O75916 (RGS9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 9
Short name=RGS9

Gene names

Name:

RGS9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	674 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction By similarity. Ref.8
Subunit structure	Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Component of the RGS9-1-Gbeta5 complex composed of isoform 3 of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP Probable.
Subcellular location	Isoform 3: Membrane; Peripheral membrane protein. Note: Isoform 3 is targeted to the membrane via its interaction with RGS9BP By similarity.
Tissue specificity	Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).
Domain	In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments. Ref.8
Post-translational modification	Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition By similarity.
Involvement in disease	Prolonged electroretinal response suppression (PERRS) [MIM:608415]: Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9
Sequence similarities	Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain.
Sequence caution	The sequence AAC25430.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Molecular function	Signal transduction inhibitor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dopamine receptor signaling pathway Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from electronic annotation. Source: InterPro nervous system development Inferred from electronic annotation. Source: Compara regulation of G-protein coupled receptor protein signaling pathway Traceable author statement Ref.1. Source: ProtInc response to estrogen stimulus Inferred from electronic annotation. Source: Compara termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75916-1)

Also known as: RGS9L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75916-2)

Also known as: RGS9S;

The sequence of this isoform differs from the canonical sequence as follows:
     470-674: Missing.

Isoform 3 (identifier: O75916-3)

Also known as: RGS9-1;

The sequence of this isoform differs from the canonical sequence as follows:
     216-218: Missing.
     470-487: PGQHMAPSPHLTVYTGTC → VMSKLDRRSQLKKELPPK
     488-674: Missing.

Isoform 4 (identifier: O75916-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.

Isoform 5 (identifier: O75916-5)

The sequence of this isoform differs from the canonical sequence as follows:
     216-218: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 674	674	Regulator of G-protein signaling 9		PRO_0000204203
Regions
	Domain	30 – 105	76	DEP
	Domain	219 – 280	62	G protein gamma
	Domain	298 – 413	116	RGS
Natural variations
	Alternative sequence	1 – 229	229	Missing in isoform 4.		VSP_005674
	Alternative sequence	216 – 218	3	Missing in isoform 3 and isoform 5.		VSP_038381
	Alternative sequence	470 – 674	205	Missing in isoform 2.		VSP_005675
	Alternative sequence	470 – 487	18	PGQHM…YTGTC → VMSKLDRRSQLKKELPPK in isoform 3.		VSP_038382
	Alternative sequence	488 – 674	187	Missing in isoform 3.		VSP_038383
	Natural variant	258	1	S → L. Corresponds to variant rs12452285 [ dbSNP | Ensembl ].		VAR_051796
	Natural variant	299	1	W → R in PERRS. Ref.9		VAR_017912
Experimental info
	Sequence conflict	112	1	Q → R in AAG09311. Ref.2
	Sequence conflict	112	1	Q → R in AAG09312. Ref.2
	Sequence conflict	142	1	E → G in AAM12647. Ref.3
	Sequence conflict	306	1	L → S in AAM12646. Ref.3
	Sequence conflict	319	1	F → S in AAM12647. Ref.3
	Sequence conflict	336	1	E → G in AAM12647. Ref.3
	Sequence conflict	392	1	Q → R in AAM12647. Ref.3
	Sequence conflict	417	1	L → Q in AAC25430. Ref.7
	Sequence conflict	422	1	E → D in AAC25430. Ref.7
	Sequence conflict	428	1	K → R in AAM12647. Ref.3
	Sequence conflict	454	1	E → G in AAM12646. Ref.3
	Sequence conflict	460	1	E → K in AAG09311. Ref.2
	Sequence conflict	460	1	E → K in AAG09312. Ref.2
	Sequence conflict	518 – 519	2	Missing in AAC25430. Ref.7
	Sequence conflict	527 – 531	5	RVALE → LVVLD in AAC25430. Ref.7
	Sequence conflict	544 – 549	6	GSMAPR → WSGANP in AAC25430. Ref.7
	Sequence conflict	555	1	E → D in AAC25430. Ref.7
	Sequence conflict	561	1	L → R in AAC25430. Ref.7
	Sequence conflict	564	1	S → P in AAM12647. Ref.3
	Sequence conflict	566	1	P → T in AAC25430. Ref.7
	Sequence conflict	574	1	P → L in AAC25430. Ref.7
	Sequence conflict	599	1	L → V in AAC25430. Ref.7
	Sequence conflict	668	1	I → T in AAM12646. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (RGS9L) [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 8E2B11104B448364	FASTA	674	76,966
	10 20 30 40 50 60 MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM TGSDVLQWIV 70 80 90 100 110 120 QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL YRFQTPYFWP TQQWPAEDTD 130 140 150 160 170 180 YAIYLAKRNI KKKGILEEYE KENYNFLNQK MNYKWDFVIM QAKEQYRAGK ERNKADRYAL 190 200 210 220 230 240 DCQEKAYWLV HRCPPGMDNV LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST 250 260 270 280 290 300 VKSSVSLGGI VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA 310 320 330 340 350 360 FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA EEIYKLFLAP 370 380 390 400 410 420 GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK KDSYARYLKS PIYKDMLAKA 430 440 450 460 470 480 IEPQETTKKS STLPFMRRHL RSSPSPVILR QLEEEAKARE AANTVDITQP GQHMAPSPHL 490 500 510 520 530 540 TVYTGTCMPP SPSSPFSSSC RSPRKPFASP SRFIRRPSTT ICPSPIRVAL ESSSGLEQKG 550 560 570 580 590 600 ECSGSMAPRG PSVTESSEAS LDTSWPRSRP RAPPKARMAL SFSRFLRRGC LASPVFARLS 610 620 630 640 650 660 PKCPAVSHGR VQPLGDVGQQ LPRLKSKRVA NFFQIKMDVP TGSGTCLMDS EDAGTGESGD 670 RATEKEVICP WESL
	Isoform 2 (RGS9S) [UniParc]. Checksum: 04A5CF08AE73AEAC	FASTA	469	54,982
	10 20 30 40 50 60 MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM TGSDVLQWIV 70 80 90 100 110 120 QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL YRFQTPYFWP TQQWPAEDTD 130 140 150 160 170 180 YAIYLAKRNI KKKGILEEYE KENYNFLNQK MNYKWDFVIM QAKEQYRAGK ERNKADRYAL 190 200 210 220 230 240 DCQEKAYWLV HRCPPGMDNV LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST 250 260 270 280 290 300 VKSSVSLGGI VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA 310 320 330 340 350 360 FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA EEIYKLFLAP 370 380 390 400 410 420 GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK KDSYARYLKS PIYKDMLAKA 430 440 450 460 IEPQETTKKS STLPFMRRHL RSSPSPVILR QLEEEAKARE AANTVDITQ
	Isoform 3 (RGS9-1) [UniParc]. Checksum: 9E7C2371DF3BE3B5	FASTA	484	56,776
	10 20 30 40 50 60 MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM TGSDVLQWIV 70 80 90 100 110 120 QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL YRFQTPYFWP TQQWPAEDTD 130 140 150 160 170 180 YAIYLAKRNI KKKGILEEYE KENYNFLNQK MNYKWDFVIM QAKEQYRAGK ERNKADRYAL 190 200 210 220 230 240 DCQEKAYWLV HRCPPGMDNV LDYGLDRVTN PNEVKKQTVV AVKKEIMYYQ QALMRSTVKS 250 260 270 280 290 300 SVSLGGIVKY SEQFSSNDAI MSGCLPSNPW ITDDTQFWDL NAKLVEIPTK MRVERWAFNF 310 320 330 340 350 360 SELIRDPKGR QSFQYFLKKE FSGENLGFWE ACEDLKYGDQ SKVKEKAEEI YKLFLAPGAR 370 380 390 400 410 420 RWINIDGKTM DITVKGLKHP HRYVLDAAQT HIYMLMKKDS YARYLKSPIY KDMLAKAIEP 430 440 450 460 470 480 QETTKKSSTL PFMRRHLRSS PSPVILRQLE EEAKAREAAN TVDITQVMSK LDRRSQLKKE LPPK
	Isoform 4 [UniParc]. Checksum: A30CF34166481356	FASTA	445	49,810
	10 20 30 40 50 60 MYYQQALMRS TVKSSVSLGG IVKYSEQFSS NDAIMSGCLP SNPWITDDTQ FWDLNAKLVE 70 80 90 100 110 120 IPTKMRVERW AFNFSELIRD PKGRQSFQYF LKKEFSGENL GFWEACEDLK YGDQSKVKEK 130 140 150 160 170 180 AEEIYKLFLA PGARRWINID GKTMDITVKG LKHPHRYVLD AAQTHIYMLM KKDSYARYLK 190 200 210 220 230 240 SPIYKDMLAK AIEPQETTKK SSTLPFMRRH LRSSPSPVIL RQLEEEAKAR EAANTVDITQ 250 260 270 280 290 300 PGQHMAPSPH LTVYTGTCMP PSPSSPFSSS CRSPRKPFAS PSRFIRRPST TICPSPIRVA 310 320 330 340 350 360 LESSSGLEQK GECSGSMAPR GPSVTESSEA SLDTSWPRSR PRAPPKARMA LSFSRFLRRG 370 380 390 400 410 420 CLASPVFARL SPKCPAVSHG RVQPLGDVGQ QLPRLKSKRV ANFFQIKMDV PTGSGTCLMD 430 440 SEDAGTGESG DRATEKEVIC PWESL
	Isoform 5 [UniParc]. Checksum: 3866AC4C0DBB9B6A	FASTA	671	76,625
	10 20 30 40 50 60 MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM TGSDVLQWIV 70 80 90 100 110 120 QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL YRFQTPYFWP TQQWPAEDTD 130 140 150 160 170 180 YAIYLAKRNI KKKGILEEYE KENYNFLNQK MNYKWDFVIM QAKEQYRAGK ERNKADRYAL 190 200 210 220 230 240 DCQEKAYWLV HRCPPGMDNV LDYGLDRVTN PNEVKKQTVV AVKKEIMYYQ QALMRSTVKS 250 260 270 280 290 300 SVSLGGIVKY SEQFSSNDAI MSGCLPSNPW ITDDTQFWDL NAKLVEIPTK MRVERWAFNF 310 320 330 340 350 360 SELIRDPKGR QSFQYFLKKE FSGENLGFWE ACEDLKYGDQ SKVKEKAEEI YKLFLAPGAR 370 380 390 400 410 420 RWINIDGKTM DITVKGLKHP HRYVLDAAQT HIYMLMKKDS YARYLKSPIY KDMLAKAIEP 430 440 450 460 470 480 QETTKKSSTL PFMRRHLRSS PSPVILRQLE EEAKAREAAN TVDITQPGQH MAPSPHLTVY 490 500 510 520 530 540 TGTCMPPSPS SPFSSSCRSP RKPFASPSRF IRRPSTTICP SPIRVALESS SGLEQKGECS 550 560 570 580 590 600 GSMAPRGPSV TESSEASLDT SWPRSRPRAP PKARMALSFS RFLRRGCLAS PVFARLSPKC 610 620 630 640 650 660 PAVSHGRVQP LGDVGQQLPR LKSKRVANFF QIKMDVPTGS GTCLMDSEDA GTGESGDRAT 670 EKEVICPWES L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of human and rat RGS9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS9 gene." Granneman J.G., Zhai Y., Zhu Z., Bannon M.J., Burchett S.A., Schmidt C.J., Andrade R., Cooper J. Mol. Pharmacol. 54:687-694(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Kidney and Retina.
[2]	"Structure, alternative splicing, and expression of the human RGS9 gene." Zhang K., Howes K.A., He W., Pettenati M.J., Palczewski K., Wensel T.G., Baehr W. Gene 240:23-34(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 3 AND 5).
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[5]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"Homo sapiens regulator of G protein signaling 9." Chatterjee T.K., Fisher R.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 218-674 (ISOFORM 1).
[8]	"The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo." Martemyanov K.A., Lishko P.V., Calero N., Keresztes G., Sokolov M., Strissel K.J., Leskov I.B., Hopp J.A., Kolesnikov A.V., Chen C.-K., Lem J., Heller S., Burns M.E., Arshavsky V.Y. J. Neurosci. 23:10175-10181(2003) [PubMed] [Europe PMC] [Abstract] Cited for: DEP DOMAIN TARGETING FUNCTION.
[9]	"Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation." Nishiguchi K.M., Sandberg M.A., Kooijman A.C., Martemyanov K.A., Pott J.W.R., Hagstrom S.A., Arshavsky V.Y., Berson E.L., Dryja T.P. Nature 427:75-78(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PERRS ARG-299.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF071476 mRNA. Translation: AAC64040.1. AF178070 , AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069 Genomic DNA. Translation: AAG09311.1. AF178072 , AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069, AF178070, AF178071 Genomic DNA. Translation: AAG09312.1. AF493932 mRNA. Translation: AAM12646.1. AF493933 mRNA. Translation: AAM12647.1. AY585190 mRNA. Translation: AAT79493.1. AY585191 mRNA. Translation: AAT79494.1. AK290535 mRNA. Translation: BAF83224.1. AC015821 Genomic DNA. No translation available. AC060771 Genomic DNA. No translation available. CH471099 Genomic DNA. Translation: EAW88998.1. AF073710 mRNA. Translation: AAC25430.1. Different initiation.
IPI	IPI00027385. IPI00216453. IPI00328241. IPI00953975. IPI01009816.
RefSeq	NP_001075424.1. NM_001081955.2. NP_003826.2. NM_003835.3.
UniGene	Hs.664380.
3D structure databases
ProteinModelPortal	O75916.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75916. 1 interaction.
STRING	9606.ENSP00000262406.
PTM databases
PhosphoSite	O75916.
Proteomic databases
PaxDb	O75916.
PRIDE	O75916.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262406; ENSP00000262406; ENSG00000108370. ENST00000449996; ENSP00000396329; ENSG00000108370.
GeneID	8787.
KEGG	hsa:8787.
UCSC	uc002jfd.3. human. uc002jfe.3. human.
Organism-specific databases
CTD	8787.
GeneCards	GC17P063133.
HGNC	HGNC:10004. RGS9.
MIM	604067. gene. 608415. phenotype.
neXtProt	NX_O75916.
Orphanet	75374. Bradyopsia.
PharmGKB	PA34380.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327614.
HOVERGEN	HBG007404.
InParanoid	O75916.
KO	K13765.
OMA	AKLVEIP.
OrthoDB	EOG44XJGT.
Enzyme and pathway databases
Pathway_Interaction_DB	cone_pathway. Visual signal transduction: Cones. rhodopsin_pathway. Visual signal transduction: Rods.
Gene expression databases
Bgee	O75916.
CleanEx	HS_RGS9.
Genevestigator	O75916.
GermOnline	ENSG00000108370. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 1.10.196.10. 1 hit. 4.10.260.10. 1 hit.
InterPro	IPR000591. DEP_dom. IPR015898. G-protein_gamma-like_dom. IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00610. DEP. 1 hit. PF00631. G-gamma. 1 hit. PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00049. DEP. 1 hit. SM00224. GGL. 1 hit. SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50186. DEP. 1 hit. PS50058. G_PROTEIN_GAMMA. False negative. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8787.
NextBio	32954.
SOURCE	Search...

Entry information

Entry name

RGS9_HUMAN

Accession

Primary (citable) accession number: O75916
Secondary accession number(s): A8K3C0 , O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 132 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.