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Protein

Calcium-binding tyrosine phosphorylation-regulated protein

Gene

CABYR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

GO - Molecular functioni

  • calcium ion binding Source: BHF-UCL
  • enzyme binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • SH3 domain binding Source: BHF-UCL

GO - Biological processi

  • epithelial cilium movement Source: BHF-UCL
  • sperm capacitation Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

SIGNORiO75952.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding tyrosine phosphorylation-regulated protein
Alternative name(s):
Calcium-binding protein 86
Cancer/testis antigen 88
Short name:
CT88
Fibrousheathin II
Fibrousheathin-2
Short name:
FSP-2
Testis-specific calcium-binding protein CBP86
Gene namesi
Name:CABYR
Synonyms:CBP86, FSP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:15569. CABYR.

Subcellular locationi

Isoform 1 :
Isoform 3 :
Isoform 5 :

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytoskeleton Source: UniProtKB-SubCell
  • motile cilium Source: BHF-UCL
  • nucleus Source: UniProtKB
  • sperm end piece Source: Ensembl
  • sperm fibrous sheath Source: BHF-UCL
  • sperm principal piece Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi146T → A: Does not affect phosphorylation. 1 Publication1
Mutagenesisi151T → A: Decreases phosphorylation. Abolishes phosphorylation; when associated with A-155. 1 Publication1
Mutagenesisi154S → A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-159. 1 Publication1
Mutagenesisi155S → A: Decreases phosphorylation and interaction with GSK3B. Abolishes phosphorylation and decreases interaction with GSK3B; when associated with A-151. 1 Publication1
Mutagenesisi159T → A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-154. 1 Publication1

Organism-specific databases

DisGeNETi26256.
OpenTargetsiENSG00000154040.
PharmGKBiPA26005.

Polymorphism and mutation databases

BioMutaiCABYR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892681 – 493Calcium-binding tyrosine phosphorylation-regulated proteinAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151Phosphothreonine1 Publication1
Modified residuei155Phosphoserine1 Publication1

Post-translational modificationi

Isoform 1 is phosphorylated on tyrosine residues during in vitro capacitation. Isoform 3 and isoform 5 are phosphorylated by GSK3B in vitro. Dephosphorylation affects its ability to bind calcium.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75952.
PaxDbiO75952.
PeptideAtlasiO75952.
PRIDEiO75952.

PTM databases

iPTMnetiO75952.
PhosphoSitePlusiO75952.

Expressioni

Tissue specificityi

Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors.3 Publications

Gene expression databases

BgeeiENSG00000154040.
CleanExiHS_CABYR.
ExpressionAtlasiO75952. baseline and differential.
GenevisibleiO75952. HS.

Organism-specific databases

HPAiHPA040703.
HPA047801.

Interactioni

Subunit structurei

Interacts with FSCB (By similarity). Isoform 3 self-associates. Isoform 3 and isoform 5 interact with GSK3B. Isoform 1 does not interact with GSK3B.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GSK3BP498413EBI-10900795,EBI-373586

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • SH3 domain binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi117642. 2 interactors.
IntActiO75952. 1 interactor.
STRINGi9606.ENSP00000432870.

Structurei

3D structure databases

ProteinModelPortaliO75952.
SMRiO75952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 49RIIaAdd BLAST38

Sequence similaritiesi

Contains 1 RIIa domain.Curated

Phylogenomic databases

eggNOGiENOG410IFPT. Eukaryota.
ENOG410ZQAQ. LUCA.
GeneTreeiENSGT00390000000444.
HOVERGENiHBG080982.
InParanoidiO75952.
OMAiEQIVIPF.
OrthoDBiEOG091G18VB.
PhylomeDBiO75952.
TreeFamiTF332959.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
PfamiPF02197. RIIa. 1 hit.
[Graphical view]
SMARTiSM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISSKPRLVV PYGLKTLLEG ISRAVLKTNP SNINQFAAAY FQELTMYRGN
60 70 80 90 100
TTMDIKDLVK QFHQIKVEKW SEGTTPQKKL ECLKEPGKTS VESKVPTQME
110 120 130 140 150
KSTDTDEDNV TRTEYSDKTT QFPSVYAVPG TEQTEAVGGL SSKPATPKTT
160 170 180 190 200
TPPSSPPPTA VSPEFAYVPA DPAQLAAQML GKVSSIHSDQ SDVLMVDVAT
210 220 230 240 250
SMPVVIKEVP SSEAAEDVMV AAPLVCSGKV LEVQVVNQTS VHVDLGSQPK
260 270 280 290 300
ENEAEPSTAS SVPLQDEQEP PAYDQAPEVT LQADIEVMST VHISSVYNDV
310 320 330 340 350
PVTEGVVYIE QLPEQIVIPF TDQVACLKEN EQSKENEQSP RVSPKSVVEK
360 370 380 390 400
TTSGMSKKSV ESVKLAQLEE NAKYSSVYME AEATALLSDT SLKGQPEVPA
410 420 430 440 450
QLLDAEGAIK IGSEKSLHLE VEITSIVSDN TGQEESGENS VPQEMEGKPV
460 470 480 490
LSGEAAEAVH SGTSVKSSSG PFPPAPEGLT APEIEPEGES TAE
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:493
Mass (Da):52,774
Last modified:January 23, 2007 - v2
Checksum:i42F97605262C8199
GO
Isoform 2 (identifier: O75952-2) [UniParc]FASTAAdd to basket
Also known as: CBP86-VII

The sequence of this isoform differs from the canonical sequence as follows:
     49-66: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:475
Mass (Da):50,676
Checksum:i01D34365BEDF945B
GO
Isoform 3 (identifier: O75952-3) [UniParc]FASTAAdd to basket
Also known as: CBP86-II

The sequence of this isoform differs from the canonical sequence as follows:
     181-379: GKVSSIHSDQ...ENAKYSSVYM → AMATSERGQP...HKRRKAETEN
     380-493: Missing.

Show »
Length:379
Mass (Da):41,120
Checksum:i9E6748129EEE16E4
GO
Isoform 4 (identifier: O75952-4) [UniParc]FASTAAdd to basket
Also known as: CBP86-IV

The sequence of this isoform differs from the canonical sequence as follows:
     181-221: GKVSSIHSDQ...SEAAEDVMVA → EDVAKKSSGS...HKRRKAETEN
     222-493: Missing.

Show »
Length:221
Mass (Da):23,964
Checksum:i0C6FA78696F9BF11
GO
Isoform 5 (identifier: O75952-5) [UniParc]FASTAAdd to basket
Also known as: CBP86-III

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     181-379: GKVSSIHSDQ...ENAKYSSVYM → AMATSERGQP...HKRRKAETEN
     380-493: Missing.

Show »
Length:281
Mass (Da):30,053
Checksum:i93966975E7AAFF08
GO
Isoform 6 (identifier: O75952-6) [UniParc]FASTAAdd to basket
Also known as: CBP86-VI

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.

Show »
Length:292
Mass (Da):30,936
Checksum:iE371F64036F2AA37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti423I → V in AAC35373 (PubMed:11820818).Curated1
Sequence conflicti423I → V in AAL56051 (PubMed:11820818).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03004074T → M.Corresponds to variant rs3786417dbSNPEnsembl.1
Natural variantiVAR_050709186I → V.Corresponds to variant rs35118855dbSNPEnsembl.1
Natural variantiVAR_030041448K → R.1 PublicationCorresponds to variant rs1049682dbSNPEnsembl.1
Natural variantiVAR_023818490S → A.1 PublicationCorresponds to variant rs1049683dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0162451 – 201Missing in isoform 6. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_0162461 – 98Missing in isoform 5. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_01624749 – 66Missing in isoform 2. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_016248181 – 379GKVSS…SSVYM → AMATSERGQPPPCSNMWTLY CLTDKNQQGHPSPPPAPGPF PQATLYLPNPKDPQFQQHPP KVTFPTYVMGDTKKTSAPPF ILVGSNVQEAQGWKPLPGHA VVSQSDVLRYVAMQVPIAVP ADEKYQKHTLSPQNANPPSG QDVPRPKSPVFLSVAFPVED VAKKSSGSGDKCAPFGSYGI AGEVTVTTAHKRRKAETEN in isoform 3 and isoform 5. 2 PublicationsAdd BLAST199
Alternative sequenceiVSP_016249181 – 221GKVSS…DVMVA → EDVAKKSSGSGDKCAPFGSY GIAGEVTVTTAHKRRKAETE N in isoform 4. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_016250222 – 493Missing in isoform 4. 1 PublicationAdd BLAST272
Alternative sequenceiVSP_016251380 – 493Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088868 mRNA. Translation: AAC35373.1.
AF295037 mRNA. Translation: AAG17889.1.
AF295038 mRNA. Translation: AAG17890.1.
AF295039 mRNA. Translation: AAG17891.1.
AF329634 mRNA. Translation: AAL56051.1.
AY007205 mRNA. Translation: AAG01891.1.
AK313243 mRNA. Translation: BAG36054.1.
AC090772 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01177.1.
BC011996 mRNA. Translation: AAH11996.1.
CCDSiCCDS11881.1. [O75952-1]
CCDS11882.1. [O75952-2]
CCDS11883.1. [O75952-5]
CCDS42420.1. [O75952-3]
CCDS45840.1. [O75952-4]
RefSeqiNP_036321.2. NM_012189.3. [O75952-1]
NP_619584.1. NM_138643.2. [O75952-5]
NP_619585.1. NM_138644.2. [O75952-3]
NP_722452.1. NM_153768.2. [O75952-2]
NP_722453.1. NM_153769.2. [O75952-3]
NP_722454.1. NM_153770.2. [O75952-4]
XP_016881195.1. XM_017025706.1. [O75952-1]
UniGeneiHs.511983.

Genome annotation databases

EnsembliENST00000327201; ENSP00000317095; ENSG00000154040. [O75952-5]
ENST00000399481; ENSP00000382404; ENSG00000154040. [O75952-2]
ENST00000399496; ENSP00000382419; ENSG00000154040. [O75952-3]
ENST00000399499; ENSP00000382421; ENSG00000154040. [O75952-3]
ENST00000415309; ENSP00000399973; ENSG00000154040. [O75952-4]
ENST00000463087; ENSP00000432870; ENSG00000154040. [O75952-1]
ENST00000486759; ENSP00000431142; ENSG00000154040. [O75952-1]
ENST00000621648; ENSP00000483621; ENSG00000154040. [O75952-1]
GeneIDi26256.
KEGGihsa:26256.
UCSCiuc002kux.5. human. [O75952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088868 mRNA. Translation: AAC35373.1.
AF295037 mRNA. Translation: AAG17889.1.
AF295038 mRNA. Translation: AAG17890.1.
AF295039 mRNA. Translation: AAG17891.1.
AF329634 mRNA. Translation: AAL56051.1.
AY007205 mRNA. Translation: AAG01891.1.
AK313243 mRNA. Translation: BAG36054.1.
AC090772 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01177.1.
BC011996 mRNA. Translation: AAH11996.1.
CCDSiCCDS11881.1. [O75952-1]
CCDS11882.1. [O75952-2]
CCDS11883.1. [O75952-5]
CCDS42420.1. [O75952-3]
CCDS45840.1. [O75952-4]
RefSeqiNP_036321.2. NM_012189.3. [O75952-1]
NP_619584.1. NM_138643.2. [O75952-5]
NP_619585.1. NM_138644.2. [O75952-3]
NP_722452.1. NM_153768.2. [O75952-2]
NP_722453.1. NM_153769.2. [O75952-3]
NP_722454.1. NM_153770.2. [O75952-4]
XP_016881195.1. XM_017025706.1. [O75952-1]
UniGeneiHs.511983.

3D structure databases

ProteinModelPortaliO75952.
SMRiO75952.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117642. 2 interactors.
IntActiO75952. 1 interactor.
STRINGi9606.ENSP00000432870.

PTM databases

iPTMnetiO75952.
PhosphoSitePlusiO75952.

Polymorphism and mutation databases

BioMutaiCABYR.

Proteomic databases

MaxQBiO75952.
PaxDbiO75952.
PeptideAtlasiO75952.
PRIDEiO75952.

Protocols and materials databases

DNASUi26256.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327201; ENSP00000317095; ENSG00000154040. [O75952-5]
ENST00000399481; ENSP00000382404; ENSG00000154040. [O75952-2]
ENST00000399496; ENSP00000382419; ENSG00000154040. [O75952-3]
ENST00000399499; ENSP00000382421; ENSG00000154040. [O75952-3]
ENST00000415309; ENSP00000399973; ENSG00000154040. [O75952-4]
ENST00000463087; ENSP00000432870; ENSG00000154040. [O75952-1]
ENST00000486759; ENSP00000431142; ENSG00000154040. [O75952-1]
ENST00000621648; ENSP00000483621; ENSG00000154040. [O75952-1]
GeneIDi26256.
KEGGihsa:26256.
UCSCiuc002kux.5. human. [O75952-1]

Organism-specific databases

CTDi26256.
DisGeNETi26256.
GeneCardsiCABYR.
HGNCiHGNC:15569. CABYR.
HPAiHPA040703.
HPA047801.
MIMi612135. gene.
neXtProtiNX_O75952.
OpenTargetsiENSG00000154040.
PharmGKBiPA26005.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFPT. Eukaryota.
ENOG410ZQAQ. LUCA.
GeneTreeiENSGT00390000000444.
HOVERGENiHBG080982.
InParanoidiO75952.
OMAiEQIVIPF.
OrthoDBiEOG091G18VB.
PhylomeDBiO75952.
TreeFamiTF332959.

Enzyme and pathway databases

SIGNORiO75952.

Miscellaneous databases

ChiTaRSiCABYR. human.
GeneWikiiCABYR.
GenomeRNAii26256.
PROiO75952.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154040.
CleanExiHS_CABYR.
ExpressionAtlasiO75952. baseline and differential.
GenevisibleiO75952. HS.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
PfamiPF02197. RIIa. 1 hit.
[Graphical view]
SMARTiSM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCABYR_HUMAN
AccessioniPrimary (citable) accession number: O75952
Secondary accession number(s): B2R857
, Q8WXW5, Q9HAY3, Q9HAY4, Q9HAY5, Q9HCY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.