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Protein

Cyclin-dependent kinase 2-associated protein 2

Gene

CDK2AP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 2
Short name:
CDK2-associated protein 2
Alternative name(s):
DOC-1-related protein
Short name:
DOC-1R
Gene namesi
Name:CDK2AP2
Synonyms:DOC1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000167797.7
HGNCiHGNC:30833 CDK2AP2
neXtProtiNX_O75956

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10263
OpenTargetsiENSG00000167797
PharmGKBiPA128394572

Chemistry databases

ChEMBLiCHEMBL6010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799631 – 126Cyclin-dependent kinase 2-associated protein 2Add BLAST126

Post-translational modificationi

Phosphorylated by MAPK1 and CDK2.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75956
PaxDbiO75956
PeptideAtlasiO75956
PRIDEiO75956

PTM databases

iPTMnetiO75956
PhosphoSitePlusiO75956

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000167797
CleanExiHS_CDK2AP2
ExpressionAtlasiO75956 baseline and differential
GenevisibleiO75956 HS

Organism-specific databases

HPAiHPA047599

Interactioni

Subunit structurei

Interacts with CDK2AP1 (PubMed:14985111). Interacts with CDK2 (PubMed:23781148). Interacts with MAPK1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi115555, 16 interactors
IntActiO75956, 19 interactors
MINTiO75956
STRINGi9606.ENSP00000301488

Chemistry databases

BindingDBiO75956

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi67 – 70Combined sources4
Helixi72 – 85Combined sources14
Helixi88 – 92Combined sources5
Helixi96 – 120Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M1LNMR-A/B61-126[»]
ProteinModelPortaliO75956
SMRiO75956
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 106Interaction with CDK21 PublicationAdd BLAST43

Sequence similaritiesi

Belongs to the CDK2AP family.Curated

Phylogenomic databases

eggNOGiKOG4713 Eukaryota
ENOG41126TJ LUCA
GeneTreeiENSGT00390000006964
HOGENOMiHOG000035115
HOVERGENiHBG002074
InParanoidiO75956
OMAiMKPPGTQ
OrthoDBiEOG091G1364
PhylomeDBiO75956
TreeFamiTF101037

Family and domain databases

InterProiView protein in InterPro
IPR017266 DOC_1/2
PANTHERiPTHR22607 PTHR22607, 1 hit
PfamiView protein in Pfam
PF09806 CDK2AP, 1 hit
PIRSFiPIRSF037709 CDK2-associated_p2, 1 hit

Sequencei

Sequence statusi: Complete.

O75956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKPIAPAP SSTPGSSTPG PGTPVPTGSV PSPSGSVPGA GAPFRPLFND
60 70 80 90 100
FGPPSMGYVQ AMKPPGAQGS QSTYTDLLSV IEEMGKEIRP TYAGSKSAME
110 120
RLKRGIIHAR ALVRECLAET ERNART
Length:126
Mass (Da):13,101
Last modified:November 1, 1998 - v1
Checksum:iD668D3FA8CE70CA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089814 mRNA Translation: AAC61745.1
BT006909 mRNA Translation: AAP35555.1
BC002850 mRNA Translation: AAH02850.1
BC016704 mRNA Translation: AAH16704.1
CCDSiCCDS8169.1
RefSeqiNP_005842.1, NM_005851.4
UniGeneiHs.523835

Genome annotation databases

EnsembliENST00000301488; ENSP00000301488; ENSG00000167797
GeneIDi10263
KEGGihsa:10263

Similar proteinsi

Entry informationi

Entry nameiCDKA2_HUMAN
AccessioniPrimary (citable) accession number: O75956
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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