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Protein

Flotillin-1

Gene

FLOT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: Ensembl
  • protease binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  • axonogenesis Source: Ensembl
  • cellular response to exogenous dsRNA Source: UniProtKB
  • dsRNA transport Source: UniProtKB
  • extracellular matrix disassembly Source: UniProtKB
  • membrane raft assembly Source: UniProtKB
  • plasma membrane raft assembly Source: UniProtKB
  • positive regulation of cell adhesion molecule production Source: UniProtKB
  • positive regulation of cell-cell adhesion mediated by cadherin Source: UniProtKB
  • positive regulation of cell junction assembly Source: UniProtKB
  • positive regulation of cytokine production Source: UniProtKB
  • positive regulation of endocytosis Source: UniProtKB
  • positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
  • positive regulation of interferon-beta production Source: UniProtKB
  • positive regulation of myoblast fusion Source: UniProtKB
  • positive regulation of protein binding Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of skeletal muscle tissue development Source: UniProtKB
  • positive regulation of synaptic transmission, dopaminergic Source: UniProtKB
  • positive regulation of toll-like receptor 3 signaling pathway Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
  • protein kinase C signaling Source: UniProtKB
  • protein localization to membrane raft Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • regulation of receptor internalization Source: UniProtKB
  • regulation of Rho protein signal transduction Source: Ensembl
  • response to endoplasmic reticulum stress Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-8849932 Synaptic adhesion-like molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Flotillin-1
Gene namesi
Name:FLOT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137312.14
HGNCiHGNC:3757 FLOT1
MIMi606998 gene
neXtProtiNX_O75955

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10211
OpenTargetsiENSG00000137312
PharmGKBiPA28175

Polymorphism and mutation databases

BioMutaiFLOT1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000940441 – 427Flotillin-1Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei387PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75955
PaxDbiO75955
PeptideAtlasiO75955
PRIDEiO75955
ProteomicsDBi50321

PTM databases

iPTMnetiO75955
PhosphoSitePlusiO75955
SwissPalmiO75955

Expressioni

Gene expression databases

BgeeiENSG00000137312
CleanExiHS_FLOT1
ExpressionAtlasiO75955 baseline and differential
GenevisibleiO75955 HS

Organism-specific databases

HPAiCAB007766
HPA001393

Interactioni

Subunit structurei

Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECPAS.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: Ensembl
  • protease binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115506, 121 interactors
CORUMiO75955
IntActiO75955, 68 interactors
MINTiO75955
STRINGi9606.ENSP00000365569

Structurei

3D structure databases

ProteinModelPortaliO75955
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2668 Eukaryota
COG2268 LUCA
GeneTreeiENSGT00560000077232
HOGENOMiHOG000240804
HOVERGENiHBG051628
InParanoidiO75955
KOiK07192
OMAiQYDSEVK
OrthoDBiEOG091G0D3R
PhylomeDBiO75955
TreeFamiTF324879

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR031905 Flotillin_C
IPR027705 Flotillin_fam
PANTHERiPTHR13806 PTHR13806, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PF15975 Flot, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75955-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV
60 70 80 90 100
KSEKVYTRHG VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA
110 120 130 140 150
LETLEGHQRA IMAHMTVEEI YKDRQKFSEQ VFKVASSDLV NMGISVVSYT
160 170 180 190 200
LKDIHDDQDY LHSLGKARTA QVQKDARIGE AEAKRDAGIR EAKAKQEKVS
210 220 230 240 250
AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL QVAKTKQQIE
260 270 280 290 300
EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA
310 320 330 340 350
EKSQLIMQAE AEAASVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE
360 370 380 390 400
AAQLDMLLEK LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI
410 420
LTRLPESVER LTGVSISQVN HKPLRTA
Length:427
Mass (Da):47,355
Last modified:November 28, 2002 - v3
Checksum:iC69E5421E565F53A
GO
Isoform 2 (identifier: O75955-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-118: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):42,080
Checksum:iA21608A67DF4509E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114H → N in AAD40192 (PubMed:11042152).Curated1
Sequence conflicti114H → N in AAF17215 (PubMed:10931946).Curated1
Sequence conflicti250 – 253EEQR → DFSQ in AAF17215 (PubMed:10931946).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04841552S → N. Corresponds to variant dbSNP:rs3180825Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05622771 – 118Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089750 mRNA Translation: AAC35387.1
AF085357 mRNA Translation: AAD40192.1
BA000025 Genomic DNA Translation: BAB63320.1
AK301291 mRNA Translation: BAG62849.1
AL662797 Genomic DNA No translation available.
BC001146 mRNA Translation: AAH01146.1
AF117234 mRNA Translation: AAF17215.1
CCDSiCCDS4688.1 [O75955-1]
RefSeqiNP_001305804.1, NM_001318875.1 [O75955-2]
NP_005794.1, NM_005803.3 [O75955-1]
XP_005248837.1, XM_005248780.3 [O75955-1]
UniGeneiHs.179986

Genome annotation databases

EnsembliENST00000376389; ENSP00000365569; ENSG00000137312 [O75955-1]
ENST00000383382; ENSP00000372873; ENSG00000206379 [O75955-1]
ENST00000383562; ENSP00000373056; ENSG00000206480 [O75955-1]
ENST00000436822; ENSP00000391438; ENSG00000232280 [O75955-1]
ENST00000444632; ENSP00000388861; ENSG00000230143 [O75955-1]
GeneIDi10211
KEGGihsa:10211

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFLOT1_HUMAN
AccessioniPrimary (citable) accession number: O75955
Secondary accession number(s): B4DVY7
, Q969J8, Q9UHW1, Q9UNV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 28, 2002
Last modified: June 20, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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