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Protein

Serine/threonine-protein kinase PAK 3

Gene

PAK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei312ATPPROSITE-ProRule annotation1
Active sitei402Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi289 – 297ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS01238-MONOMER.
BRENDAi2.7.11.1. 2681.
ReactomeiR-HSA-202433. Generation of second messenger molecules.
R-HSA-389359. CD28 dependent Vav1 pathway.
R-HSA-3928664. Ephrin signaling.
R-HSA-399954. Sema3A PAK dependent Axon repulsion.
R-HSA-428540. Activation of Rac.
R-HSA-5218920. VEGFR2 mediated vascular permeability.
R-HSA-5621575. CD209 (DC-SIGN) signaling.
R-HSA-5627123. RHO GTPases activate PAKs.
R-HSA-5687128. MAPK6/MAPK4 signaling.
SignaLinkiO75914.
SIGNORiO75914.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PAK 3 (EC:2.7.11.1)
Alternative name(s):
Beta-PAK
Oligophrenin-3
p21-activated kinase 3
Short name:
PAK-3
Gene namesi
Name:PAK3
Synonyms:OPHN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:8592. PAK3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked 30 (MRX30)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
See also OMIM:300558
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02382567R → C in MRX30. 1 PublicationCorresponds to variant rs121434612dbSNPEnsembl.1
Natural variantiVAR_023826380A → E in MRX30. 1 PublicationCorresponds to variant rs121434613dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi5063.
MalaCardsiPAK3.
MIMi300558. phenotype.
OpenTargetsiENSG00000077264.
Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA32919.

Chemistry databases

ChEMBLiCHEMBL2999.
GuidetoPHARMACOLOGYi2135.

Polymorphism and mutation databases

BioMutaiPAK3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864691 – 559Serine/threonine-protein kinase PAK 3Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei50Phosphoserine; by autocatalysisBy similarity1
Modified residuei154Phosphoserine; by autocatalysisBy similarity1
Modified residuei186PhosphoserineBy similarity1
Modified residuei436Phosphothreonine; by autocatalysisBy similarity1

Post-translational modificationi

Autophosphorylated when activated by CDC42/p21.
Neddylated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO75914.
PeptideAtlasiO75914.
PRIDEiO75914.

PTM databases

iPTMnetiO75914.
PhosphoSitePlusiO75914.

Expressioni

Tissue specificityi

Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.1 Publication

Gene expression databases

BgeeiENSG00000077264.
ExpressionAtlasiO75914. baseline and differential.
GenevisibleiO75914. HS.

Organism-specific databases

HPAiHPA044791.
HPA060219.

Interactioni

Subunit structurei

Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. Interacts with the C-terminal of APP (By similarity). Interacts with ARHGEF6 and ARHGEF7.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC42P60953-22EBI-3389553,EBI-287394
RAC1P630002EBI-3389553,EBI-413628

Protein-protein interaction databases

BioGridi111099. 8 interactors.
IntActiO75914. 4 interactors.
MINTiMINT-3001915.
STRINGi9606.ENSP00000353864.

Chemistry databases

BindingDBiO75914.

Structurei

3D structure databases

ProteinModelPortaliO75914.
SMRiO75914.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 83CRIBPROSITE-ProRule annotationAdd BLAST14
Domaini283 – 534Protein kinasePROSITE-ProRule annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 150Autoregulatory regionBy similarityAdd BLAST86
Regioni65 – 123GTPase-bindingBy similarityAdd BLAST59
Regioni84 – 282LinkerAdd BLAST199

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 201Poly-GluAdd BLAST15

Sequence similaritiesi

Contains 1 CRIB domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG0578. Eukaryota.
ENOG410XP4K. LUCA.
GeneTreeiENSGT00860000133680.
HOGENOMiHOG000234202.
HOVERGENiHBG108518.
InParanoidiO75914.
KOiK05733.
OMAiXKPPAPP.
OrthoDBiEOG091G04H8.
PhylomeDBiO75914.
TreeFamiTF105351.

Family and domain databases

CDDicd01093. CRIB_PAK_like. 1 hit.
Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR033923. PAK_BD.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75914-1) [UniParc]FASTAAdd to basket
Also known as: PAK3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS
60 70 80 90 100
IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM
110 120 130 140 150
CPGKLPEGIP EQWARLLQTS NITKLEQKKN PQAVLDVLKF YDSKETVNNQ
160 170 180 190 200
KYMSFTSGDK SAHGYIAAHP SSTKTASEPP LAPPVSEEED EEEEEEEDEN
210 220 230 240 250
EPPPVIAPRP EHTKSIYTRS VVESIASPAV PNKEVTPPSA ENANSSTLYR
260 270 280 290 300
NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA
310 320 330 340 350
LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG
360 370 380 390 400
DELWVVMEYL AGGSLTDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH
410 420 430 440 450
RDIKSDNILL GMDGSVKLTD FGFCAQITPE QSKRSTMVGT PYWMAPEVVT
460 470 480 490 500
RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE NPLRALYLIA TNGTPELQNP
510 520 530 540 550
ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL SSLTPLIIAA

KEAIKNSSR
Length:559
Mass (Da):62,310
Last modified:May 10, 2004 - v2
Checksum:iBC39AEC6F0A5478B
GO
Isoform 2 (identifier: O75914-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-107: Missing.

Show »
Length:544
Mass (Da):60,693
Checksum:i230AF6952CB049E2
GO
Isoform 3 (identifier: O75914-3) [UniParc]FASTAAdd to basket
Also known as: PAK3cb

The sequence of this isoform differs from the canonical sequence as follows:
     92-92: T → TNSPFQTSRPVTVASSQSEGKM

Show »
Length:580
Mass (Da):64,530
Checksum:i9646E127F2F007A2
GO
Isoform 4 (identifier: O75914-4) [UniParc]FASTAAdd to basket
Also known as: PAK3c

The sequence of this isoform differs from the canonical sequence as follows:
     92-107: TPDLYGSQMCPGKLPE → TNSPFQTSRPVTVASSQSEGKM

Show »
Length:565
Mass (Da):62,913
Checksum:i6A0C2190BBBBDC1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32S → F in AAF67008 (Ref. 2) Curated1
Sequence conflicti36P → S in AAF67008 (Ref. 2) Curated1
Sequence conflicti73P → S in AAF67008 (Ref. 2) Curated1
Sequence conflicti106 – 107PE → SL in AAF67008 (Ref. 2) Curated2
Sequence conflicti123T → P in AAF67008 (Ref. 2) Curated1
Sequence conflicti127 – 130QKKN → PEEE in AAF67008 (Ref. 2) Curated4
Sequence conflicti134 – 137VLDV → CSRC in AAF67008 (Ref. 2) Curated4
Sequence conflicti146 – 148TVN → PVT in AAF67008 (Ref. 2) Curated3
Sequence conflicti175T → P in AAF67008 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02382567R → C in MRX30. 1 PublicationCorresponds to variant rs121434612dbSNPEnsembl.1
Natural variantiVAR_023826380A → E in MRX30. 1 PublicationCorresponds to variant rs121434613dbSNPEnsembl.1
Natural variantiVAR_046764440T → S in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04184092 – 107TPDLY…GKLPE → TNSPFQTSRPVTVASSQSEG KM in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04183992T → TNSPFQTSRPVTVASSQSEG KM in isoform 3. 1 Publication1
Alternative sequenceiVSP_01024293 – 107Missing in isoform 2. 3 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068864 mRNA. Translation: AAC36097.1.
AF155651 mRNA. Translation: AAF67008.1.
AB102659 mRNA. Translation: BAC81128.1.
AB102251 Genomic DNA. Translation: BAC80750.1.
AB102252 Genomic DNA. Translation: BAC80751.1.
AB102253 Genomic DNA. Translation: BAC80752.1.
AB102254 Genomic DNA. Translation: BAC80753.1.
AB102255 Genomic DNA. Translation: BAC80754.1.
AB102256 Genomic DNA. Translation: BAC80755.1.
AB102257 Genomic DNA. Translation: BAC80756.1.
AB102258 Genomic DNA. Translation: BAC80757.1.
AB102259 Genomic DNA. Translation: BAC80758.1.
AB102260 Genomic DNA. Translation: BAC80759.1.
AB102261 Genomic DNA. Translation: BAC80760.1.
AB102262 Genomic DNA. Translation: BAC80761.1.
AB102263 Genomic DNA. Translation: BAC80762.1.
AB102264 Genomic DNA. Translation: BAC80763.1.
AB102265 Genomic DNA. Translation: BAC80764.1.
AB102266 Genomic DNA. Translation: BAC80765.1.
AB102267 Genomic DNA. Translation: BAC80766.1.
AB102268 Genomic DNA. Translation: BAC80767.1.
AB102269 Genomic DNA. Translation: BAC80768.1.
AB102270 Genomic DNA. Translation: BAC80769.1.
AB102281 Genomic DNA. Translation: BAC80780.1.
AB102282 Genomic DNA. Translation: BAC80781.1.
AB102283 Genomic DNA. Translation: BAC80782.1.
AB102284 Genomic DNA. Translation: BAC80783.1.
AB102285 Genomic DNA. Translation: BAC80784.1.
AB102286 Genomic DNA. Translation: BAC80785.1.
AB102287 Genomic DNA. Translation: BAC80786.1.
AB102288 Genomic DNA. Translation: BAC80787.1.
AB102289 Genomic DNA. Translation: BAC80788.1.
AB102290 Genomic DNA. Translation: BAC80789.1.
AB102291 Genomic DNA. Translation: BAC80790.1.
AB102292 Genomic DNA. Translation: BAC80791.1.
AB102293 Genomic DNA. Translation: BAC80792.1.
AB102294 Genomic DNA. Translation: BAC80793.1.
AB102295 Genomic DNA. Translation: BAC80794.1.
AB102296 Genomic DNA. Translation: BAC80795.1.
AB102297 Genomic DNA. Translation: BAC80796.1.
AB102298 Genomic DNA. Translation: BAC80797.1.
AB102299 Genomic DNA. Translation: BAC80798.1.
AB102300 Genomic DNA. Translation: BAC80799.1.
AM943850 mRNA. Translation: CAQ16016.1.
AM943851 mRNA. Translation: CAQ16017.1.
AM943852 mRNA. Translation: CAQ16018.1.
AK290504 mRNA. Translation: BAF83193.1.
AL356578 Genomic DNA. No translation available.
AL357774, AL031117, AL117326 Genomic DNA. Translation: CAI40843.1.
AL357774, AL031117, AL117326 Genomic DNA. Translation: CAI40844.1.
AL031117, AL117326, AL357774 Genomic DNA. Translation: CAI43157.1.
AL031117, AL117326, AL357774 Genomic DNA. Translation: CAI43158.1.
AL117326, AL031117, AL357774 Genomic DNA. Translation: CAI43167.1.
AL117326, AL031117, AL357774 Genomic DNA. Translation: CAI43168.1.
CH471120 Genomic DNA. Translation: EAX02654.1.
CCDSiCCDS14554.1. [O75914-2]
CCDS48151.1. [O75914-3]
CCDS48152.1. [O75914-4]
CCDS48153.1. [O75914-1]
RefSeqiNP_001121638.1. NM_001128166.2. [O75914-2]
NP_001121639.1. NM_001128167.2. [O75914-2]
NP_001121640.1. NM_001128168.2. [O75914-3]
NP_001121644.1. NM_001128172.2. [O75914-4]
NP_001121645.1. NM_001128173.2. [O75914-1]
NP_001311254.1. NM_001324325.1. [O75914-2]
NP_001311255.1. NM_001324326.1. [O75914-2]
NP_001311256.1. NM_001324327.1. [O75914-1]
NP_001311257.1. NM_001324328.1. [O75914-1]
NP_001311258.1. NM_001324329.1. [O75914-1]
NP_001311259.1. NM_001324330.1. [O75914-2]
NP_001311260.1. NM_001324331.1. [O75914-2]
NP_001311261.1. NM_001324332.1. [O75914-2]
NP_001311262.1. NM_001324333.1. [O75914-1]
NP_001311263.1. NM_001324334.1. [O75914-2]
NP_002569.1. NM_002578.4. [O75914-2]
XP_016885046.1. XM_017029557.1. [O75914-1]
XP_016885050.1. XM_017029561.1. [O75914-2]
XP_016885052.1. XM_017029563.1. [O75914-3]
UniGeneiHs.593599.
Hs.655757.
Hs.656789.

Genome annotation databases

EnsembliENST00000262836; ENSP00000262836; ENSG00000077264. [O75914-1]
ENST00000360648; ENSP00000353864; ENSG00000077264. [O75914-3]
ENST00000372007; ENSP00000361077; ENSG00000077264. [O75914-2]
ENST00000372010; ENSP00000361080; ENSG00000077264. [O75914-1]
ENST00000417227; ENSP00000389172; ENSG00000077264. [O75914-4]
ENST00000425146; ENSP00000401982; ENSG00000077264. [O75914-2]
ENST00000446737; ENSP00000410853; ENSG00000077264. [O75914-2]
ENST00000518291; ENSP00000428921; ENSG00000077264. [O75914-3]
ENST00000519681; ENSP00000429113; ENSG00000077264. [O75914-4]
GeneIDi5063.
KEGGihsa:5063.
UCSCiuc004eoz.3. human. [O75914-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068864 mRNA. Translation: AAC36097.1.
AF155651 mRNA. Translation: AAF67008.1.
AB102659 mRNA. Translation: BAC81128.1.
AB102251 Genomic DNA. Translation: BAC80750.1.
AB102252 Genomic DNA. Translation: BAC80751.1.
AB102253 Genomic DNA. Translation: BAC80752.1.
AB102254 Genomic DNA. Translation: BAC80753.1.
AB102255 Genomic DNA. Translation: BAC80754.1.
AB102256 Genomic DNA. Translation: BAC80755.1.
AB102257 Genomic DNA. Translation: BAC80756.1.
AB102258 Genomic DNA. Translation: BAC80757.1.
AB102259 Genomic DNA. Translation: BAC80758.1.
AB102260 Genomic DNA. Translation: BAC80759.1.
AB102261 Genomic DNA. Translation: BAC80760.1.
AB102262 Genomic DNA. Translation: BAC80761.1.
AB102263 Genomic DNA. Translation: BAC80762.1.
AB102264 Genomic DNA. Translation: BAC80763.1.
AB102265 Genomic DNA. Translation: BAC80764.1.
AB102266 Genomic DNA. Translation: BAC80765.1.
AB102267 Genomic DNA. Translation: BAC80766.1.
AB102268 Genomic DNA. Translation: BAC80767.1.
AB102269 Genomic DNA. Translation: BAC80768.1.
AB102270 Genomic DNA. Translation: BAC80769.1.
AB102281 Genomic DNA. Translation: BAC80780.1.
AB102282 Genomic DNA. Translation: BAC80781.1.
AB102283 Genomic DNA. Translation: BAC80782.1.
AB102284 Genomic DNA. Translation: BAC80783.1.
AB102285 Genomic DNA. Translation: BAC80784.1.
AB102286 Genomic DNA. Translation: BAC80785.1.
AB102287 Genomic DNA. Translation: BAC80786.1.
AB102288 Genomic DNA. Translation: BAC80787.1.
AB102289 Genomic DNA. Translation: BAC80788.1.
AB102290 Genomic DNA. Translation: BAC80789.1.
AB102291 Genomic DNA. Translation: BAC80790.1.
AB102292 Genomic DNA. Translation: BAC80791.1.
AB102293 Genomic DNA. Translation: BAC80792.1.
AB102294 Genomic DNA. Translation: BAC80793.1.
AB102295 Genomic DNA. Translation: BAC80794.1.
AB102296 Genomic DNA. Translation: BAC80795.1.
AB102297 Genomic DNA. Translation: BAC80796.1.
AB102298 Genomic DNA. Translation: BAC80797.1.
AB102299 Genomic DNA. Translation: BAC80798.1.
AB102300 Genomic DNA. Translation: BAC80799.1.
AM943850 mRNA. Translation: CAQ16016.1.
AM943851 mRNA. Translation: CAQ16017.1.
AM943852 mRNA. Translation: CAQ16018.1.
AK290504 mRNA. Translation: BAF83193.1.
AL356578 Genomic DNA. No translation available.
AL357774, AL031117, AL117326 Genomic DNA. Translation: CAI40843.1.
AL357774, AL031117, AL117326 Genomic DNA. Translation: CAI40844.1.
AL031117, AL117326, AL357774 Genomic DNA. Translation: CAI43157.1.
AL031117, AL117326, AL357774 Genomic DNA. Translation: CAI43158.1.
AL117326, AL031117, AL357774 Genomic DNA. Translation: CAI43167.1.
AL117326, AL031117, AL357774 Genomic DNA. Translation: CAI43168.1.
CH471120 Genomic DNA. Translation: EAX02654.1.
CCDSiCCDS14554.1. [O75914-2]
CCDS48151.1. [O75914-3]
CCDS48152.1. [O75914-4]
CCDS48153.1. [O75914-1]
RefSeqiNP_001121638.1. NM_001128166.2. [O75914-2]
NP_001121639.1. NM_001128167.2. [O75914-2]
NP_001121640.1. NM_001128168.2. [O75914-3]
NP_001121644.1. NM_001128172.2. [O75914-4]
NP_001121645.1. NM_001128173.2. [O75914-1]
NP_001311254.1. NM_001324325.1. [O75914-2]
NP_001311255.1. NM_001324326.1. [O75914-2]
NP_001311256.1. NM_001324327.1. [O75914-1]
NP_001311257.1. NM_001324328.1. [O75914-1]
NP_001311258.1. NM_001324329.1. [O75914-1]
NP_001311259.1. NM_001324330.1. [O75914-2]
NP_001311260.1. NM_001324331.1. [O75914-2]
NP_001311261.1. NM_001324332.1. [O75914-2]
NP_001311262.1. NM_001324333.1. [O75914-1]
NP_001311263.1. NM_001324334.1. [O75914-2]
NP_002569.1. NM_002578.4. [O75914-2]
XP_016885046.1. XM_017029557.1. [O75914-1]
XP_016885050.1. XM_017029561.1. [O75914-2]
XP_016885052.1. XM_017029563.1. [O75914-3]
UniGeneiHs.593599.
Hs.655757.
Hs.656789.

3D structure databases

ProteinModelPortaliO75914.
SMRiO75914.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111099. 8 interactors.
IntActiO75914. 4 interactors.
MINTiMINT-3001915.
STRINGi9606.ENSP00000353864.

Chemistry databases

BindingDBiO75914.
ChEMBLiCHEMBL2999.
GuidetoPHARMACOLOGYi2135.

PTM databases

iPTMnetiO75914.
PhosphoSitePlusiO75914.

Polymorphism and mutation databases

BioMutaiPAK3.

Proteomic databases

PaxDbiO75914.
PeptideAtlasiO75914.
PRIDEiO75914.

Protocols and materials databases

DNASUi5063.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262836; ENSP00000262836; ENSG00000077264. [O75914-1]
ENST00000360648; ENSP00000353864; ENSG00000077264. [O75914-3]
ENST00000372007; ENSP00000361077; ENSG00000077264. [O75914-2]
ENST00000372010; ENSP00000361080; ENSG00000077264. [O75914-1]
ENST00000417227; ENSP00000389172; ENSG00000077264. [O75914-4]
ENST00000425146; ENSP00000401982; ENSG00000077264. [O75914-2]
ENST00000446737; ENSP00000410853; ENSG00000077264. [O75914-2]
ENST00000518291; ENSP00000428921; ENSG00000077264. [O75914-3]
ENST00000519681; ENSP00000429113; ENSG00000077264. [O75914-4]
GeneIDi5063.
KEGGihsa:5063.
UCSCiuc004eoz.3. human. [O75914-1]

Organism-specific databases

CTDi5063.
DisGeNETi5063.
GeneCardsiPAK3.
HGNCiHGNC:8592. PAK3.
HPAiHPA044791.
HPA060219.
MalaCardsiPAK3.
MIMi300142. gene.
300558. phenotype.
neXtProtiNX_O75914.
OpenTargetsiENSG00000077264.
Orphaneti777. X-linked non-syndromic intellectual disability.
PharmGKBiPA32919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0578. Eukaryota.
ENOG410XP4K. LUCA.
GeneTreeiENSGT00860000133680.
HOGENOMiHOG000234202.
HOVERGENiHBG108518.
InParanoidiO75914.
KOiK05733.
OMAiXKPPAPP.
OrthoDBiEOG091G04H8.
PhylomeDBiO75914.
TreeFamiTF105351.

Enzyme and pathway databases

BioCyciZFISH:HS01238-MONOMER.
BRENDAi2.7.11.1. 2681.
ReactomeiR-HSA-202433. Generation of second messenger molecules.
R-HSA-389359. CD28 dependent Vav1 pathway.
R-HSA-3928664. Ephrin signaling.
R-HSA-399954. Sema3A PAK dependent Axon repulsion.
R-HSA-428540. Activation of Rac.
R-HSA-5218920. VEGFR2 mediated vascular permeability.
R-HSA-5621575. CD209 (DC-SIGN) signaling.
R-HSA-5627123. RHO GTPases activate PAKs.
R-HSA-5687128. MAPK6/MAPK4 signaling.
SignaLinkiO75914.
SIGNORiO75914.

Miscellaneous databases

ChiTaRSiPAK3. human.
GeneWikiiPAK3.
GenomeRNAii5063.
PROiO75914.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000077264.
ExpressionAtlasiO75914. baseline and differential.
GenevisibleiO75914. HS.

Family and domain databases

CDDicd01093. CRIB_PAK_like. 1 hit.
Gene3Di3.90.810.10. 1 hit.
InterProiIPR000095. CRIB_dom.
IPR011009. Kinase-like_dom.
IPR033923. PAK_BD.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00786. PBD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50108. CRIB. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAK3_HUMAN
AccessioniPrimary (citable) accession number: O75914
Secondary accession number(s): A8K389
, B1GX77, B1GX78, B1GX79, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 10, 2004
Last modified: November 30, 2016
This is version 175 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.