##gff-version 3 O75943 UniProtKB Chain 1 681 . . . ID=PRO_0000209948;Note=Cell cycle checkpoint protein RAD17 O75943 UniProtKB Region 42 61 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75943 UniProtKB Region 344 377 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75943 UniProtKB Region 432 681 . . . Note=Interaction with MCM7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15538388;Dbxref=PMID:15538388 O75943 UniProtKB Region 606 681 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75943 UniProtKB Motif 17 25 . . . Note=RAD1-binding motif;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:36841485;Dbxref=PMID:36841485 O75943 UniProtKB Compositional bias 42 58 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75943 UniProtKB Compositional bias 349 377 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75943 UniProtKB Compositional bias 627 664 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75943 UniProtKB Binding site 137 144 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O75943 UniProtKB Modified residue 55 55 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9XT62 O75943 UniProtKB Modified residue 71 71 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O75943 UniProtKB Modified residue 86 86 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O75943 UniProtKB Modified residue 359 359 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O75943 UniProtKB Modified residue 646 646 . . . Note=Phosphoserine%3B by ATR and ATM;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11418864,ECO:0000269|PubMed:11687627,ECO:0000269|PubMed:14500819,ECO:0000269|PubMed:14871926;Dbxref=PMID:11418864,PMID:11687627,PMID:14500819,PMID:14871926 O75943 UniProtKB Modified residue 656 656 . . . Note=Phosphoserine%3B by ATR and ATM;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11418864,ECO:0000269|PubMed:11687627,ECO:0000269|PubMed:14500819;Dbxref=PMID:11418864,PMID:11687627,PMID:14500819 O75943 UniProtKB Alternative sequence 1 176 . . . ID=VSP_013306;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11602352;Dbxref=PMID:11602352 O75943 UniProtKB Alternative sequence 1 97 . . . ID=VSP_013307;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11602352;Dbxref=PMID:11602352 O75943 UniProtKB Alternative sequence 1 14 . . . ID=VSP_013308;Note=In isoform 2. MSKTFLRPKVSSTK->MNQ;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10208430,ECO:0000303|PubMed:10232579,ECO:0000303|PubMed:10480350,ECO:0000303|PubMed:11230166,ECO:0000303|PubMed:11602352,ECO:0000303|PubMed:11715513,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005,ECO:0000303|PubMed:9660800,ECO:0000303|PubMed:9878245;Dbxref=PMID:10208430,PMID:10232579,PMID:10480350,PMID:11230166,PMID:11602352,PMID:11715513,PMID:14702039,PMID:15489334,PMID:17974005,PMID:9660800,PMID:9878245 O75943 UniProtKB Alternative sequence 98 99 . . . ID=VSP_013309;Note=In isoform 4. ET->MN;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11602352;Dbxref=PMID:11602352 O75943 UniProtKB Natural variant 32 32 . . . ID=VAR_021574;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.13;Dbxref=dbSNP:rs17229831 O75943 UniProtKB Natural variant 487 487 . . . ID=VAR_021575;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.13;Dbxref=dbSNP:rs17236478 O75943 UniProtKB Natural variant 535 535 . . . ID=VAR_021576;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.13;Dbxref=dbSNP:rs17236485 O75943 UniProtKB Natural variant 557 557 . . . ID=VAR_021577;Note=L->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10232579,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.13;Dbxref=dbSNP:rs1045051,PMID:10232579,PMID:15489334 O75943 UniProtKB Mutagenesis 18 23 . . . Note=Strongly reduced interaction with RAD1. WVDPSF->AADPSA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:36841485;Dbxref=PMID:36841485 O75943 UniProtKB Mutagenesis 143 143 . . . Note=Impairs phosphorylation on S-656. Abolishes interaction with the RAD1-RAD9-HUS1 complex%3B does not affect interaction with RFC3. K->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10884395,ECO:0000269|PubMed:11799063,ECO:0000269|PubMed:15235112;Dbxref=PMID:10884395,PMID:11799063,PMID:15235112 O75943 UniProtKB Mutagenesis 143 143 . . . Note=Impairs phosphorylation. Impairs interaction with DNA and the RAD1-RAD9-HUS1 complex%3B does not affect interaction with RFC3. K->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10884395,ECO:0000269|PubMed:11799063,ECO:0000269|PubMed:15235112;Dbxref=PMID:10884395,PMID:11799063,PMID:15235112 O75943 UniProtKB Mutagenesis 191 191 . . . Note=No effect on phosphorylation by ATR. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11687627;Dbxref=PMID:11687627 O75943 UniProtKB Mutagenesis 646 646 . . . Note=Reduces by 50%25 phosphorylation by ATR%2C and abolishes interaction with RAD1. Abolishes phosphorylation by ATR and checkpoint activation without affecting interaction with RFC3%2C RFC4%2C ATM or ATR%3B when associated with A-656. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11418864,ECO:0000269|PubMed:11687627,ECO:0000269|PubMed:14500819,ECO:0000269|PubMed:15235112;Dbxref=PMID:11418864,PMID:11687627,PMID:14500819,PMID:15235112 O75943 UniProtKB Mutagenesis 646 646 . . . Note=Abolishes interaction with RAD1%3B when associated with D-656. S->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11418864,ECO:0000269|PubMed:11687627,ECO:0000269|PubMed:14500819,ECO:0000269|PubMed:15235112;Dbxref=PMID:11418864,PMID:11687627,PMID:14500819,PMID:15235112 O75943 UniProtKB Mutagenesis 656 656 . . . Note=Reduces by 50%25 phosphorylation by ATR%2C and abolishes interaction with RAD1. Abolishes phosphorylation by ATR and checkpoint activation without affecting interaction with RFC3%2C RFC4%2C ATM or ATR%3B when associated with A-646. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11418864,ECO:0000269|PubMed:11687627,ECO:0000269|PubMed:14500819,ECO:0000269|PubMed:15235112;Dbxref=PMID:11418864,PMID:11687627,PMID:14500819,PMID:15235112 O75943 UniProtKB Mutagenesis 656 656 . . . Note=Abolishes interaction with RAD1%3B when associated with D-646. S->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11418864,ECO:0000269|PubMed:11687627,ECO:0000269|PubMed:14500819,ECO:0000269|PubMed:15235112;Dbxref=PMID:11418864,PMID:11687627,PMID:14500819,PMID:15235112 O75943 UniProtKB Sequence conflict 75 75 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75943 UniProtKB Sequence conflict 187 187 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75943 UniProtKB Sequence conflict 194 194 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75943 UniProtKB Sequence conflict 340 340 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75943 UniProtKB Sequence conflict 445 445 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75943 UniProtKB Sequence conflict 462 462 . . . Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75943 UniProtKB Sequence conflict 648 648 . . . Note=N->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75943 UniProtKB Sequence conflict 672 672 . . . Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305