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Protein

Major prion protein

Gene

PRNP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

PrionUniRule annotationImported

Keywords - Ligandi

CopperSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Major prion proteinUniRule annotation
Gene namesi
Name:PRNPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cell membrane SAAS annotation; Lipid-anchorGPI-anchor SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei144 – 163HelicalSequence analysisAdd BLAST20
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cell membraneUniRule annotationSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500415973123 – 285Major prion proteinSequence analysisAdd BLAST263

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiO75942.
PaxDbiO75942.
PeptideAtlasiO75942.
PRIDEiO75942.

Expressioni

Gene expression databases

BgeeiENSG00000171867.

Interactioni

Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000368752.

Structurei

3D structure databases

ProteinModelPortaliO75942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 160Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST16
Domaini232 – 250Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST19

Sequence similaritiesi

Belongs to the prion family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJMM. Eukaryota.
ENOG410YXUU. LUCA.
HOGENOMiHOG000232077.
HOVERGENiHBG008260.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR020949. Prion_copper_b_octapeptide.
IPR025860. Prion_N_dom.
[Graphical view]
PANTHERiPTHR10502:SF11. PTHR10502:SF11. 1 hit.
PfamiPF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
PF03991. Prion_octapep. 9 hits.
[Graphical view]
PRINTSiPR00341. PRION.
SMARTiSM00157. PRP. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiPS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP
60 70 80 90 100
PQGGGGWGQP HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QPHGGGWGQP
110 120 130 140 150
HGGGWGQPHG GGWGQPHGGG WGQGGGTHSQ WNKPSKPKTN MKHMAGAAAA
160 170 180 190 200
GAVVGGLGGY MLGSAMSRPI IHFGSDYEDR YYRENMHRYP NQVYYRPMDE
210 220 230 240 250
YSNQNNFVHD CVNITIKQHT VTTTTKGENF TETDVKMMER VVEQMCITQY
260 270 280
ERESQAYYQR GSSMVLFSSP PVILLISFLI FLIVG
Length:285
Mass (Da):30,768
Last modified:March 1, 2001 - v2
Checksum:iC14244BB1183F653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085477 Genomic DNA. Translation: AAC62750.2.
UniGeneiHs.472010.
Hs.610285.
Hs.721670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085477 Genomic DNA. Translation: AAC62750.2.
UniGeneiHs.472010.
Hs.610285.
Hs.721670.

3D structure databases

ProteinModelPortaliO75942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368752.

Proteomic databases

MaxQBiO75942.
PaxDbiO75942.
PeptideAtlasiO75942.
PRIDEiO75942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IJMM. Eukaryota.
ENOG410YXUU. LUCA.
HOGENOMiHOG000232077.
HOVERGENiHBG008260.

Miscellaneous databases

ChiTaRSiPRNP. human.

Gene expression databases

BgeeiENSG00000171867.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiIPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR020949. Prion_copper_b_octapeptide.
IPR025860. Prion_N_dom.
[Graphical view]
PANTHERiPTHR10502:SF11. PTHR10502:SF11. 1 hit.
PfamiPF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
PF03991. Prion_octapep. 9 hits.
[Graphical view]
PRINTSiPR00341. PRION.
SMARTiSM00157. PRP. 1 hit.
[Graphical view]
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiPS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO75942_HUMAN
AccessioniPrimary (citable) accession number: O75942
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: March 1, 2001
Last modified: October 5, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.