O75951 (LYZL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme-like protein 6
EC=3.2.1.17

Gene names

Name:	LYZL6
Synonyms:	LYC1
ORF Names:	UNQ754/PRO1485

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer Probable.
Subcellular location	Secreted Probable.
Tissue specificity	Expressed in testis and epididymis. Ref.2
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 148	129	Lysozyme-like protein 6		PRO_0000240640
Sites
	Active site	54	1	By similarity
	Active site	71	1	By similarity
Amino acid modifications
	Disulfide bond	25 ↔ 145		By similarity
	Disulfide bond	49 ↔ 133		By similarity
	Disulfide bond	83 ↔ 98		By similarity
	Disulfide bond	94 ↔ 112		By similarity
Natural variations
	Natural variant	139	1	F → S. [dbSNP:rs9754] Ref.3		VAR_026819

Sequences

	Sequence		Length	Mass (Da)
	O75951-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: C79DEC3B68ADF117	FASTA	148	16,956
	10 20 30 40 50 60 MTKALLIYLV SSFLALNQAS LISRCDLAQV LQLEDLDGFE GYSLSDWLCL AFVESKFNIS 70 80 90 100 110 120 KINENADGSF DYGLFQINSH YWCNDYKSYS ENLCHVDCQD LLNPNLLAGI HCAKRIVSGA 130 140 RGMNNWVEWR LHCSGRPLFY WLTGCRLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES." Nomiyama H., Fukuda S., Iio M., Tanase S., Miura R., Yoshie O. J. Interferon Cytokine Res. 19:227-234(1999) [PubMed: 10213461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family." Zhang K., Gao R., Zhang H., Cai X., Shen C., Wu C., Zhao S., Yu L. Biol. Reprod. 73:1064-1071(2005) [PubMed: 16014814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Testis.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-139.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF088219 Genomic DNA. Translation: AAC63332.1. AY742214 mRNA. Translation: AAU93343.1. AY359018 mRNA. Translation: AAQ89377.1. BC054481 mRNA. Translation: AAH54481.1.
IPI	IPI00007010.
RefSeq	NP_065159.1.
UniGene	Hs.97477.
3D structure databases
ProteinModelPortal	O75951.
SMR	O75951. Positions 21-147.
ModBase	Search...
Protein-protein interaction databases
STRING	O75951.
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Proteomic databases
PRIDE	O75951.
Genome annotation databases
Ensembl	ENST00000293274; ENSP00000293274; ENSG00000161572; Homo sapiens. [Genome view] ENST00000394523; ENSP00000378031; ENSG00000161572; Homo sapiens. [Genome view]
GeneID	57151.
KEGG	hsa:57151.
UCSC	uc002hkj.1. human.
Organism-specific databases
CTD	57151.
GeneCards	GC17M034261.
HGNC	HGNC:29614. LYZL6.
HPA	HPA025734.
MIM	612751. gene.
PharmGKB	PA134942111.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12299.
HOGENOM	HBG505822.
HOVERGEN	HBG052297.
InParanoid	O75951.
OMA	WCNDYKS.
OrthoDB	EOG9MD0K1.
PhylomeDB	O75951.
Enzyme and pathway databases
BRENDA	3.2.1.17. 247.
Gene expression databases
ArrayExpress	O75951.
Bgee	O75951.
CleanEx	HS_LYZL6.
Genevestigator	O75951.
GermOnline	ENSG00000161572. Homo sapiens.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	63121.
SOURCE	Search...

Entry information

Entry name

LYZL6_HUMAN

Accession

Primary (citable) accession number: O75951
Secondary accession number(s): Q6UW30

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 1, 1998
Last modified:	August 10, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.