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Protein

Cyclin-dependent kinase 2-associated protein 2

Gene

CDK2AP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 2
Short name:
CDK2-associated protein 2
Alternative name(s):
DOC-1-related protein
Short name:
DOC-1R
Gene namesi
Name:CDK2AP2
Synonyms:DOC1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:30833. CDK2AP2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126Cyclin-dependent kinase 2-associated protein 2PRO_0000079963Add
BLAST

Proteomic databases

MaxQBiO75956.
PaxDbiO75956.
PRIDEiO75956.

PTM databases

PhosphoSiteiO75956.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO75956.
CleanExiHS_CDK2AP2.
ExpressionAtlasiO75956. baseline and differential.
GenevestigatoriO75956.

Organism-specific databases

HPAiHPA047599.

Interactioni

Protein-protein interaction databases

BioGridi115555. 16 interactions.
IntActiO75956. 17 interactions.
MINTiMINT-1408989.
STRINGi9606.ENSP00000301488.

Structurei

Secondary structure

1
126
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi67 – 704Combined sources
Helixi72 – 8514Combined sources
Helixi88 – 925Combined sources
Helixi96 – 12025Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M1LNMR-A/B61-126[»]
ProteinModelPortaliO75956.
SMRiO75956. Positions 61-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDK2AP family.Curated

Phylogenomic databases

eggNOGiNOG235568.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiO75956.
OMAiMKPPGTQ.
OrthoDBiEOG71RXN6.
PhylomeDBiO75956.
TreeFamiTF101037.

Family and domain databases

InterProiIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamiPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

O75956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKPIAPAP SSTPGSSTPG PGTPVPTGSV PSPSGSVPGA GAPFRPLFND
60 70 80 90 100
FGPPSMGYVQ AMKPPGAQGS QSTYTDLLSV IEEMGKEIRP TYAGSKSAME
110 120
RLKRGIIHAR ALVRECLAET ERNART
Length:126
Mass (Da):13,101
Last modified:November 1, 1998 - v1
Checksum:iD668D3FA8CE70CA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089814 mRNA. Translation: AAC61745.1.
BT006909 mRNA. Translation: AAP35555.1.
BC002850 mRNA. Translation: AAH02850.1.
BC016704 mRNA. Translation: AAH16704.1.
CCDSiCCDS8169.1.
RefSeqiNP_005842.1. NM_005851.4.
UniGeneiHs.523835.

Genome annotation databases

EnsembliENST00000301488; ENSP00000301488; ENSG00000167797.
GeneIDi10263.
KEGGihsa:10263.
UCSCiuc001oma.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089814 mRNA. Translation: AAC61745.1.
BT006909 mRNA. Translation: AAP35555.1.
BC002850 mRNA. Translation: AAH02850.1.
BC016704 mRNA. Translation: AAH16704.1.
CCDSiCCDS8169.1.
RefSeqiNP_005842.1. NM_005851.4.
UniGeneiHs.523835.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M1LNMR-A/B61-126[»]
ProteinModelPortaliO75956.
SMRiO75956. Positions 61-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115555. 16 interactions.
IntActiO75956. 17 interactions.
MINTiMINT-1408989.
STRINGi9606.ENSP00000301488.

Chemistry

BindingDBiO75956.
ChEMBLiCHEMBL6010.

PTM databases

PhosphoSiteiO75956.

Proteomic databases

MaxQBiO75956.
PaxDbiO75956.
PRIDEiO75956.

Protocols and materials databases

DNASUi10263.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301488; ENSP00000301488; ENSG00000167797.
GeneIDi10263.
KEGGihsa:10263.
UCSCiuc001oma.4. human.

Organism-specific databases

CTDi10263.
GeneCardsiGC11M067273.
HGNCiHGNC:30833. CDK2AP2.
HPAiHPA047599.
neXtProtiNX_O75956.
PharmGKBiPA128394572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG235568.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiO75956.
OMAiMKPPGTQ.
OrthoDBiEOG71RXN6.
PhylomeDBiO75956.
TreeFamiTF101037.

Miscellaneous databases

ChiTaRSiCDK2AP2. human.
GenomeRNAii10263.
NextBioi38884.
PROiO75956.

Gene expression databases

BgeeiO75956.
CleanExiHS_CDK2AP2.
ExpressionAtlasiO75956. baseline and differential.
GenevestigatoriO75956.

Family and domain databases

InterProiIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamiPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene."
    Zhang X., Tsao H., Tsuji T., Minoshima S., McBride J., Majewski P., Todd R., Shimizu N., Wong D.T., Housman D.E., Haluska F.G.
    Biochem. Biophys. Res. Commun. 255:59-63(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.

Entry informationi

Entry nameiCDKA2_HUMAN
AccessioniPrimary (citable) accession number: O75956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.