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Protein

ATP synthase subunit d, mitochondrial

Gene

ATP5H

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

  • proton transmembrane transporter activity Source: InterPro
  • transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit d, mitochondrial
Short name:
ATPase subunit d
Gene namesi
Name:ATP5H
ORF Names:My032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167863.11
HGNCiHGNC:845 ATP5H
neXtProtiNX_O75947

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10476
OpenTargetsiENSG00000167863
PharmGKBiPA25135

Polymorphism and mutation databases

BioMutaiATP5H

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000716732 – 161ATP synthase subunit d, mitochondrialAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei32N6-acetyllysineBy similarity1
Modified residuei63N6-acetyllysineBy similarity1
Modified residuei72N6-acetyllysineBy similarity1
Modified residuei78N6-acetyllysine; alternateBy similarity1
Modified residuei78N6-succinyllysine; alternateBy similarity1
Modified residuei85N6-acetyllysine; alternateCombined sources1
Modified residuei85N6-succinyllysine; alternateBy similarity1
Modified residuei95N6-acetyllysine; alternateCombined sources1
Modified residuei95N6-succinyllysine; alternateBy similarity1
Modified residuei117N6-acetyllysineCombined sources1
Modified residuei144N6-acetyllysine; alternateBy similarity1
Modified residuei144N6-succinyllysine; alternateBy similarity1
Modified residuei149N6-acetyllysine; alternateCombined sources1
Modified residuei149N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO75947
MaxQBiO75947
PaxDbiO75947
PeptideAtlasiO75947
PRIDEiO75947
ProteomicsDBi50308
50309 [O75947-2]
TopDownProteomicsiO75947-1 [O75947-1]
O75947-2 [O75947-2]

2D gel databases

OGPiO75947
REPRODUCTION-2DPAGEiIPI00456049
UCD-2DPAGEiO75947

PTM databases

CarbonylDBiO75947
iPTMnetiO75947
PhosphoSitePlusiO75947
SwissPalmiO75947

Expressioni

Gene expression databases

BgeeiENSG00000167863
CleanExiHS_ATP5H
ExpressionAtlasiO75947 baseline and differential
GenevisibleiO75947 HS

Organism-specific databases

HPAiHPA042777
HPA048459

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi115739, 65 interactors
CORUMiO75947
IntActiO75947, 38 interactors
MINTiO75947
STRINGi9606.ENSP00000301587

Structurei

3D structure databases

ProteinModelPortaliO75947
SMRiO75947
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase d subunit family.Curated

Phylogenomic databases

eggNOGiKOG3366 Eukaryota
ENOG4111IHJ LUCA
GeneTreeiENSGT00390000003582
HOGENOMiHOG000267023
HOVERGENiHBG050612
InParanoidiO75947
KOiK02138
OMAiRIQNYQK
OrthoDBiEOG091G0MQA
PhylomeDBiO75947
TreeFamiTF314031

Family and domain databases

Gene3Di1.20.58.880, 1 hit
InterProiView protein in InterPro
IPR008689 ATP_synth_F0_dsu_mt
IPR036228 ATP_synth_F0_dsu_sf_mt
PANTHERiPTHR12700 PTHR12700, 1 hit
PfamiView protein in Pfam
PF05873 Mt_ATP-synt_D, 1 hit
PIRSFiPIRSF005514 ATPase_F0_D_mt, 1 hit
SUPFAMiSSF161065 SSF161065, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75947-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRKLALKT IDWVAFAEII PQNQKAIASS LKSWNETLTS RLAALPENPP
60 70 80 90 100
AIDWAYYKAN VAKAGLVDDF EKKFNALKVP VPEDKYTAQV DAEEKEDVKS
110 120 130 140 150
CAEWVSLSKA RIVEYEKEME KMKNLIPFDQ MTIEDLNEAF PETKLDKKKY
160
PYWPHQPIEN L
Length:161
Mass (Da):18,491
Last modified:January 23, 2007 - v3
Checksum:iE93020ADA1BA1694
GO
Isoform 2 (identifier: O75947-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-97: Missing.

Show »
Length:137
Mass (Da):15,773
Checksum:i0796685CD2CC605E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00043674 – 97Missing in isoform 2. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087135 mRNA Translation: AAC36338.1
AF070650 mRNA Translation: AAD20956.1
AF061735 mRNA Translation: AAG43146.1
AK312230 mRNA Translation: BAG35163.1
CH471099 Genomic DNA Translation: EAW89228.1
BC032245 mRNA Translation: AAH32245.1
BC038092 mRNA Translation: AAH38092.1
CCDSiCCDS11712.1 [O75947-1]
CCDS32727.1 [O75947-2]
RefSeqiNP_001003785.1, NM_001003785.1 [O75947-2]
NP_006347.1, NM_006356.2 [O75947-1]
UniGeneiHs.514465

Genome annotation databases

EnsembliENST00000301587; ENSP00000301587; ENSG00000167863 [O75947-1]
ENST00000344546; ENSP00000344230; ENSG00000167863 [O75947-2]
GeneIDi10476
KEGGihsa:10476
UCSCiuc002jmn.2 human [O75947-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATP5H_HUMAN
AccessioniPrimary (citable) accession number: O75947
Secondary accession number(s): B2R5L6, Q9H3J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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