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Protein

DnaJ homolog subfamily C member 8

Gene

DNAJC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716).1 Publication

GO - Molecular functioni

  • Hsp70 protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 8
Alternative name(s):
Splicing protein spf31
Gene namesi
Name:DNAJC8
Synonyms:SPF31
ORF Names:HSPC315, HSPC331
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000126698.10.
HGNCiHGNC:15470. DNAJC8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22826.
OpenTargetsiENSG00000126698.
PharmGKBiPA27425.

Polymorphism and mutation databases

BioMutaiDNAJC8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000710602 – 253DnaJ homolog subfamily C member 8Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei146N6-acetyllysineCombined sources1
Modified residuei222PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75937.
MaxQBiO75937.
PaxDbiO75937.
PeptideAtlasiO75937.
PRIDEiO75937.
TopDownProteomicsiO75937.

PTM databases

iPTMnetiO75937.
PhosphoSitePlusiO75937.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000126698.
CleanExiHS_DNAJC8.
ExpressionAtlasiO75937. baseline and differential.
GenevisibleiO75937. HS.

Organism-specific databases

HPAiHPA026275.
HPA026283.

Interactioni

Subunit structurei

Interacts with SRPK1 (PubMed:19240134). Interacts with HSP70 (HSPA1A or HSPA1B) (PubMed:27133716).2 Publications

GO - Molecular functioni

  • Hsp70 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116501. 52 interactors.
CORUMiO75937.
IntActiO75937. 21 interactors.
MINTiMINT-3002069.
STRINGi9606.ENSP00000263697.

Structurei

3D structure databases

ProteinModelPortaliO75937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 124JPROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 253Essential for polyglutamine aggregation suppression1 PublicationAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi189 – 192Nuclear localization signal1 Publication4
Motifi203 – 206Nuclear localization signal1 Publication4

Phylogenomic databases

eggNOGiKOG1150. Eukaryota.
ENOG4110ZJ4. LUCA.
GeneTreeiENSGT00390000012569.
HOVERGENiHBG051377.
InParanoidiO75937.
KOiK09528.
OMAiRAQMAFD.
OrthoDBiEOG091G0MI7.
PhylomeDBiO75937.
TreeFamiTF105167.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR036869. DnaJ_dom_sf.
IPR001623. DnaJ_domain.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiView protein in PROSITE
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGESGTS GGGGSTEEAF MTFYSEVKQI EKRDSVLTSK NQIERLTRPG
60 70 80 90 100
SSYFNLNPFE VLQIDPEVTD EEIKKRFRQL SILVHPDKNQ DDADRAQKAF
110 120 130 140 150
EAVDKAYKLL LDQEQKKRAL DVIQAGKEYV EHTVKERKKQ LKKEGKPTIV
160 170 180 190 200
EEDDPELFKQ AVYKQTMKLF AELEIKRKER EAKEMHERKR QREEEIEAQE
210 220 230 240 250
KAKREREWQK NFEESRDGRV DSWRNFQANT KGKKEKKNRT FLRPPKVKME

QRE
Length:253
Mass (Da):29,842
Last modified:April 26, 2005 - v2
Checksum:iC69D6189D69D1588
GO

Sequence cautioni

O75937: The sequence AAC35352 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
O75937: The sequence CAG33181 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253E → D in CAG33181 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083190 mRNA. Translation: AAC35352.1. Different initiation.
CR456900 mRNA. Translation: CAG33181.1. Different initiation.
AK300797 mRNA. Translation: BAG62456.1.
AL353354, AL353622 Genomic DNA. Translation: CAI20826.1.
AL353622, AL353354 Genomic DNA. Translation: CAI19135.1.
CH471059 Genomic DNA. Translation: EAX07707.1.
CH471059 Genomic DNA. Translation: EAX07710.1.
BC033159 mRNA. Translation: AAH33159.1.
AF161433 mRNA. Translation: AAF28993.1.
AF161449 mRNA. Translation: AAF29009.1.
CCDSiCCDS41292.1.
RefSeqiNP_055095.2. NM_014280.2.
UniGeneiHs.433540.

Genome annotation databases

EnsembliENST00000263697; ENSP00000263697; ENSG00000126698.
GeneIDi22826.
KEGGihsa:22826.
UCSCiuc001bpn.4. human.

Similar proteinsi

Entry informationi

Entry nameiDNJC8_HUMAN
AccessioniPrimary (citable) accession number: O75937
Secondary accession number(s): B4DUU4
, D3DPM0, Q6IBA4, Q8N4Z5, Q9P051, Q9P067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: April 26, 2005
Last modified: October 25, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM