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Protein

DnaJ homolog subfamily C member 8

Gene

DNAJC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126698-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 8
Alternative name(s):
Splicing protein spf31
Gene namesi
Name:DNAJC8
Synonyms:SPF31
ORF Names:HSPC315, HSPC331
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15470. DNAJC8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi22826.
OpenTargetsiENSG00000126698.
PharmGKBiPA27425.

Polymorphism and mutation databases

BioMutaiDNAJC8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000710602 – 253DnaJ homolog subfamily C member 8Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei146N6-acetyllysineCombined sources1
Modified residuei222PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75937.
MaxQBiO75937.
PaxDbiO75937.
PeptideAtlasiO75937.
PRIDEiO75937.
TopDownProteomicsiO75937.

PTM databases

iPTMnetiO75937.
PhosphoSitePlusiO75937.

Expressioni

Gene expression databases

BgeeiENSG00000126698.
CleanExiHS_DNAJC8.
ExpressionAtlasiO75937. baseline and differential.
GenevisibleiO75937. HS.

Organism-specific databases

HPAiHPA026275.
HPA026283.

Interactioni

Protein-protein interaction databases

BioGridi116501. 37 interactors.
IntActiO75937. 21 interactors.
MINTiMINT-3002069.
STRINGi9606.ENSP00000263697.

Structurei

3D structure databases

ProteinModelPortaliO75937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 124JPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1150. Eukaryota.
ENOG4110ZJ4. LUCA.
GeneTreeiENSGT00390000012569.
HOVERGENiHBG051377.
InParanoidiO75937.
KOiK09528.
OMAiQNFYTEV.
OrthoDBiEOG091G0MI7.
PhylomeDBiO75937.
TreeFamiTF105167.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGESGTS GGGGSTEEAF MTFYSEVKQI EKRDSVLTSK NQIERLTRPG
60 70 80 90 100
SSYFNLNPFE VLQIDPEVTD EEIKKRFRQL SILVHPDKNQ DDADRAQKAF
110 120 130 140 150
EAVDKAYKLL LDQEQKKRAL DVIQAGKEYV EHTVKERKKQ LKKEGKPTIV
160 170 180 190 200
EEDDPELFKQ AVYKQTMKLF AELEIKRKER EAKEMHERKR QREEEIEAQE
210 220 230 240 250
KAKREREWQK NFEESRDGRV DSWRNFQANT KGKKEKKNRT FLRPPKVKME

QRE
Length:253
Mass (Da):29,842
Last modified:April 26, 2005 - v2
Checksum:iC69D6189D69D1588
GO

Sequence cautioni

The sequence AAC35352 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG33181 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253E → D in CAG33181 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083190 mRNA. Translation: AAC35352.1. Different initiation.
CR456900 mRNA. Translation: CAG33181.1. Different initiation.
AK300797 mRNA. Translation: BAG62456.1.
AL353354, AL353622 Genomic DNA. Translation: CAI20826.1.
AL353622, AL353354 Genomic DNA. Translation: CAI19135.1.
CH471059 Genomic DNA. Translation: EAX07707.1.
CH471059 Genomic DNA. Translation: EAX07710.1.
BC033159 mRNA. Translation: AAH33159.1.
AF161433 mRNA. Translation: AAF28993.1.
AF161449 mRNA. Translation: AAF29009.1.
CCDSiCCDS41292.1.
RefSeqiNP_055095.2. NM_014280.2.
UniGeneiHs.433540.

Genome annotation databases

EnsembliENST00000263697; ENSP00000263697; ENSG00000126698.
GeneIDi22826.
KEGGihsa:22826.
UCSCiuc001bpn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083190 mRNA. Translation: AAC35352.1. Different initiation.
CR456900 mRNA. Translation: CAG33181.1. Different initiation.
AK300797 mRNA. Translation: BAG62456.1.
AL353354, AL353622 Genomic DNA. Translation: CAI20826.1.
AL353622, AL353354 Genomic DNA. Translation: CAI19135.1.
CH471059 Genomic DNA. Translation: EAX07707.1.
CH471059 Genomic DNA. Translation: EAX07710.1.
BC033159 mRNA. Translation: AAH33159.1.
AF161433 mRNA. Translation: AAF28993.1.
AF161449 mRNA. Translation: AAF29009.1.
CCDSiCCDS41292.1.
RefSeqiNP_055095.2. NM_014280.2.
UniGeneiHs.433540.

3D structure databases

ProteinModelPortaliO75937.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116501. 37 interactors.
IntActiO75937. 21 interactors.
MINTiMINT-3002069.
STRINGi9606.ENSP00000263697.

PTM databases

iPTMnetiO75937.
PhosphoSitePlusiO75937.

Polymorphism and mutation databases

BioMutaiDNAJC8.

Proteomic databases

EPDiO75937.
MaxQBiO75937.
PaxDbiO75937.
PeptideAtlasiO75937.
PRIDEiO75937.
TopDownProteomicsiO75937.

Protocols and materials databases

DNASUi22826.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263697; ENSP00000263697; ENSG00000126698.
GeneIDi22826.
KEGGihsa:22826.
UCSCiuc001bpn.4. human.

Organism-specific databases

CTDi22826.
DisGeNETi22826.
GeneCardsiDNAJC8.
HGNCiHGNC:15470. DNAJC8.
HPAiHPA026275.
HPA026283.
neXtProtiNX_O75937.
OpenTargetsiENSG00000126698.
PharmGKBiPA27425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1150. Eukaryota.
ENOG4110ZJ4. LUCA.
GeneTreeiENSGT00390000012569.
HOVERGENiHBG051377.
InParanoidiO75937.
KOiK09528.
OMAiQNFYTEV.
OrthoDBiEOG091G0MI7.
PhylomeDBiO75937.
TreeFamiTF105167.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126698-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

GenomeRNAii22826.
PROiO75937.

Gene expression databases

BgeeiENSG00000126698.
CleanExiHS_DNAJC8.
ExpressionAtlasiO75937. baseline and differential.
GenevisibleiO75937. HS.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJC8_HUMAN
AccessioniPrimary (citable) accession number: O75937
Secondary accession number(s): B4DUU4
, D3DPM0, Q6IBA4, Q8N4Z5, Q9P051, Q9P067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.