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Protein

Tetraspanin-9

Gene

TSPAN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011105-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-9
Short name:
Tspan-9
Alternative name(s):
Tetraspan NET-5
Gene namesi
Name:TSPAN9
Synonyms:NET5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:21640. TSPAN9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 55ExtracellularSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 85CytoplasmicSequence analysis9
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 203ExtracellularSequence analysisAdd BLAST97
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 239CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: UniProtKB
  • tetraspanin-enriched microdomain Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10867.
OpenTargetsiENSG00000011105.
PharmGKBiPA142670694.

Polymorphism and mutation databases

BioMutaiTSPAN9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192531 – 239Tetraspanin-9Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75954.
PaxDbiO75954.
PeptideAtlasiO75954.
PRIDEiO75954.

PTM databases

SwissPalmiO75954.

Expressioni

Tissue specificityi

Expressed in megakaryocytes and platelets (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000011105.
CleanExiHS_TSPAN9.
ExpressionAtlasiO75954. baseline and differential.
GenevisibleiO75954. HS.

Organism-specific databases

HPAiHPA014002.

Interactioni

Subunit structurei

Found in a complex with GP6.By similarity

Protein-protein interaction databases

BioGridi116076. 1 interactor.
IntActiO75954. 1 interactor.
MINTiMINT-6772283.
STRINGi9606.ENSP00000011898.

Structurei

3D structure databases

ProteinModelPortaliO75954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO75954.
KOiK17350.
OMAiNENAKQD.
PhylomeDBiO75954.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGCLCCLK YMMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS
60 70 80 90 100
LSAANLVIAI GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LVILLAELIL
110 120 130 140 150
LILFFVYMDK VNENAKKDLK EGLLLYHTEN NVGLKNAWNI IQAEMRCCGV
160 170 180 190 200
TDYTDWYPVL GENTVPDRCC MENSQGCGRN ATTPLWRTGC YEKVKMWFDD
210 220 230
NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA
Length:239
Mass (Da):26,779
Last modified:November 1, 1998 - v1
Checksum:iDD7BA332BF6584EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216Q → R in BAD96899 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089749 mRNA. Translation: AAC35859.1.
AK027366 mRNA. Translation: BAG51307.1.
CR542109 mRNA. Translation: CAG46906.1.
AK223179 mRNA. Translation: BAD96899.1.
AC005912 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88868.1.
CH471116 Genomic DNA. Translation: EAW88869.1.
BC071881 mRNA. Translation: AAH71881.1.
CCDSiCCDS8520.1.
RefSeqiNP_001161792.1. NM_001168320.1.
NP_006666.1. NM_006675.4.
UniGeneiHs.504517.

Genome annotation databases

EnsembliENST00000011898; ENSP00000011898; ENSG00000011105.
ENST00000537971; ENSP00000444799; ENSG00000011105.
GeneIDi10867.
KEGGihsa:10867.
UCSCiuc001qlp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089749 mRNA. Translation: AAC35859.1.
AK027366 mRNA. Translation: BAG51307.1.
CR542109 mRNA. Translation: CAG46906.1.
AK223179 mRNA. Translation: BAD96899.1.
AC005912 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88868.1.
CH471116 Genomic DNA. Translation: EAW88869.1.
BC071881 mRNA. Translation: AAH71881.1.
CCDSiCCDS8520.1.
RefSeqiNP_001161792.1. NM_001168320.1.
NP_006666.1. NM_006675.4.
UniGeneiHs.504517.

3D structure databases

ProteinModelPortaliO75954.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116076. 1 interactor.
IntActiO75954. 1 interactor.
MINTiMINT-6772283.
STRINGi9606.ENSP00000011898.

PTM databases

SwissPalmiO75954.

Polymorphism and mutation databases

BioMutaiTSPAN9.

Proteomic databases

MaxQBiO75954.
PaxDbiO75954.
PeptideAtlasiO75954.
PRIDEiO75954.

Protocols and materials databases

DNASUi10867.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000011898; ENSP00000011898; ENSG00000011105.
ENST00000537971; ENSP00000444799; ENSG00000011105.
GeneIDi10867.
KEGGihsa:10867.
UCSCiuc001qlp.4. human.

Organism-specific databases

CTDi10867.
DisGeNETi10867.
GeneCardsiTSPAN9.
HGNCiHGNC:21640. TSPAN9.
HPAiHPA014002.
MIMi613137. gene.
neXtProtiNX_O75954.
OpenTargetsiENSG00000011105.
PharmGKBiPA142670694.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO75954.
KOiK17350.
OMAiNENAKQD.
PhylomeDBiO75954.
TreeFamiTF352892.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011105-MONOMER.

Miscellaneous databases

ChiTaRSiTSPAN9. human.
GenomeRNAii10867.
PROiO75954.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011105.
CleanExiHS_TSPAN9.
ExpressionAtlasiO75954. baseline and differential.
GenevisibleiO75954. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN9_HUMAN
AccessioniPrimary (citable) accession number: O75954
Secondary accession number(s): D3DUQ7, Q53FV2, Q6FGJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.