene

CDK2AP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 2-associated protein 2
    Short name:
    CDK2-associated protein 2
    Alternative name(s):
    DOC-1-related protein
    Short name:
    DOC-1R
    Gene namesi
    Name:CDK2AP2
    Synonyms:DOC1R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:30833. CDK2AP2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394572.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 126126Cyclin-dependent kinase 2-associated protein 2PRO_0000079963Add
    BLAST

    Proteomic databases

    PaxDbiO75956.
    PRIDEiO75956.

    PTM databases

    PhosphoSiteiO75956.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiO75956.
    BgeeiO75956.
    CleanExiHS_CDK2AP2.
    GenevestigatoriO75956.

    Organism-specific databases

    HPAiHPA047599.

    Interactioni

    Protein-protein interaction databases

    BioGridi115555. 16 interactions.
    IntActiO75956. 17 interactions.
    MINTiMINT-1408989.
    STRINGi9606.ENSP00000301488.

    Structurei

    Secondary structure

    1
    126
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi67 – 704
    Helixi72 – 8514
    Helixi88 – 925
    Helixi96 – 12025

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2M1LNMR-A/B61-126[»]
    ProteinModelPortaliO75956.
    SMRiO75956. Positions 61-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDK2AP family.Curated

    Phylogenomic databases

    eggNOGiNOG235568.
    HOGENOMiHOG000035115.
    HOVERGENiHBG002074.
    InParanoidiO75956.
    OMAiMKPPGTQ.
    OrthoDBiEOG71RXN6.
    PhylomeDBiO75956.
    TreeFamiTF101037.

    Family and domain databases

    InterProiIPR017266. CDK2-associated_2.
    IPR019187. Cyclin-dep_kinase2-assoc_pr.
    [Graphical view]
    PfamiPF09806. CDK2AP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O75956-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYKPIAPAP SSTPGSSTPG PGTPVPTGSV PSPSGSVPGA GAPFRPLFND    50
    FGPPSMGYVQ AMKPPGAQGS QSTYTDLLSV IEEMGKEIRP TYAGSKSAME 100
    RLKRGIIHAR ALVRECLAET ERNART 126
    Length:126
    Mass (Da):13,101
    Last modified:November 1, 1998 - v1
    Checksum:iD668D3FA8CE70CA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089814 mRNA. Translation: AAC61745.1.
    BT006909 mRNA. Translation: AAP35555.1.
    BC002850 mRNA. Translation: AAH02850.1.
    BC016704 mRNA. Translation: AAH16704.1.
    CCDSiCCDS8169.1.
    RefSeqiNP_005842.1. NM_005851.4.
    UniGeneiHs.523835.

    Genome annotation databases

    EnsembliENST00000301488; ENSP00000301488; ENSG00000167797.
    GeneIDi10263.
    KEGGihsa:10263.
    UCSCiuc001oma.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089814 mRNA. Translation: AAC61745.1 .
    BT006909 mRNA. Translation: AAP35555.1 .
    BC002850 mRNA. Translation: AAH02850.1 .
    BC016704 mRNA. Translation: AAH16704.1 .
    CCDSi CCDS8169.1.
    RefSeqi NP_005842.1. NM_005851.4.
    UniGenei Hs.523835.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2M1L NMR - A/B 61-126 [» ]
    ProteinModelPortali O75956.
    SMRi O75956. Positions 61-126.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115555. 16 interactions.
    IntActi O75956. 17 interactions.
    MINTi MINT-1408989.
    STRINGi 9606.ENSP00000301488.

    Chemistry

    BindingDBi O75956.
    ChEMBLi CHEMBL6010.

    PTM databases

    PhosphoSitei O75956.

    Proteomic databases

    PaxDbi O75956.
    PRIDEi O75956.

    Protocols and materials databases

    DNASUi 10263.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301488 ; ENSP00000301488 ; ENSG00000167797 .
    GeneIDi 10263.
    KEGGi hsa:10263.
    UCSCi uc001oma.4. human.

    Organism-specific databases

    CTDi 10263.
    GeneCardsi GC11M067273.
    HGNCi HGNC:30833. CDK2AP2.
    HPAi HPA047599.
    neXtProti NX_O75956.
    PharmGKBi PA128394572.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235568.
    HOGENOMi HOG000035115.
    HOVERGENi HBG002074.
    InParanoidi O75956.
    OMAi MKPPGTQ.
    OrthoDBi EOG71RXN6.
    PhylomeDBi O75956.
    TreeFami TF101037.

    Miscellaneous databases

    ChiTaRSi CDK2AP2. human.
    GenomeRNAii 10263.
    NextBioi 38884.
    PROi O75956.

    Gene expression databases

    ArrayExpressi O75956.
    Bgeei O75956.
    CleanExi HS_CDK2AP2.
    Genevestigatori O75956.

    Family and domain databases

    InterProi IPR017266. CDK2-associated_2.
    IPR019187. Cyclin-dep_kinase2-assoc_pr.
    [Graphical view ]
    Pfami PF09806. CDK2AP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037709. CDK2-associated_p2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene."
      Zhang X., Tsao H., Tsuji T., Minoshima S., McBride J., Majewski P., Todd R., Shimizu N., Wong D.T., Housman D.E., Haluska F.G.
      Biochem. Biophys. Res. Commun. 255:59-63(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Ovary.

    Entry informationi

    Entry nameiCDKA2_HUMAN
    AccessioniPrimary (citable) accession number: O75956
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3