Unreviewed, UniProtKB/TrEMBL O75942 (O75942_HUMAN)

Names and origin

Protein names

Recommended name:
    Major prion protein RuleBase RU003883V4

Gene names

Name:

PRNP EMBL AAC62750.2

Organism

Homo sapiens (Human) EMBL AAC62750.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the prion family. RuleBase RU003882V4

Ontologies

Keywords
Cellular component	Cell membrane Spearmint SPM000817 Membrane
Disease	Prion RuleBase RU003882V4
Domain	Repeat Spearmint SPM000817
Gene Ontology (GO)
Biological process	protein homooligomerization Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O75942-1 [UniParc]. Last modified March 1, 2001. Version 2. Checksum: C14244BB1183F653	FASTA	285	30,768
	10 20 30 40 50 60 MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP 70 80 90 100 110 120 HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QPHGGGWGQP HGGGWGQPHG GGWGQPHGGG 130 140 150 160 170 180 WGQGGGTHSQ WNKPSKPKTN MKHMAGAAAA GAVVGGLGGY MLGSAMSRPI IHFGSDYEDR 190 200 210 220 230 240 YYRENMHRYP NQVYYRPMDE YSNQNNFVHD CVNITIKQHT VTTTTKGENF TETDVKMMER 250 260 270 280 VVEQMCITQY ERESQAYYQR GSSMVLFSSP PVILLISFLI FLIVG

References

[1]	"A new Creutzfeldt-Jakob disease family with 96bp insertion mutation in the PRNP gene." Cervenakova L., Halperin J.J., Stone G., Taller I., Gibbs C.J. Jr. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF085477 Genomic DNA. Translation: AAC62750.2.
UniGene	Hs.472010 Hs.610285
3D structure databases
HSSP	HSSP built from PDB template 1I4M based on UniProtKB P04156.
SMR	O75942. Positions 151-258.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000171867. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:9449. PRNP.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	O75942.
HOVERGEN	O75942.
Gene expression databases
ArrayExpress	O75942.
Family and domain databases
InterPro	IPR013286. AnnexinVII. IPR000817. Prion. [Graphical view]
Gene3D	G3DSA:1.10.790.10. Prion. 1 hit.
PANTHER	PTHR11522. Prion. 1 hit.
Pfam	PF00377. Prion. 1 hit. PF03991. Prion_octapep. 9 hits. [Graphical view]
PRINTS	PR01871. ANNEXINVII. PR00341. PRION.
SMART	SM00157. PRP. 1 hit. [Graphical view]
PROSITE	PS00291. PRION_1. 1 hit. PS00706. PRION_2. 1 hit. [Graphical view]

Entry information

Entry name

O75942_HUMAN

Accession

Primary (citable) accession number: O75942

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	March 1, 2001
Last modified:	September 23, 2008
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)