O75923 (DYSF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dysferlin

Alternative name(s):
Dystrophy-associated fer-1-like protein
Fer-1-like protein 1

Gene names

Name:	DYSF
Synonyms:	FER1L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2080 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Key calcium ion sensor involved in the Ca2+-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress By similarity.
Subunit structure	Interacts with CACNA1S. Interacts with ANXA1; the interaction is Ca2+- and injury state-dependent. Interacts with ANXA2; the interaction is Ca2+- and injury state-dependent. Interacts with CACNA1S and PARVB. Interacts with TRIM72/MG53; interaction is required for transport to sites of cell injury during repair patch formation By similarity. Interacts with CAV3 and PARVB. Interacts with AHNAK; the interaction is direct and Ca2+-independent. Interacts with AHNAK2; the interaction is direct and Ca2+-independent. Ref.15 Ref.18 Ref.20
Subcellular location	Cell membrane › sarcolemma; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein By similarity. Note: Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the site of contact between two myotubes or a myoblast and a myotube. Wounding of myotubes led to its focal enrichment to the site of injury and to its relocalization in a Ca2+-dependent manner toward the plasma membrane. Colocalizes with AHNAK, AHNAK2 and PARVB at the sarcolemma of skeletal muscle. Detected on the apical plasma membrane of the syncytiotrophoblast. Reaches the plasmma membrane through a caveolin-independent mechanism. Retained by caveolin at the plasmma membrane By similarity. Colocalizes, during muscle differentiation, with CACNA1S in the T-tubule system of myotubules By similarity. Accumulates and colocalizes with fusion vesicles at the sarcolemma disruption sites By similarity. Ref.10 Ref.12 Ref.13 Ref.18 Ref.19 Ref.20 Ref.21
Tissue specificity	Expressed in skeletal muscle, myoblast, myotube and in the syncytiotrophoblast (STB) of the placenta (at protein level). Highly expressed in skeletal muscle. Also found in heart, brain, spleen, intestine, placenta and at lower levels in liver, lung, kidney and pancreas. Ref.2 Ref.10 Ref.15 Ref.16 Ref.17 Ref.19 Ref.20 Ref.21
Developmental stage	Expression in limb tissue from 5-6 weeks embryos; persists throughout development. Ref.10
Domain	The C2 domain 1 associates with lipid membranes in a calcium-dependent manner.
Involvement in disease	Limb-girdle muscular dystrophy 2B (LGMD2B) [MIM:253601]: An autosomal recessive degenerative myopathy characterized by weakness and atrophy starting in the proximal pelvifemoral muscles, with onset in the late teens or later, massive elevation of serum creatine kinase levels and slow progression. Scapular muscle involvement is minor and not present at onset. Upper limb girdle involvement follows some years after the onset in lower limbs. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.13 Ref.24 Ref.27 Ref.29 Ref.32 Ref.34 Ref.35 Ref.36 Ref.38 Ref.39 Ref.40 Miyoshi muscular dystrophy 1 (MMD1) [MIM:254130]: A late-onset muscular dystrophy involving the distal lower limb musculature. It is characterized by weakness that initially affects the gastrocnemius muscle during early adulthood. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.13 Ref.16 Ref.23 Ref.24 Ref.25 Ref.26 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32 Ref.34 Ref.38 Ref.39 Ref.40 Distal myopathy with anterior tibial onset (DMAT) [MIM:606768]: Onset of the disorder is between 14 and 28 years of age and the anterior tibial muscles are the first muscle group to be involved. Inheritance is autosomal recessive. Note: The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities	Belongs to the ferlin family. Contains 5 C2 domains.
Sequence caution	The sequence BAG51981.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA07603.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAA07603.1 differs from that shown. Reason: Frameshift at position 1972.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Limb-girdle muscular dystrophy
Domain	Repeat Signal-anchor Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	plasma membrane repair Inferred from electronic annotation. Source: Compara vesicle fusion Inferred from electronic annotation. Source: Compara
Cellular_component	T-tubule Inferred from electronic annotation. Source: Compara cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lamellipodium Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement Ref.12. Source: ProtInc
Molecular_function	calcium-dependent phospholipid binding Inferred from mutant phenotype Ref.16. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ACTN2	P35609	2	EBI-2799016,EBI-77797
ALMS1	Q8TCU4	3	EBI-2799016,EBI-308651
APPL1	Q9UKG1	2	EBI-2799016,EBI-741243
CMYA5	Q8N3K9	3	EBI-2799016,EBI-2323272
DES	P17661	3	EBI-2799016,EBI-1055572
DGKD	Q16760	3	EBI-2799016,EBI-719333
DNAJB6	O75190	2	EBI-2799016,EBI-1053164
FLNC	Q14315	3	EBI-2799016,EBI-489954
MYBPC1	Q00872	4	EBI-2799016,EBI-5652924
MYOM1	P52179	3	EBI-2799016,EBI-5353249
MYOM2	P54296	3	EBI-2799016,EBI-5357134
NEB	P20929	6	EBI-2799016,EBI-1049657
OPTN	Q96CV9	3	EBI-2799016,EBI-748974
SAMHD1	Q9Y3Z3	2	EBI-2799016,EBI-1054601
SGCG	Q13326	3	EBI-2799016,EBI-5357343
SNAPIN	O95295	3	EBI-2799016,EBI-296723
TTN	Q8WZ42	17	EBI-2799016,EBI-681210

Alternative products

This entry describes 15 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75923-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75923-2)

The sequence of this isoform differs from the canonical sequence as follows:
     152-152: A → AGGGQSRAETWSLLSDSTMDTRYSGKKWPAPT

Isoform 3 (identifier: O75923-3)

The sequence of this isoform differs from the canonical sequence as follows:
     494-508: EEPAGAVKPSKASDL → V

Isoform 4 (identifier: O75923-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1470-1470: Q → QLADGLSSLAPTNTASPPSSPH

Isoform 5 (identifier: O75923-5)

The sequence of this isoform differs from the canonical sequence as follows:
     152-152: A → AGGGQSRAETWSLLSDSTMDTRYSGKKWPAPT
     494-508: EEPAGAVKPSKASDL → V

Isoform 6 (identifier: O75923-6)

The sequence of this isoform differs from the canonical sequence as follows:
     494-508: EEPAGAVKPSKASDL → V
     1470-1470: Q → QLADGLSSLAPTNTASPPSSPH

Isoform 7 (identifier: O75923-7)

The sequence of this isoform differs from the canonical sequence as follows:
     152-152: A → AGGGQSRAETWSLLSDSTMDTRYSGKKWPAPT
     494-508: EEPAGAVKPSKASDL → V
     1470-1470: Q → QLADGLSSLAPTNTASPPSSPH

Isoform 8 (identifier: O75923-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MLRVFILYAENVHTPDTDISDAYCSAVFA → MLCCLLVRASNLPSAKKDRRSDPVASLTFR
     152-152: A → AGGGQSRAETWSLLSDSTMDTRYSGKKWPAPT

Isoform 9 (identifier: O75923-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MLRVFILYAENVHTPDTDISDAYCSAVFA → MLCCLLVRASNLPSAKKDRRSDPVASLTFR
     494-508: EEPAGAVKPSKASDL → V

Isoform 10 (identifier: O75923-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MLRVFILYAENVHTPDTDISDAYCSAVFA → MLCCLLVRASNLPSAKKDRRSDPVASLTFR
     1470-1470: Q → QLADGLSSLAPTNTASPPSSPH

Isoform 11 (identifier: O75923-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MLRVFILYAENVHTPDTDISDAYCSAVFA → MLCCLLVRASNLPSAKKDRRSDPVASLTFR
     152-152: A → AGGGQSRAETWSLLSDSTMDTRYSGKKWPAPT
     494-508: EEPAGAVKPSKASDL → V

Isoform 12 (identifier: O75923-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MLRVFILYAENVHTPDTDISDAYCSAVFA → MLCCLLVRASNLPSAKKDRRSDPVASLTFR
     494-508: EEPAGAVKPSKASDL → V
     1470-1470: Q → QLADGLSSLAPTNTASPPSSPH

Isoform 13 (identifier: O75923-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MLRVFILYAENVHTPDTDISDAYCSAVFA → MLCCLLVRASNLPSAKKDRRSDPVASLTFR
     152-152: A → AGGGQSRAETWSLLSDSTMDTRYSGKKWPAPT
     494-508: EEPAGAVKPSKASDL → V
     1470-1470: Q → QLADGLSSLAPTNTASPPSSPH

Isoform 14 (identifier: O75923-14)

Also known as: Dysferlin_v1; DYSF_v1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MLRVFILYAENVHTPDTDISDAYCSAVFA → MLCCLLVRASNLPSAKKDRRSDPVASLTFR

Isoform 15 (identifier: O75923-15)

The sequence of this isoform differs from the canonical sequence as follows:
     494-508: EEPAGAVKPSKASDL → V
     1934-1968: KPAKTAKKCSLDQLDDAFHPEWFVSLFEQKTVKGW → SSASSSRPPRPDCPARVGRQTDGPAHTPRVANMEL
     1969-2080: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2080	2080	Dysferlin		PRO_0000057879
Regions
	Topological domain	1 – 2046	2046	Cytoplasmic Potential
	Transmembrane	2047 – 2067	21	Helical; Potential
	Topological domain	2068 – 2080	13	Extracellular Potential
	Domain	1 – 85	85	C2 1
	Domain	207 – 302	96	C2 2
	Domain	366 – 479	114	C2 3
	Domain	1139 – 1244	106	C2 4
	Domain	1565 – 1663	99	C2 5
	Compositional bias	1038 – 1097	60	Arg-rich
Natural variations
	Alternative sequence	1 – 29	29	MLRVF…SAVFA → MLCCLLVRASNLPSAKKDRR SDPVASLTFR in isoform 8, isoform 9, isoform 10, isoform 11, isoform 12, isoform 13 and isoform 14.		VSP_035924
	Alternative sequence	152	1	A → AGGGQSRAETWSLLSDSTMD TRYSGKKWPAPT in isoform 2, isoform 5, isoform 7, isoform 8, isoform 11 and isoform 13.		VSP_035925
	Alternative sequence	494 – 508	15	EEPAG…KASDL → V in isoform 3, isoform 5, isoform 6, isoform 7, isoform 9, isoform 11, isoform 12, isoform 13 and isoform 15.		VSP_035926
	Alternative sequence	1470	1	Q → QLADGLSSLAPTNTASPPSS PH in isoform 4, isoform 6, isoform 7, isoform 10, isoform 12 and isoform 13.		VSP_035927
	Alternative sequence	1934 – 1968	35	KPAKT…TVKGW → SSASSSRPPRPDCPARVGRQ TDGPAHTPRVANMEL in isoform 15.		VSP_035928
	Alternative sequence	1969 – 2080	112	Missing in isoform 15.		VSP_035929
	Natural variant	52	1	W → R in LGMD2B. Ref.40		VAR_057834
	Natural variant	67	1	V → D in MMD1 and LGMD2B; Reduces calcium-sensitive phospholipid binding and interaction with AHNAK and AHNAK2. Ref.16 Ref.24		VAR_057835
	Natural variant	84	1	A → V. Ref.40		VAR_057836
	Natural variant	155	1	G → R in LGMD2B. Ref.40		VAR_057837
	Natural variant	170	1	A → E in MMD1, LGMD2B and isolated hyperCKemia. Ref.32 Ref.34 Ref.40 Corresponds to variant rs34999029 [ dbSNP | Ensembl ].		VAR_024853
	Natural variant	189	1	L → V. Ref.32 Ref.40 Corresponds to variant rs13407355 [ dbSNP | Ensembl ].		VAR_024854
	Natural variant	234	1	G → E in LGMD2B. Ref.40		VAR_057838
	Natural variant	253	1	R → W in isolated hyperCKemia. Ref.32 Ref.40		VAR_024855
	Natural variant	266	1	L → P in pseudometabolic myopathy. Ref.32 Ref.40		VAR_024856
	Natural variant	284	1	I → T in LGMD2B. Ref.40		VAR_057839
	Natural variant	299	1	G → E in MMD1. Ref.32 Ref.40		VAR_024857
	Natural variant	299	1	G → R in LGMD2B and proximodistal myopathy. Ref.35 Ref.39 Ref.40		VAR_057840
	Natural variant	299	1	G → W in MMD1. Ref.39		VAR_057841
	Natural variant	335	1	G → A. Ref.40		VAR_057842
	Natural variant	340	1	S → R in proximodistal myopathy. Ref.40		VAR_057843
	Natural variant	374	1	V → L in MMD1; uncertain pathogenicity. Ref.34 Ref.40		VAR_057844
	Natural variant	386 – 390	5	FRAED → Y in MMD1.		VAR_057845
	Natural variant	389	1	E → Q in MMD1. Ref.31		VAR_057846
	Natural variant	390	1	D → N. Ref.40		VAR_057847
	Natural variant	426	1	G → R in MMD1. Ref.40		VAR_057848
	Natural variant	426	1	G → V in MMD1. Ref.28		VAR_057849
	Natural variant	456	1	C → W in MMD1. Ref.32 Ref.40		VAR_024858
	Natural variant	519	1	G → R in MMD1. Ref.38		VAR_057850
	Natural variant	555	1	R → W in isolated hyperCKemia, LGMD2B and MMD1. Ref.32 Ref.40		VAR_024859
	Natural variant	618	1	G → R in MMD1 and LGMD2B. Ref.29 Ref.40		VAR_057851
	Natural variant	621	1	G → R in LGMD2B. Ref.34		VAR_057852
	Natural variant	625	1	D → Y in LGMD2B. Ref.38		VAR_057853
	Natural variant	731	1	P → R in LGMD2B. Ref.40		VAR_057854
	Natural variant	791	1	P → R in MMD1 and LGMD2B. Ref.13 Ref.36		VAR_012308
	Natural variant	819	1	R → Q. Ref.40		VAR_057855
	Natural variant	834	1	I → V. Corresponds to variant rs34671418 [ dbSNP | Ensembl ].		VAR_049055
	Natural variant	930	1	W → C in LGMD2B; uncetain pathogenicity. Ref.36 Ref.40		VAR_057856
	Natural variant	959	1	R → W in MMD1 and LGMD2B. Ref.27 Ref.34		VAR_024860
	Natural variant	999	1	W → C in MMD1. Ref.23 Ref.26 Corresponds to variant rs28937581 [ dbSNP | Ensembl ].		VAR_057857
	Natural variant	1022	1	R → Q in LGMD2B; uncertain pathogenicity. Ref.27 Ref.29 Ref.40 Corresponds to variant rs34211915 [ dbSNP | Ensembl ].		VAR_024861
	Natural variant	1029	1	P → L in MMD1. Ref.40		VAR_057858
	Natural variant	1038	1	R → Q in LGMD2B; uncertain pathogenicity. Ref.27 Ref.34 Ref.40		VAR_024862
	Natural variant	1041	1	R → C in MMD1. Ref.29		VAR_057859
	Natural variant	1046	1	R → H in MMD1; dbNP:28939700. Ref.25 Ref.32 Ref.40 Corresponds to variant rs28939700 [ dbSNP | Ensembl ].		VAR_024863
	Natural variant	1065	1	E → EAE.		VAR_024864
	Natural variant	1072	1	A → P. Corresponds to variant rs34660230 [ dbSNP | Ensembl ].		VAR_049056
	Natural variant	1096	1	R → H. Corresponds to variant rs59915619 [ dbSNP | Ensembl ].		VAR_061170
	Natural variant	1208	1	I → M in LGMD2B. Ref.32		VAR_024865
	Natural variant	1228	1	L → P in LGMD2B. Ref.40		VAR_057860
	Natural variant	1242	1	R → H. Corresponds to variant rs2303603 [ dbSNP | Ensembl ].		VAR_020308
	Natural variant	1276	1	L → V in proximodistal myopathy. Ref.32 Ref.40		VAR_024866
	Natural variant	1298	1	I → V in MMD1 and LGMD2B. Ref.1		VAR_012309
	Natural variant	1325	1	I → M in a breast cancer sample; somatic mutation. Ref.37		VAR_035893
	Natural variant	1325	1	I → V. Ref.40		VAR_057861
	Natural variant	1331	1	R → L. Ref.27 Ref.32 Corresponds to variant rs61742872 [ dbSNP | Ensembl ].		VAR_024867
	Natural variant	1335	1	E → K in MMD1 and LGMD2B. Ref.27 Ref.29 Ref.34		VAR_024868
	Natural variant	1341	1	L → P in LGMD2B. Ref.35		VAR_057862
	Natural variant	1349	1	L → V in a breast cancer sample; somatic mutation. Ref.37		VAR_035894
	Natural variant	1351	1	N → S. Ref.32		VAR_024869
	Natural variant	1361	1	C → R in MMD1. Ref.29		VAR_057863
	Natural variant	1505	1	Y → C in LGMD2B. Ref.29		VAR_057864
	Natural variant	1526	1	K → T in LGMD2B. Ref.40		VAR_057865
	Natural variant	1543	1	G → D in LGMD2B. Ref.40		VAR_057866
	Natural variant	1581	1	R → H. Ref.26		VAR_057867
	Natural variant	1662	1	T → R in MMD1. Ref.29		VAR_057868
	Natural variant	1678	1	C → S in isolated hyperCKemia. Ref.34		VAR_057869
	Natural variant	1679	1	G → E in MMD1. Ref.26		VAR_057870
	Natural variant	1693	1	R → Q in MMD1. Ref.32 Ref.40		VAR_024870
	Natural variant	1693	1	R → W in MMD1. Ref.34		VAR_057871
	Natural variant	1734	1	E → G in LGMD2B. Ref.38		VAR_057872
	Natural variant	1748	1	E → V in proximodistal myopathy. Ref.32 Ref.40		VAR_024871
	Natural variant	1768	1	R → W in LGMD2B and proximodistal myopathy; uncetain pathogenicity. Ref.36 Ref.40		VAR_057873
	Natural variant	1837	1	D → N in MMD1. Ref.34 Ref.40		VAR_057874
	Natural variant	1842	1	G → D in MMD1. Ref.30		VAR_057875
	Natural variant	1857	1	H → R in MMD1. Ref.1		VAR_012310
	Natural variant	1922	1	L → P in MMD1. Ref.30		VAR_057876
	Natural variant	1938 – 1939	2	Missing in MMD1.		VAR_057877
	Natural variant	1942	1	C → G in MMD1. Ref.34		VAR_057878
	Natural variant	1967	1	G → S. Ref.40		VAR_057879
	Natural variant	1970	1	P → S in LGMD2B. Ref.40		VAR_057880
	Natural variant	2000	1	R → Q in MMD1. Ref.25		VAR_024872
	Natural variant	2042	1	R → C in MMD1, LGMD2B and proximodistal myopathy. Ref.1 Ref.34 Ref.36 Ref.40		VAR_012311
	Natural variant	2068	1	P → L in MMD1. Ref.28		VAR_057881

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 376E25A5AB9BE398	FASTA	2,080	237,295
	10 20 30 40 50 60 MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD 70 80 90 100 110 120 QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ 130 140 150 160 170 180 VSYTPLPGAV PLFPPPTPLE PSPTLPDLDV VADTGGEEDT EDQGLTGDEA EPFLDQSGGP 190 200 210 220 230 240 GAPTTPRKLP SRPPPHYPGI KRKRSAPTSR KLLSDKPQDF QIRVQVIEGR QLPGVNIKPV 250 260 270 280 290 300 VKVTAAGQTK RTRIHKGNSP LFNETLFFNL FDSPGELFDE PIFITVVDSR SLRTDALLGE 310 320 330 340 350 360 FRMDVGTIYR EPRHAYLRKW LLLSDPDDFS AGARGYLKTS LCVLGPGDEA PLERKDPSED 370 380 390 400 410 420 KEDIESNLLR PTGVALRGAH FCLKVFRAED LPQMDDAVMD NVKQIFGFES NKKNLVDPFV 430 440 450 460 470 480 EVSFAGKMLC SKILEKTANP QWNQNITLPA MFPSMCEKMR IRIIDWDRLT HNDIVATTYL 490 500 510 520 530 540 SMSKISAPGG EIEEEPAGAV KPSKASDLDD YLGFLPTFGP CYINLYGSPR EFTGFPDPYT 550 560 570 580 590 600 ELNTGKGEGV AYRGRLLLSL ETKLVEHSEQ KVEDLPADDI LRVEKYLRRR KYSLFAAFYS 610 620 630 640 650 660 ATMLQDVDDA IQFEVSIGNY GNKFDMTCLP LASTTQYSRA VFDGCHYYYL PWGNVKPVVV 670 680 690 700 710 720 LSSYWEDISH RIETQNQLLG IADRLEAGLE QVHLALKAQC STEDVDSLVA QLTDELIAGC 730 740 750 760 770 780 SQPLGDIHET PSATHLDQYL YQLRTHHLSQ ITEAALALKL GHSELPAALE QAEDWLLRLR 790 800 810 820 830 840 ALAEEPQNSL PDIVIWMLQG DKRVAYQRVP AHQVLFSRRG ANYCGKNCGK LQTIFLKYPM 850 860 870 880 890 900 EKVPGARMPV QIRVKLWFGL SVDEKEFNQF AEGKLSVFAE TYENETKLAL VGNWGTTGLT 910 920 930 940 950 960 YPKFSDVTGK IKLPKDSFRP SAGWTWAGDW FVCPEKTLLH DMDAGHLSFV EEVFENQTRL 970 980 990 1000 1010 1020 PGGQWIYMSD NYTDVNGEKV LPKDDIECPL GWKWEDEEWS TDLNRAVDEQ GWEYSITIPP 1030 1040 1050 1060 1070 1080 ERKPKHWVPA EKMYYTHRRR RWVRLRRRDL SQMEALKRHR QAEAEGEGWE YASLFGWKFH 1090 1100 1110 1120 1130 1140 LEYRKTDAFR RRRWRRRMEP LEKTGPAAVF ALEGALGGVM DDKSEDSMSV STLSFGVNRP 1150 1160 1170 1180 1190 1200 TISCIFDYGN RYHLRCYMYQ ARDLAAMDKD SFSDPYAIVS FLHQSQKTVV VKNTLNPTWD 1210 1220 1230 1240 1250 1260 QTLIFYEIEI FGEPATVAEQ PPSIVVELYD HDTYGADEFM GRCICQPSLE RMPRLAWFPL 1270 1280 1290 1300 1310 1320 TRGSQPSGEL LASFELIQRE KPAIHHIPGF EVQETSRILD ESEDTDLPYP PPQREANIYM 1330 1340 1350 1360 1370 1380 VPQNIKPALQ RTAIEILAWG LRNMKSYQLA NISSPSLVVE CGGQTVQSCV IRNLRKNPNF 1390 1400 1410 1420 1430 1440 DICTLFMEVM LPREELYCPP ITVKVIDNRQ FGRRPVVGQC TIRSLESFLC DPYSAESPSP 1450 1460 1470 1480 1490 1500 QGGPDDVSLL SPGEDVLIDI DDKEPLIPIQ EEEFIDWWSK FFASIGEREK CGSYLEKDFD 1510 1520 1530 1540 1550 1560 TLKVYDTQLE NVEAFEGLSD FCNTFKLYRG KTQEETEDPS VIGEFKGLFK IYPLPEDPAI 1570 1580 1590 1600 1610 1620 PMPPRQFHQL AAQGPQECLV RIYIVRAFGL QPKDPNGKCD PYIKISIGKK SVSDQDNYIP 1630 1640 1650 1660 1670 1680 CTLEPVFGKM FELTCTLPLE KDLKITLYDY DLLSKDEKIG ETVVDLENRL LSKFGARCGL 1690 1700 1710 1720 1730 1740 PQTYCVSGPN QWRDQLRPSQ LLHLFCQQHR VKAPVYRTDR VMFQDKEYSI EEIEAGRIPN 1750 1760 1770 1780 1790 1800 PHLGPVEERL ALHVLQQQGL VPEHVESRPL YSPLQPDIEQ GKLQMWVDLF PKALGRPGPP 1810 1820 1830 1840 1850 1860 FNITPRRARR FFLRCIIWNT RDVILDDLSL TGEKMSDIYV KGWMIGFEEH KQKTDVHYRS 1870 1880 1890 1900 1910 1920 LGGEGNFNWR FIFPFDYLPA EQVCTIAKKD AFWRLDKTES KIPARVVFQI WDNDKFSFDD 1930 1940 1950 1960 1970 1980 FLGSLQLDLN RMPKPAKTAK KCSLDQLDDA FHPEWFVSLF EQKTVKGWWP CVAEEGEKKI 1990 2000 2010 2020 2030 2040 LAGKLEMTLE IVAESEHEER PAGQGRDEPN MNPKLEDPRR PDTSFLWFTS PYKTMKFILW 2050 2060 2070 2080 RRFRWAIILF IILFILLLFL AIFIYAFPNY AAMKLVKPFS
	Isoform 2 [UniParc]. Checksum: AE2E2536294E3F8E	FASTA	2,111	240,649
	10 20 30 40 50 60 MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD 70 80 90 100 110 120 QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ 130 140 150 160 170 180 VSYTPLPGAV PLFPPPTPLE PSPTLPDLDV VAGGGQSRAE TWSLLSDSTM DTRYSGKKWP 190 200 210 220 230 240 APTDTGGEED TEDQGLTGDE AEPFLDQSGG PGAPTTPRKL PSRPPPHYPG IKRKRSAPTS 250 260 270 280 290 300 RKLLSDKPQD FQIRVQVIEG RQLPGVNIKP VVKVTAAGQT KRTRIHKGNS PLFNETLFFN 310 320 330 340 350 360 LFDSPGELFD EPIFITVVDS RSLRTDALLG EFRMDVGTIY REPRHAYLRK WLLLSDPDDF 370 380 390 400 410 420 SAGARGYLKT SLCVLGPGDE APLERKDPSE DKEDIESNLL RPTGVALRGA HFCLKVFRAE 430 440 450 460 470 480 DLPQMDDAVM DNVKQIFGFE SNKKNLVDPF VEVSFAGKML CSKILEKTAN PQWNQNITLP 490 500 510 520 530 540 AMFPSMCEKM RIRIIDWDRL THNDIVATTY LSMSKISAPG GEIEEEPAGA VKPSKASDLD 550 560 570 580 590 600 DYLGFLPTFG PCYINLYGSP REFTGFPDPY TELNTGKGEG VAYRGRLLLS LETKLVEHSE 610 620 630 640 650 660 QKVEDLPADD ILRVEKYLRR RKYSLFAAFY SATMLQDVDD AIQFEVSIGN YGNKFDMTCL 670 680 690 700 710 720 PLASTTQYSR AVFDGCHYYY LPWGNVKPVV VLSSYWEDIS HRIETQNQLL GIADRLEAGL 730 740 750 760 770 780 EQVHLALKAQ CSTEDVDSLV AQLTDELIAG CSQPLGDIHE TPSATHLDQY LYQLRTHHLS 790 800 810 820 830 840 QITEAALALK LGHSELPAAL EQAEDWLLRL RALAEEPQNS LPDIVIWMLQ GDKRVAYQRV 850 860 870 880 890 900 PAHQVLFSRR GANYCGKNCG KLQTIFLKYP MEKVPGARMP VQIRVKLWFG LSVDEKEFNQ 910 920 930 940 950 960 FAEGKLSVFA ETYENETKLA LVGNWGTTGL TYPKFSDVTG KIKLPKDSFR PSAGWTWAGD 970 980 990 1000 1010 1020 WFVCPEKTLL HDMDAGHLSF VEEVFENQTR LPGGQWIYMS DNYTDVNGEK VLPKDDIECP 1030 1040 1050 1060 1070 1080 LGWKWEDEEW STDLNRAVDE QGWEYSITIP PERKPKHWVP AEKMYYTHRR RRWVRLRRRD 1090 1100 1110 1120 1130 1140 LSQMEALKRH RQAEAEGEGW EYASLFGWKF HLEYRKTDAF RRRRWRRRME PLEKTGPAAV 1150 1160 1170 1180 1190 1200 FALEGALGGV MDDKSEDSMS VSTLSFGVNR PTISCIFDYG NRYHLRCYMY QARDLAAMDK 1210 1220 1230 1240 1250 1260 DSFSDPYAIV SFLHQSQKTV VVKNTLNPTW DQTLIFYEIE IFGEPATVAE QPPSIVVELY 1270 1280 1290 1300 1310 1320 DHDTYGADEF MGRCICQPSL ERMPRLAWFP LTRGSQPSGE LLASFELIQR EKPAIHHIPG 1330 1340 1350 1360 1370 1380 FEVQETSRIL DESEDTDLPY PPPQREANIY MVPQNIKPAL QRTAIEILAW GLRNMKSYQL 1390 1400 1410 1420 1430 1440 ANISSPSLVV ECGGQTVQSC VIRNLRKNPN FDICTLFMEV MLPREELYCP PITVKVIDNR 1450 1460 1470 1480 1490 1500 QFGRRPVVGQ CTIRSLESFL CDPYSAESPS PQGGPDDVSL LSPGEDVLID IDDKEPLIPI 1510 1520 1530 1540 1550 1560 QEEEFIDWWS KFFASIGERE KCGSYLEKDF DTLKVYDTQL ENVEAFEGLS DFCNTFKLYR 1570 1580 1590 1600 1610 1620 GKTQEETEDP SVIGEFKGLF KIYPLPEDPA IPMPPRQFHQ LAAQGPQECL VRIYIVRAFG 1630 1640 1650 1660 1670 1680 LQPKDPNGKC DPYIKISIGK KSVSDQDNYI PCTLEPVFGK MFELTCTLPL EKDLKITLYD 1690 1700 1710 1720 1730 1740 YDLLSKDEKI GETVVDLENR LLSKFGARCG LPQTYCVSGP NQWRDQLRPS QLLHLFCQQH 1750 1760 1770 1780 1790 1800 RVKAPVYRTD RVMFQDKEYS IEEIEAGRIP NPHLGPVEER LALHVLQQQG LVPEHVESRP 1810 1820 1830 1840 1850 1860 LYSPLQPDIE QGKLQMWVDL FPKALGRPGP PFNITPRRAR RFFLRCIIWN TRDVILDDLS 1870 1880 1890 1900 1910 1920 LTGEKMSDIY VKGWMIGFEE HKQKTDVHYR SLGGEGNFNW RFIFPFDYLP AEQVCTIAKK 1930 1940 1950 1960 1970 1980 DAFWRLDKTE SKIPARVVFQ IWDNDKFSFD DFLGSLQLDL NRMPKPAKTA KKCSLDQLDD 1990 2000 2010 2020 2030 2040 AFHPEWFVSL FEQKTVKGWW PCVAEEGEKK ILAGKLEMTL EIVAESEHEE RPAGQGRDEP 2050 2060 2070 2080 2090 2100 NMNPKLEDPR RPDTSFLWFT SPYKTMKFIL WRRFRWAIIL FIILFILLLF LAIFIYAFPN 2110 YAAMKLVKPF S
	Isoform 3 [UniParc]. Checksum: BB177D29C6673190	FASTA	2,066	235,913
	10 20 30 40 50 60 MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD 70 80 90 100 110 120 QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ 130 140 150 160 170 180 VSYTPLPGAV PLFPPPTPLE PSPTLPDLDV VADTGGEEDT EDQGLTGDEA EPFLDQSGGP 190 200 210 220 230 240 GAPTTPRKLP SRPPPHYPGI KRKRSAPTSR KLLSDKPQDF QIRVQVIEGR QLPGVNIKPV 250 260 270 280 290 300 VKVTAAGQTK RTRIHKGNSP LFNETLFFNL FDSPGELFDE PIFITVVDSR SLRTDALLGE 310 320 330 340 350 360 FRMDVGTIYR EPRHAYLRKW LLLSDPDDFS AGARGYLKTS LCVLGPGDEA PLERKDPSED 370 380 390 400 410 420 KEDIESNLLR PTGVALRGAH FCLKVFRAED LPQMDDAVMD NVKQIFGFES NKKNLVDPFV 430 440 450 460 470 480 EVSFAGKMLC SKILEKTANP QWNQNITLPA MFPSMCEKMR IRIIDWDRLT HNDIVATTYL 490 500 510 520 530 540 SMSKISAPGG EIEVDDYLGF LPTFGPCYIN LYGSPREFTG FPDPYTELNT GKGEGVAYRG 550 560 570 580 590 600 RLLLSLETKL VEHSEQKVED LPADDILRVE KYLRRRKYSL FAAFYSATML QDVDDAIQFE 610 620 630 640 650 660 VSIGNYGNKF DMTCLPLAST TQYSRAVFDG CHYYYLPWGN VKPVVVLSSY WEDISHRIET 670 680 690 700 710 720 QNQLLGIADR LEAGLEQVHL ALKAQCSTED VDSLVAQLTD ELIAGCSQPL GDIHETPSAT 730 740 750 760 770 780 HLDQYLYQLR THHLSQITEA ALALKLGHSE LPAALEQAED WLLRLRALAE EPQNSLPDIV 790 800 810 820 830 840 IWMLQGDKRV AYQRVPAHQV LFSRRGANYC GKNCGKLQTI FLKYPMEKVP GARMPVQIRV 850 860 870 880 890 900 KLWFGLSVDE KEFNQFAEGK LSVFAETYEN ETKLALVGNW GTTGLTYPKF SDVTGKIKLP 910 920 930 940 950 960 KDSFRPSAGW TWAGDWFVCP EKTLLHDMDA GHLSFVEEVF ENQTRLPGGQ WIYMSDNYTD 970 980 990 1000 1010 1020 VNGEKVLPKD DIECPLGWKW EDEEWSTDLN RAVDEQGWEY SITIPPERKP KHWVPAEKMY 1030 1040 1050 1060 1070 1080 YTHRRRRWVR LRRRDLSQME ALKRHRQAEA EGEGWEYASL FGWKFHLEYR KTDAFRRRRW 1090 1100 1110 1120 1130 1140 RRRMEPLEKT GPAAVFALEG ALGGVMDDKS EDSMSVSTLS FGVNRPTISC IFDYGNRYHL 1150 1160 1170 1180 1190 1200 RCYMYQARDL AAMDKDSFSD PYAIVSFLHQ SQKTVVVKNT LNPTWDQTLI FYEIEIFGEP 1210 1220 1230 1240 1250 1260 ATVAEQPPSI VVELYDHDTY GADEFMGRCI CQPSLERMPR LAWFPLTRGS QPSGELLASF 1270 1280 1290 1300 1310 1320 ELIQREKPAI HHIPGFEVQE TSRILDESED TDLPYPPPQR EANIYMVPQN IKPALQRTAI 1330 1340 1350 1360 1370 1380 EILAWGLRNM KSYQLANISS PSLVVECGGQ TVQSCVIRNL RKNPNFDICT LFMEVMLPRE 1390 1400 1410 1420 1430 1440 ELYCPPITVK VIDNRQFGRR PVVGQCTIRS LESFLCDPYS AESPSPQGGP DDVSLLSPGE 1450 1460 1470 1480 1490 1500 DVLIDIDDKE PLIPIQEEEF IDWWSKFFAS IGEREKCGSY LEKDFDTLKV YDTQLENVEA 1510 1520 1530 1540 1550 1560 FEGLSDFCNT FKLYRGKTQE ETEDPSVIGE FKGLFKIYPL PEDPAIPMPP RQFHQLAAQG 1570 1580 1590 1600 1610 1620 PQECLVRIYI VRAFGLQPKD PNGKCDPYIK ISIGKKSVSD QDNYIPCTLE PVFGKMFELT 1630 1640 1650 1660 1670 1680 CTLPLEKDLK ITLYDYDLLS KDEKIGETVV DLENRLLSKF GARCGLPQTY CVSGPNQWRD 1690 1700 1710 1720 1730 1740 QLRPSQLLHL FCQQHRVKAP VYRTDRVMFQ DKEYSIEEIE AGRIPNPHLG PVEERLALHV 1750 1760 1770 1780 1790 1800 LQQQGLVPEH VESRPLYSPL QPDIEQGKLQ MWVDLFPKAL GRPGPPFNIT PRRARRFFLR 1810 1820 1830 1840 1850 1860 CIIWNTRDVI LDDLSLTGEK MSDIYVKGWM IGFEEHKQKT DVHYRSLGGE GNFNWRFIFP 1870 1880 1890 1900 1910 1920 FDYLPAEQVC TIAKKDAFWR LDKTESKIPA RVVFQIWDND KFSFDDFLGS LQLDLNRMPK 1930 1940 1950 1960 1970 1980 PAKTAKKCSL DQLDDAFHPE WFVSLFEQKT VKGWWPCVAE EGEKKILAGK LEMTLEIVAE 1990 2000 2010 2020 2030 2040 SEHEERPAGQ GRDEPNMNPK LEDPRRPDTS FLWFTSPYKT MKFILWRRFR WAIILFIILF 2050 2060 ILLLFLAIFI YAFPNYAAMK LVKPFS
	Isoform 4 [UniParc]. Checksum: 26EEDCF011956BE1	FASTA	2,101	239,297
	10 20 30 40 50 60 MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD 70 80 90 100 110 120 QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ 130 140 150 160 170 180 VSYTPLPGAV PLFPPPTPLE PSPTLPDLDV VADTGGEEDT EDQGLTGDEA EPFLDQSGGP 190 200 210 220 230 240 GAPTTPRKLP SRPPPHYPGI KRKRSAPTSR KLLSDKPQDF QIRVQVIEGR QLPGVNIKPV 250 260 270 280 290 300 VKVTAAGQTK RTRIHKGNSP LFNETLFFNL FDSPGELFDE PIFITVVDSR SLRTDALLGE 310 320 330 340 350 360 FRMDVGTIYR EPRHAYLRKW LLLSDPDDFS AGARGYLKTS LCVLGPGDEA PLERKDPSED 370 380 390 400 410 420 KEDIESNLLR PTGVALRGAH FCLKVFRAED LPQMDDAVMD NVKQIFGFES NKKNLVDPFV 430 440 450 460 470 480 EVSFAGKMLC SKILEKTANP QWNQNITLPA MFPSMCEKMR IRIIDWDRLT HNDIVATTYL 490 500 510 520 530 540 SMSKISAPGG EIEEEPAGAV KPSKASDLDD YLGFLPTFGP CYINLYGSPR EFTGFPDPYT 550 560 570 580 590 600 ELNTGKGEGV AYRGRLLLSL ETKLVEHSEQ KVEDLPADDI LRVEKYLRRR KYSLFAAFYS 610 620 630 640 650 660 ATMLQDVDDA IQFEVSIGNY GNKFDMTCLP LASTTQYSRA VFDGCHYYYL PWGNVKPVVV 670 680 690 700 710 720 LSSYWEDISH RIETQNQLLG IADRLEAGLE QVHLALKAQC STEDVDSLVA QLTDELIAGC 730 740 750 760 770 780 SQPLGDIHET PSATHLDQYL YQLRTHHLSQ ITEAALALKL GHSELPAALE QAEDWLLRLR 790 800 810 820 830 840 ALAEEPQNSL PDIVIWMLQG DKRVAYQRVP AHQVLFSRRG ANYCGKNCGK LQTIFLKYPM 850 860 870 880 890 900 EKVPGARMPV QIRVKLWFGL SVDEKEFNQF AEGKLSVFAE TYENETKLAL VGNWGTTGLT 910 920 930 940 950 960 YPKFSDVTGK IKLPKDSFRP SAGWTWAGDW FVCPEKTLLH DMDAGHLSFV EEVFENQTRL 970 980 990 1000 1010 1020 PGGQWIYMSD NYTDVNGEKV LPKDDIECPL GWKWEDEEWS TDLNRAVDEQ GWEYSITIPP 1030 1040 1050 1060 1070 1080 ERKPKHWVPA EKMYYTHRRR RWVRLRRRDL SQMEALKRHR QAEAEGEGWE YASLFGWKFH 1090 1100 1110 1120 1130 1140 LEYRKTDAFR RRRWRRRMEP LEKTGPAAVF ALEGALGGVM DDKSEDSMSV STLSFGVNRP 1150 1160 1170 1180 1190 1200 TISCIFDYGN RYHLRCYMYQ ARDLAAMDKD SFSDPYAIVS FLHQSQKTVV VKNTLNPTWD 1210 1220 1230 1240 1250 1260 QTLIFYEIEI FGEPATVAEQ PPSIVVELYD HDTYGADEFM GRCICQPSLE RMPRLAWFPL 1270 1280 1290 1300 1310 1320 TRGSQPSGEL LASFELIQRE KPAIHHIPGF EVQETSRILD ESEDTDLPYP PPQREANIYM 1330 1340 1350 1360 1370 1380 VPQNIKPALQ RTAIEILAWG LRNMKSYQLA NISSPSLVVE CGGQTVQSCV IRNLRKNPNF 1390 1400 1410 1420 1430 1440 DICTLFMEVM LPREELYCPP ITVKVIDNRQ FGRRPVVGQC TIRSLESFLC DPYSAESPSP 1450 1460 1470 1480 1490 1500 QGGPDDVSLL SPGEDVLIDI DDKEPLIPIQ LADGLSSLAP TNTASPPSSP HEEEFIDWWS 1510 1520 1530 1540 1550 1560 KFFASIGERE KCGSYLEKDF DTLKVYDTQL ENVEAFEGLS DFCNTFKLYR GKTQEETEDP 1570 1580 1590 1600 1610 1620 SVIGEFKGLF KIYPLPEDPA IPMPPRQFHQ LAAQGPQECL VRIYIVRAFG LQPKDPNGKC 1630 1640 1650 1660 1670 1680 DPYIKISIGK KSVSDQDNYI PCTLEPVFGK MFELTCTLPL EKDLKITLYD YDLLSKDEKI 1690 1700 1710 1720 1730 1740 GETVVDLENR LLSKFGARCG LPQTYCVSGP NQWRDQLRPS QLLHLFCQQH RVKAPVYRTD 1750 1760 1770 1780 1790 1800 RVMFQDKEYS IEEIEAGRIP NPHLGPVEER LALHVLQQQG LVPEHVESRP LYSPLQPDIE 1810 1820 1830 1840 1850 1860 QGKLQMWVDL FPKALGRPGP PFNITPRRAR RFFLRCIIWN TRDVILDDLS LTGEKMSDIY 1870 1880 1890 1900 1910 1920 VKGWMIGFEE HKQKTDVHYR SLGGEGNFNW RFIFPFDYLP AEQVCTIAKK DAFWRLDKTE 1930 1940 1950 1960 1970 1980 SKIPARVVFQ IWDNDKFSFD DFLGSLQLDL NRMPKPAKTA KKCSLDQLDD AFHPEWFVSL 1990 2000 2010 2020 2030 2040 FEQKTVKGWW PCVAEEGEKK ILAGKLEMTL EIVAESEHEE RPAGQGRDEP NMNPKLEDPR 2050 2060 2070 2080 2090 2100 RPDTSFLWFT SPYKTMKFIL WRRFRWAIIL FIILFILLLF LAIFIYAFPN YAAMKLVKPF S
	Isoform 5 [UniParc]. Checksum: 5E5A7D7DC399343D	FASTA	2,097	239,267
	10 20 30 40 50 60 MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD 70 80 90 100 110 120 QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ 130 140 150 160 170 180 VSYTPLPGAV PLFPPPTPLE PSPTLPDLDV VAGGGQSRAE TWSLLSDSTM DTRYSGKKWP 190 200 210 220 230 240 APTDTGGEED TEDQGLTGDE AEPFLDQSGG PGAPTTPRKL PSRPPPHYPG IKRKRSAPTS 250 260 270 280 290 300 RKLLSDKPQD FQIRVQVIEG RQLPGVNIKP VVKVTAAGQT KRTRIHKGNS PLFNETLFFN 310 320 330 340 350 360 LFDSPGELFD EPIFITVVDS RSLRTDALLG EFRMDVGTIY REPRHAYLRK WLLLSDPDDF 370 380 390 400 410 420 SAGARGYLKT SLCVLGPGDE APLERKDPSE DKEDIESNLL RPTGVALRGA HFCLKVFRAE 430 440 450 460 470 480 DLPQMDDAVM DNVKQIFGFE SNKKNLVDPF VEVSFAGKML CSKILEKTAN PQWNQNITLP 490 500 510 520 530 540 AMFPSMCEKM RIRIIDWDRL THNDIVATTY LSMSKISAPG GEIEVDDYLG FLPTFGPCYI 550 560 570 580 590 600 NLYGSPREFT GFPDPYTELN TGKGEGVAYR GRLLLSLETK LVEHSEQKVE DLPADDILRV 610 620 630 640 650 660 EKYLRRRKYS LFAAFYSATM LQDVDDAIQF EVSIGNYGNK FDMTCLPLAS TTQYSRAVFD 670 680 690 700 710 720 GCHYYYLPWG NVKPVVVLSS YWEDISHRIE TQNQLLGIAD RLEAGLEQVH LALKAQCSTE 730 740 750 760 770 780 DVDSLVAQLT DELIAGCSQP LGDIHETPSA THLDQYLYQL RTHHLSQITE AALALKLGHS 790 800 810 820 830 840 ELPAALEQAE DWLLRLRALA EEPQNSLPDI VIWMLQGDKR VAYQRVPAHQ VLFSRRGANY 850 860 870 880 890 900 CGKNCGKLQT IFLKYPMEKV PGARMPVQIR VKLWFGLSVD EKEFNQFAEG KLSVFAETYE 910 920 930 940 950 960 NETKLALVGN WGTTGLTYPK FSDVTGKIKL PKDSFRPSAG WTWAGDWFVC PEKTLLHDMD 970 980 990 1000 1010 1020 AGHLSFVEEV FENQTRLPGG QWIYMSDNYT DVNGEKVLPK DDIECPLGWK WEDEEWSTDL 1030 1040 1050 1060 1070 1080 NRAVDEQGWE YSITIPPERK PKHWVPAEKM YYTHRRRRWV RLRRRDLSQM EALKRHRQAE 1090 1100 1110 1120 1130 1140 AEGEGWEYAS LFGWKFHLEY RKTDAFRRRR WRRRMEPLEK TGPAAVFALE GALGGVMDDK 1150 1160 1170 1180 1190 1200 SEDSMSVSTL SFGVNRPTIS CIFDYGNRYH LRCYMYQARD LAAMDKDSFS DPYAIVSFLH 1210 1220 1230 1240 1250 1260 QSQKTVVVKN TLNPTWDQTL IFYEIEIFGE PATVAEQPPS IVVELYDHDT YGADEFMGRC 1270 1280 1290 1300 1310 1320 ICQPSLERMP RLAWFPLTRG SQPSGELLAS FELIQREKPA IHHIPGFEVQ ETSRILDESE 1330 1340 1350 1360 1370 1380 DTDLPYPPPQ REANIYMVPQ NIKPALQRTA IEILAWGLRN MKSYQLANIS SPSLVVECGG 1390 1400 1410 1420 1430 1440 QTVQSCVIRN LRKNPNFDIC TLFMEVMLPR EELYCPPITV KVIDNRQFGR RPVVGQCTIR 1450 1460 1470 1480 1490 1500 SLESFLCDPY SAESPSPQGG PDDVSLLSPG EDVLIDIDDK EPLIPIQEEE FIDWWSKFFA 1510 1520 1530 1540 1550 1560 SIGEREKCGS YLEKDFDTLK VYDTQLENVE AFEGLSDFCN TFKLYRGKTQ EETEDPSVIG 1570 1580 1590 1600 1610 1620 EFKGLFKIYP LPEDPAIPMP PRQFHQLAAQ GPQECLVRIY IVRAFGLQPK DPNGKCDPYI 1630 1640 1650 1660 1670 1680 KISIGKKSVS DQDNYIPCTL EPVFGKMFEL TCTLPLEKDL KITLYDYDLL SKDEKIGETV 1690 1700 1710 1720 1730 1740 VDLENRLLSK FGARCGLPQT YCVSGPNQWR DQLRPSQLLH LFCQQHRVKA PVYRTDRVMF 1750 1760 1770 1780 1790 1800 QDKEYSIEEI EAGRIPNPHL GPVEERLALH VLQQQGLVPE HVESRPLYSP LQPDIEQGKL 1810 1820 1830 1840 1850 1860 QMWVDLFPKA LGRPGPPFNI TPRRARRFFL RCIIWNTRDV ILDDLSLTGE KMSDIYVKGW 1870 1880 1890 1900 1910 1920 MIGFEEHKQK TDVHYRSLGG EGNFNWRFIF PFDYLPAEQV CTIAKKDAFW RLDKTESKIP 1930 1940 1950 1960 1970 1980 ARVVFQIWDN DKFSFDDFLG SLQLDLNRMP KPAKTAKKCS LDQLDDAFHP EWFVSLFEQK 1990 2000 2010 2020 2030 2040 TVKGWWPCVA EEGEKKILAG KLEMTLEIVA ESEHEERPAG QGRDEPNMNP KLEDPRRPDT 2050 2060 2070 2080 2090 SFLWFTSPYK TMKFILWRRF RWAIILFIIL FILLLFLAIF IYAFPNYAAM KLVKPFS
	Isoform 6 [UniParc]. Checksum: E225F74E3A033173	FASTA	2,087	237,916
	10 20 30 40 50 60 MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD 70 80 90 100 110 120 QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ 130 140 150 160 170 180 VSYTPLPGAV PLFPPPTPLE PSPTLPDLDV VADTGGEEDT EDQGLTGDEA EPFLDQSGGP 190 200 210 220 230 240 GAPTTPRKLP SRPPPHYPGI KRKRSAPTSR KLLSDKPQDF QIRVQVIEGR QLPGVNIKPV 250 260 270 280 290 300 VKVTAAGQTK RTRIHKGNSP LFNETLFFNL FDSPGELFDE PIFITVVDSR SLRTDALLGE 310 320 330 340 350 360 FRMDVGTIYR EPRHAYLRKW LLLSDPDDFS AGARGYLKTS LCVLGPGDEA PLERKDPSED 370 380 390 400 410 420 KEDIESNLLR PTGVALRGAH FCLKVFRAED LPQMDDAVMD NVKQIFGFES NKKNLVDPFV 430 440 450 460 470 480 EVSFAGKMLC SKILEKTANP QWNQNITLPA MFPSMCEKMR IRIIDWDRLT HNDIVATTYL 490 500 510 520 530 540 SMSKISAPGG EIEVDDYLGF LPTFGPCYIN LYGSPREFTG FPDPYTELNT GKGEGVAYRG 550 560 570 580 590 600 RLLLSLETKL VEHSEQKVED LPADDILRVE KYLRRRKYSL FAAFYSATML QDVDDAIQFE 610 620 630 640 650 660 VSIGNYGNKF DMTCLPLAST TQYSRAVFDG CHYYYLPWGN VKPVVVLSSY WEDISHRIET 670 680 690 700 710 720 QNQLLGIADR LEAGLEQVHL ALKAQCSTED VDSLVAQLTD ELIAGCSQPL GDIHETPSAT 730 740 750 760 770 780 HLDQYLYQLR THHLSQITEA ALALKLGHSE LPAALEQAED WLLRLRALAE EPQNSLPDIV 790 800 810 820 830 840 IWMLQGDKRV AYQRVPAHQV LFSRRGANYC GKNCGKLQTI FLKYPMEKVP GARMPVQIRV 850 860 870 880 890 900 KLWFGLSVDE KEFNQFAEGK LSVFAETYEN ETKLALVGNW GTTGLTYPKF SDVTGKIKLP 910 920 930 940 950 960 KDSFRPSAGW TWAGDWFVCP EKTLLHDMDA GHLSFVEEVF ENQTRLPGGQ WIYMSDNYTD 970 980 990 1000 1010 1020 VNGEKVLPKD DIECPLGWKW EDEEWSTDLN RAVDEQGWEY SITIPPERKP KHWVPAEKMY 1030 1040 1050 1060 1070 1080 YTHRRRRWVR LRRRDLSQME ALKRHRQAEA EGEGWEYASL FGWKFHLEYR KTDAFRRRRW 1090 1100 1110 1120 1130 1140 RRRMEPLEKT GPAAVFALEG ALGGVMDDKS EDSMSVSTLS FGVNRPTISC IFDYGNRYHL 1150 1160 1170 1180 1190 1200 RCYMYQARDL AAMDKDSFSD PYAIVSFLHQ SQKTVVVKNT LNPTWDQTLI FYEIEIFGEP 1210 1220 1230 1240 1250 1260 ATVAEQPPSI VVELYDHDTY GADEFMGRCI CQPSLERMPR LAWFPLTRGS QPSGELLASF 1270 1280 1290 1300 1310 1320 ELIQREKPAI HHIPGFEVQE TSRILDESED TDLPYPPPQR EANIYMVPQN IKPALQRTAI 1330 1340 1350 1360 1370 1380 EILAWGLRNM KSYQLANISS PSLVVECGGQ TVQSCVIRNL RKNPNFDICT LFMEVMLPRE 1390 1400 1410 1420 1430 1440 ELYCPPITVK VIDNRQFGRR PVVGQCTIRS LESFLCDPYS AESPSPQGGP DDVSLLSPGE 1450 1460 1470 1480 1490 1500 DVLIDIDDKE PLIPIQLADG LSSLAPTNTA SPPSSPHEEE FIDWWSKFFA SIGEREKCGS 1510 1520 1530 1540 1550 1560 YLEKDFDTLK VYDTQLENVE AFEGLSDFCN TFKLYRGKTQ EETEDPSVIG EFKGLFKIYP 1570 1580 1590 1600 1610 1620 LPEDPAIPMP PRQFHQLAAQ GPQECLVRIY IVRAFGLQPK DPNGKCDPYI KISIGKKSVS 1630 1640 1650 1660 1670 1680 DQDNYIPCTL EPVFGKMFEL TCTLPLEKDL KITLYDYDLL SKDEKIGETV VDLENRLLSK 1690 1700 1710 1720 1730 1740 FGARCGLPQT YCVSGPNQWR DQLRPSQLLH LFCQQHRVKA PVYRTDRVMF QDKEYSIEEI 1750 1760 1770 1780 1790 1800 EAGRIPNPHL GPVEERLALH VLQQQGLVPE HVESRPLYSP LQPDIEQGKL QMWVDLFPKA 1810 1820 1830 1840 1850 1860 LGRPGPPFNI TPRRARRFFL RCIIWNTRDV ILDDLSLTGE KMSDIYVKGW MIGFEEHKQK 1870 1880 1890 1900 1910 1920 TDVHYRSLGG EGNFNWRFIF PFDYLPAEQV CTIAKKDAFW RLDKTESKIP ARVVFQIWDN 1930 1940 1950 1960 1970 1980 DKFSFDDFLG SLQLDLNRMP KPAKTAKKCS LDQLDDAFHP EWFVSLFEQK TVKGWWPCVA 1990 2000 2010 2020 2030 2040 EEGEKKILAG KLEMTLEIVA ESEHEERPAG QGRDEPNMNP KLEDPRRPDT SFLWFTSPYK 2050 2060 2070 2080 TMKFILWRRF RWAIILFIIL FILLLFLAIF IYAFPNYAAM KLVKPFS
	Isoform 7 [UniParc]. Checksum: 8E253645F2D76F4A	FASTA	2,118	241,269
	10 20 30 40 50 60 MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD 70 80 90 100 110 120 QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ 130 140 150 160 170 180 VSYTPLPGAV PLFPPPTPLE PSPTLPDLDV VAGGGQSRAE TWSLLSDSTM DTRYSGKKWP 190 200 210 220 230 240 APTDTGGEED TEDQGLTGDE AEPFLDQSGG PGAPTTPRKL PSRPPPHYPG IKRKRSAPTS 250 260 270 280 290 300 RKLLSDKPQD FQIRVQVIEG RQLPGVNIKP VVKVTAAGQT KRTRIHKGNS PLFNETLFFN 310 320 330 340 350 360 LFDSPGELFD EPIFITVVDS RSLRTDALLG EFRMDVGTIY REPRHAYLRK WLLLSDPDDF 370 380 390 400 410 420 SAGARGYLKT SLCVLGPGDE APLERKDPSE DKEDIESNLL RPTGVALRGA HFCLKVFRAE 430 440 450 460 470 480 DLPQMDDAVM DNVKQIFGFE SNKKNLVDPF VEVSFAGKML CSKILEKTAN PQWNQNITLP 490 500 510 520 530 540 AMFPSMCEKM RIRIIDWDRL THNDIVATTY LSMSKISAPG GEIEVDDYLG FLPTFGPCYI 550 560 570 580 590 600 NLYGSPREFT GFPDPYTELN TGKGEGVAYR GRLLLSLETK LVEHSEQKVE DLPADDILRV 610 620 630 640 650 660 EKYLRRRKYS LFAAFYSATM LQDVDDAIQF EVSIGNYGNK FDMTCLPLAS TTQYSRAVFD 670 680 690 700 710 720 GCHYYYLPWG NVKPVVVLSS YWEDISHRIE TQNQLLGIAD RLEAGLEQVH LALKAQCSTE 730 740 750 760 770 780 DVDSLVAQLT DELIAGCSQP LGDIHETPSA THLDQYLYQL RTHHLSQITE AALALKLGHS 790 800 810 820 830 840 ELPAALEQAE DWLLRLRALA EEPQNSLPDI VIWMLQGDKR VAYQRVPAHQ VLFSRRGANY 850 860 870 880 890 900 CGKNCGKLQT IFLKYPMEKV PGARMPVQIR VKLWFGLSVD EKEFNQFAEG KLSVFAETYE 910 920 930 940 950 960 NETKLALVGN WGTTGLTYPK FSDVTGKIKL PKDSFRPSAG WTWAGDWFVC PEKTLLHDMD 970 980 990 1000 1010 1020 AGHLSFVEEV FENQTRLPGG QWIYMSDNYT DVNGEKVLPK DDIECPLGWK WEDEEWSTDL 1030 1040 1050 1060 1070 1080 NRAVDEQGWE YSITIPPERK PKHWVPAEKM YYTHRRRRWV RLRRRDLSQM EALKRHRQAE 1090 1100 1110 1120 1130 1140 AEGEGWEYAS LFGWKFHLEY RKTDAFRRRR WRRRMEPLEK TGPAAVFALE GALGGVMDDK 1150 1160 1170 1180 1190 1200 SEDSMSVSTL SFGVNRPTIS CIFDYGNRYH LRCYMYQARD LAAMDKDSFS DPYAIVSFLH 1210 1220 1230 1240 1250 1260 QSQKTVVVKN TLNPTWDQTL IFYEIEIFGE PATVAEQPPS IVVELYDHDT YGADEFMGRC 1270 1280 1290 1300 1310 1320 ICQPSLERMP RLAWFPLTRG SQPSGELLAS FELIQREKPA IHHIPGFEVQ ETSRILDESE 1330 1340 1350 1360 1370 1380 DTDLPYPPPQ REANIYMVPQ NIKPALQRTA IEILAWGLRN MKSYQLANIS SPSLVVECGG 1390 1400 1410 1420 1430 1440 QTVQSCVIRN LRKNPNFDIC TLFMEVMLPR EELYCPPITV KVIDNRQFGR RPVVGQCTIR 1450 1460 1470 1480 1490 1500 SLESFLCDPY SAESPSPQGG PDDVSLLSPG EDVLIDIDDK EPLIPIQLAD GLSSLAPTNT 1510 1520 1530 1540 1550 1560 ASPPSSPHEE EFIDWWSKFF ASIGEREKCG SYLEKDFDTL KVYDTQLENV EAFEGLSDFC 1570 1580 1590 1600 1610 1620 NTFKLYRGKT QEETEDPSVI GEFKGLFKIY PLPEDPAIPM PPRQFHQLAA QGPQECLVRI 1630 1640 1650 1660 1670 1680 YIVRAFGLQP KDPNGKCDPY IKISIGKKSV SDQDNYIPCT LEPVFGKMFE LTCTLPLEKD 1690 1700 1710 1720 1730 1740 LKITLYDYDL LSKDEKIGET VVDLENRLLS KFGARCGLPQ TYCVSGPNQW RDQLRPSQLL 1750 1760 1770 1780 1790 1800 HLFCQQHRVK APVYRTDRVM FQDKEYSIEE IEAGRIPNPH LGPVEERLAL HVLQQQGLVP 1810 1820 1830 1840 1850 1860 EHVESRPLYS PLQPDIEQGK LQMWVDLFPK ALGRPGPPFN ITPRRARRFF LRCIIWNTRD 1870 1880 1890 1900 1910 1920 VILDDLSLTG EKMSDIYVKG WMIGFEEHKQ KTDVHYRSLG GEGNFNWRFI FPFDYLPAEQ 1930 1940 1950 1960 1970 1980 VCTIAKKDAF WRLDKTESKI PARVVFQIWD NDKFSFDDFL GSLQLDLNRM PKPAKTAKKC 1990 2000 2010 2020 2030 2040 SLDQLDDAFH PEWFVSLFEQ KTVKGWWPCV AEEGEKKILA GKLEMTLEIV AESEHEERPA 2050 2060 2070 2080 2090 2100 GQGRDEPNMN PKLEDPRRPD TSFLWFTSPY KTMKFILWRR FRWAIILFII LFILLLFLAI 2110 FIYAFPNYAA MKLVKPFS
	Isoform 8 [UniParc]. Checksum: 65D105E2EA06A54E	FASTA	2,112	240,735
	10 20 30 40 50 60 MLCCLLVRAS NLPSAKKDRR SDPVASLTFR GVKKRTKVIK NSVNPVWNEG FEWDLKGIPL 70 80 90 100 110 120 DQGSELHVVV KDHETMGRNR FLGEAKVPLR EVLATPSLSA SFNAPLLDTK KQPTGASLVL 130 140 150 160 170 180 QVSYTPLPGA VPLFPPPTPL EPSPTLPDLD VVAGGGQSRA ETWSLLSDST MDTRYSGKKW 190 200 210 220 230 240 PAPTDTGGEE DTEDQGLTGD EAEPFLDQSG GPGAPTTPRK LPSRPPPHYP GIKRKRSAPT 250 260 270 280 290 300 SRKLLSDKPQ DFQIRVQVIE GRQLPGVNIK PVVKVTAAGQ TKRTRIHKGN SPLFNETLFF 310 320 330 340 350 360 NLFDSPGELF DEPIFITVVD SRSLRTDALL GEFRMDVGTI YREPRHAYLR KWLLLSDPDD 370 380 390 400 410 420 FSAGARGYLK TSLCVLGPGD EAPLERKDPS EDKEDIESNL LRPTGVALRG AHFCLKVFRA 430 440 450 460 470 480 EDLPQMDDAV MDNVKQIFGF ESNKKNLVDP FVEVSFAGKM LCSKILEKTA NPQWNQNITL 490 500 510 520 530 540 PAMFPSMCEK MRIRIIDWDR LTHNDIVATT YLSMSKISAP GGEIEEEPAG AVKPSKASDL 550 560 570 580 590 600 DDYLGFLPTF GPCYINLYGS PREFTGFPDP YTELNTGKGE GVAYRGRLLL SLETKLVEHS 610 620 630 640 650 660 EQKVEDLPAD DILRVEKYLR RRKYSLFAAF YSATMLQDVD DAIQFEVSIG NYGNKFDMTC 670 680 690 700 710 720 LPLASTTQYS RAVFDGCHYY YLPWGNVKPV VVLSSYWEDI SHRIETQNQL LGIADRLEAG 730 740 750 760 770 780 LEQVHLALKA QCSTEDVDSL VAQLTDELIA GCSQPLGDIH ETPSATHLDQ YLYQLRTHHL 790 800 810 820 830 840 SQITEAALAL KLGHSELPAA LEQAEDWLLR LRALAEEPQN SLPDIVIWML QGDKRVAYQR 850 860 870 880 890 900 VPAHQVLFSR RGANYCGKNC GKLQTIFLKY PMEKVPGARM PVQIRVKLWF GLSVDEKEFN 910 920 930 940 950 960 QFAEGKLSVF AETYENETKL ALVGNWGTTG LTYPKFSDVT GKIKLPKDSF RPSAGWTWAG 970 980 990 1000 1010 1020 DWFVCPEKTL LHDMDAGHLS FVEEVFENQT RLPGGQWIYM SDNYTDVNGE KVLPKDDIEC 1030 1040 1050 1060 1070 1080 PLGWKWEDEE WSTDLNRAVD EQGWEYSITI PPERKPKHWV PAEKMYYTHR RRRWVRLRRR 1090 1100 1110 1120 1130 1140 DLSQMEALKR HRQAEAEGEG WEYASLFGWK FHLEYRKTDA FRRRRWRRRM EPLEKTGPAA 1150 1160 1170 1180 1190 1200 VFALEGALGG VMDDKSEDSM SVSTLSFGVN RPTISCIFDY GNRYHLRCYM YQARDLAAMD 1210 1220 1230 1240 1250 1260 KDSFSDPYAI VSFLHQSQKT VVVKNTLNPT WDQTLIFYEI EIFGEPATVA EQPPSIVVEL 1270 1280 1290 1300 1310 1320 YDHDTYGADE FMGRCICQPS LERMPRLAWF PLTRGSQPSG ELLASFELIQ REKPAIHHIP 1330 1340 1350 1360 1370 1380 GFEVQETSRI LDESEDTDLP YPPPQREANI YMVPQNIKPA LQRTAIEILA WGLRNMKSYQ 1390 1400 1410 1420 1430 1440 LANISSPSLV VECGGQTVQS CVIRNLRKNP NFDICTLFME VMLPREELYC PPITVKVIDN 1450 1460 1470 1480 1490 1500 RQFGRRPVVG QCTIRSLESF LCDPYSAESP SPQGGPDDVS LLSPGEDVLI DIDDKEPLIP 1510 1520 1530 1540 1550 1560 IQEEEFIDWW SKFFASIGER EKCGSYLEKD FDTLKVYDTQ LENVEAFEGL SDFCNTFKLY 1570 1580 1590 1600 1610 1620 RGKTQEETED PSVIGEFKGL FKIYPLPEDP AIPMPPRQFH QLAAQGPQEC LVRIYIVRAF 1630 1640 1650 1660 1670 1680 GLQPKDPNGK CDPYIKISIG KKSVSDQDNY IPCTLEPVFG KMFELTCTLP LEKDLKITLY 1690 1700 1710 1720 1730 1740 DYDLLSKDEK IGETVVDLEN RLLSKFGARC GLPQTYCVSG PNQWRDQLRP SQLLHLFCQQ 1750 1760 1770 1780 1790 1800 HRVKAPVYRT DRVMFQDKEY SIEEIEAGRI PNPHLGPVEE RLALHVLQQQ GLVPEHVESR 1810 1820 1830 1840 1850 1860 PLYSPLQPDI EQGKLQMWVD LFPKALGRPG PPFNITPRRA RRFFLRCIIW NTRDVILDDL 1870 1880 1890 1900 1910 1920 SLTGEKMSDI YVKGWMIGFE EHKQKTDVHY RSLGGEGNFN WRFIFPFDYL PAEQVCTIAK 1930 1940 1950 1960 1970 1980 KDAFWRLDKT ESKIPARVVF QIWDNDKFSF DDFLGSLQLD LNRMPKPAKT AKKCSLDQLD 1990 2000 2010 2020 2030 2040 DAFHPEWFVS LFEQKTVKGW WPCVAEEGEK KILAGKLEMT LEIVAESEHE ERPAGQGRDE 2050 2060 2070 2080 2090 2100 PNMNPKLEDP RRPDTSFLWF TSPYKTMKFI LWRRFRWAII LFIILFILLL FLAIFIYAFP 2110 NYAAMKLVKP FS
	Isoform 9 [UniParc]. Checksum: 5BE7B5C3285A6CBD	FASTA	2,067	236,000
	10 20 30 40 50 60 MLCCLLVRAS NLPSAKKDRR SDPVASLTFR GVKKRTKVIK NSVNPVWNEG FEWDLKGIPL 70 80 90 100 110 120 DQGSELHVVV KDHETMGRNR FLGEAKVPLR EVLATPSLSA SFNAPLLDTK KQPTGASLVL 130 140 150 160 170 180 QVSYTPLPGA VPLFPPPTPL EPSPTLPDLD VVADTGGEED TEDQGLTGDE AEPFLDQSGG 190 200 210 220 230 240 PGAPTTPRKL PSRPPPHYPG IKRKRSAPTS RKLLSDKPQD FQIRVQVIEG RQLPGVNIKP 250 260 270 280 290 300 VVKVTAAGQT KRTRIHKGNS PLFNETLFFN LFDSPGELFD EPIFITVVDS RSLRTDALLG 310 320 330 340 350 360 EFRMDVGTIY REPRHAYLRK WLLLSDPDDF SAGARGYLKT SLCVLGPGDE APLERKDPSE 370 380 390 400 410 420 DKEDIESNLL RPTGVALRGA HFCLKVFRAE DLPQMDDAVM DNVKQIFGFE SNKKNLVDPF 430 440 450 460 470 480 VEVSFAGKML CSKILEKTAN PQWNQNITLP AMFPSMCEKM RIRIIDWDRL THNDIVATTY 490 500 510 520 530 540 LSMSKISAPG GEIEVDDYLG FLPTFGPCYI NLYGSPREFT GFPDPYTELN TGKGEGVAYR 550 560 570 580 590 600 GRLLLSLETK LVEHSEQKVE DLPADDILRV EKYLRRRKYS LFAAFYSATM LQDVDDAIQF 610 620 630 640 650 660 EVSIGNYGNK FDMTCLPLAS TTQYSRAVFD GCHYYYLPWG NVKPVVVLSS YWEDISHRIE 670 680 690 700 710 720 TQNQLLGIAD RLEAGLEQVH LALKAQCSTE DVDSLVAQLT DELIAGCSQP LGDIHETPSA 730 740 750 760 770 780 THLDQYLYQL RTHHLSQITE AALALKLGHS ELPAALEQAE DWLLRLRALA EEPQNSLPDI 790 800 810 820 830 840 VIWMLQGDKR VAYQRVPAHQ VLFSRRGANY CGKNCGKLQT IFLKYPMEKV PGARMPVQIR 850 860 870 880 890 900 VKLWFGLSVD EKEFNQFAEG KLSVFAETYE NETKLALVGN WGTTGLTYPK FSDVTGKIKL 910 920 930 940 950 960 PKDSFRPSAG WTWAGDWFVC PEKTLLHDMD AGHLSFVEEV FENQTRLPGG QWIYMSDNYT 970 980 990 1000 1010 1020 DVNGEKVLPK DDIECPLGWK WEDEEWSTDL NRAVDEQGWE YSITIPPERK PKHWVPAEKM 1030 1040 1050 1060 1070 1080 YYTHRRRRWV RLRRRDLSQM EALKRHRQAE AEGEGWEYAS LFGWKFHLEY RKTDAFRRRR 1090 1100 1110 1120 1130 1140 WRRRMEPLEK TGPAAVFALE GALGGVMDDK SEDSMSVSTL SFGVNRPTIS CIFDYGNRYH 1150 1160 1170 1180 1190 1200 LRCYMYQARD LAAMDKDSFS DPYAIVSFLH QSQKTVVVKN TLNPTWDQTL IFYEIEIFGE 1210 1220 1230 1240 1250 1260 PATVAEQPPS IVVELYDHDT YGADEFMGRC ICQPSLERMP RLAWFPLTRG SQPSGELLAS 1270 1280 1290 1300 1310 1320 FELIQREKPA IHHIPGFEVQ ETSRILDESE DTDLPYPPPQ REANIYMVPQ NIKPALQRTA 1330 1340 1350 1360 1370 1380 IEILAWGLRN MKSYQLANIS SPSLVVECGG QTVQSCVIRN LRKNPNFDIC TLFMEVMLPR 1390 1400 1410 1420 1430 1440 EELYCPPITV KVIDNRQFGR RPVVGQCTIR SLESFLCDPY SAESPSPQGG PDDVSLLSPG 1450 1460 1470 1480 1490 1500 EDVLIDIDDK EPLIPIQEEE FIDWWSKFFA SIGEREKCGS YLEKDFDTLK VYDTQLENVE 1510 1520 1530 1540 1550 1560 AFEGLSDFCN TFKLYRGKTQ EETEDPSVIG EFKGLFKIYP LPEDPAIPMP PRQFHQLAAQ 1570 1580 1590 1600 1610 1620 GPQECLVRIY IVRAFGLQPK DPNGKCDPYI KISIGKKSVS DQDNYIPCTL EPVFGKMFEL 1630 1640 1650 1660 1670 1680 TCTLPLEKDL KITLYDYDLL SKDEKIGETV VDLENRLLSK FGARCGLPQT YCVSGPNQWR 1690 1700 1710 1720 1730 1740 DQLRPSQLLH LFCQQHRVKA PVYRTDRVMF QDKEYSIEEI EAGRIPNPHL GPVEERLALH 1750 1760 1770 1780 1790 1800 VLQQQGLVPE HVESRPLYSP LQPDIEQGKL QMWVDLFPKA LGRPGPPFNI TPRRARRFFL 1810 1820 1830 1840 1850 1860 RCIIWNTRDV ILDDLSLTGE KMSDIYVKGW MIGFEEHKQK TDVHYRSLGG EGNFNWRFIF 1870 1880 1890 1900 1910 1920 PFDYLPAEQV CTIAKKDAFW RLDKTESKIP ARVVFQIWDN DKFSFDDFLG SLQLDLNRMP 1930 1940 1950 1960 1970 1980 KPAKTAKKCS LDQLDDAFHP EWFVSLFEQK TVKGWWPCVA EEGEKKILAG KLEMTLEIVA 1990 2000 2010 2020 2030 2040 ESEHEERPAG QGRDEPNMNP KLEDPRRPDT SFLWFTSPYK TMKFILWRRF RWAIILFIIL 2050 2060 FILLLFLAIF IYAFPNYAAM KLVKPFS
	Isoform 10 [UniParc]. Checksum: EBD1B370E34EF3E7	FASTA	2,102	239,383
	10 20 30 40 50 60 MLCCLLVRAS NLPSAKKDRR SDPVASLTFR GVKKRTKVIK NSVNPVWNEG FEWDLKGIPL 70 80 90 100 110 120 DQGSELHVVV KDHETMGRNR FLGEAKVPLR EVLATPSLSA SFNAPLLDTK KQPTGASLVL 130 140 150 160 170 180 QVSYTPLPGA VPLFPPPTPL EPSPTLPDLD VVADTGGEED TEDQGLTGDE AEPFLDQSGG 190 200 210 220 230 240 PGAPTTPRKL PSRPPPHYPG IKRKRSAPTS RKLLSDKPQD FQIRVQVIEG RQLPGVNIKP 250 260 270 280 290 300 VVKVTAAGQT KRTRIHKGNS PLFNETLFFN LFDSPGELFD EPIFITVVDS RSLRTDALLG 310 320 330 340 350 360 EFRMDVGTIY REPRHAYLRK WLLLSDPDDF SAGARGYLKT SLCVLGPGDE APLERKDPSE 370 380 390 400 410 420 DKEDIESNLL RPTGVALRGA HFCLKVFRAE DLPQMDDAVM DNVKQIFGFE SNKKNLVDPF 430 440 450 460 470 480 VEVSFAGKML CSKILEKTAN PQWNQNITLP AMFPSMCEKM RIRIIDWDRL THNDIVATTY 490 500 510 520 530 540 LSMSKISAPG GEIEEEPAGA VKPSKASDLD DYLGFLPTFG PCYINLYGSP REFTGFPDPY 550 560 570 580 590 600 TELNTGKGEG VAYRGRLLLS LETKLVEHSE QKVEDLPADD ILRVEKYLRR RKYSLFAAFY 610 620 630 640 650 660 SATMLQDVDD AIQFEVSIGN YGNKFDMTCL PLASTTQYSR AVFDGCHYYY LPWGNVKPVV 670 680 690 700 710 720 VLSSYWEDIS HRIETQNQLL GIADRLEAGL EQVHLALKAQ CSTEDVDSLV AQLTDELIAG 730 740 750 760 770 780 CSQPLGDIHE TPSATHLDQY LYQLRTHHLS QITEAALALK LGHSELPAAL EQAEDWLLRL 790 800 810 820 830 840 RALAEEPQNS LPDIVIWMLQ GDKRVAYQRV PAHQVLFSRR GANYCGKNCG KLQTIFLKYP 850 860 870 880 890 900 MEKVPGARMP VQIRVKLWFG LSVDEKEFNQ FAEGKLSVFA ETYENETKLA LVGNWGTTGL 910 920 930 940 950 960 TYPKFSDVTG KIKLPKDSFR PSAGWTWAGD WFVCPEKTLL HDMDAGHLSF VEEVFENQTR 970 980 990 1000 1010 1020 LPGGQWIYMS DNYTDVNGEK VLPKDDIECP LGWKWEDEEW STDLNRAVDE QGWEYSITIP 1030 1040 1050 1060 1070 1080 PERKPKHWVP AEKMYYTHRR RRWVRLRRRD LSQMEALKRH RQAEAEGEGW EYASLFGWKF 1090 1100 1110 1120 1130 1140 HLEYRKTDAF RRRRWRRRME PLEKTGPAAV FALEGALGGV MDDKSEDSMS VSTLSFGVNR 1150 1160 1170 1180 1190 1200 PTISCIFDYG NRYHLRCYMY QARDLAAMDK DSFSDPYAIV SFLHQSQKTV VVKNTLNPTW 1210 1220 1230 1240 1250 1260 DQTLIFYEIE IFGEPATVAE QPPSIVVELY DHDTYGADEF MGRCICQPSL ERMPRLAWFP 1270 1280 1290 1300 1310 1320 LTRGSQPSGE LLASFELIQR EKPAIHHIPG FEVQETSRIL DESEDTDLPY PPPQREANIY 1330 1340 1350 1360 1370 1380 MVPQNIKPAL QRTAIEILAW GLRNMKSYQL ANISSPSLVV ECGGQTVQSC VIRNLRKNPN 1390 1400 1410 1420 1430 1440 FDICTLFMEV MLPREELYCP PITVKVIDNR QFGRRPVVGQ CTIRSLESFL CDPYSAESPS 1450 1460 1470 1480 1490 1500 PQGGPDDVSL LSPGEDVLID IDDKEPLIPI QLADGLSSLA PTNTASPPSS PHEEEFIDWW 1510 1520 1530 1540 1550 1560 SKFFASIGER EKCGSYLEKD FDTLKVYDTQ LENVEAFEGL SDFCNTFKLY RGKTQEETED 1570 1580 1590 1600 1610 1620 PSVIGEFKGL FKIYPLPEDP AIPMPPRQFH QLAAQGPQEC LVRIYIVRAF GLQPKDPNGK 1630 1640 1650 1660 1670 1680 CDPYIKISIG KKSVSDQDNY IPCTLEPVFG KMFELTCTLP LEKDLKITLY DYDLLSKDEK 1690 1700 1710 1720 1730 1740 IGETVVDLEN RLLSKFGARC GLPQTYCVSG PNQWRDQLRP SQLLHLFCQQ HRVKAPVYRT 1750 1760 1770 1780 1790 1800 DRVMFQDKEY SIEEIEAGRI PNPHLGPVEE RLALHVLQQQ GLVPEHVESR PLYSPLQPDI 1810 1820 1830 1840 1850 1860 EQGKLQMWVD LFPKALGRPG PPFNITPRRA RRFFLRCIIW NTRDVILDDL SLTGEKMSDI 1870 1880 1890 1900 1910 1920 YVKGWMIGFE EHKQKTDVHY RSLGGEGNFN WRFIFPFDYL PAEQVCTIAK KDAFWRLDKT 1930 1940 1950 1960 1970 1980 ESKIPARVVF QIWDNDKFSF DDFLGSLQLD LNRMPKPAKT AKKCSLDQLD DAFHPEWFVS 1990 2000 2010 2020 2030 2040 LFEQKTVKGW WPCVAEEGEK KILAGKLEMT LEIVAESEHE ERPAGQGRDE PNMNPKLEDP 2050 2060 2070 2080 2090 2100 RRPDTSFLWF TSPYKTMKFI LWRRFRWAII LFIILFILLL FLAIFIYAFP NYAAMKLVKP FS
	Isoform 11 [UniParc]. Checksum: 3C81E57B591C23C2	FASTA	2,098	239,353
	10 20 30 40 50 60 MLCCLLVRAS NLPSAKKDRR SDPVASLTFR GVKKRTKVIK NSVNPVWNEG FEWDLKGIPL 70 80 90 100 110 120 DQGSELHVVV KDHETMGRNR FLGEAKVPLR EVLATPSLSA SFNAPLLDTK KQPTGASLVL 130 140 150 160 170 180 QVSYTPLPGA VPLFPPPTPL EPSPTLPDLD VVAGGGQSRA ETWSLLSDST MDTRYSGKKW 190 200 210 220 230 240 PAPTDTGGEE DTEDQGLTGD EAEPFLDQSG GPGAPTTPRK LPSRPPPHYP GIKRKRSAPT 250 260 270 280 290 300 SRKLLSDKPQ DFQIRVQVIE GRQLPGVNIK PVVKVTAAGQ TKRTRIHKGN SPLFNETLFF 310 320 330 340 350 360 NLFDSPGELF DEPIFITVVD SRSLRTDALL GEFRMDVGTI YREPRHAYLR KWLLLSDPDD 370 380 390 400 410 420 FSAGARGYLK TSLCVLGPGD EAPLERKDPS EDKEDIESNL LRPTGVALRG AHFCLKVFRA 430 440 450 460 470 480 EDLPQMDDAV MDNVKQIFGF ESNKKNLVDP FVEVSFAGKM LCSKILEKTA NPQWNQNITL 490 500 510 520 530 540 PAMFPSMCEK MRIRIIDWDR LTHNDIVATT YLSMSKISAP GGEIEVDDYL GFLPTFGPCY 550 560 570 580 590 600 INLYGSPREF TGFPDPYTEL NTGKGEGVAY RGRLLLSLET KLVEHSEQKV EDLPADDILR 610 620 630 640 650 660 VEKYLRRRKY SLFAAFYSAT MLQDVDDAIQ FEVSIGNYGN KFDMTCLPLA STTQYSRAVF 670 680 690 700 710 720 DGCHYYYLPW GNVKPVVVLS SYWEDISHRI ETQNQLLGIA DRLEAGLEQV HLALKAQCST 730 740 750 760 770 780 EDVDSLVAQL TDELIAGCSQ PLGDIHETPS ATHLDQYLYQ LRTHHLSQIT EAALALKLGH 790 800 810 820 830 840 SELPAALEQA EDWLLRLRAL AEEPQNSLPD IVIWMLQGDK RVAYQRVPAH QVLFSRRGAN 850 860 870 880 890 900 YCGKNCGKLQ TIFLKYPMEK VPGARMPVQI RVKLWFGLSV DEKEFNQFAE GKLSVFAETY 910 920 930 940 950 960 ENETKLALVG NWGTTGLTYP KFSDVTGKIK LPKDSFRPSA GWTWAGDWFV CPEKTLLHDM 970 980 990 1000 1010 1020 DAGHLSFVEE VFENQTRLPG GQWIYMSDNY TDVNGEKVLP KDDIECPLGW KWEDEEWSTD 1030 1040 1050 1060 1070 1080 LNRAVDEQGW EYSITIPPER KPKHWVPAEK MYYTHRRRRW VRLRRRDLSQ MEALKRHRQA 1090 1100 1110 1120 1130 1140 EAEGEGWEYA SLFGWKFHLE YRKTDAFRRR RWRRRMEPLE KTGPAAVFAL EGALGGVMDD 1150 1160 1170 1180 1190 1200 KSEDSMSVST LSFGVNRPTI SCIFDYGNRY HLRCYMYQAR DLAAMDKDSF SDPYAIVSFL 1210 1220 1230 1240 1250 1260 HQSQKTVVVK NTLNPTWDQT LIFYEIEIFG EPATVAEQPP SIVVELYDHD TYGADEFMGR 1270 1280 1290 1300 1310 1320 CICQPSLERM PRLAWFPLTR GSQPSGELLA SFELIQREKP AIHHIPGFEV QETSRILDES 1330 1340 1350 1360 1370 1380 EDTDLPYPPP QREANIYMVP QNIKPALQRT AIEILAWGLR NMKSYQLANI SSPSLVVECG 1390 1400 1410 1420 1430 1440 GQTVQSCVIR NLRKNPNFDI CTLFMEVMLP REELYCPPIT VKVIDNRQFG RRPVVGQCTI 1450 1460 1470 1480 1490 1500 RSLESFLCDP YSAESPSPQG GPDDVSLLSP GEDVLIDIDD KEPLIPIQEE EFIDWWSKFF 1510 1520 1530 1540 1550 1560 ASIGEREKCG SYLEKDFDTL KVYDTQLENV EAFEGLSDFC NTFKLYRGKT QEETEDPSVI 1570 1580 1590 1600 1610 1620 GEFKGLFKIY PLPEDPAIPM PPRQFHQLAA QGPQECLVRI YIVRAFGLQP KDPNGKCDPY 1630 1640 1650 1660 1670 1680 IKISIGKKSV SDQDNYIPCT LEPVFGKMFE LTCTLPLEKD LKITLYDYDL LSKDEKIGET 1690 1700 1710 1720 1730 1740 VVDLENRLLS KFGARCGLPQ TYCVSGPNQW RDQLRPSQLL HLFCQQHRVK APVYRTDRVM 1750 1760 1770 1780 1790 1800 FQDKEYSIEE IEAGRIPNPH LGPVEERLAL HVLQQQGLVP EHVESRPLYS PLQPDIEQGK 1810 1820 1830 1840 1850 1860 LQMWVDLFPK ALGRPGPPFN ITPRRARRFF LRCIIWNTRD VILDDLSLTG EKMSDIYVKG 1870 1880 1890 1900 1910 1920 WMIGFEEHKQ KTDVHYRSLG GEGNFNWRFI FPFDYLPAEQ VCTIAKKDAF WRLDKTESKI 1930 1940 1950 1960 1970 1980 PARVVFQIWD NDKFSFDDFL GSLQLDLNRM PKPAKTAKKC SLDQLDDAFH PEWFVSLFEQ 1990 2000 2010 2020 2030 2040 KTVKGWWPCV AEEGEKKILA GKLEMTLEIV AESEHEERPA GQGRDEPNMN PKLEDPRRPD 2050 2060 2070 2080 2090 TSFLWFTSPY KTMKFILWRR FRWAIILFII LFILLLFLAI FIYAFPNYAA MKLVKPFS
	Isoform 12 [UniParc]. Checksum: C068B3393FEBAEBA	FASTA	2,088	238,002
	10 20 30 40 50 60 MLCCLLVRAS NLPSAKKDRR SDPVASLTFR GVKKRTKVIK NSVNPVWNEG FEWDLKGIPL 70 80 90 100 110 120 DQGSELHVVV KDHETMGRNR FLGEAKVPLR EVLATPSLSA SFNAPLLDTK KQPTGASLVL 130 140 150 160 170 180 QVSYTPLPGA VPLFPPPTPL EPSPTLPDLD VVADTGGEED TEDQGLTGDE AEPFLDQSGG 190 200 210 220 230 240 PGAPTTPRKL PSRPPPHYPG IKRKRSAPTS RKLLSDKPQD FQIRVQVIEG RQLPGVNIKP 250 260 270 280 290 300 VVKVTAAGQT KRTRIHKGNS PLFNETLFFN LFDSPGELFD EPIFITVVDS RSLRTDALLG 310 320 330 340 350 360 EFRMDVGTIY REPRHAYLRK WLLLSDPDDF SAGARGYLKT SLCVLGPGDE APLERKDPSE 370 380 390 400 410 420 DKEDIESNLL RPTGVALRGA HFCLKVFRAE DLPQMDDAVM DNVKQIFGFE SNKKNLVDPF 430 440 450 460 470 480 VEVSFAGKML CSKILEKTAN PQWNQNITLP AMFPSMCEKM RIRIIDWDRL THNDIVATTY 490 500 510 520 530 540 LSMSKISAPG GEIEVDDYLG FLPTFGPCYI NLYGSPREFT GFPDPYTELN TGKGEGVAYR 550 560 570 580 590 600 GRLLLSLETK LVEHSEQKVE DLPADDILRV EKYLRRRKYS LFAAFYSATM LQDVDDAIQF 610 620 630 640 650 660 EVSIGNYGNK FDMTCLPLAS TTQYSRAVFD GCHYYYLPWG NVKPVVVLSS YWEDISHRIE 670 680 690 700 710 720 TQNQLLGIAD RLEAGLEQVH LALKAQCSTE DVDSLVAQLT DELIAGCSQP LGDIHETPSA 730 740 750 760 770 780 THLDQYLYQL RTHHLSQITE AALALKLGHS ELPAALEQAE DWLLRLRALA EEPQNSLPDI 790 800 810 820 830 840 VIWMLQGDKR VAYQRVPAHQ VLFSRRGANY CGKNCGKLQT IFLKYPMEKV PGARMPVQIR 850 860 870 880 890 900 VKLWFGLSVD EKEFNQFAEG KLSVFAETYE NETKLALVGN WGTTGLTYPK FSDVTGKIKL 910 920 930 940 950 960 PKDSFRPSAG WTWAGDWFVC PEKTLLHDMD AGHLSFVEEV FENQTRLPGG QWIYMSDNYT 970 980 990 1000 1010 1020 DVNGEKVLPK DDIECPLGWK WEDEEWSTDL NRAVDEQGWE YSITIPPERK PKHWVPAEKM 1030 1040 1050 1060 1070 1080 YYTHRRRRWV RLRRRDLSQM EALKRHRQAE AEGEGWEYAS LFGWKFHLEY RKTDAFRRRR 1090 1100 1110 1120 1130 1140 WRRRMEPLEK TGPAAVFALE GALGGVMDDK SEDSMSVSTL SFGVNRPTIS CIFDYGNRYH 1150 1160 1170 1180 1190 1200 LRCYMYQARD LAAMDKDSFS DPYAIVSFLH QSQKTVVVKN TLNPTWDQTL IFYEIEIFGE 1210 1220 1230 1240 1250 1260 PATVAEQPPS IVVELYDHDT YGADEFMGRC ICQPSLERMP RLAWFPLTRG SQPSGELLAS 1270 1280 1290 1300 1310 1320 FELIQREKPA IHHIPGFEVQ ETSRILDESE DTDLPYPPPQ REANIYMVPQ NIKPALQRTA 1330 1340 1350 1360 1370 1380 IEILAWGLRN MKSYQLANIS SPSLVVECGG QTVQSCVIRN LRKNPNFDIC TLFMEVMLPR 1390 1400 1410 1420 1430 1440 EELYCPPITV KVIDNRQFGR RPVVGQCTIR SLESFLCDPY SAESPSPQGG PDDVSLLSPG 1450 1460 1470 1480 1490 1500 EDVLIDIDDK EPLIPIQLAD GLSSLAPTNT ASPPSSPHEE EFIDWWSKFF ASIGEREKCG 1510 1520 1530 1540 1550 1560 SYLEKDFDTL KVYDTQLENV EAFEGLSDFC NTFKLYRGKT QEETEDPSVI GEFKGLFKIY 1570 1580 1590 1600 1610 1620 PLPEDPAIPM PPRQFHQLAA QGPQECLVRI YIVRAFGLQP KDPNGKCDPY IKISIGKKSV 1630 1640 1650 1660 1670 1680 SDQDNYIPCT LEPVFGKMFE LTCTLPLEKD LKITLYDYDL LSKDEKIGET VVDLENRLLS 1690 1700 1710 1720 1730 1740 KFGARCGLPQ TYCVSGPNQW RDQLRPSQLL HLFCQQHRVK APVYRTDRVM FQDKEYSIEE 1750 1760 1770 1780 1790 1800 IEAGRIPNPH LGPVEERLAL HVLQQQGLVP EHVESRPLYS PLQPDIEQGK LQMWVDLFPK 1810 1820 1830 1840 1850 1860 ALGRPGPPFN ITPRRARRFF LRCIIWNTRD VILDDLSLTG EKMSDIYVKG WMIGFEEHKQ 1870 1880 1890 1900 1910 1920 KTDVHYRSLG GEGNFNWRFI FPFDYLPAEQ VCTIAKKDAF WRLDKTESKI PARVVFQIWD 1930 1940 1950 1960 1970 1980 NDKFSFDDFL GSLQLDLNRM PKPAKTAKKC SLDQLDDAFH PEWFVSLFEQ KTVKGWWPCV 1990 2000 2010 2020 2030 2040 AEEGEKKILA GKLEMTLEIV AESEHEERPA GQGRDEPNMN PKLEDPRRPD TSFLWFTSPY 2050 2060 2070 2080 KTMKFILWRR FRWAIILFII LFILLLFLAI FIYAFPNYAA MKLVKPFS
	Isoform 13 [UniParc]. Checksum: 1E839F33439A3B81	FASTA	2,119	241,356
	10 20 30 40 50 60 MLCCLLVRAS NLPSAKKDRR SDPVASLTFR GVKKRTKVIK NSVNPVWNEG FEWDLKGIPL 70 80 90 100 110 120 DQGSELHVVV KDHETMGRNR FLGEAKVPLR EVLATPSLSA SFNAPLLDTK KQPTGASLVL 130 140 150 160 170 180 QVSYTPLPGA VPLFPPPTPL EPSPTLPDLD VVAGGGQSRA ETWSLLSDST MDTRYSGKKW 190 200 210 220 230 240 PAPTDTGGEE DTEDQGLTGD EAEPFLDQSG GPGAPTTPRK LPSRPPPHYP GIKRKRSAPT 250 260 270 280 290 300 SRKLLSDKPQ DFQIRVQVIE GRQLPGVNIK PVVKVTAAGQ TKRTRIHKGN SPLFNETLFF 310 320 330 340 350 360 NLFDSPGELF DEPIFITVVD SRSLRTDALL GEFRMDVGTI YREPRHAYLR KWLLLSDPDD 370 380 390 400 410 420 FSAGARGYLK TSLCVLGPGD EAPLERKDPS EDKEDIESNL LRPTGVALRG AHFCLKVFRA 430 440 450 460 470 480 EDLPQMDDAV MDNVKQIFGF ESNKKNLVDP FVEVSFAGKM LCSKILEKTA NPQWNQNITL 490 500 510 520 530 540 PAMFPSMCEK MRIRIIDWDR LTHNDIVATT YLSMSKISAP GGEIEVDDYL GFLPTFGPCY 550 560 570 580 590 600 INLYGSPREF TGFPDPYTEL NTGKGEGVAY RGRLLLSLET KLVEHSEQKV EDLPADDILR 610 620 630 640 650 660 VEKYLRRRKY SLFAAFYSAT MLQDVDDAIQ FEVSIGNYGN KFDMTCLPLA STTQYSRAVF 670 680 690 700 710 720 DGCHYYYLPW GNVKPVVVLS SYWEDISHRI ETQNQLLGIA DRLEAGLEQV HLALKAQCST 730 740 750 760 770 780 EDVDSLVAQL TDELIAGCSQ PLGDIHETPS ATHLDQYLYQ LRTHHLSQIT EAALALKLGH 790 800 810 820 830 840 SELPAALEQA EDWLLRLRAL AEEPQNSLPD IVIWMLQGDK RVAYQRVPAH QVLFSRRGAN 850 860 870 880 890 900 YCGKNCGKLQ TIFLKYPMEK VPGARMPVQI RVKLWFGLSV DEKEFNQFAE GKLSVFAETY 910 920 930 940 950 960 ENETKLALVG NWGTTGLTYP KFSDVTGKIK LPKDSFRPSA GWTWAGDWFV CPEKTLLHDM 970 980 990 1000 1010 1020 DAGHLSFVEE VFENQTRLPG GQWIYMSDNY TDVNGEKVLP KDDIECPLGW KWEDEEWSTD 1030 1040 1050 1060 1070 1080 LNRAVDEQGW EYSITIPPER KPKHWVPAEK MYYTHRRRRW VRLRRRDLSQ MEALKRHRQA 1090 1100 1110 1120 1130 1140 EAEGEGWEYA SLFGWKFHLE YRKTDAFRRR RWRRRMEPLE KTGPAAVFAL EGALGGVMDD 1150 1160 1170 1180 1190 1200 KSEDSMSVST LSFGVNRPTI SCIFDYGNRY HLRCYMYQAR DLAAMDKDSF SDPYAIVSFL 1210 1220 1230 1240 1250 1260 HQSQKTVVVK NTLNPTWDQT LIFYEIEIFG EPATVAEQPP SIVVELYDHD TYGADEFMGR 1270 1280 1290 1300 1310 1320 CICQPSLERM PRLAWFPLTR GSQPSGELLA SFELIQREKP AIHHIPGFEV QETSRILDES 1330 1340 1350 1360 1370 1380 EDTDLPYPPP QREANIYMVP QNIKPALQRT AIEILAWGLR NMKSYQLANI SSPSLVVECG 1390 1400 1410 1420 1430 1440 GQTVQSCVIR NLRKNPNFDI CTLFMEVMLP REELYCPPIT VKVIDNRQFG RRPVVGQCTI 1450 1460 1470 1480 1490 1500 RSLESFLCDP YSAESPSPQG GPDDVSLLSP GEDVLIDIDD KEPLIPIQLA DGLSSLAPTN 1510 1520 1530 1540 1550 1560 TASPPSSPHE EEFIDWWSKF FASIGEREKC GSYLEKDFDT LKVYDTQLEN VEAFEGLSDF 1570 1580 1590 1600 1610 1620 CNTFKLYRGK TQEETEDPSV IGEFKGLFKI YPLPEDPAIP MPPRQFHQLA AQGPQECLVR 1630 1640 1650 1660 1670 1680 IYIVRAFGLQ PKDPNGKCDP YIKISIGKKS VSDQDNYIPC TLEPVFGKMF ELTCTLPLEK 1690 1700 1710 1720 1730 1740 DLKITLYDYD LLSKDEKIGE TVVDLENRLL SKFGARCGLP QTYCVSGPNQ WRDQLRPSQL 1750 1760 1770 1780 1790 1800 LHLFCQQHRV KAPVYRTDRV MFQDKEYSIE EIEAGRIPNP HLGPVEERLA LHVLQQQGLV 1810 1820 1830 1840 1850 1860 PEHVESRPLY SPLQPDIEQG KLQMWVDLFP KALGRPGPPF NITPRRARRF FLRCIIWNTR 1870 1880 1890 1900 1910 1920 DVILDDLSLT GEKMSDIYVK GWMIGFEEHK QKTDVHYRSL GGEGNFNWRF IFPFDYLPAE 1930 1940 1950 1960 1970 1980 QVCTIAKKDA FWRLDKTESK IPARVVFQIW DNDKFSFDDF LGSLQLDLNR MPKPAKTAKK 1990 2000 2010 2020 2030 2040 CSLDQLDDAF HPEWFVSLFE QKTVKGWWPC VAEEGEKKIL AGKLEMTLEI VAESEHEERP 2050 2060 2070 2080 2090 2100 AGQGRDEPNM NPKLEDPRRP DTSFLWFTSP YKTMKFILWR RFRWAIILFI ILFILLLFLA 2110 IFIYAFPNYA AMKLVKPFS
	Isoform 14 (Dysferlin_v1) (DYSF_v1) [UniParc]. Checksum: CE55314169D4B801	FASTA	2,081	237,381
	10 20 30 40 50 60 MLCCLLVRAS NLPSAKKDRR SDPVASLTFR GVKKRTKVIK NSVNPVWNEG FEWDLKGIPL 70 80 90 100 110 120 DQGSELHVVV KDHETMGRNR FLGEAKVPLR EVLATPSLSA SFNAPLLDTK KQPTGASLVL 130 140 150 160 170 180 QVSYTPLPGA VPLFPPPTPL EPSPTLPDLD VVADTGGEED TEDQGLTGDE AEPFLDQSGG 190 200 210 220 230 240 PGAPTTPRKL PSRPPPHYPG IKRKRSAPTS RKLLSDKPQD FQIRVQVIEG RQLPGVNIKP 250 260 270 280 290 300 VVKVTAAGQT KRTRIHKGNS PLFNETLFFN LFDSPGELFD EPIFITVVDS RSLRTDALLG 310 320 330 340 350 360 EFRMDVGTIY REPRHAYLRK WLLLSDPDDF SAGARGYLKT SLCVLGPGDE APLERKDPSE 370 380 390 400 410 420 DKEDIESNLL RPTGVALRGA HFCLKVFRAE DLPQMDDAVM DNVKQIFGFE SNKKNLVDPF 430 440 450 460 470 480 VEVSFAGKML CSKILEKTAN PQWNQNITLP AMFPSMCEKM RIRIIDWDRL THNDIVATTY 490 500 510 520 530 540 LSMSKISAPG GEIEEEPAGA VKPSKASDLD DYLGFLPTFG PCYINLYGSP REFTGFPDPY 550 560 570 580 590 600 TELNTGKGEG VAYRGRLLLS LETKLVEHSE QKVEDLPADD ILRVEKYLRR RKYSLFAAFY 610 620 630 640 650 660 SATMLQDVDD AIQFEVSIGN YGNKFDMTCL PLASTTQYSR AVFDGCHYYY LPWGNVKPVV 670 680 690 700 710 720 VLSSYWEDIS HRIETQNQLL GIADRLEAGL EQVHLALKAQ CSTEDVDSLV AQLTDELIAG 730 740 750 760 770 780 CSQPLGDIHE TPSATHLDQY LYQLRTHHLS QITEAALALK LGHSELPAAL EQAEDWLLRL 790 800 810 820 830 840 RALAEEPQNS LPDIVIWMLQ GDKRVAYQRV PAHQVLFSRR GANYCGKNCG KLQTIFLKYP 850 860 870 880 890 900 MEKVPGARMP VQIRVKLWFG LSVDEKEFNQ FAEGKLSVFA ETYENETKLA LVGNWGTTGL 910 920 930 940 950 960 TYPKFSDVTG KIKLPKDSFR PSAGWTWAGD WFVCPEKTLL HDMDAGHLSF VEEVFENQTR 970 980 990 1000 1010 1020 LPGGQWIYMS DNYTDVNGEK VLPKDDIECP LGWKWEDEEW STDLNRAVDE QGWEYSITIP 1030 1040 1050 1060 1070 1080 PERKPKHWVP AEKMYYTHRR RRWVRLRRRD LSQMEALKRH RQAEAEGEGW EYASLFGWKF 1090 1100 1110 1120 1130 1140 HLEYRKTDAF RRRRWRRRME PLEKTGPAAV FALEGALGGV MDDKSEDSMS VSTLSFGVNR 1150 1160 1170 1180 1190 1200 PTISCIFDYG NRYHLRCYMY QARDLAAMDK DSFSDPYAIV SFLHQSQKTV VVKNTLNPTW 1210 1220 1230 1240 1250 1260 DQTLIFYEIE IFGEPATVAE QPPSIVVELY DHDTYGADEF MGRCICQPSL ERMPRLAWFP 1270 1280 1290 1300 1310 1320 LTRGSQPSGE LLASFELIQR EKPAIHHIPG FEVQETSRIL DESEDTDLPY PPPQREANIY 1330 1340 1350 1360 1370 1380 MVPQNIKPAL QRTAIEILAW GLRNMKSYQL ANISSPSLVV ECGGQTVQSC VIRNLRKNPN 1390 1400 1410 1420 1430 1440 FDICTLFMEV MLPREELYCP PITVKVIDNR QFGRRPVVGQ CTIRSLESFL CDPYSAESPS 1450 1460 1470 1480 1490 1500 PQGGPDDVSL LSPGEDVLID IDDKEPLIPI QEEEFIDWWS KFFASIGERE KCGSYLEKDF 1510 1520 1530 1540 1550 1560 DTLKVYDTQL ENVEAFEGLS DFCNTFKLYR GKTQEETEDP SVIGEFKGLF KIYPLPEDPA 1570 1580 1590 1600 1610 1620 IPMPPRQFHQ LAAQGPQECL VRIYIVRAFG LQPKDPNGKC DPYIKISIGK KSVSDQDNYI 1630 1640 1650 1660 1670 1680 PCTLEPVFGK MFELTCTLPL EKDLKITLYD YDLLSKDEKI GETVVDLENR LLSKFGARCG 1690 1700 1710 1720 1730 1740 LPQTYCVSGP NQWRDQLRPS QLLHLFCQQH RVKAPVYRTD RVMFQDKEYS IEEIEAGRIP 1750 1760 1770 1780 1790 1800 NPHLGPVEER LALHVLQQQG LVPEHVESRP LYSPLQPDIE QGKLQMWVDL FPKALGRPGP 1810 1820 1830 1840 1850 1860 PFNITPRRAR RFFLRCIIWN TRDVILDDLS LTGEKMSDIY VKGWMIGFEE HKQKTDVHYR 1870 1880 1890 1900 1910 1920 SLGGEGNFNW RFIFPFDYLP AEQVCTIAKK DAFWRLDKTE SKIPARVVFQ IWDNDKFSFD 1930 1940 1950 1960 1970 1980 DFLGSLQLDL NRMPKPAKTA KKCSLDQLDD AFHPEWFVSL FEQKTVKGWW PCVAEEGEKK 1990 2000 2010 2020 2030 2040 ILAGKLEMTL EIVAESEHEE RPAGQGRDEP NMNPKLEDPR RPDTSFLWFT SPYKTMKFIL 2050 2060 2070 2080 WRRFRWAIIL FIILFILLLF LAIFIYAFPN YAAMKLVKPF S
	Isoform 15 [UniParc]. Checksum: 99D137284A468A65	FASTA	1,954	222,315
	10 20 30 40 50 60 MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD 70 80 90 100 110 120 QGSELHVVVK DHETMGRNRF LGEAKVPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ 130 140 150 160 170 180 VSYTPLPGAV PLFPPPTPLE PSPTLPDLDV VADTGGEEDT EDQGLTGDEA EPFLDQSGGP 190 200 210 220 230 240 GAPTTPRKLP SRPPPHYPGI KRKRSAPTSR KLLSDKPQDF QIRVQVIEGR QLPGVNIKPV 250 260 270 280 290 300 VKVTAAGQTK RTRIHKGNSP LFNETLFFNL FDSPGELFDE PIFITVVDSR SLRTDALLGE 310 320 330 340 350 360 FRMDVGTIYR EPRHAYLRKW LLLSDPDDFS AGARGYLKTS LCVLGPGDEA PLERKDPSED 370 380 390 400 410 420 KEDIESNLLR PTGVALRGAH FCLKVFRAED LPQMDDAVMD NVKQIFGFES NKKNLVDPFV 430 440 450 460 470 480 EVSFAGKMLC SKILEKTANP QWNQNITLPA MFPSMCEKMR IRIIDWDRLT HNDIVATTYL 490 500 510 520 530 540 SMSKISAPGG EIEVDDYLGF LPTFGPCYIN LYGSPREFTG FPDPYTELNT GKGEGVAYRG 550 560 570 580 590 600 RLLLSLETKL VEHSEQKVED LPADDILRVE KYLRRRKYSL FAAFYSATML QDVDDAIQFE 610 620 630 640 650 660 VSIGNYGNKF DMTCLPLAST TQYSRAVFDG CHYYYLPWGN VKPVVVLSSY WEDISHRIET 670 680 690 700 710 720 QNQLLGIADR LEAGLEQVHL ALKAQCSTED VDSLVAQLTD ELIAGCSQPL GDIHETPSAT 730 740 750 760 770 780 HLDQYLYQLR THHLSQITEA ALALKLGHSE LPAALEQAED WLLRLRALAE EPQNSLPDIV 790 800 810 820 830 840 IWMLQGDKRV AYQRVPAHQV LFSRRGANYC GKNCGKLQTI FLKYPMEKVP GARMPVQIRV 850 860 870 880 890 900 KLWFGLSVDE KEFNQFAEGK LSVFAETYEN ETKLALVGNW GTTGLTYPKF SDVTGKIKLP 910 920 930 940 950 960 KDSFRPSAGW TWAGDWFVCP EKTLLHDMDA GHLSFVEEVF ENQTRLPGGQ WIYMSDNYTD 970 980 990 1000 1010 1020 VNGEKVLPKD DIECPLGWKW EDEEWSTDLN RAVDEQGWEY SITIPPERKP KHWVPAEKMY 1030 1040 1050 1060 1070 1080 YTHRRRRWVR LRRRDLSQME ALKRHRQAEA EGEGWEYASL FGWKFHLEYR KTDAFRRRRW 1090 1100 1110 1120 1130 1140 RRRMEPLEKT GPAAVFALEG ALGGVMDDKS EDSMSVSTLS FGVNRPTISC IFDYGNRYHL 1150 1160 1170 1180 1190 1200 RCYMYQARDL AAMDKDSFSD PYAIVSFLHQ SQKTVVVKNT LNPTWDQTLI FYEIEIFGEP 1210 1220 1230 1240 1250 1260 ATVAEQPPSI VVELYDHDTY GADEFMGRCI CQPSLERMPR LAWFPLTRGS QPSGELLASF 1270 1280 1290 1300 1310 1320 ELIQREKPAI HHIPGFEVQE TSRILDESED TDLPYPPPQR EANIYMVPQN IKPALQRTAI 1330 1340 1350 1360 1370 1380 EILAWGLRNM KSYQLANISS PSLVVECGGQ TVQSCVIRNL RKNPNFDICT LFMEVMLPRE 1390 1400 1410 1420 1430 1440 ELYCPPITVK VIDNRQFGRR PVVGQCTIRS LESFLCDPYS AESPSPQGGP DDVSLLSPGE 1450 1460 1470 1480 1490 1500 DVLIDIDDKE PLIPIQEEEF IDWWSKFFAS IGEREKCGSY LEKDFDTLKV YDTQLENVEA 1510 1520 1530 1540 1550 1560 FEGLSDFCNT FKLYRGKTQE ETEDPSVIGE FKGLFKIYPL PEDPAIPMPP RQFHQLAAQG 1570 1580 1590 1600 1610 1620 PQECLVRIYI VRAFGLQPKD PNGKCDPYIK ISIGKKSVSD QDNYIPCTLE PVFGKMFELT 1630 1640 1650 1660 1670 1680 CTLPLEKDLK ITLYDYDLLS KDEKIGETVV DLENRLLSKF GARCGLPQTY CVSGPNQWRD 1690 1700 1710 1720 1730 1740 QLRPSQLLHL FCQQHRVKAP VYRTDRVMFQ DKEYSIEEIE AGRIPNPHLG PVEERLALHV 1750 1760 1770 1780 1790 1800 LQQQGLVPEH VESRPLYSPL QPDIEQGKLQ MWVDLFPKAL GRPGPPFNIT PRRARRFFLR 1810 1820 1830 1840 1850 1860 CIIWNTRDVI LDDLSLTGEK MSDIYVKGWM IGFEEHKQKT DVHYRSLGGE GNFNWRFIFP 1870 1880 1890 1900 1910 1920 FDYLPAEQVC TIAKKDAFWR LDKTESKIPA RVVFQIWDND KFSFDDFLGS LQLDLNRMPS 1930 1940 1950 SASSSRPPRP DCPARVGRQT DGPAHTPRVA NMEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy." Liu J., Aoki M., Illa I., Wu C., Fardeau M., Angelini C., Serrano C., Urtizberea J.A., Hentati F., Hamida M.B., Bohlega S., Culper E.J., Amato A.A., Bossie K., Oeltjen J., Bejaoui K., McKenna-Yasek D., Hosler B.A. , Schurr E., Arahata K., de Jong P.J., Brown R.H. Jr. Nat. Genet. 20:31-36(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS MMD1 VAL-1298; ARG-1857 AND CYS-2042, VARIANTS LGMD2B VAL-1298 AND CYS-2042. Tissue: Skeletal muscle.
[2]	"Identification and characterization of a novel human dysferlin transcript: dysferlin_v1." Pramono Z.A.D., Lai P.S., Tan C.L., Takeda S., Yee W.C. Hum. Genet. 120:410-419(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 14), TISSUE SPECIFICITY.
[3]	"Human dysferlin variants from alternative splicing: implications for dysferlin mutational screening and isoforms." Pramono Z.A.D., Kam S.Y., Ho M.F., Tan C.L., Lim C.C., See J.S.L., Lai P.S., Yee W.C. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12 AND 13).
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Spectrum of dysferlin transcripts in human skeletal muscle and blood." Pramono Z.A.D., Tan C.L., Lim C.C., See J.S.L., Seah I., Ho M.F., Yee W.C., Lai P.S. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 115-221 (ISOFORMS 2/5/7/8/11/13).
[7]	"A gene related to Caenorhabditis elegans spermatogenesis factor fer-1 is mutated in limb-girdle muscular dystrophy type 2B." Bashir R., Britton S., Strachan T., Keers S., Vafiadaki E., Lako M., Richard I., Marchand S., Bourg N., Argov Z., Sadeh M., Mahjneh I., Marconi G., Passos-Bueno M.R., de Sa Moreira E., Zatz M., Beckmann J.S., Bushby K.M.D. Nat. Genet. 20:37-42(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 569-2080 (ISOFORMS 1/2/3/5/8/9/11), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1471-1628 (ISOFORMS 1/2/3/5/8/9/11). Tissue: Placenta and Skeletal muscle.
[8]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 439-2080 (ISOFORM 15). Tissue: Spleen.
[9]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1497-2080 (ISOFORMS 1/2/3/4/5/6/7/8/9/10/11/12/13/14). Tissue: Mammary gland.
[10]	"Dysferlin is a plasma membrane protein and is expressed early in human development." Anderson L.V.B., Davison K., Moss J.A., Young C., Cullen M.J., Walsh J., Johnson M.A., Bashir R., Britton S., Keers S., Argov Z., Mahjneh I., Fougerousse F., Beckmann J.S., Bushby K.M.D. Hum. Mol. Genet. 8:855-861(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[11]	Erratum Anderson L.V.B., Davison K., Moss J.A., Young C., Cullen M.J., Walsh J., Johnson M.A., Bashir R., Britton S., Keers S., Argov Z., Mahjneh I., Fougerousse F., Beckmann J.S., Bushby K.M.D. Hum. Mol. Genet. 8:1141-1141(1999)
[12]	"Dysferlin is a surface membrane-associated protein that is absent in Miyoshi myopathy." Matsuda C., Aoki M., Hayashi Y.K., Ho M.F., Arahata K., Brown R.H. Jr. Neurology 53:1119-1122(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[13]	"Identical mutation in patients with limb girdle muscular dystrophy type 2B or Miyoshi myopathy suggests a role for modifier gene(s)." Weiler T., Bashir R., Anderson L.V.B., Davison K., Moss J.A., Britton S., Nylen E., Keers S., Vafiadaki E., Greenberg C.R., Bushby K.M.D., Wrogemann K. Hum. Mol. Genet. 8:871-877(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, VARIANT MMD1 ARG-791, VARIANT LGMD2B ARG-791.
[14]	"Distal anterior compartment myopathy: a dysferlin mutation causing a new muscular dystrophy phenotype." Illa I., Serrano-Munuera C., Gallardo E., Lasa A., Rojas-Garcia R., Palmer J., Gallano P., Baiget M., Matsuda C., Brown R.H. Ann. Neurol. 49:130-134(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN DYSTAL MYOPATHY.
[15]	"The sarcolemmal proteins dysferlin and caveolin-3 interact in skeletal muscle." Matsuda C., Hayashi Y.K., Ogawa M., Aoki M., Murayama K., Nishino I., Nonaka I., Arahata K., Brown R.H. Jr. Hum. Mol. Genet. 10:1761-1766(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CAV3, TISSUE SPECIFICITY.
[16]	"Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains." Davis D.B., Doherty K.R., Delmonte A.J., McNally E.M. J. Biol. Chem. 277:22883-22888(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, CHARACTERIZATION OF VARIANT MMD1 ASP-67.
[17]	"Developmental and tissue-specific regulation of a novel dysferlin isoform." Salani S., Lucchiari S., Fortunato F., Crimi M., Corti S., Locatelli F., Bossolasco P., Bresolin N., Comi G.P. Muscle Nerve 30:366-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[18]	"Dysferlin interacts with affixin (beta-parvin) at the sarcolemma." Matsuda C., Kameyama K., Tagawa K., Ogawa M., Suzuki A., Yamaji S., Okamoto H., Nishino I., Hayashi Y.K. J. Neuropathol. Exp. Neurol. 64:334-340(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PARVB, SUBCELLULAR LOCATION.
[19]	"Dysferlin is expressed in human placenta but does not associate with caveolin." Vandre D.D., Ackerman W.E., Kniss D.A., Tewari A.K., Mori M., Takizawa T., Robinson J.M. Biol. Reprod. 77:533-542(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[20]	"AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration." Huang Y., Laval S.H., van Remoortere A., Baudier J., Benaud C., Anderson L.V., Straub V., Deelder A., Frants R.R., den Dunnen J.T., Bushby K., van der Maarel S.M. FASEB J. 21:732-742(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AHNAK AND AHNAK2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF VAL-67, MASS SPECTROMETRY.
[21]	"From T-tubule to sarcolemma: damage-induced dysferlin translocation in early myogenesis." Klinge L., Laval S., Keers S., Haldane F., Straub V., Barresi R., Bushby K. FASEB J. 21:1768-1776(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[22]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[23]	"Molecular genetic analysis of dysferlin in Japanese patients with Miyoshi myopathy." Matsumura T., Aoki M., Nagano A., Hayashi Y.K., Asada C., Ogawa M., Yamanaka G., Goto K., Nakagawa M., Oka H., Sahashi K., Kouhara N., Saito Y., Brown R.H. Jr., Nonaka I., Arahata K. Proc. Jpn. Acad. 75B:207-212(1999) Cited for: VARIANT MMD1 CYS-999.
[24]	"Identical dysferlin mutation in limb-girdle muscular dystrophy type 2B and distal myopathy." Illarioshkin S.N., Ivanova-Smolenskaya I.A., Greenberg C.R., Nylen E., Sukhorukov V.S., Poleshchuk V.V., Markova E.D., Wrogemann K. Neurology 55:1931-1933(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MMD1 ASP-67, VARIANT LGMD2B ASP-67.
[25]	"Genomic organization of the dysferlin gene and novel mutations in Miyoshi myopathy." Aoki M., Liu J., Richard I., Bashir R., Britton S., Keers S.M., Oeltjen J., Brown H.E.V., Marchand S., Bourg N., Beley C., McKenna-Yasek D., Arahata K., Bohlega S., Cupler E., Illa I., Majneh I., Barohn R.J. , Urtizberea J.A., Fardeau M., Amato A., Angelini C., Bushby K., Beckmann J.S., Brown R.H. Jr. Neurology 57:271-278(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MMD1 HIS-1046 AND GLN-2000.
[26]	"Dysferlin mutations in Japanese Miyoshi myopathy: relationship to phenotype." Takahashi T., Aoki M., Tateyama M., Kondo E., Mizuno T., Onodera Y., Takano R., Kawai H., Kamakura K., Mochizuki H., Shizuka-Ikeda M., Nakagawa M., Yoshida Y., Akanuma J., Hoshino K., Saito H., Nishizawa M., Kato S. , Saito K., Miyachi T., Yamashita H., Kawai M., Matsumura T., Kuzuhara S., Ibi T., Sahashi K., Nakai H., Kohnosu T., Nonaka I., Arahata K., Brown R.H. Jr., Saito H., Itoyama Y. Neurology 60:1799-1804(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MMD1 CYS-999 AND GLU-1679, VARIANT HIS-1581.
[27]	"Molecular analysis of LGMD-2B and MM patients: identification of novel DYSF mutations and possible founder effect in the Italian population." Cagliani R., Fortunato F., Giorda R., Rodolico C., Bonaglia M.C., Sironi M., D'Angelo M.G., Prelle A., Locatelli F., Toscano A., Bresolin N., Comi G.P. Neuromuscul. Disord. 13:788-795(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LGMD2B TRP-959; GLN-1038 AND LYS-1335, VARIANTS GLN-1022; ALA-GLU-1065 INS AND LEU-1331.
[28]	"Phenotypic features and genetic findings in 2 Chinese families with Miyoshi distal myopathy." Ro L.-S., Lee-Chen G.-J., Lin T.-C., Wu Y.-R., Chen C.-M., Lin C.-Y., Chen S.-T. Arch. Neurol. 61:1594-1599(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MMD1 VAL-426 AND LEU-2068.
[29]	"Dysferlin mutation analysis in a group of Italian patients with limb-girdle muscular dystrophy and Miyoshi myopathy." Kawabe K., Goto K., Nishino I., Angelini C., Hayashi Y.K. Eur. J. Neurol. 11:657-661(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MMD1 ARG-618; CYS-1041; LYS-1335; ARG-1361 AND ARG-1662, VARIANTS LGMD2B LYS-1335 AND CYS-1505, VARIANTS GLN-1022 AND ALA-GLU-1065 INS.
[30]	"Novel dysferlin mutations and characteristic muscle atrophy in late-onset Miyoshi myopathy." Suzuki N., Aoki M., Takahashi T., Takano D., Asano M., Shiga Y., Onodera Y., Tateyama M., Itoyama Y. Muscle Nerve 29:721-723(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MMD1 ASP-1842 AND PRO-1922.
[31]	"Identification of a dysferlin gene mutation in a Korean case with Miyoshi myopathy." Oh S.-H., Kim T.-S., Choi Y.-C. Yonsei Med. J. 45:927-930(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MMD1 GLN-389.
[32]	"Dysferlin mutations in LGMD2B, Miyoshi myopathy, and atypical dysferlinopathies." Nguyen K., Bassez G., Bernard R., Krahn M., Labelle V., Figarella-Branger D., Pouget J., Hammouda el H., Beroud C., Urtizberea A., Eymard B., Leturcq F., Ben-Yaou R., Levy N. Hum. Mutat. 26:165-165(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ISOLATED HYPERCKEMIA GLU-170 AND TRP-253, VARIANTS LGMD2B TRP-555 AND MET-1208, VARIANTS MMD1 GLU-299; TRP-456; TRP-555; HIS-1046 AND GLN-1693, VARIANT PROXIMODISTAL MYOPATHY VAL-1276, VARIANT PSEUDOMETABOLIC MYOPATHY PRO-266, VARIANTS VAL-189; LEU-1331; SER-1351 AND VAL-1748.
[33]	Erratum Nguyen K., Bassez G., Bernard R., Krahn M., Labelle V., Figarella-Branger D., Pouget J., Hammouda el H., Beroud C., Urtizberea A., Eymard B., Leturcq F., Levy N. Hum. Mutat. 26:592-592(2005)
[34]	"Mutation finding in patients with dysferlin deficiency and role of the dysferlin interacting proteins annexin A1 and A2 in muscular dystrophies." Cagliani R., Magri F., Toscano A., Merlini L., Fortunato F., Lamperti C., Rodolico C., Prelle A., Sironi M., Aguennouz M., Ciscato P., Uncini A., Moggio M., Bresolin N., Comi G.P. Hum. Mutat. 26:283-283(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MMD1 GLU-170; LEU-374; TRP-959; TRP-1693; ASN-1837 AND GLY-1942 AND CYS-2042, VARIANTS LGMD2B ARG-621; TRP-959; GLN-1038; LYS-1335 AND CYS-2042, VARIANT ISOLATED HYPERCKEMIA SER-1678.
[35]	"Novel sequence variants in dysferlin-deficient muscular dystrophy leading to mRNA decay and possible C2-domain misfolding." Wenzel K., Carl M., Perrot A., Zabojszcza J., Assadi M., Ebeling M., Geier C., Robinson P.N., Kress W., Osterziel K.-J., Spuler S. Hum. Mutat. 27:599-600(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LGMD2B ARG-299 AND PRO-1341.
[36]	"Mutation impact on dysferlin inferred from database analysis and computer-based structural predictions." Therrien C., Dodig D., Karpati G., Sinnreich M. J. Neurol. Sci. 250:71-78(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LGMD2B ARG-791; CYS-930; TRP-1768 AND CYS-2042, VARIANT ALA-GLU-1065 INS.
[37]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-1325 AND VAL-1349.
[38]	"Symptomatic dysferlin gene mutation carriers: characterization of two cases." Illa I., De Luna N., Dominguez-Perles R., Rojas-Garcia R., Paradas C., Palmer J., Marquez C., Gallano P., Gallardo E. Neurology 68:1284-1289(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LGMD2B TYR-625 AND GLY-1734, VARIANT MMD1 ARG-519.
[39]	"Dysferlin-deficient muscular dystrophy features amyloidosis." Spuler S., Carl M., Zabojszcza J., Straub V., Bushby K., Moore S.A., Baehring S., Wenzel K., Vinkemeier U., Rocken C. Ann. Neurol. 63:323-328(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LGMD2B ARG-299, VARIANT MMD1 TRP-299.
[40]	"Analysis of the DYSF mutational spectrum in a large cohort of patients." Krahn M., Beroud C., Labelle V., Nguyen K., Bernard R., Bassez G., Figarella-Branger D., Fernandez C., Bouvenot J., Richard I., Ollagnon-Roman E., Bevilacqua J.A., Salvo E., Attarian S., Chapon F., Pellissier J.-F., Pouget J., Hammouda el H. , Laforet P., Urtizberea J.A., Eymard B., Leturcq F., Levy N. Hum. Mutat. 30:E345-E375(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LGMD2B ARG-52; ARG-155; GLU-170; GLU-234; THR-284; TRP-555; ARG-618; ARG-731; CYS-930; GLN-1022; PRO-1228; THR-1526; ASP-1543; TRP-1768; SER-1970 AND CYS-2042, VARIANTS MMD1 GLU-299; 386-PHE--ASP-390 DELINS TYR; ARG-426; TRP-456; TRP-555; LEU-1029; HIS-1046; HIS-1046; GLN-1693; 1938-THR-ALA-1939 DEL AND CYS-2042, VARIANTS ISOLATED HYPERCKEMIA GLU-170; TRP-253 AND TRP-555, VARIANTS PROXIMODISTAL MYOPATHY ARG-299; ARG-340; VAL-1748; TRP-1768 AND CYS-2042, VARIANT PSEUDOMETABOLIC MYOPATHY PRO-266, VARIANTS VAL-84; VAL-189; ALA-335; LEU-374; ASN-390; GLN-819; GLN-1038; VAL-1276; VAL-1325; ASN-1837 AND SER-1967.
+	Additional computationally mapped references.

Web resources

Leiden Muscular Dystrophy pages

Dysferlin

GeneReviews

Wikipedia

Dysferlin entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF075575 mRNA. Translation: AAC63519.1. DQ267935 mRNA. Translation: ABB89736.1. EU515155 mRNA. Translation: ACB12752.1. EU515156 mRNA. Translation: ACB12753.1. EU515157 mRNA. Translation: ACB12754.1. EU515158 mRNA. Translation: ACB12755.1. EU515159 mRNA. Translation: ACB12756.1. EU515160 mRNA. Translation: ACB12757.1. EU515161 mRNA. Translation: ACB12758.1. EU515162 mRNA. Translation: ACB12759.1. EU515163 mRNA. Translation: ACB12760.1. EU515164 mRNA. Translation: ACB12761.1. EU515165 mRNA. Translation: ACB12762.1. EU515166 mRNA. Translation: ACB12763.1. AC010147 Genomic DNA. Translation: AAY14954.1. AC104084 Genomic DNA. Translation: AAY24199.1. CH471053 Genomic DNA. Translation: EAW99763.1. DQ976379 Genomic DNA. Translation: ABI75150.1. AJ007670 mRNA. Translation: CAA07603.1. Sequence problems. AJ007973 Genomic DNA. Translation: CAA07800.1. AK074104 mRNA. Translation: BAB84930.1. AK074649 mRNA. Translation: BAG51981.1. Different initiation.
IPI	IPI00020210. IPI00793867. IPI00871702. IPI00890768. IPI00890779. IPI00908443. IPI00908579. IPI00908658. IPI00908764. IPI00908826. IPI00908936. IPI00910445. IPI00910624. IPI00911101. IPI00915417.
RefSeq	NP_001123927.1. NM_001130455.1. NP_001124448.1. NM_001130976.1. NP_001124449.1. NM_001130977.1. NP_001124450.1. NM_001130978.1. NP_001124451.1. NM_001130979.1. NP_001124452.1. NM_001130980.1. NP_001124453.1. NM_001130981.1. NP_001124454.1. NM_001130982.1. NP_001124455.1. NM_001130983.1. NP_001124456.1. NM_001130984.1. NP_001124457.1. NM_001130985.1. NP_001124458.1. NM_001130986.1. NP_001124459.1. NM_001130987.1. NP_003485.1. NM_003494.3.
UniGene	Hs.252180.
3D structure databases
ProteinModelPortal	O75923.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75923. 44 interactions.
PTM databases
PhosphoSite	O75923.
Proteomic databases
PaxDb	O75923.
PRIDE	O75923.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258104; ENSP00000258104; ENSG00000135636. ENST00000394120; ENSP00000377678; ENSG00000135636. ENST00000409366; ENSP00000386512; ENSG00000135636. ENST00000409582; ENSP00000386547; ENSG00000135636. ENST00000409651; ENSP00000386683; ENSG00000135636. ENST00000409744; ENSP00000386285; ENSG00000135636. ENST00000409762; ENSP00000387137; ENSG00000135636. ENST00000410020; ENSP00000386881; ENSG00000135636. ENST00000410041; ENSP00000386617; ENSG00000135636. ENST00000413539; ENSP00000407046; ENSG00000135636. ENST00000429174; ENSP00000398305; ENSG00000135636.
GeneID	8291.
KEGG	hsa:8291.
UCSC	uc002sie.3. human. uc002sif.3. human. uc002sig.4. human. uc010fee.3. human. uc010fef.3. human. uc010feg.3. human. uc010feh.3. human. uc010fei.3. human. uc010fej.3. human. uc010fek.3. human. uc010fel.3. human. uc010fem.3. human. uc010fen.3. human. uc010feo.3. human.
Organism-specific databases
CTD	8291.
GeneCards	GC02P071680.
HGNC	HGNC:3097. DYSF.
HPA	CAB002510. HPA017071. HPA021945.
MIM	253601. phenotype. 254130. phenotype. 603009. gene. 606768. phenotype.
neXtProt	NX_O75923.
Orphanet	268. Autosomal recessive limb-girdle muscular dystrophy type 2B. 199329. Congenital myopathy, Paradas type. 178400. Distal myopathy with anterior tibial onset. 45448. Miyoshi myopathy.
PharmGKB	PA27554.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG330124.
HOVERGEN	HBG018972.
OMA	KRHRQAE.
PhylomeDB	O75923.
Gene expression databases
ArrayExpress	O75923.
Bgee	O75923.
Genevestigator	O75923.
GermOnline	ENSG00000135636. Homo sapiens.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR012968. FerIin-domain. IPR012560. Ferlin_A-domain. IPR012561. Ferlin_B-domain. IPR010482. Peroxin/Dysferlin. IPR006614. Peroxin/Ferlin. [Graphical view]
Pfam	PF00168. C2. 7 hits. PF08165. FerA. 1 hit. PF08150. FerB. 1 hit. PF08151. FerI. 1 hit. PF06398. Pex24p. 1 hit. [Graphical view]
SMART	SM00239. C2. 7 hits. SM00694. DysFC. 2 hits. SM00693. DysFN. 2 hits. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 7 hits.
PROSITE	PS50004. C2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8291.
NextBio	31071.
SOURCE	Search...

Entry information

Entry name

DYSF_HUMAN

Accession

Primary (citable) accession number: O75923
Secondary accession number(s): B1PZ70 , B1PZ71, B1PZ72, B1PZ73, B1PZ74, B1PZ75, B1PZ76, B1PZ77, B1PZ78, B1PZ79, B1PZ80, B1PZ81, B3KQB9, O75696, Q09EX5, Q0H395, Q53QY3, Q53TD2, Q8TEL8, Q9UEN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.