UniProtKB - O75934 (SPF27_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Pre-mRNA-splicing factor SPF27
Gene
BCAS2
Organism
Homo sapiens (Human)
Status
Functioni
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).1 Publication
GO - Biological processi
- mRNA splicing, via spliceosome Source: Reactome
- RNA splicing Source: UniProtKB
- RNA splicing, via transesterification reactions Source: UniProtKB
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
Reactomei | R-HSA-72163. mRNA Splicing - Major Pathway. |
Names & Taxonomyi
Protein namesi | Recommended name: Pre-mRNA-splicing factor SPF27Alternative name(s): Breast carcinoma-amplified sequence 2 DNA amplified in mammary carcinoma 1 protein Spliceosome-associated protein SPF 27 |
Gene namesi | Name:BCAS2 Synonyms:DAM1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000116752.5. |
HGNCi | HGNC:975. BCAS2. |
MIMi | 605783. gene. |
neXtProti | NX_O75934. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10286. |
OpenTargetsi | ENSG00000116752. |
PharmGKBi | PA25285. |
Polymorphism and mutation databases
BioMutai | BCAS2. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000064861 | 2 – 225 | Pre-mRNA-splicing factor SPF27Add BLAST | 224 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 94 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O75934. |
MaxQBi | O75934. |
PaxDbi | O75934. |
PeptideAtlasi | O75934. |
PRIDEi | O75934. |
TopDownProteomicsi | O75934. |
2D gel databases
SWISS-2DPAGEi | O75934. |
PTM databases
iPTMneti | O75934. |
PhosphoSitePlusi | O75934. |
Miscellaneous databases
PMAP-CutDBi | O75934. |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000116752. |
CleanExi | HS_BCAS2. |
ExpressionAtlasi | O75934. baseline and differential. |
Genevisiblei | O75934. HS. |
Organism-specific databases
HPAi | HPA067881. |
Interactioni
Subunit structurei
Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly in the complex with PRPF19, CDC5L and PLRG1.2 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 115575. 111 interactors. |
CORUMi | O75934. |
IntActi | O75934. 71 interactors. |
MINTi | O75934. |
STRINGi | 9606.ENSP00000358554. |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5MQF | electron microscopy | 5.90 | K | 1-225 | [»] | |
5XJC | electron microscopy | 3.60 | K | 1-225 | [»] | |
ProteinModelPortali | O75934. | |||||
SMRi | O75934. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 138 – 222 | Sequence analysisAdd BLAST | 85 |
Sequence similaritiesi
Belongs to the SPF27 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3096. Eukaryota. ENOG41101IB. LUCA. |
GeneTreei | ENSGT00390000014494. |
HOGENOMi | HOG000007540. |
HOVERGENi | HBG050675. |
InParanoidi | O75934. |
KOi | K12861. |
OMAi | LPYIDHG. |
OrthoDBi | EOG091G0NMJ. |
PhylomeDBi | O75934. |
TreeFami | TF105818. |
Family and domain databases
InterProi | View protein in InterPro IPR008409. SPF27. |
PANTHERi | PTHR13296. PTHR13296. 1 hit. |
Pfami | View protein in Pfam PF05700. BCAS2. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O75934-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGTGLVAGE VVVDALPYFD QGYEAPGVRE AAAALVEEET RRYRPTKNYL
60 70 80 90 100
SYLTAPDYSA FETDIMRNEF ERLAARQPIE LLSMKRYELP APSSGQKNDI
110 120 130 140 150
TAWQECVNNS MAQLEHQAVR IENLELMSQH GCNAWKVYNE NLVHMIEHAQ
160 170 180 190 200
KELQKLRKHI QDLNWQRKNM QLTAGSKLRE MESNWVSLVS KNYEIERTIV
210 220
QLENEIYQIK QQHGEANKEN IRQDF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | E → D in CAG46834 (Ref. 3) Curated | 1 | |
Sequence conflicti | 89 | L → V in CAG46834 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035799 | 139 | N → S in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF081788 mRNA. Translation: AAC64059.1. AB020623 mRNA. Translation: BAA34863.1. CR542037 mRNA. Translation: CAG46834.1. BT019390 mRNA. Translation: AAV38197.1. AL390241 Genomic DNA. No translation available. BC005285 mRNA. Translation: AAH05285.1. BC012623 mRNA. Translation: AAH12623.1. BC022880 mRNA. Translation: AAH22880.1. |
CCDSi | CCDS874.1. |
RefSeqi | NP_005863.1. NM_005872.2. |
UniGenei | Hs.22960. |
Genome annotation databases
Ensembli | ENST00000369541; ENSP00000358554; ENSG00000116752. |
GeneIDi | 10286. |
KEGGi | hsa:10286. |
UCSCi | uc001efa.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | SPF27_HUMAN | |
Accessioni | O75934Primary (citable) accession number: O75934 Secondary accession number(s): Q6FGS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | November 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |