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O75916

- RGS9_HUMAN

UniProt

O75916 - RGS9_HUMAN

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Protein

Regulator of G-protein signaling 9

Gene
RGS9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction By similarity.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. dopamine receptor signaling pathway Source: Ensembl
  2. intracellular signal transduction Source: InterPro
  3. nervous system development Source: Ensembl
  4. phototransduction, visible light Source: Reactome
  5. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
  6. regulation of rhodopsin mediated signaling pathway Source: Reactome
  7. response to estrogen Source: Ensembl
  8. rhodopsin mediated signaling pathway Source: Reactome
  9. termination of G-protein coupled receptor signaling pathway Source: InterPro
  10. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiREACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 9
Short name:
RGS9
Gene namesi
Name:RGS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10004. RGS9.

Subcellular locationi

Isoform 3 : Membrane; Peripheral membrane protein
Note: Isoform 3 is targeted to the membrane via its interaction with RGS9BP By similarity.

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. heterotrimeric G-protein complex Source: InterPro
  3. nucleus Source: Ensembl
  4. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Prolonged electroretinal response suppression (PERRS) [MIM:608415]: Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti299 – 2991W → R in PERRS. 1 Publication
VAR_017912

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi608415. phenotype.
Orphaneti75374. Bradyopsia.
PharmGKBiPA34380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674Regulator of G-protein signaling 9PRO_0000204203Add
BLAST

Post-translational modificationi

Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75916.
PRIDEiO75916.

PTM databases

PhosphoSiteiO75916.

Expressioni

Tissue specificityi

Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).

Gene expression databases

ArrayExpressiO75916.
BgeeiO75916.
CleanExiHS_RGS9.
GenevestigatoriO75916.

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Component of the RGS9-1-Gbeta5 complex composed of isoform 3 of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP Inferred.

Protein-protein interaction databases

BioGridi114315. 7 interactions.
IntActiO75916. 2 interactions.
MINTiMINT-3001991.
STRINGi9606.ENSP00000262406.

Structurei

3D structure databases

ProteinModelPortaliO75916.
SMRiO75916. Positions 7-424.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 10576DEPAdd
BLAST
Domaini219 – 28062G protein gammaAdd
BLAST
Domaini298 – 413116RGSAdd
BLAST

Domaini

In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments.1 Publication

Sequence similaritiesi

Contains 1 DEP domain.
Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG327614.
HOVERGENiHBG007404.
InParanoidiO75916.
KOiK13765.
OMAiLVKDMQN.
PhylomeDBiO75916.
TreeFamiTF351956.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75916-1) [UniParc]FASTAAdd to Basket

Also known as: RGS9L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM    50
TGSDVLQWIV QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL 100
YRFQTPYFWP TQQWPAEDTD YAIYLAKRNI KKKGILEEYE KENYNFLNQK 150
MNYKWDFVIM QAKEQYRAGK ERNKADRYAL DCQEKAYWLV HRCPPGMDNV 200
LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST VKSSVSLGGI 250
VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA 300
FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA 350
EEIYKLFLAP GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK 400
KDSYARYLKS PIYKDMLAKA IEPQETTKKS STLPFMRRHL RSSPSPVILR 450
QLEEEAKARE AANTVDITQP GQHMAPSPHL TVYTGTCMPP SPSSPFSSSC 500
RSPRKPFASP SRFIRRPSTT ICPSPIRVAL ESSSGLEQKG ECSGSMAPRG 550
PSVTESSEAS LDTSWPRSRP RAPPKARMAL SFSRFLRRGC LASPVFARLS 600
PKCPAVSHGR VQPLGDVGQQ LPRLKSKRVA NFFQIKMDVP TGSGTCLMDS 650
EDAGTGESGD RATEKEVICP WESL 674
Length:674
Mass (Da):76,966
Last modified:November 1, 1998 - v1
Checksum:i8E2B11104B448364
GO
Isoform 2 (identifier: O75916-2) [UniParc]FASTAAdd to Basket

Also known as: RGS9S

The sequence of this isoform differs from the canonical sequence as follows:
     470-674: Missing.

Show »
Length:469
Mass (Da):54,982
Checksum:i04A5CF08AE73AEAC
GO
Isoform 3 (identifier: O75916-3) [UniParc]FASTAAdd to Basket

Also known as: RGS9-1

The sequence of this isoform differs from the canonical sequence as follows:
     216-218: Missing.
     470-487: PGQHMAPSPHLTVYTGTC → VMSKLDRRSQLKKELPPK
     488-674: Missing.

Show »
Length:484
Mass (Da):56,776
Checksum:i9E7C2371DF3BE3B5
GO
Isoform 4 (identifier: O75916-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.

Show »
Length:445
Mass (Da):49,810
Checksum:iA30CF34166481356
GO
Isoform 5 (identifier: O75916-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-218: Missing.

Show »
Length:671
Mass (Da):76,625
Checksum:i3866AC4C0DBB9B6A
GO

Sequence cautioni

The sequence AAC25430.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti258 – 2581S → L.
Corresponds to variant rs12452285 [ dbSNP | Ensembl ].
VAR_051796
Natural varianti299 – 2991W → R in PERRS. 1 Publication
VAR_017912

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 229229Missing in isoform 4. VSP_005674Add
BLAST
Alternative sequencei216 – 2183Missing in isoform 3 and isoform 5. VSP_038381
Alternative sequencei470 – 674205Missing in isoform 2. VSP_005675Add
BLAST
Alternative sequencei470 – 48718PGQHM…YTGTC → VMSKLDRRSQLKKELPPK in isoform 3. VSP_038382Add
BLAST
Alternative sequencei488 – 674187Missing in isoform 3. VSP_038383Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121Q → R in AAG09311. 1 Publication
Sequence conflicti112 – 1121Q → R in AAG09312. 1 Publication
Sequence conflicti142 – 1421E → G in AAM12647. 1 Publication
Sequence conflicti306 – 3061L → S in AAM12646. 1 Publication
Sequence conflicti319 – 3191F → S in AAM12647. 1 Publication
Sequence conflicti336 – 3361E → G in AAM12647. 1 Publication
Sequence conflicti392 – 3921Q → R in AAM12647. 1 Publication
Sequence conflicti417 – 4171L → Q in AAC25430. 1 Publication
Sequence conflicti422 – 4221E → D in AAC25430. 1 Publication
Sequence conflicti428 – 4281K → R in AAM12647. 1 Publication
Sequence conflicti454 – 4541E → G in AAM12646. 1 Publication
Sequence conflicti460 – 4601E → K in AAG09311. 1 Publication
Sequence conflicti460 – 4601E → K in AAG09312. 1 Publication
Sequence conflicti518 – 5192Missing in AAC25430. 1 Publication
Sequence conflicti527 – 5315RVALE → LVVLD in AAC25430. 1 Publication
Sequence conflicti544 – 5496GSMAPR → WSGANP in AAC25430. 1 Publication
Sequence conflicti555 – 5551E → D in AAC25430. 1 Publication
Sequence conflicti561 – 5611L → R in AAC25430. 1 Publication
Sequence conflicti564 – 5641S → P in AAM12647. 1 Publication
Sequence conflicti566 – 5661P → T in AAC25430. 1 Publication
Sequence conflicti574 – 5741P → L in AAC25430. 1 Publication
Sequence conflicti599 – 5991L → V in AAC25430. 1 Publication
Sequence conflicti668 – 6681I → T in AAM12646. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071476 mRNA. Translation: AAC64040.1.
AF178070
, AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069 Genomic DNA. Translation: AAG09311.1.
AF178072
, AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069, AF178070, AF178071 Genomic DNA. Translation: AAG09312.1.
AF493932 mRNA. Translation: AAM12646.1.
AF493933 mRNA. Translation: AAM12647.1.
AY585190 mRNA. Translation: AAT79493.1.
AY585191 mRNA. Translation: AAT79494.1.
AK290535 mRNA. Translation: BAF83224.1.
AC015821 Genomic DNA. No translation available.
AC060771 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW88998.1.
AF073710 mRNA. Translation: AAC25430.1. Different initiation.
CCDSiCCDS42373.1. [O75916-1]
CCDS45764.1. [O75916-5]
RefSeqiNP_001075424.1. NM_001081955.2. [O75916-5]
NP_003826.2. NM_003835.3. [O75916-1]
UniGeneiHs.664380.

Genome annotation databases

EnsembliENST00000262406; ENSP00000262406; ENSG00000108370. [O75916-1]
ENST00000449996; ENSP00000396329; ENSG00000108370. [O75916-5]
GeneIDi8787.
KEGGihsa:8787.
UCSCiuc002jfd.3. human. [O75916-5]
uc002jfe.3. human. [O75916-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071476 mRNA. Translation: AAC64040.1 .
AF178070
, AF178056 , AF178057 , AF178058 , AF178059 , AF178060 , AF178061 , AF178062 , AF178063 , AF178064 , AF178065 , AF178066 , AF178067 , AF178068 , AF178069 Genomic DNA. Translation: AAG09311.1 .
AF178072
, AF178056 , AF178057 , AF178058 , AF178059 , AF178060 , AF178061 , AF178062 , AF178063 , AF178064 , AF178065 , AF178066 , AF178067 , AF178068 , AF178069 , AF178070 , AF178071 Genomic DNA. Translation: AAG09312.1 .
AF493932 mRNA. Translation: AAM12646.1 .
AF493933 mRNA. Translation: AAM12647.1 .
AY585190 mRNA. Translation: AAT79493.1 .
AY585191 mRNA. Translation: AAT79494.1 .
AK290535 mRNA. Translation: BAF83224.1 .
AC015821 Genomic DNA. No translation available.
AC060771 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW88998.1 .
AF073710 mRNA. Translation: AAC25430.1 . Different initiation.
CCDSi CCDS42373.1. [O75916-1 ]
CCDS45764.1. [O75916-5 ]
RefSeqi NP_001075424.1. NM_001081955.2. [O75916-5 ]
NP_003826.2. NM_003835.3. [O75916-1 ]
UniGenei Hs.664380.

3D structure databases

ProteinModelPortali O75916.
SMRi O75916. Positions 7-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114315. 7 interactions.
IntActi O75916. 2 interactions.
MINTi MINT-3001991.
STRINGi 9606.ENSP00000262406.

PTM databases

PhosphoSitei O75916.

Proteomic databases

PaxDbi O75916.
PRIDEi O75916.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262406 ; ENSP00000262406 ; ENSG00000108370 . [O75916-1 ]
ENST00000449996 ; ENSP00000396329 ; ENSG00000108370 . [O75916-5 ]
GeneIDi 8787.
KEGGi hsa:8787.
UCSCi uc002jfd.3. human. [O75916-5 ]
uc002jfe.3. human. [O75916-1 ]

Organism-specific databases

CTDi 8787.
GeneCardsi GC17P063133.
HGNCi HGNC:10004. RGS9.
MIMi 604067. gene.
608415. phenotype.
neXtProti NX_O75916.
Orphaneti 75374. Bradyopsia.
PharmGKBi PA34380.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327614.
HOVERGENi HBG007404.
InParanoidi O75916.
KOi K13765.
OMAi LVKDMQN.
PhylomeDBi O75916.
TreeFami TF351956.

Enzyme and pathway databases

Reactomei REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii RGS9.
GenomeRNAii 8787.
NextBioi 32954.
PROi O75916.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75916.
Bgeei O75916.
CleanExi HS_RGS9.
Genevestigatori O75916.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of human and rat RGS9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS9 gene."
    Granneman J.G., Zhai Y., Zhu Z., Bannon M.J., Burchett S.A., Schmidt C.J., Andrade R., Cooper J.
    Mol. Pharmacol. 54:687-694(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney and Retina.
  2. "Structure, alternative splicing, and expression of the human RGS9 gene."
    Zhang K., Howes K.A., He W., Pettenati M.J., Palczewski K., Wensel T.G., Baehr W.
    Gene 240:23-34(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 3 AND 5).
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Homo sapiens regulator of G protein signaling 9."
    Chatterjee T.K., Fisher R.A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 218-674 (ISOFORM 1).
  8. "The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo."
    Martemyanov K.A., Lishko P.V., Calero N., Keresztes G., Sokolov M., Strissel K.J., Leskov I.B., Hopp J.A., Kolesnikov A.V., Chen C.-K., Lem J., Heller S., Burns M.E., Arshavsky V.Y.
    J. Neurosci. 23:10175-10181(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEP DOMAIN TARGETING FUNCTION.
  9. "Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation."
    Nishiguchi K.M., Sandberg M.A., Kooijman A.C., Martemyanov K.A., Pott J.W.R., Hagstrom S.A., Arshavsky V.Y., Berson E.L., Dryja T.P.
    Nature 427:75-78(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PERRS ARG-299.

Entry informationi

Entry nameiRGS9_HUMAN
AccessioniPrimary (citable) accession number: O75916
Secondary accession number(s): A8K3C0
, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi