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O75956

- CDKA2_HUMAN

UniProt

O75956 - CDKA2_HUMAN

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Protein

Cyclin-dependent kinase 2-associated protein 2

Gene

CDK2AP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 2
Short name:
CDK2-associated protein 2
Alternative name(s):
DOC-1-related protein
Short name:
DOC-1R
Gene namesi
Name:CDK2AP2
Synonyms:DOC1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:30833. CDK2AP2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126Cyclin-dependent kinase 2-associated protein 2PRO_0000079963Add
BLAST

Proteomic databases

MaxQBiO75956.
PaxDbiO75956.
PRIDEiO75956.

PTM databases

PhosphoSiteiO75956.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO75956.
CleanExiHS_CDK2AP2.
ExpressionAtlasiO75956. baseline and differential.
GenevestigatoriO75956.

Organism-specific databases

HPAiHPA047599.

Interactioni

Protein-protein interaction databases

BioGridi115555. 16 interactions.
IntActiO75956. 17 interactions.
MINTiMINT-1408989.
STRINGi9606.ENSP00000301488.

Structurei

Secondary structure

1
126
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi67 – 704Combined sources
Helixi72 – 8514Combined sources
Helixi88 – 925Combined sources
Helixi96 – 12025Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M1LNMR-A/B61-126[»]
ProteinModelPortaliO75956.
SMRiO75956. Positions 61-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDK2AP family.Curated

Phylogenomic databases

eggNOGiNOG235568.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiO75956.
OMAiMKPPGTQ.
OrthoDBiEOG71RXN6.
PhylomeDBiO75956.
TreeFamiTF101037.

Family and domain databases

InterProiIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamiPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

O75956-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYKPIAPAP SSTPGSSTPG PGTPVPTGSV PSPSGSVPGA GAPFRPLFND
60 70 80 90 100
FGPPSMGYVQ AMKPPGAQGS QSTYTDLLSV IEEMGKEIRP TYAGSKSAME
110 120
RLKRGIIHAR ALVRECLAET ERNART
Length:126
Mass (Da):13,101
Last modified:November 1, 1998 - v1
Checksum:iD668D3FA8CE70CA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089814 mRNA. Translation: AAC61745.1.
BT006909 mRNA. Translation: AAP35555.1.
BC002850 mRNA. Translation: AAH02850.1.
BC016704 mRNA. Translation: AAH16704.1.
CCDSiCCDS8169.1.
RefSeqiNP_005842.1. NM_005851.4.
UniGeneiHs.523835.

Genome annotation databases

EnsembliENST00000301488; ENSP00000301488; ENSG00000167797.
GeneIDi10263.
KEGGihsa:10263.
UCSCiuc001oma.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089814 mRNA. Translation: AAC61745.1 .
BT006909 mRNA. Translation: AAP35555.1 .
BC002850 mRNA. Translation: AAH02850.1 .
BC016704 mRNA. Translation: AAH16704.1 .
CCDSi CCDS8169.1.
RefSeqi NP_005842.1. NM_005851.4.
UniGenei Hs.523835.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2M1L NMR - A/B 61-126 [» ]
ProteinModelPortali O75956.
SMRi O75956. Positions 61-126.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115555. 16 interactions.
IntActi O75956. 17 interactions.
MINTi MINT-1408989.
STRINGi 9606.ENSP00000301488.

Chemistry

BindingDBi O75956.
ChEMBLi CHEMBL6010.

PTM databases

PhosphoSitei O75956.

Proteomic databases

MaxQBi O75956.
PaxDbi O75956.
PRIDEi O75956.

Protocols and materials databases

DNASUi 10263.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301488 ; ENSP00000301488 ; ENSG00000167797 .
GeneIDi 10263.
KEGGi hsa:10263.
UCSCi uc001oma.4. human.

Organism-specific databases

CTDi 10263.
GeneCardsi GC11M067273.
HGNCi HGNC:30833. CDK2AP2.
HPAi HPA047599.
neXtProti NX_O75956.
PharmGKBi PA128394572.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235568.
HOGENOMi HOG000035115.
HOVERGENi HBG002074.
InParanoidi O75956.
OMAi MKPPGTQ.
OrthoDBi EOG71RXN6.
PhylomeDBi O75956.
TreeFami TF101037.

Miscellaneous databases

ChiTaRSi CDK2AP2. human.
GenomeRNAii 10263.
NextBioi 38884.
PROi O75956.

Gene expression databases

Bgeei O75956.
CleanExi HS_CDK2AP2.
ExpressionAtlasi O75956. baseline and differential.
Genevestigatori O75956.

Family and domain databases

InterProi IPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view ]
Pfami PF09806. CDK2AP. 1 hit.
[Graphical view ]
PIRSFi PIRSF037709. CDK2-associated_p2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene."
    Zhang X., Tsao H., Tsuji T., Minoshima S., McBride J., Majewski P., Todd R., Shimizu N., Wong D.T., Housman D.E., Haluska F.G.
    Biochem. Biophys. Res. Commun. 255:59-63(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.

Entry informationi

Entry nameiCDKA2_HUMAN
AccessioniPrimary (citable) accession number: O75956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3