O75942 (O75942_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Major prion protein RuleBase RU003882

Gene names

Name:

PRNP EMBL AAC62750.2

Organism

Homo sapiens (Human) EMBL AAC62750.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the prion family. RuleBase RU003882

Ontologies

Keywords
Cellular component	Amyloid Cell membrane SAAS SAAS022416 RuleBase RU003882 Membrane
Domain	Repeat SAAS SAAS022416
Molecular function	Prion RuleBase RU003882 EMBL AAC62750.2
PTM	Disulfide bond SAAS SAAS022416
Gene Ontology (GO)
Biological process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Cellular component	nucleolus Inferred from direct assay. Source: HPA plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O75942 [UniParc]. Last modified March 1, 2001. Version 2. Checksum: C14244BB1183F653	FASTA	285	30,768
	10 20 30 40 50 60 MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP 70 80 90 100 110 120 HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QPHGGGWGQP HGGGWGQPHG GGWGQPHGGG 130 140 150 160 170 180 WGQGGGTHSQ WNKPSKPKTN MKHMAGAAAA GAVVGGLGGY MLGSAMSRPI IHFGSDYEDR 190 200 210 220 230 240 YYRENMHRYP NQVYYRPMDE YSNQNNFVHD CVNITIKQHT VTTTTKGENF TETDVKMMER 250 260 270 280 VVEQMCITQY ERESQAYYQR GSSMVLFSSP PVILLISFLI FLIVG

References

[1]	"A new Creutzfeldt-Jakob disease family with 96bp insertion mutation in the PRNP gene." Cervenakova L., Halperin J.J., Stone G., Taller I., Gibbs C.J. Jr. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF085477 Genomic DNA. Translation: AAC62750.2.
IPI	IPI00382843.
UniGene	Hs.472010. Hs.610285. Hs.727471.
3D structure databases
HSSP	HSSP built from PDB template 1I4M based on UniProtKB P04156.
ProteinModelPortal	O75942.
SMR	O75942. Positions 2-28, 157-260.
ModBase	Search...
Protein-protein interaction databases
STRING	O75942.
Proteomic databases
PRIDE	O75942.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HBG278973.
HOVERGEN	HBG008260.
Gene expression databases
ArrayExpress	O75942.
Bgee	O75942.
Family and domain databases
InterPro	IPR000817. Prion. IPR022416. Prion/Doppel_prot_b-ribbon_dom. IPR020949. Prion_copper_b_octapeptide. [Graphical view]
Gene3D	G3DSA:1.10.790.10. Prion. 1 hit.
PANTHER	PTHR11522. Prion. 1 hit.
Pfam	PF00377. Prion. 1 hit. PF03991. Prion_octapep. 9 hits. [Graphical view]
PRINTS	PR00341. PRION.
SMART	SM00157. PRP. 1 hit. [Graphical view]
SUPFAM	SSF54098. Prion. 1 hit.
PROSITE	PS00291. PRION_1. 1 hit. PS00706. PRION_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O75942_HUMAN

Accession

Primary (citable) accession number: O75942

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.