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Protein

Lysozyme-like protein 6

Gene

LYZL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541PROSITE-ProRule annotation
Active sitei71 – 711PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme-like protein 6 (EC:3.2.1.17)
Gene namesi
Name:LYZL6
Synonyms:LYC1
ORF Names:UNQ754/PRO1485
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29614. LYZL6.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134942111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 148129Lysozyme-like protein 6PRO_0000240640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 145PROSITE-ProRule annotation
Disulfide bondi49 ↔ 133PROSITE-ProRule annotation
Disulfide bondi83 ↔ 98PROSITE-ProRule annotation
Disulfide bondi94 ↔ 112PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO75951.
PRIDEiO75951.

Expressioni

Tissue specificityi

Expressed in testis and epididymis.1 Publication

Gene expression databases

BgeeiO75951.
CleanExiHS_LYZL6.
GenevestigatoriO75951.

Organism-specific databases

HPAiHPA025734.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000293274.

Structurei

3D structure databases

ProteinModelPortaliO75951.
SMRiO75951. Positions 24-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG69444.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiO75951.
KOiK01185.
OMAiWCNDYKS.
OrthoDBiEOG7BW0M5.
PhylomeDBiO75951.
TreeFamiTF324882.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030063. LYZL6.
[Graphical view]
PANTHERiPTHR11407:SF9. PTHR11407:SF9. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75951-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKALLIYLV SSFLALNQAS LISRCDLAQV LQLEDLDGFE GYSLSDWLCL
60 70 80 90 100
AFVESKFNIS KINENADGSF DYGLFQINSH YWCNDYKSYS ENLCHVDCQD
110 120 130 140
LLNPNLLAGI HCAKRIVSGA RGMNNWVEWR LHCSGRPLFY WLTGCRLR
Length:148
Mass (Da):16,956
Last modified:November 1, 1998 - v1
Checksum:iC79DEC3B68ADF117
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391F → S.1 Publication
Corresponds to variant rs9754 [ dbSNP | Ensembl ].
VAR_026819

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088219 Genomic DNA. Translation: AAC63332.1.
AY742214 mRNA. Translation: AAU93343.1.
AY359018 mRNA. Translation: AAQ89377.1.
BC054481 mRNA. Translation: AAH54481.1.
CCDSiCCDS11302.1.
RefSeqiNP_001186880.1. NM_001199951.1.
NP_065159.1. NM_020426.2.
XP_005258070.1. XM_005258013.2.
XP_006725392.1. XM_006725329.1.
UniGeneiHs.97477.

Genome annotation databases

EnsembliENST00000612374; ENSP00000483358; ENSG00000277042.
ENST00000615905; ENSP00000483897; ENSG00000275722.
ENST00000618542; ENSP00000482955; ENSG00000275722.
GeneIDi57151.
KEGGihsa:57151.
UCSCiuc002hkj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088219 Genomic DNA. Translation: AAC63332.1.
AY742214 mRNA. Translation: AAU93343.1.
AY359018 mRNA. Translation: AAQ89377.1.
BC054481 mRNA. Translation: AAH54481.1.
CCDSiCCDS11302.1.
RefSeqiNP_001186880.1. NM_001199951.1.
NP_065159.1. NM_020426.2.
XP_005258070.1. XM_005258013.2.
XP_006725392.1. XM_006725329.1.
UniGeneiHs.97477.

3D structure databases

ProteinModelPortaliO75951.
SMRiO75951. Positions 24-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000293274.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Proteomic databases

PaxDbiO75951.
PRIDEiO75951.

Protocols and materials databases

DNASUi57151.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612374; ENSP00000483358; ENSG00000277042.
ENST00000615905; ENSP00000483897; ENSG00000275722.
ENST00000618542; ENSP00000482955; ENSG00000275722.
GeneIDi57151.
KEGGihsa:57151.
UCSCiuc002hkj.2. human.

Organism-specific databases

CTDi57151.
GeneCardsiGC17M034261.
HGNCiHGNC:29614. LYZL6.
HPAiHPA025734.
MIMi612751. gene.
neXtProtiNX_O75951.
PharmGKBiPA134942111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG69444.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiO75951.
KOiK01185.
OMAiWCNDYKS.
OrthoDBiEOG7BW0M5.
PhylomeDBiO75951.
TreeFamiTF324882.

Miscellaneous databases

GenomeRNAii57151.
NextBioi63121.
PROiO75951.
SOURCEiSearch...

Gene expression databases

BgeeiO75951.
CleanExiHS_LYZL6.
GenevestigatoriO75951.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030063. LYZL6.
[Graphical view]
PANTHERiPTHR11407:SF9. PTHR11407:SF9. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES."
    Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O.
    J. Interferon Cytokine Res. 19:227-234(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family."
    Zhang K., Gao R., Zhang H., Cai X., Shen C., Wu C., Zhao S., Yu L.
    Biol. Reprod. 73:1064-1071(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-139.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiLYZL6_HUMAN
AccessioniPrimary (citable) accession number: O75951
Secondary accession number(s): Q6UW30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.