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O75916

- RGS9_HUMAN

UniProt

O75916 - RGS9_HUMAN

Protein

Regulator of G-protein signaling 9

Gene

RGS9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome
    2. signal transducer activity Source: InterPro

    GO - Biological processi

    1. dopamine receptor signaling pathway Source: Ensembl
    2. intracellular signal transduction Source: InterPro
    3. nervous system development Source: Ensembl
    4. phototransduction, visible light Source: Reactome
    5. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc
    6. regulation of rhodopsin mediated signaling pathway Source: Reactome
    7. response to estrogen Source: Ensembl
    8. rhodopsin mediated signaling pathway Source: Reactome
    9. termination of G-protein coupled receptor signaling pathway Source: InterPro
    10. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Keywords - Biological processi

    Sensory transduction, Vision

    Enzyme and pathway databases

    ReactomeiREACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 9
    Short name:
    RGS9
    Gene namesi
    Name:RGS9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10004. RGS9.

    Subcellular locationi

    Isoform 3 : Membrane; Peripheral membrane protein
    Note: Isoform 3 is targeted to the membrane via its interaction with RGS9BP.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. heterotrimeric G-protein complex Source: InterPro
    3. nucleus Source: Ensembl
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Prolonged electroretinal response suppression (PERRS) [MIM:608415]: Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti299 – 2991W → R in PERRS. 1 Publication
    VAR_017912

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi608415. phenotype.
    Orphaneti75374. Bradyopsia.
    PharmGKBiPA34380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 674674Regulator of G-protein signaling 9PRO_0000204203Add
    BLAST

    Post-translational modificationi

    Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO75916.
    PRIDEiO75916.

    PTM databases

    PhosphoSiteiO75916.

    Expressioni

    Tissue specificityi

    Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).

    Gene expression databases

    ArrayExpressiO75916.
    BgeeiO75916.
    CleanExiHS_RGS9.
    GenevestigatoriO75916.

    Interactioni

    Subunit structurei

    Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Component of the RGS9-1-Gbeta5 complex composed of isoform 3 of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP Probable.Curated

    Protein-protein interaction databases

    BioGridi114315. 7 interactions.
    IntActiO75916. 2 interactions.
    MINTiMINT-3001991.
    STRINGi9606.ENSP00000262406.

    Structurei

    3D structure databases

    ProteinModelPortaliO75916.
    SMRiO75916. Positions 7-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 10576DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini219 – 28062G protein gammaAdd
    BLAST
    Domaini298 – 413116RGSPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments.

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 G protein gamma domain.Curated
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327614.
    HOVERGENiHBG007404.
    InParanoidiO75916.
    KOiK13765.
    OMAiLVKDMQN.
    PhylomeDBiO75916.
    TreeFamiTF351956.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75916-1) [UniParc]FASTAAdd to Basket

    Also known as: RGS9L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM    50
    TGSDVLQWIV QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL 100
    YRFQTPYFWP TQQWPAEDTD YAIYLAKRNI KKKGILEEYE KENYNFLNQK 150
    MNYKWDFVIM QAKEQYRAGK ERNKADRYAL DCQEKAYWLV HRCPPGMDNV 200
    LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST VKSSVSLGGI 250
    VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA 300
    FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA 350
    EEIYKLFLAP GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK 400
    KDSYARYLKS PIYKDMLAKA IEPQETTKKS STLPFMRRHL RSSPSPVILR 450
    QLEEEAKARE AANTVDITQP GQHMAPSPHL TVYTGTCMPP SPSSPFSSSC 500
    RSPRKPFASP SRFIRRPSTT ICPSPIRVAL ESSSGLEQKG ECSGSMAPRG 550
    PSVTESSEAS LDTSWPRSRP RAPPKARMAL SFSRFLRRGC LASPVFARLS 600
    PKCPAVSHGR VQPLGDVGQQ LPRLKSKRVA NFFQIKMDVP TGSGTCLMDS 650
    EDAGTGESGD RATEKEVICP WESL 674
    Length:674
    Mass (Da):76,966
    Last modified:November 1, 1998 - v1
    Checksum:i8E2B11104B448364
    GO
    Isoform 2 (identifier: O75916-2) [UniParc]FASTAAdd to Basket

    Also known as: RGS9S

    The sequence of this isoform differs from the canonical sequence as follows:
         470-674: Missing.

    Show »
    Length:469
    Mass (Da):54,982
    Checksum:i04A5CF08AE73AEAC
    GO
    Isoform 3 (identifier: O75916-3) [UniParc]FASTAAdd to Basket

    Also known as: RGS9-1

    The sequence of this isoform differs from the canonical sequence as follows:
         216-218: Missing.
         470-487: PGQHMAPSPHLTVYTGTC → VMSKLDRRSQLKKELPPK
         488-674: Missing.

    Show »
    Length:484
    Mass (Da):56,776
    Checksum:i9E7C2371DF3BE3B5
    GO
    Isoform 4 (identifier: O75916-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-229: Missing.

    Show »
    Length:445
    Mass (Da):49,810
    Checksum:iA30CF34166481356
    GO
    Isoform 5 (identifier: O75916-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         216-218: Missing.

    Show »
    Length:671
    Mass (Da):76,625
    Checksum:i3866AC4C0DBB9B6A
    GO

    Sequence cautioni

    The sequence AAC25430.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti112 – 1121Q → R in AAG09311. (PubMed:10564809)Curated
    Sequence conflicti112 – 1121Q → R in AAG09312. (PubMed:10564809)Curated
    Sequence conflicti142 – 1421E → G in AAM12647. 1 PublicationCurated
    Sequence conflicti306 – 3061L → S in AAM12646. 1 PublicationCurated
    Sequence conflicti319 – 3191F → S in AAM12647. 1 PublicationCurated
    Sequence conflicti336 – 3361E → G in AAM12647. 1 PublicationCurated
    Sequence conflicti392 – 3921Q → R in AAM12647. 1 PublicationCurated
    Sequence conflicti417 – 4171L → Q in AAC25430. 1 PublicationCurated
    Sequence conflicti422 – 4221E → D in AAC25430. 1 PublicationCurated
    Sequence conflicti428 – 4281K → R in AAM12647. 1 PublicationCurated
    Sequence conflicti454 – 4541E → G in AAM12646. 1 PublicationCurated
    Sequence conflicti460 – 4601E → K in AAG09311. (PubMed:10564809)Curated
    Sequence conflicti460 – 4601E → K in AAG09312. (PubMed:10564809)Curated
    Sequence conflicti518 – 5192Missing in AAC25430. 1 PublicationCurated
    Sequence conflicti527 – 5315RVALE → LVVLD in AAC25430. 1 PublicationCurated
    Sequence conflicti544 – 5496GSMAPR → WSGANP in AAC25430. 1 PublicationCurated
    Sequence conflicti555 – 5551E → D in AAC25430. 1 PublicationCurated
    Sequence conflicti561 – 5611L → R in AAC25430. 1 PublicationCurated
    Sequence conflicti564 – 5641S → P in AAM12647. 1 PublicationCurated
    Sequence conflicti566 – 5661P → T in AAC25430. 1 PublicationCurated
    Sequence conflicti574 – 5741P → L in AAC25430. 1 PublicationCurated
    Sequence conflicti599 – 5991L → V in AAC25430. 1 PublicationCurated
    Sequence conflicti668 – 6681I → T in AAM12646. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti258 – 2581S → L.
    Corresponds to variant rs12452285 [ dbSNP | Ensembl ].
    VAR_051796
    Natural varianti299 – 2991W → R in PERRS. 1 Publication
    VAR_017912

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 229229Missing in isoform 4. 1 PublicationVSP_005674Add
    BLAST
    Alternative sequencei216 – 2183Missing in isoform 3 and isoform 5. 2 PublicationsVSP_038381
    Alternative sequencei470 – 674205Missing in isoform 2. 1 PublicationVSP_005675Add
    BLAST
    Alternative sequencei470 – 48718PGQHM…YTGTC → VMSKLDRRSQLKKELPPK in isoform 3. CuratedVSP_038382Add
    BLAST
    Alternative sequencei488 – 674187Missing in isoform 3. CuratedVSP_038383Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071476 mRNA. Translation: AAC64040.1.
    AF178070
    , AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069 Genomic DNA. Translation: AAG09311.1.
    AF178072
    , AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069, AF178070, AF178071 Genomic DNA. Translation: AAG09312.1.
    AF493932 mRNA. Translation: AAM12646.1.
    AF493933 mRNA. Translation: AAM12647.1.
    AY585190 mRNA. Translation: AAT79493.1.
    AY585191 mRNA. Translation: AAT79494.1.
    AK290535 mRNA. Translation: BAF83224.1.
    AC015821 Genomic DNA. No translation available.
    AC060771 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW88998.1.
    AF073710 mRNA. Translation: AAC25430.1. Different initiation.
    CCDSiCCDS42373.1. [O75916-1]
    CCDS45764.1. [O75916-5]
    RefSeqiNP_001075424.1. NM_001081955.2. [O75916-5]
    NP_003826.2. NM_003835.3. [O75916-1]
    UniGeneiHs.664380.

    Genome annotation databases

    EnsembliENST00000262406; ENSP00000262406; ENSG00000108370. [O75916-1]
    ENST00000449996; ENSP00000396329; ENSG00000108370. [O75916-5]
    GeneIDi8787.
    KEGGihsa:8787.
    UCSCiuc002jfd.3. human. [O75916-5]
    uc002jfe.3. human. [O75916-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071476 mRNA. Translation: AAC64040.1 .
    AF178070
    , AF178056 , AF178057 , AF178058 , AF178059 , AF178060 , AF178061 , AF178062 , AF178063 , AF178064 , AF178065 , AF178066 , AF178067 , AF178068 , AF178069 Genomic DNA. Translation: AAG09311.1 .
    AF178072
    , AF178056 , AF178057 , AF178058 , AF178059 , AF178060 , AF178061 , AF178062 , AF178063 , AF178064 , AF178065 , AF178066 , AF178067 , AF178068 , AF178069 , AF178070 , AF178071 Genomic DNA. Translation: AAG09312.1 .
    AF493932 mRNA. Translation: AAM12646.1 .
    AF493933 mRNA. Translation: AAM12647.1 .
    AY585190 mRNA. Translation: AAT79493.1 .
    AY585191 mRNA. Translation: AAT79494.1 .
    AK290535 mRNA. Translation: BAF83224.1 .
    AC015821 Genomic DNA. No translation available.
    AC060771 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW88998.1 .
    AF073710 mRNA. Translation: AAC25430.1 . Different initiation.
    CCDSi CCDS42373.1. [O75916-1 ]
    CCDS45764.1. [O75916-5 ]
    RefSeqi NP_001075424.1. NM_001081955.2. [O75916-5 ]
    NP_003826.2. NM_003835.3. [O75916-1 ]
    UniGenei Hs.664380.

    3D structure databases

    ProteinModelPortali O75916.
    SMRi O75916. Positions 7-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114315. 7 interactions.
    IntActi O75916. 2 interactions.
    MINTi MINT-3001991.
    STRINGi 9606.ENSP00000262406.

    PTM databases

    PhosphoSitei O75916.

    Proteomic databases

    PaxDbi O75916.
    PRIDEi O75916.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262406 ; ENSP00000262406 ; ENSG00000108370 . [O75916-1 ]
    ENST00000449996 ; ENSP00000396329 ; ENSG00000108370 . [O75916-5 ]
    GeneIDi 8787.
    KEGGi hsa:8787.
    UCSCi uc002jfd.3. human. [O75916-5 ]
    uc002jfe.3. human. [O75916-1 ]

    Organism-specific databases

    CTDi 8787.
    GeneCardsi GC17P063133.
    HGNCi HGNC:10004. RGS9.
    MIMi 604067. gene.
    608415. phenotype.
    neXtProti NX_O75916.
    Orphaneti 75374. Bradyopsia.
    PharmGKBi PA34380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327614.
    HOVERGENi HBG007404.
    InParanoidi O75916.
    KOi K13765.
    OMAi LVKDMQN.
    PhylomeDBi O75916.
    TreeFami TF351956.

    Enzyme and pathway databases

    Reactomei REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii RGS9.
    GenomeRNAii 8787.
    NextBioi 32954.
    PROi O75916.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75916.
    Bgeei O75916.
    CleanExi HS_RGS9.
    Genevestigatori O75916.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of human and rat RGS9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS9 gene."
      Granneman J.G., Zhai Y., Zhu Z., Bannon M.J., Burchett S.A., Schmidt C.J., Andrade R., Cooper J.
      Mol. Pharmacol. 54:687-694(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney and Retina.
    2. "Structure, alternative splicing, and expression of the human RGS9 gene."
      Zhang K., Howes K.A., He W., Pettenati M.J., Palczewski K., Wensel T.G., Baehr W.
      Gene 240:23-34(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 3 AND 5).
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Brain.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Homo sapiens regulator of G protein signaling 9."
      Chatterjee T.K., Fisher R.A.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 218-674 (ISOFORM 1).
    8. "The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo."
      Martemyanov K.A., Lishko P.V., Calero N., Keresztes G., Sokolov M., Strissel K.J., Leskov I.B., Hopp J.A., Kolesnikov A.V., Chen C.-K., Lem J., Heller S., Burns M.E., Arshavsky V.Y.
      J. Neurosci. 23:10175-10181(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEP DOMAIN TARGETING FUNCTION.
    9. "Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation."
      Nishiguchi K.M., Sandberg M.A., Kooijman A.C., Martemyanov K.A., Pott J.W.R., Hagstrom S.A., Arshavsky V.Y., Berson E.L., Dryja T.P.
      Nature 427:75-78(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PERRS ARG-299.

    Entry informationi

    Entry nameiRGS9_HUMAN
    AccessioniPrimary (citable) accession number: O75916
    Secondary accession number(s): A8K3C0
    , O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3