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Protein

Transmembrane protein FAM155B

Gene

FAM155B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein FAM155B
Alternative name(s):
Protein TED
Transmembrane protein 28
Gene namesi
Name:FAM155B
Synonyms:TED, TMEM28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30701. FAM155B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6721HelicalSequence analysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386687.

Polymorphism and mutation databases

BioMutaiFAM155B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Transmembrane protein FAM155BPRO_0000072598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75949.
PeptideAtlasiO75949.
PRIDEiO75949.

PTM databases

iPTMnetiO75949.
PhosphoSiteiO75949.

Expressioni

Gene expression databases

BgeeiENSG00000130054.
CleanExiHS_FAM155B.
GenevisibleiO75949. HS.

Organism-specific databases

HPAiHPA036093.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252338.

Structurei

3D structure databases

ProteinModelPortaliO75949.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 246Poly-Cys
Compositional biasi98 – 1047Poly-Pro
Compositional biasi369 – 3757Poly-Lys
Compositional biasi453 – 4586Poly-Gly

Sequence similaritiesi

Belongs to the FAM155 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKAJ. Eukaryota.
ENOG410ZYWZ. LUCA.
GeneTreeiENSGT00390000006985.
HOGENOMiHOG000090197.
HOVERGENiHBG107868.
InParanoidiO75949.
OMAiSRPVCGG.
OrthoDBiEOG091G07ZK.
PhylomeDBiO75949.
TreeFamiTF331752.

Family and domain databases

InterProiIPR029604. FAM155.
[Graphical view]
PANTHERiPTHR15819:SF8. PTHR15819:SF8. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75949-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRGAWMWPG KDAAALTICC CCCCWAPRPS DKPCADSERA QRWRLSLASL
60 70 80 90 100
LFFTVLLADH LWLCAGARPR ARELSSAMRP PWGAGRERQP VPPRAVLPLP
110 120 130 140 150
PPPPGEPSAP PGTCGPRYSN LTKAAPAAGS RPVCGGVPEP TGLDAACTKL
160 170 180 190 200
QSLQRLFEPT TPAPPLRPPD SLSRAPAEFP SAKKNLLKGH FRNFTLSFCD
210 220 230 240 250
TYTVWDLLLG MDRPDSLDCS LDTLMGDLLA VVASPGSGAW EACSNCIEAY
260 270 280 290 300
QRLDRHAQEK YDEFDLVLHK YLQAEEYSIR SCTKGCKAVY KAWLCSEYFS
310 320 330 340 350
VTQQECQRWV PCKQYCLEVQ TRCPFILPDN EEMVYGGLPG FICTGLLDTS
360 370 380 390 400
PKRLETKCCD VQWVSCEAKK KKKFKESEAP KTHQQQFHHS YFHHYHQQYH
410 420 430 440 450
HYHPHHDPPG RVSNKPALLP VSGGSRLSPS RIRLCVLVLM LLHTVVSFSS
460 470
NQGGGGLGLE TLPALEEGLT REE
Length:473
Mass (Da):52,605
Last modified:June 10, 2008 - v2
Checksum:i3AAA780E6D3ED8AF
GO
Isoform 2 (identifier: O75949-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     369-369: Missing.

Note: No experimental confirmation available.
Show »
Length:472
Mass (Da):52,477
Checksum:i709FAB4CEF99B54C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991L → V in AAC62086 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721L → P.1 Publication
Corresponds to variant rs1171942 [ dbSNP | Ensembl ].
VAR_043975

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei369 – 3691Missing in isoform 2. 1 PublicationVSP_034157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087142 mRNA. Translation: AAC62086.1.
AL158069 Genomic DNA. Translation: CAD18889.1.
CH471132 Genomic DNA. Translation: EAX05363.1.
CH471132 Genomic DNA. Translation: EAX05364.1.
BC136518 mRNA. Translation: AAI36519.1.
BC136519 mRNA. Translation: AAI36520.1.
CCDSiCCDS35317.1. [O75949-2]
RefSeqiNP_056501.2. NM_015686.2. [O75949-2]
UniGeneiHs.87619.

Genome annotation databases

EnsembliENST00000252338; ENSP00000252338; ENSG00000130054. [O75949-2]
GeneIDi27112.
KEGGihsa:27112.
UCSCiuc004dxk.4. human. [O75949-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087142 mRNA. Translation: AAC62086.1.
AL158069 Genomic DNA. Translation: CAD18889.1.
CH471132 Genomic DNA. Translation: EAX05363.1.
CH471132 Genomic DNA. Translation: EAX05364.1.
BC136518 mRNA. Translation: AAI36519.1.
BC136519 mRNA. Translation: AAI36520.1.
CCDSiCCDS35317.1. [O75949-2]
RefSeqiNP_056501.2. NM_015686.2. [O75949-2]
UniGeneiHs.87619.

3D structure databases

ProteinModelPortaliO75949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000252338.

PTM databases

iPTMnetiO75949.
PhosphoSiteiO75949.

Polymorphism and mutation databases

BioMutaiFAM155B.

Proteomic databases

PaxDbiO75949.
PeptideAtlasiO75949.
PRIDEiO75949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252338; ENSP00000252338; ENSG00000130054. [O75949-2]
GeneIDi27112.
KEGGihsa:27112.
UCSCiuc004dxk.4. human. [O75949-1]

Organism-specific databases

CTDi27112.
GeneCardsiFAM155B.
HGNCiHGNC:30701. FAM155B.
HPAiHPA036093.
neXtProtiNX_O75949.
PharmGKBiPA162386687.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKAJ. Eukaryota.
ENOG410ZYWZ. LUCA.
GeneTreeiENSGT00390000006985.
HOGENOMiHOG000090197.
HOVERGENiHBG107868.
InParanoidiO75949.
OMAiSRPVCGG.
OrthoDBiEOG091G07ZK.
PhylomeDBiO75949.
TreeFamiTF331752.

Miscellaneous databases

GenomeRNAii27112.
PROiO75949.

Gene expression databases

BgeeiENSG00000130054.
CleanExiHS_FAM155B.
GenevisibleiO75949. HS.

Family and domain databases

InterProiIPR029604. FAM155.
[Graphical view]
PANTHERiPTHR15819:SF8. PTHR15819:SF8. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF155B_HUMAN
AccessioniPrimary (citable) accession number: O75949
Secondary accession number(s): B1ALV6, B9EGK1, D3DVU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.