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O75954

- TSN9_HUMAN

UniProt

O75954 - TSN9_HUMAN

Protein

Tetraspanin-9

Gene

TSPAN9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-9
    Short name:
    Tspan-9
    Alternative name(s):
    Tetraspan NET-5
    Gene namesi
    Name:TSPAN9
    Synonyms:NET5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:21640. TSPAN9.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity
    Note: Colocalizes with GP6 in tetraspanin microdomains on the platelet surface.By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670694.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239Tetraspanin-9PRO_0000219253Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO75954.
    PaxDbiO75954.
    PRIDEiO75954.

    Expressioni

    Tissue specificityi

    Expressed in megakaryocytes and platelets (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiO75954.
    BgeeiO75954.
    CleanExiHS_TSPAN9.
    GenevestigatoriO75954.

    Organism-specific databases

    HPAiHPA014002.

    Interactioni

    Subunit structurei

    Found in a complex with GP6.By similarity

    Protein-protein interaction databases

    BioGridi116076. 2 interactions.
    IntActiO75954. 1 interaction.
    MINTiMINT-6772283.

    Structurei

    3D structure databases

    ProteinModelPortaliO75954.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 5521ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 859CytoplasmicSequence Analysis
    Topological domaini107 – 20397ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 23915CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290117.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    KOiK17350.
    OMAiDSCCRQL.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiO75954.
    TreeFamiTF352892.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O75954-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGCLCCLK YMMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS    50
    LSAANLVIAI GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LVILLAELIL 100
    LILFFVYMDK VNENAKKDLK EGLLLYHTEN NVGLKNAWNI IQAEMRCCGV 150
    TDYTDWYPVL GENTVPDRCC MENSQGCGRN ATTPLWRTGC YEKVKMWFDD 200
    NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA 239
    Length:239
    Mass (Da):26,779
    Last modified:November 1, 1998 - v1
    Checksum:iDD7BA332BF6584EB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti216 – 2161Q → R in BAD96899. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089749 mRNA. Translation: AAC35859.1.
    AK027366 mRNA. Translation: BAG51307.1.
    CR542109 mRNA. Translation: CAG46906.1.
    AK223179 mRNA. Translation: BAD96899.1.
    AC005912 Genomic DNA. No translation available.
    CH471116 Genomic DNA. Translation: EAW88868.1.
    CH471116 Genomic DNA. Translation: EAW88869.1.
    BC071881 mRNA. Translation: AAH71881.1.
    CCDSiCCDS8520.1.
    RefSeqiNP_001161792.1. NM_001168320.1.
    NP_006666.1. NM_006675.4.
    UniGeneiHs.504517.

    Genome annotation databases

    EnsembliENST00000011898; ENSP00000011898; ENSG00000011105.
    ENST00000537971; ENSP00000444799; ENSG00000011105.
    GeneIDi10867.
    KEGGihsa:10867.
    UCSCiuc001qlp.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089749 mRNA. Translation: AAC35859.1 .
    AK027366 mRNA. Translation: BAG51307.1 .
    CR542109 mRNA. Translation: CAG46906.1 .
    AK223179 mRNA. Translation: BAD96899.1 .
    AC005912 Genomic DNA. No translation available.
    CH471116 Genomic DNA. Translation: EAW88868.1 .
    CH471116 Genomic DNA. Translation: EAW88869.1 .
    BC071881 mRNA. Translation: AAH71881.1 .
    CCDSi CCDS8520.1.
    RefSeqi NP_001161792.1. NM_001168320.1.
    NP_006666.1. NM_006675.4.
    UniGenei Hs.504517.

    3D structure databases

    ProteinModelPortali O75954.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116076. 2 interactions.
    IntActi O75954. 1 interaction.
    MINTi MINT-6772283.

    Proteomic databases

    MaxQBi O75954.
    PaxDbi O75954.
    PRIDEi O75954.

    Protocols and materials databases

    DNASUi 10867.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000011898 ; ENSP00000011898 ; ENSG00000011105 .
    ENST00000537971 ; ENSP00000444799 ; ENSG00000011105 .
    GeneIDi 10867.
    KEGGi hsa:10867.
    UCSCi uc001qlp.3. human.

    Organism-specific databases

    CTDi 10867.
    GeneCardsi GC12P003186.
    HGNCi HGNC:21640. TSPAN9.
    HPAi HPA014002.
    MIMi 613137. gene.
    neXtProti NX_O75954.
    PharmGKBi PA142670694.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290117.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    KOi K17350.
    OMAi DSCCRQL.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi O75954.
    TreeFami TF352892.

    Miscellaneous databases

    ChiTaRSi TSPAN9. human.
    GenomeRNAii 10867.
    NextBioi 41261.
    PROi O75954.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75954.
    Bgeei O75954.
    CleanExi HS_TSPAN9.
    Genevestigatori O75954.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Salivary gland.
    8. "Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains."
      Protty M.B., Watkins N.A., Colombo D., Thomas S.G., Heath V.L., Herbert J.M., Bicknell R., Senis Y.A., Ashman L.K., Berditchevski F., Ouwehand W.H., Watson S.P., Tomlinson M.G.
      Biochem. J. 417:391-400(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTSN9_HUMAN
    AccessioniPrimary (citable) accession number: O75954
    Secondary accession number(s): D3DUQ7, Q53FV2, Q6FGJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3