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O75951 (LYZL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme-like protein 6

EC=3.2.1.17
Gene names
Name:LYZL6
Synonyms:LYC1
ORF Names:UNQ754/PRO1485
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subunit structure

Monomer Probable.

Subcellular location

Secreted Probable.

Tissue specificity

Expressed in testis and epididymis. Ref.2

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell wall macromolecule catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysozyme activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 148129Lysozyme-like protein 6
PRO_0000240640

Sites

Active site541 By similarity
Active site711 By similarity

Amino acid modifications

Disulfide bond25 ↔ 145 By similarity
Disulfide bond49 ↔ 133 By similarity
Disulfide bond83 ↔ 98 By similarity
Disulfide bond94 ↔ 112 By similarity

Natural variations

Natural variant1391F → S. Ref.3
Corresponds to variant rs9754 [ dbSNP | Ensembl ].
VAR_026819

Sequences

Sequence LengthMass (Da)Tools
O75951 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: C79DEC3B68ADF117

FASTA14816,956
        10         20         30         40         50         60 
MTKALLIYLV SSFLALNQAS LISRCDLAQV LQLEDLDGFE GYSLSDWLCL AFVESKFNIS 

        70         80         90        100        110        120 
KINENADGSF DYGLFQINSH YWCNDYKSYS ENLCHVDCQD LLNPNLLAGI HCAKRIVSGA 

       130        140 
RGMNNWVEWR LHCSGRPLFY WLTGCRLR 

« Hide

References

« Hide 'large scale' references
[1]"Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family."
Zhang K., Gao R., Zhang H., Cai X., Shen C., Wu C., Zhao S., Yu L.
Biol. Reprod. 73:1064-1071(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Testis.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-139.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF088219 Genomic DNA. Translation: AAC63332.1.
AY742214 mRNA. Translation: AAU93343.1.
AY359018 mRNA. Translation: AAQ89377.1.
BC054481 mRNA. Translation: AAH54481.1.
CCDSCCDS11302.1.
RefSeqNP_001186880.1. NM_001199951.1.
NP_065159.1. NM_020426.2.
XP_005258070.1. XM_005258013.2.
XP_006725392.1. XM_006725329.1.
UniGeneHs.97477.

3D structure databases

ProteinModelPortalO75951.
SMRO75951. Positions 24-147.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000293274.

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbO75951.
PRIDEO75951.

Protocols and materials databases

DNASU57151.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293274; ENSP00000293274; ENSG00000161572.
ENST00000394523; ENSP00000378031; ENSG00000161572.
ENST00000585556; ENSP00000468094; ENSG00000161572.
GeneID57151.
KEGGhsa:57151.
UCSCuc002hkj.2. human.

Organism-specific databases

CTD57151.
GeneCardsGC17M034261.
HGNCHGNC:29614. LYZL6.
HPAHPA025734.
MIM612751. gene.
neXtProtNX_O75951.
PharmGKBPA134942111.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69444.
HOGENOMHOG000037357.
HOVERGENHBG052297.
InParanoidO75951.
KOK01185.
OMAWCNDYKS.
OrthoDBEOG7BW0M5.
PhylomeDBO75951.
TreeFamTF324882.

Gene expression databases

BgeeO75951.
CleanExHS_LYZL6.
GenevestigatorO75951.

Family and domain databases

InterProIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00062. Lys. 1 hit.
[Graphical view]
PRINTSPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57151.
NextBio63121.
PROO75951.
SOURCESearch...

Entry information

Entry nameLYZL6_HUMAN
AccessionPrimary (citable) accession number: O75951
Secondary accession number(s): Q6UW30
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries