Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O75955

- FLOT1_HUMAN

UniProt

O75955 - FLOT1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Flotillin-1

Gene

FLOT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

GO - Molecular functioni

  1. protease binding Source: UniProtKB

GO - Biological processi

  1. axonogenesis Source: Ensembl
  2. establishment of protein localization to plasma membrane Source: UniProtKB
  3. extracellular matrix disassembly Source: UniProt
  4. regulation of Rho protein signal transduction Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Flotillin-1
Gene namesi
Name:FLOT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:3757. FLOT1.

Subcellular locationi

Cell membrane; Peripheral membrane protein. Membranecaveola; Peripheral membrane protein. Melanosome. Endosome
Note: Membrane-associated protein of caveolae. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

GO - Cellular componenti

  1. caveola Source: ProtInc
  2. centriolar satellite Source: BHF-UCL
  3. endosome Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProtKB
  5. flotillin complex Source: Ensembl
  6. focal adhesion Source: UniProtKB
  7. integral component of membrane Source: ProtInc
  8. lysosomal membrane Source: UniProtKB
  9. membrane Source: UniProtKB
  10. membrane raft Source: BHF-UCL
  11. microtubule organizing center Source: BHF-UCL
  12. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Flotillin-1PRO_0000094044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Phosphoserine1 Publication
Modified residuei385 – 3851Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75955.
PaxDbiO75955.
PRIDEiO75955.

PTM databases

PhosphoSiteiO75955.

Expressioni

Gene expression databases

BgeeiO75955.
CleanExiHS_FLOT1.
ExpressionAtlasiO75955. baseline and differential.
GenevestigatoriO75955.

Organism-specific databases

HPAiCAB007766.
HPA001393.

Interactioni

Subunit structurei

Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECM29.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APPP050675EBI-603643,EBI-77613
FLOT2Q142543EBI-603643,EBI-348613

Protein-protein interaction databases

BioGridi115506. 70 interactions.
IntActiO75955. 23 interactions.
MINTiMINT-3002104.
STRINGi9606.ENSP00000372873.

Structurei

3D structure databases

ProteinModelPortaliO75955.
SMRiO75955. Positions 39-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2268.
HOGENOMiHOG000240804.
HOVERGENiHBG051628.
InParanoidiO75955.
KOiK07192.
OMAiNEIDMAK.
PhylomeDBiO75955.
TreeFamiTF324879.

Family and domain databases

InterProiIPR001107. Band_7.
IPR027705. Flotillin_fam.
[Graphical view]
PANTHERiPTHR13806. PTHR13806. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
SMARTiSM00244. PHB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75955-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV
60 70 80 90 100
KSEKVYTRHG VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA
110 120 130 140 150
LETLEGHQRA IMAHMTVEEI YKDRQKFSEQ VFKVASSDLV NMGISVVSYT
160 170 180 190 200
LKDIHDDQDY LHSLGKARTA QVQKDARIGE AEAKRDAGIR EAKAKQEKVS
210 220 230 240 250
AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL QVAKTKQQIE
260 270 280 290 300
EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA
310 320 330 340 350
EKSQLIMQAE AEAASVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE
360 370 380 390 400
AAQLDMLLEK LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI
410 420
LTRLPESVER LTGVSISQVN HKPLRTA
Length:427
Mass (Da):47,355
Last modified:November 28, 2002 - v3
Checksum:iC69E5421E565F53A
GO
Isoform 2 (identifier: O75955-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-118: Missing.

Note: No experimental confirmation available.

Show »
Length:379
Mass (Da):42,080
Checksum:iA21608A67DF4509E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141H → N in AAD40192. (PubMed:11042152)Curated
Sequence conflicti114 – 1141H → N in AAF17215. (PubMed:10931946)Curated
Sequence conflicti250 – 2534EEQR → DFSQ in AAF17215. (PubMed:10931946)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521S → N.
Corresponds to variant rs3180825 [ dbSNP | Ensembl ].
VAR_048415

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei71 – 11848Missing in isoform 2. 1 PublicationVSP_056227Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089750 mRNA. Translation: AAC35387.1.
AF085357 mRNA. Translation: AAD40192.1.
BA000025 Genomic DNA. Translation: BAB63320.1.
AK301291 mRNA. Translation: BAG62849.1.
AL662797 Genomic DNA. No translation available.
BC001146 mRNA. Translation: AAH01146.1.
AF117234 mRNA. Translation: AAF17215.1.
CCDSiCCDS4688.1. [O75955-1]
RefSeqiNP_005794.1. NM_005803.2.
XP_005248837.1. XM_005248780.2.
XP_005248838.1. XM_005248781.2.
XP_005272816.1. XM_005272759.2.
XP_005272817.1. XM_005272760.2.
XP_005274966.1. XM_005274909.2.
XP_005274967.1. XM_005274910.2.
XP_005275392.1. XM_005275335.2.
XP_005275393.1. XM_005275336.2.
XP_005275559.1. XM_005275502.2.
XP_005275560.1. XM_005275503.2.
UniGeneiHs.179986.

Genome annotation databases

EnsembliENST00000376389; ENSP00000365569; ENSG00000137312. [O75955-1]
ENST00000383382; ENSP00000372873; ENSG00000206379. [O75955-1]
ENST00000383562; ENSP00000373056; ENSG00000206480. [O75955-1]
ENST00000436822; ENSP00000391438; ENSG00000232280. [O75955-1]
ENST00000444632; ENSP00000388861; ENSG00000230143. [O75955-1]
GeneIDi10211.
KEGGihsa:10211.
UCSCiuc003nrm.3. human. [O75955-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089750 mRNA. Translation: AAC35387.1 .
AF085357 mRNA. Translation: AAD40192.1 .
BA000025 Genomic DNA. Translation: BAB63320.1 .
AK301291 mRNA. Translation: BAG62849.1 .
AL662797 Genomic DNA. No translation available.
BC001146 mRNA. Translation: AAH01146.1 .
AF117234 mRNA. Translation: AAF17215.1 .
CCDSi CCDS4688.1. [O75955-1 ]
RefSeqi NP_005794.1. NM_005803.2.
XP_005248837.1. XM_005248780.2.
XP_005248838.1. XM_005248781.2.
XP_005272816.1. XM_005272759.2.
XP_005272817.1. XM_005272760.2.
XP_005274966.1. XM_005274909.2.
XP_005274967.1. XM_005274910.2.
XP_005275392.1. XM_005275335.2.
XP_005275393.1. XM_005275336.2.
XP_005275559.1. XM_005275502.2.
XP_005275560.1. XM_005275503.2.
UniGenei Hs.179986.

3D structure databases

ProteinModelPortali O75955.
SMRi O75955. Positions 39-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115506. 70 interactions.
IntActi O75955. 23 interactions.
MINTi MINT-3002104.
STRINGi 9606.ENSP00000372873.

PTM databases

PhosphoSitei O75955.

Proteomic databases

MaxQBi O75955.
PaxDbi O75955.
PRIDEi O75955.

Protocols and materials databases

DNASUi 10211.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376389 ; ENSP00000365569 ; ENSG00000137312 . [O75955-1 ]
ENST00000383382 ; ENSP00000372873 ; ENSG00000206379 . [O75955-1 ]
ENST00000383562 ; ENSP00000373056 ; ENSG00000206480 . [O75955-1 ]
ENST00000436822 ; ENSP00000391438 ; ENSG00000232280 . [O75955-1 ]
ENST00000444632 ; ENSP00000388861 ; ENSG00000230143 . [O75955-1 ]
GeneIDi 10211.
KEGGi hsa:10211.
UCSCi uc003nrm.3. human. [O75955-1 ]

Organism-specific databases

CTDi 10211.
GeneCardsi GC06M030695.
GC06Mj30685.
GC06Mk30685.
GC06Mn30685.
GC06Mo30686.
H-InvDB HIX0166980.
HGNCi HGNC:3757. FLOT1.
HPAi CAB007766.
HPA001393.
MIMi 606998. gene.
neXtProti NX_O75955.
PharmGKBi PA28175.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2268.
HOGENOMi HOG000240804.
HOVERGENi HBG051628.
InParanoidi O75955.
KOi K07192.
OMAi NEIDMAK.
PhylomeDBi O75955.
TreeFami TF324879.

Miscellaneous databases

ChiTaRSi FLOT1. human.
GeneWikii FLOT1.
GenomeRNAii 10211.
NextBioi 35475588.
PROi O75955.
SOURCEi Search...

Gene expression databases

Bgeei O75955.
CleanExi HS_FLOT1.
ExpressionAtlasi O75955. baseline and differential.
Genevestigatori O75955.

Family and domain databases

InterProi IPR001107. Band_7.
IPR027705. Flotillin_fam.
[Graphical view ]
PANTHERi PTHR13806. PTHR13806. 1 hit.
Pfami PF01145. Band_7. 1 hit.
[Graphical view ]
SMARTi SM00244. PHB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals."
    Edgar A.J., Polak J.M.
    Int. J. Biochem. Cell Biol. 33:53-64(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Stomach.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-253 (ISOFORM 1).
    Tissue: Adrenal gland.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Melanoma.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-385, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."
    Gorbea C., Pratt G., Ustrell V., Bell R., Sahasrabudhe S., Hughes R.E., Rechsteiner M.
    J. Biol. Chem. 285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ECM29.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFLOT1_HUMAN
AccessioniPrimary (citable) accession number: O75955
Secondary accession number(s): B4DVY7
, Q969J8, Q9UHW1, Q9UNV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 28, 2002
Last modified: October 29, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3