O75956 (CDKA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 2-associated protein 2
Short name=CDK2-associated protein 2

Alternative name(s):
DOC-1-related protein
Short name=DOC-1R

Gene names

Name:	CDK2AP2
Synonyms:	DOC1R

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the CDK2AP family.

Ontologies

Keywords
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 126

126

Cyclin-dependent kinase 2-associated protein 2

PRO_0000079963

Secondary structure

1

.

.

.

.

.

.

.

.

.

126

Helix Strand Turn

Details...

Beta strand

67 – 70

4

Helix

72 – 85

14

Helix

88 – 92

5

Helix

96 – 120

25

Sequences

	Sequence		Length	Mass (Da)
	O75956 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: D668D3FA8CE70CA5	FASTA	126	13,101
	10 20 30 40 50 60 MSYKPIAPAP SSTPGSSTPG PGTPVPTGSV PSPSGSVPGA GAPFRPLFND FGPPSMGYVQ 70 80 90 100 110 120 AMKPPGAQGS QSTYTDLLSV IEEMGKEIRP TYAGSKSAME RLKRGIIHAR ALVRECLAET ERNART

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene." Zhang X., Tsao H., Tsuji T., Minoshima S., McBride J., Majewski P., Todd R., Shimizu N., Wong D.T., Housman D.E., Haluska F.G. Biochem. Biophys. Res. Commun. 255:59-63(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF089814 mRNA. Translation: AAC61745.1.
BT006909 mRNA. Translation: AAP35555.1.
BC002850 mRNA. Translation: AAH02850.1.
BC016704 mRNA. Translation: AAH16704.1.

IPI

IPI00027439.

RefSeq

NP_005842.1. NM_005851.4.

UniGene

Hs.523835.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2M1L	NMR	-	A/B	61-126	[»]

ProteinModelPortal

O75956.

ModBase

Search...

Protein-protein interaction databases

IntAct

O75956. 4 interactions.

MINT

MINT-1408989.

STRING

9606.ENSP00000301488.

PTM databases

PhosphoSite

O75956.

Proteomic databases

PaxDb

O75956.

PRIDE

O75956.

Protocols and materials databases

DNASU

10263.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000301488; ENSP00000301488; ENSG00000167797.

GeneID

10263.

KEGG

hsa:10263.

UCSC

uc001oma.3. human.

Organism-specific databases

CTD

10263.

GeneCards

GC11M067273.

HGNC

HGNC:30833. CDK2AP2.

HPA

HPA047599.

neXtProt

NX_O75956.

PharmGKB

PA128394572.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG235568.

HOGENOM

HOG000035115.

HOVERGEN

HBG002074.

InParanoid

O75956.

OMA

MKPPGTQ.

OrthoDB

EOG4DZ1WW.

PhylomeDB

O75956.

Gene expression databases

ArrayExpress

O75956.

Bgee

O75956.

CleanEx

HS_CDK2AP2.

Genevestigator

O75956.

GermOnline

ENSG00000167797. Homo sapiens.

Family and domain databases

InterPro

IPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]

Pfam

PF09806. CDK2AP. 1 hit.
[Graphical view]

PIRSF

PIRSF037709. CDK2-associated_p2. 1 hit.

ProtoNet

Search...

Other

BindingDB

O75956.

ChEMBL

CHEMBL6010.

ChiTaRS

CDK2AP2. human.

GenomeRNAi

10263.

NextBio

38884.

Entry information

Entry name

CDKA2_HUMAN

Accession

Primary (citable) accession number: O75956

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.