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Protein

Major prion protein

Gene

PRNP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrionUniRule annotationImported
LigandCopperSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Major prion proteinUniRule annotation
Gene namesi
Name:PRNPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei144 – 163HelicalSequence analysisAdd BLAST20
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Amyloid, Cell membraneUniRule annotationSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500415973123 – 285Major prion proteinSequence analysisAdd BLAST263

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiO75942.
PaxDbiO75942.
PeptideAtlasiO75942.
PRIDEiO75942.

Interactioni

Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliO75942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 160Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST16
Domaini232 – 250Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST19

Sequence similaritiesi

Belongs to the prion family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJMM. Eukaryota.
ENOG410YXUU. LUCA.
HOGENOMiHOG000232077.
HOVERGENiHBG008260.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiView protein in InterPro
IPR000817. Prion.
IPR036924. Prion/Doppel_b-ribbon_dom_sf.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR020949. Prion_copper_b_octapeptide.
IPR025860. Prion_N_dom.
PANTHERiPTHR10502:SF134. PTHR10502:SF134. 2 hits.
PfamiView protein in Pfam
PF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
PF03991. Prion_octapep. 9 hits.
PRINTSiPR00341. PRION.
SMARTiView protein in SMART
SM00157. PRP. 1 hit.
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiView protein in PROSITE
PS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O75942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP
60 70 80 90 100
PQGGGGWGQP HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QPHGGGWGQP
110 120 130 140 150
HGGGWGQPHG GGWGQPHGGG WGQGGGTHSQ WNKPSKPKTN MKHMAGAAAA
160 170 180 190 200
GAVVGGLGGY MLGSAMSRPI IHFGSDYEDR YYRENMHRYP NQVYYRPMDE
210 220 230 240 250
YSNQNNFVHD CVNITIKQHT VTTTTKGENF TETDVKMMER VVEQMCITQY
260 270 280
ERESQAYYQR GSSMVLFSSP PVILLISFLI FLIVG
Length:285
Mass (Da):30,768
Last modified:March 1, 2001 - v2
Checksum:iC14244BB1183F653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085477 Genomic DNA. Translation: AAC62750.2.
UniGeneiHs.472010.
Hs.610285.
Hs.721670.

Similar proteinsi

Entry informationi

Entry nameiO75942_HUMAN
AccessioniPrimary (citable) accession number: O75942
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.