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O75951

- LYZL6_HUMAN

UniProt

O75951 - LYZL6_HUMAN

Protein

Lysozyme-like protein 6

Gene

LYZL6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei54 – 541PROSITE-ProRule annotation
    Active sitei71 – 711PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme-like protein 6 (EC:3.2.1.17)
    Gene namesi
    Name:LYZL6
    Synonyms:LYC1
    ORF Names:UNQ754/PRO1485
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:29614. LYZL6.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134942111.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 148129Lysozyme-like protein 6PRO_0000240640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 145PROSITE-ProRule annotation
    Disulfide bondi49 ↔ 133PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi94 ↔ 112PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiO75951.
    PRIDEiO75951.

    Expressioni

    Tissue specificityi

    Expressed in testis and epididymis.1 Publication

    Gene expression databases

    BgeeiO75951.
    CleanExiHS_LYZL6.
    GenevestigatoriO75951.

    Organism-specific databases

    HPAiHPA025734.

    Interactioni

    Subunit structurei

    Monomer.Curated

    Protein-protein interaction databases

    STRINGi9606.ENSP00000293274.

    Structurei

    3D structure databases

    ProteinModelPortaliO75951.
    SMRiO75951. Positions 24-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG69444.
    HOGENOMiHOG000037357.
    HOVERGENiHBG052297.
    InParanoidiO75951.
    KOiK01185.
    OMAiWCNDYKS.
    OrthoDBiEOG7BW0M5.
    PhylomeDBiO75951.
    TreeFamiTF324882.

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75951-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKALLIYLV SSFLALNQAS LISRCDLAQV LQLEDLDGFE GYSLSDWLCL    50
    AFVESKFNIS KINENADGSF DYGLFQINSH YWCNDYKSYS ENLCHVDCQD 100
    LLNPNLLAGI HCAKRIVSGA RGMNNWVEWR LHCSGRPLFY WLTGCRLR 148
    Length:148
    Mass (Da):16,956
    Last modified:November 1, 1998 - v1
    Checksum:iC79DEC3B68ADF117
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti139 – 1391F → S.1 Publication
    Corresponds to variant rs9754 [ dbSNP | Ensembl ].
    VAR_026819

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF088219 Genomic DNA. Translation: AAC63332.1.
    AY742214 mRNA. Translation: AAU93343.1.
    AY359018 mRNA. Translation: AAQ89377.1.
    BC054481 mRNA. Translation: AAH54481.1.
    CCDSiCCDS11302.1.
    RefSeqiNP_001186880.1. NM_001199951.1.
    NP_065159.1. NM_020426.2.
    XP_005258070.1. XM_005258013.2.
    XP_006725392.1. XM_006725329.1.
    UniGeneiHs.97477.

    Genome annotation databases

    GeneIDi57151.
    KEGGihsa:57151.
    UCSCiuc002hkj.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF088219 Genomic DNA. Translation: AAC63332.1 .
    AY742214 mRNA. Translation: AAU93343.1 .
    AY359018 mRNA. Translation: AAQ89377.1 .
    BC054481 mRNA. Translation: AAH54481.1 .
    CCDSi CCDS11302.1.
    RefSeqi NP_001186880.1. NM_001199951.1.
    NP_065159.1. NM_020426.2.
    XP_005258070.1. XM_005258013.2.
    XP_006725392.1. XM_006725329.1.
    UniGenei Hs.97477.

    3D structure databases

    ProteinModelPortali O75951.
    SMRi O75951. Positions 24-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000293274.

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    Proteomic databases

    PaxDbi O75951.
    PRIDEi O75951.

    Protocols and materials databases

    DNASUi 57151.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 57151.
    KEGGi hsa:57151.
    UCSCi uc002hkj.2. human.

    Organism-specific databases

    CTDi 57151.
    GeneCardsi GC17M034261.
    HGNCi HGNC:29614. LYZL6.
    HPAi HPA025734.
    MIMi 612751. gene.
    neXtProti NX_O75951.
    PharmGKBi PA134942111.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69444.
    HOGENOMi HOG000037357.
    HOVERGENi HBG052297.
    InParanoidi O75951.
    KOi K01185.
    OMAi WCNDYKS.
    OrthoDBi EOG7BW0M5.
    PhylomeDBi O75951.
    TreeFami TF324882.

    Miscellaneous databases

    GenomeRNAii 57151.
    NextBioi 63121.
    PROi O75951.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75951.
    CleanExi HS_LYZL6.
    Genevestigatori O75951.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
      Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
      J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family."
      Zhang K., Gao R., Zhang H., Cai X., Shen C., Wu C., Zhao S., Yu L.
      Biol. Reprod. 73:1064-1071(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-139.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiLYZL6_HUMAN
    AccessioniPrimary (citable) accession number: O75951
    Secondary accession number(s): Q6UW30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3