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O75920 (SERF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small EDRK-rich factor 1
Alternative name(s):
Protein 4F5
Short name=h4F5
SMA modifier 1
Gene names
Name:SERF1A
Synonyms:FAM2A, SERF1, SMAM1
AND
Name:SERF1B
Synonyms:FAM2B, SERF1, SMAM1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length110 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Isoform Long is predominantly expressed in heart, brain and skeletal muscle. Isoform Short and Isoform Long are expressed throughout the central nervous system, including spinal cord.

Sequence similarities

Belongs to the SERF family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnervous system development

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: O75920-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: O75920-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-110: SSGGQKSESK...SFYEDFCCWI → RDSEIMQEKQKAANEKKSMQTREK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 110110Small EDRK-rich factor 1
PRO_0000050710

Natural variations

Alternative sequence39 – 11072SSGGQ…FCCWI → RDSEIMQEKQKAANEKKSMQ TREK in isoform Short.
VSP_006057

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: ED9143455DB925AB

FASTA11012,349
        10         20         30         40         50         60 
MARGNQRELA RQKNMKKTQE ISKGKRKEDS LTASQRKQSS GGQKSESKMS AGPHLPLKAP 

        70         80         90        100        110 
RENPCFPLPA AGGSRYYLAY GSITPISAFV FVVFFSVFFP SFYEDFCCWI 

« Hide

Isoform Short [UniParc].

Checksum: A8920C1B0C575F10
Show »

FASTA627,336

References

« Hide 'large scale' references
[1]"Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics."
Scharf J.M., Endrizzi M.G., Wetter A., Huang S., Thompson T.G., Zerres K., Dietrich W.F., Wirth B., Kunkel L.M.
Nat. Genet. 20:83-86(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS SHORT AND LONG).
Tissue: Brain and Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF073518 mRNA. Translation: AAC63517.1.
AF073519 mRNA. Translation: AAC63518.1.
BC021174 mRNA. Translation: AAH21174.1.
BC035932 mRNA. Translation: AAH35932.1.
BC093880 mRNA. Translation: AAH93880.1.
BC093882 mRNA. Translation: AAH93882.1.
BC101970 mRNA. Translation: AAI01971.1.
BC104738 mRNA. Translation: AAI04739.1.
BC103687 mRNA. Translation: AAI03688.1.
BC143255 mRNA. Translation: AAI43256.1.
BC143260 mRNA. Translation: AAI43261.1.
BC171749 mRNA. Translation: AAI71749.1.
CCDSCCDS43326.1. [O75920-1]
CCDS47228.1. [O75920-1]
CCDS47229.1. [O75920-2]
CCDS54866.1. [O75920-2]
RefSeqNP_001171558.1. NM_001178087.1. [O75920-2]
NP_068802.1. NM_021967.2. [O75920-1]
NP_075257.1. NM_022968.1. [O75920-2]
NP_075267.1. NM_022978.2. [O75920-1]
UniGeneHs.559428.
Hs.726820.

3D structure databases

ProteinModelPortalO75920.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113898. 3 interactions.
608917. 1 interaction.
IntActO75920. 3 interactions.
STRING9606.ENSP00000346892.

PTM databases

PhosphoSiteO75920.

Proteomic databases

MaxQBO75920.
PRIDEO75920.

Protocols and materials databases

DNASU8293.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317633; ENSP00000321791; ENSG00000172058. [O75920-2]
ENST00000354833; ENSP00000346892; ENSG00000172058. [O75920-1]
ENST00000380750; ENSP00000370126; ENSG00000205572. [O75920-1]
ENST00000380751; ENSP00000370127; ENSG00000205572. [O75920-2]
ENST00000572521; ENSP00000458786; ENSG00000262305. [O75920-2]
ENST00000576191; ENSP00000461578; ENSG00000262305. [O75920-1]
GeneID728492.
8293.
KEGGhsa:728492.
hsa:8293.
UCSCuc003jxz.3. human. [O75920-2]
uc003jyb.3. human. [O75920-1]

Organism-specific databases

CTD728492.
8293.
GeneCardsGC05P069322.
GC05P070235.
HGNCHGNC:10755. SERF1A.
HGNC:10756. SERF1B.
MIM603011. gene.
neXtProtNX_O75920.
PharmGKBPA35675.
GenAtlasSearch...

Phylogenomic databases

eggNOGKOG4488.
HOGENOMHOG000231842.
InParanoidO75920.
OMAKTHSSIF.
OrthoDBEOG7W6WQB.
PhylomeDBO75920.

Gene expression databases

BgeeO75920.
CleanExHS_SERF1A.
HS_SERF1B.
GenevestigatorO75920.

Family and domain databases

InterProIPR007513. Uncharacterised_SERF.
[Graphical view]
PfamPF04419. 4F5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio127355.
PROO75920.
SOURCESearch...

Entry information

Entry nameSERF1_HUMAN
AccessionPrimary (citable) accession number: O75920
Secondary accession number(s): B7ZKM2, O75919, Q52LK5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM