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Protein

Small EDRK-rich factor 1

Gene

SERF1A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • nervous system development Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Small EDRK-rich factor 1
Alternative name(s):
Protein 4F5
Short name:
h4F5
SMA modifier 1
Gene namesi
Name:SERF1A
Synonyms:FAM2A, SERF1, SMAM1
AND
Name:SERF1B
Synonyms:FAM2B, SERF1, SMAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000172058.15
HostDB:ENSG00000205572.9
HGNCiHGNC:10755 SERF1A
HGNC:10756 SERF1B
MIMi603011 gene
neXtProtiNX_O75920

Pathology & Biotechi

Organism-specific databases

DisGeNETi728492
8293
OpenTargetsiENSG00000172058
ENSG00000205572
PharmGKBiPA35675

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507101 – 110Small EDRK-rich factor 1Add BLAST110

Proteomic databases

MaxQBiO75920
PaxDbiO75920
PeptideAtlasiO75920
PRIDEiO75920
TopDownProteomicsiO75920-2 [O75920-2]

PTM databases

iPTMnetiO75920
PhosphoSitePlusiO75920

Expressioni

Tissue specificityi

Isoform Long is predominantly expressed in heart, brain and skeletal muscle. Isoform Short and Isoform Long are expressed throughout the central nervous system, including spinal cord.

Gene expression databases

BgeeiENSG00000172058
CleanExiHS_SERF1A
HS_SERF1B
ExpressionAtlasiO75920 baseline and differential
GenevisibleiO75920 HS

Organism-specific databases

HPAiHPA075271

Interactioni

Protein-protein interaction databases

BioGridi113898, 3 interactors
IntActiO75920, 3 interactors
STRINGi9606.ENSP00000370126

Structurei

3D structure databases

ProteinModelPortaliO75920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SERF family.Curated

Phylogenomic databases

eggNOGiKOG4488 Eukaryota
ENOG410XWDZ LUCA
GeneTreeiENSGT00910000144304
HOGENOMiHOG000231842
InParanoidiO75920
OMAiDADIMRI
OrthoDBiEOG091G126W
PhylomeDBiO75920

Family and domain databases

InterProiView protein in InterPro
IPR007513 Uncharacterised_SERF
PfamiView protein in Pfam
PF04419 4F5, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: O75920-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGNQRELA RQKNMKKTQE ISKGKRKEDS LTASQRKQSS GGQKSESKMS
60 70 80 90 100
AGPHLPLKAP RENPCFPLPA AGGSRYYLAY GSITPISAFV FVVFFSVFFP
110
SFYEDFCCWI
Length:110
Mass (Da):12,349
Last modified:November 1, 1998 - v1
Checksum:iED9143455DB925AB
GO
Isoform Short (identifier: O75920-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-110: SSGGQKSESK...SFYEDFCCWI → RDSEIMQEKQKAANEKKSMQTREK

Show »
Length:62
Mass (Da):7,336
Checksum:iA8920C1B0C575F10
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00605739 – 110SSGGQ…FCCWI → RDSEIMQEKQKAANEKKSMQ TREK in isoform Short. 2 PublicationsAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073518 mRNA Translation: AAC63517.1
AF073519 mRNA Translation: AAC63518.1
BC021174 mRNA Translation: AAH21174.1
BC035932 mRNA Translation: AAH35932.1
BC093880 mRNA Translation: AAH93880.1
BC093882 mRNA Translation: AAH93882.1
BC101970 mRNA Translation: AAI01971.1
BC104738 mRNA Translation: AAI04739.1
BC103687 mRNA Translation: AAI03688.1
BC143255 mRNA Translation: AAI43256.1
BC143260 mRNA Translation: AAI43261.1
BC171749 mRNA Translation: AAI71749.1
CCDSiCCDS43326.1 [O75920-1]
CCDS47228.1 [O75920-1]
CCDS47229.1 [O75920-2]
CCDS54866.1 [O75920-2]
RefSeqiNP_001171558.1, NM_001178087.1 [O75920-2]
NP_068802.1, NM_021967.2 [O75920-1]
NP_075257.1, NM_022968.1 [O75920-2]
NP_075267.1, NM_022978.2 [O75920-1]
UniGeneiHs.559428
Hs.726820

Genome annotation databases

EnsembliENST00000317633; ENSP00000321791; ENSG00000172058 [O75920-2]
ENST00000354833; ENSP00000346892; ENSG00000172058 [O75920-1]
ENST00000380750; ENSP00000370126; ENSG00000205572 [O75920-1]
ENST00000380751; ENSP00000370127; ENSG00000205572 [O75920-2]
ENST00000611616; ENSP00000482392; ENSG00000278839 [O75920-2]
ENST00000613172; ENSP00000484795; ENSG00000277429 [O75920-1]
ENST00000614527; ENSP00000479724; ENSG00000275581 [O75920-1]
ENST00000621283; ENSP00000481118; ENSG00000277429 [O75920-2]
ENST00000622553; ENSP00000480543; ENSG00000278839 [O75920-1]
ENST00000627372; ENSP00000487374; ENSG00000275581 [O75920-2]
ENST00000630567; ENSP00000487531; ENSG00000275581 [O75920-1]
GeneIDi728492
8293
KEGGihsa:728492
hsa:8293
UCSCiuc003jxz.4 human [O75920-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSERF1_HUMAN
AccessioniPrimary (citable) accession number: O75920
Secondary accession number(s): B7ZKM2, O75919, Q52LK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health