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O75914

- PAK3_HUMAN

UniProt

O75914 - PAK3_HUMAN

Protein

Serine/threonine-protein kinase PAK 3

Gene

PAK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei312 – 3121ATPPROSITE-ProRule annotation
    Active sitei402 – 4021Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi289 – 2979ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct
    5. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. activation of MAPK activity Source: GOC
    2. axonogenesis Source: UniProtKB
    3. dendrite development Source: UniProtKB
    4. dendritic spine morphogenesis Source: UniProtKB
    5. MAPK cascade Source: GOC
    6. regulation of actin filament polymerization Source: UniProtKB
    7. synapse organization Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 2681.
    ReactomeiREACT_19226. Activation of Rac.
    SignaLinkiO75914.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PAK 3 (EC:2.7.11.1)
    Alternative name(s):
    Beta-PAK
    Oligophrenin-3
    p21-activated kinase 3
    Short name:
    PAK-3
    Gene namesi
    Name:PAK3
    Synonyms:OPHN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:8592. PAK3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Mental retardation, X-linked 30 (MRX30) [MIM:300558]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671R → C in MRX30. 1 Publication
    VAR_023825
    Natural varianti380 – 3801A → E in MRX30. 1 Publication
    VAR_023826

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi300558. phenotype.
    Orphaneti777. X-linked non-syndromic intellectual disability.
    PharmGKBiPA32919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Serine/threonine-protein kinase PAK 3PRO_0000086469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei50 – 501Phosphoserine; by autocatalysisBy similarity
    Modified residuei154 – 1541Phosphoserine; by autocatalysisBy similarity
    Modified residuei436 – 4361Phosphothreonine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated when activated by CDC42/p21.
    Neddylated.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiO75914.
    PRIDEiO75914.

    PTM databases

    PhosphoSiteiO75914.

    Expressioni

    Tissue specificityi

    Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.1 Publication

    Gene expression databases

    ArrayExpressiO75914.
    BgeeiO75914.
    GenevestigatoriO75914.

    Organism-specific databases

    HPAiHPA044791.

    Interactioni

    Subunit structurei

    Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. Interacts with the C-terminal of APP By similarity. Interacts with ARHGEF6 and ARHGEF7.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC42P60953-22EBI-3389553,EBI-287394
    RAC1P630002EBI-3389553,EBI-413628

    Protein-protein interaction databases

    BioGridi111099. 7 interactions.
    IntActiO75914. 3 interactions.
    MINTiMINT-3001915.

    Structurei

    3D structure databases

    ProteinModelPortaliO75914.
    SMRiO75914. Positions 65-156, 181-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 8314CRIBPROSITE-ProRule annotationAdd
    BLAST
    Domaini283 – 534252Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni65 – 15086Autoregulatory regionBy similarityAdd
    BLAST
    Regioni65 – 12359GTPase-bindingBy similarityAdd
    BLAST
    Regioni84 – 282199LinkerAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi187 – 20115Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CRIB domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3-binding

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000234202.
    HOVERGENiHBG108518.
    KOiK05733.
    OMAiSANENDM.
    OrthoDBiEOG7CK36J.
    PhylomeDBiO75914.
    TreeFamiTF105351.

    Family and domain databases

    Gene3Di3.90.810.10. 1 hit.
    InterProiIPR000095. CRIB_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00786. PBD. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00285. PBD. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50108. CRIB. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75914-1) [UniParc]FASTAAdd to Basket

    Also known as: PAK3b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS    50
    IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM 100
    CPGKLPEGIP EQWARLLQTS NITKLEQKKN PQAVLDVLKF YDSKETVNNQ 150
    KYMSFTSGDK SAHGYIAAHP SSTKTASEPP LAPPVSEEED EEEEEEEDEN 200
    EPPPVIAPRP EHTKSIYTRS VVESIASPAV PNKEVTPPSA ENANSSTLYR 250
    NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA 300
    LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG 350
    DELWVVMEYL AGGSLTDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH 400
    RDIKSDNILL GMDGSVKLTD FGFCAQITPE QSKRSTMVGT PYWMAPEVVT 450
    RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE NPLRALYLIA TNGTPELQNP 500
    ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL SSLTPLIIAA 550
    KEAIKNSSR 559
    Length:559
    Mass (Da):62,310
    Last modified:May 10, 2004 - v2
    Checksum:iBC39AEC6F0A5478B
    GO
    Isoform 2 (identifier: O75914-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         93-107: Missing.

    Show »
    Length:544
    Mass (Da):60,693
    Checksum:i230AF6952CB049E2
    GO
    Isoform 3 (identifier: O75914-3) [UniParc]FASTAAdd to Basket

    Also known as: PAK3cb

    The sequence of this isoform differs from the canonical sequence as follows:
         92-92: T → TNSPFQTSRPVTVASSQSEGKM

    Show »
    Length:580
    Mass (Da):64,530
    Checksum:i9646E127F2F007A2
    GO
    Isoform 4 (identifier: O75914-4) [UniParc]FASTAAdd to Basket

    Also known as: PAK3c

    The sequence of this isoform differs from the canonical sequence as follows:
         92-107: TPDLYGSQMCPGKLPE → TNSPFQTSRPVTVASSQSEGKM

    Show »
    Length:565
    Mass (Da):62,913
    Checksum:i6A0C2190BBBBDC1F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321S → F in AAF67008. 1 PublicationCurated
    Sequence conflicti36 – 361P → S in AAF67008. 1 PublicationCurated
    Sequence conflicti73 – 731P → S in AAF67008. 1 PublicationCurated
    Sequence conflicti106 – 1072PE → SL in AAF67008. 1 PublicationCurated
    Sequence conflicti123 – 1231T → P in AAF67008. 1 PublicationCurated
    Sequence conflicti127 – 1304QKKN → PEEE in AAF67008. 1 PublicationCurated
    Sequence conflicti134 – 1374VLDV → CSRC in AAF67008. 1 PublicationCurated
    Sequence conflicti146 – 1483TVN → PVT in AAF67008. 1 PublicationCurated
    Sequence conflicti175 – 1751T → P in AAF67008. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671R → C in MRX30. 1 Publication
    VAR_023825
    Natural varianti380 – 3801A → E in MRX30. 1 Publication
    VAR_023826
    Natural varianti440 – 4401T → S in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_046764

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei92 – 10716TPDLY…GKLPE → TNSPFQTSRPVTVASSQSEG KM in isoform 4. 1 PublicationVSP_041840Add
    BLAST
    Alternative sequencei92 – 921T → TNSPFQTSRPVTVASSQSEG KM in isoform 3. 1 PublicationVSP_041839
    Alternative sequencei93 – 10715Missing in isoform 2. 3 PublicationsVSP_010242Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068864 mRNA. Translation: AAC36097.1.
    AF155651 mRNA. Translation: AAF67008.1.
    AB102659 mRNA. Translation: BAC81128.1.
    AB102251 Genomic DNA. Translation: BAC80750.1.
    AB102252 Genomic DNA. Translation: BAC80751.1.
    AB102253 Genomic DNA. Translation: BAC80752.1.
    AB102254 Genomic DNA. Translation: BAC80753.1.
    AB102255 Genomic DNA. Translation: BAC80754.1.
    AB102256 Genomic DNA. Translation: BAC80755.1.
    AB102257 Genomic DNA. Translation: BAC80756.1.
    AB102258 Genomic DNA. Translation: BAC80757.1.
    AB102259 Genomic DNA. Translation: BAC80758.1.
    AB102260 Genomic DNA. Translation: BAC80759.1.
    AB102261 Genomic DNA. Translation: BAC80760.1.
    AB102262 Genomic DNA. Translation: BAC80761.1.
    AB102263 Genomic DNA. Translation: BAC80762.1.
    AB102264 Genomic DNA. Translation: BAC80763.1.
    AB102265 Genomic DNA. Translation: BAC80764.1.
    AB102266 Genomic DNA. Translation: BAC80765.1.
    AB102267 Genomic DNA. Translation: BAC80766.1.
    AB102268 Genomic DNA. Translation: BAC80767.1.
    AB102269 Genomic DNA. Translation: BAC80768.1.
    AB102270 Genomic DNA. Translation: BAC80769.1.
    AB102281 Genomic DNA. Translation: BAC80780.1.
    AB102282 Genomic DNA. Translation: BAC80781.1.
    AB102283 Genomic DNA. Translation: BAC80782.1.
    AB102284 Genomic DNA. Translation: BAC80783.1.
    AB102285 Genomic DNA. Translation: BAC80784.1.
    AB102286 Genomic DNA. Translation: BAC80785.1.
    AB102287 Genomic DNA. Translation: BAC80786.1.
    AB102288 Genomic DNA. Translation: BAC80787.1.
    AB102289 Genomic DNA. Translation: BAC80788.1.
    AB102290 Genomic DNA. Translation: BAC80789.1.
    AB102291 Genomic DNA. Translation: BAC80790.1.
    AB102292 Genomic DNA. Translation: BAC80791.1.
    AB102293 Genomic DNA. Translation: BAC80792.1.
    AB102294 Genomic DNA. Translation: BAC80793.1.
    AB102295 Genomic DNA. Translation: BAC80794.1.
    AB102296 Genomic DNA. Translation: BAC80795.1.
    AB102297 Genomic DNA. Translation: BAC80796.1.
    AB102298 Genomic DNA. Translation: BAC80797.1.
    AB102299 Genomic DNA. Translation: BAC80798.1.
    AB102300 Genomic DNA. Translation: BAC80799.1.
    AM943850 mRNA. Translation: CAQ16016.1.
    AM943851 mRNA. Translation: CAQ16017.1.
    AM943852 mRNA. Translation: CAQ16018.1.
    AK290504 mRNA. Translation: BAF83193.1.
    AL356578 Genomic DNA. No translation available.
    AL357774, AL031117, AL117326 Genomic DNA. Translation: CAI40843.1.
    AL357774, AL031117, AL117326 Genomic DNA. Translation: CAI40844.1.
    AL031117, AL117326, AL357774 Genomic DNA. Translation: CAI43157.1.
    AL031117, AL117326, AL357774 Genomic DNA. Translation: CAI43158.1.
    AL117326, AL031117, AL357774 Genomic DNA. Translation: CAI43167.1.
    AL117326, AL031117, AL357774 Genomic DNA. Translation: CAI43168.1.
    CH471120 Genomic DNA. Translation: EAX02654.1.
    CCDSiCCDS14554.1. [O75914-2]
    CCDS48151.1. [O75914-3]
    CCDS48152.1. [O75914-4]
    CCDS48153.1. [O75914-1]
    RefSeqiNP_001121638.1. NM_001128166.1. [O75914-2]
    NP_001121639.1. NM_001128167.1. [O75914-2]
    NP_001121640.1. NM_001128168.1. [O75914-3]
    NP_001121644.1. NM_001128172.1. [O75914-4]
    NP_001121645.1. NM_001128173.1. [O75914-1]
    NP_002569.1. NM_002578.3. [O75914-2]
    XP_006724719.1. XM_006724656.1. [O75914-1]
    UniGeneiHs.593599.
    Hs.656789.

    Genome annotation databases

    EnsembliENST00000262836; ENSP00000262836; ENSG00000077264. [O75914-1]
    ENST00000360648; ENSP00000353864; ENSG00000077264. [O75914-3]
    ENST00000372007; ENSP00000361077; ENSG00000077264. [O75914-2]
    ENST00000372010; ENSP00000361080; ENSG00000077264. [O75914-1]
    ENST00000417227; ENSP00000389172; ENSG00000077264. [O75914-4]
    ENST00000425146; ENSP00000401982; ENSG00000077264. [O75914-2]
    ENST00000446737; ENSP00000410853; ENSG00000077264. [O75914-2]
    ENST00000518291; ENSP00000428921; ENSG00000077264. [O75914-3]
    ENST00000519681; ENSP00000429113; ENSG00000077264. [O75914-4]
    GeneIDi5063.
    KEGGihsa:5063.
    UCSCiuc004eoz.2. human. [O75914-2]
    uc004epa.2. human. [O75914-1]
    uc010npv.1. human. [O75914-3]
    uc010npw.1. human. [O75914-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068864 mRNA. Translation: AAC36097.1 .
    AF155651 mRNA. Translation: AAF67008.1 .
    AB102659 mRNA. Translation: BAC81128.1 .
    AB102251 Genomic DNA. Translation: BAC80750.1 .
    AB102252 Genomic DNA. Translation: BAC80751.1 .
    AB102253 Genomic DNA. Translation: BAC80752.1 .
    AB102254 Genomic DNA. Translation: BAC80753.1 .
    AB102255 Genomic DNA. Translation: BAC80754.1 .
    AB102256 Genomic DNA. Translation: BAC80755.1 .
    AB102257 Genomic DNA. Translation: BAC80756.1 .
    AB102258 Genomic DNA. Translation: BAC80757.1 .
    AB102259 Genomic DNA. Translation: BAC80758.1 .
    AB102260 Genomic DNA. Translation: BAC80759.1 .
    AB102261 Genomic DNA. Translation: BAC80760.1 .
    AB102262 Genomic DNA. Translation: BAC80761.1 .
    AB102263 Genomic DNA. Translation: BAC80762.1 .
    AB102264 Genomic DNA. Translation: BAC80763.1 .
    AB102265 Genomic DNA. Translation: BAC80764.1 .
    AB102266 Genomic DNA. Translation: BAC80765.1 .
    AB102267 Genomic DNA. Translation: BAC80766.1 .
    AB102268 Genomic DNA. Translation: BAC80767.1 .
    AB102269 Genomic DNA. Translation: BAC80768.1 .
    AB102270 Genomic DNA. Translation: BAC80769.1 .
    AB102281 Genomic DNA. Translation: BAC80780.1 .
    AB102282 Genomic DNA. Translation: BAC80781.1 .
    AB102283 Genomic DNA. Translation: BAC80782.1 .
    AB102284 Genomic DNA. Translation: BAC80783.1 .
    AB102285 Genomic DNA. Translation: BAC80784.1 .
    AB102286 Genomic DNA. Translation: BAC80785.1 .
    AB102287 Genomic DNA. Translation: BAC80786.1 .
    AB102288 Genomic DNA. Translation: BAC80787.1 .
    AB102289 Genomic DNA. Translation: BAC80788.1 .
    AB102290 Genomic DNA. Translation: BAC80789.1 .
    AB102291 Genomic DNA. Translation: BAC80790.1 .
    AB102292 Genomic DNA. Translation: BAC80791.1 .
    AB102293 Genomic DNA. Translation: BAC80792.1 .
    AB102294 Genomic DNA. Translation: BAC80793.1 .
    AB102295 Genomic DNA. Translation: BAC80794.1 .
    AB102296 Genomic DNA. Translation: BAC80795.1 .
    AB102297 Genomic DNA. Translation: BAC80796.1 .
    AB102298 Genomic DNA. Translation: BAC80797.1 .
    AB102299 Genomic DNA. Translation: BAC80798.1 .
    AB102300 Genomic DNA. Translation: BAC80799.1 .
    AM943850 mRNA. Translation: CAQ16016.1 .
    AM943851 mRNA. Translation: CAQ16017.1 .
    AM943852 mRNA. Translation: CAQ16018.1 .
    AK290504 mRNA. Translation: BAF83193.1 .
    AL356578 Genomic DNA. No translation available.
    AL357774 , AL031117 , AL117326 Genomic DNA. Translation: CAI40843.1 .
    AL357774 , AL031117 , AL117326 Genomic DNA. Translation: CAI40844.1 .
    AL031117 , AL117326 , AL357774 Genomic DNA. Translation: CAI43157.1 .
    AL031117 , AL117326 , AL357774 Genomic DNA. Translation: CAI43158.1 .
    AL117326 , AL031117 , AL357774 Genomic DNA. Translation: CAI43167.1 .
    AL117326 , AL031117 , AL357774 Genomic DNA. Translation: CAI43168.1 .
    CH471120 Genomic DNA. Translation: EAX02654.1 .
    CCDSi CCDS14554.1. [O75914-2 ]
    CCDS48151.1. [O75914-3 ]
    CCDS48152.1. [O75914-4 ]
    CCDS48153.1. [O75914-1 ]
    RefSeqi NP_001121638.1. NM_001128166.1. [O75914-2 ]
    NP_001121639.1. NM_001128167.1. [O75914-2 ]
    NP_001121640.1. NM_001128168.1. [O75914-3 ]
    NP_001121644.1. NM_001128172.1. [O75914-4 ]
    NP_001121645.1. NM_001128173.1. [O75914-1 ]
    NP_002569.1. NM_002578.3. [O75914-2 ]
    XP_006724719.1. XM_006724656.1. [O75914-1 ]
    UniGenei Hs.593599.
    Hs.656789.

    3D structure databases

    ProteinModelPortali O75914.
    SMRi O75914. Positions 65-156, 181-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111099. 7 interactions.
    IntActi O75914. 3 interactions.
    MINTi MINT-3001915.

    Chemistry

    BindingDBi O75914.
    ChEMBLi CHEMBL2999.
    GuidetoPHARMACOLOGYi 2135.

    PTM databases

    PhosphoSitei O75914.

    Proteomic databases

    PaxDbi O75914.
    PRIDEi O75914.

    Protocols and materials databases

    DNASUi 5063.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262836 ; ENSP00000262836 ; ENSG00000077264 . [O75914-1 ]
    ENST00000360648 ; ENSP00000353864 ; ENSG00000077264 . [O75914-3 ]
    ENST00000372007 ; ENSP00000361077 ; ENSG00000077264 . [O75914-2 ]
    ENST00000372010 ; ENSP00000361080 ; ENSG00000077264 . [O75914-1 ]
    ENST00000417227 ; ENSP00000389172 ; ENSG00000077264 . [O75914-4 ]
    ENST00000425146 ; ENSP00000401982 ; ENSG00000077264 . [O75914-2 ]
    ENST00000446737 ; ENSP00000410853 ; ENSG00000077264 . [O75914-2 ]
    ENST00000518291 ; ENSP00000428921 ; ENSG00000077264 . [O75914-3 ]
    ENST00000519681 ; ENSP00000429113 ; ENSG00000077264 . [O75914-4 ]
    GeneIDi 5063.
    KEGGi hsa:5063.
    UCSCi uc004eoz.2. human. [O75914-2 ]
    uc004epa.2. human. [O75914-1 ]
    uc010npv.1. human. [O75914-3 ]
    uc010npw.1. human. [O75914-4 ]

    Organism-specific databases

    CTDi 5063.
    GeneCardsi GC0XP110226.
    HGNCi HGNC:8592. PAK3.
    HPAi HPA044791.
    MIMi 300142. gene.
    300558. phenotype.
    neXtProti NX_O75914.
    Orphaneti 777. X-linked non-syndromic intellectual disability.
    PharmGKBi PA32919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000234202.
    HOVERGENi HBG108518.
    KOi K05733.
    OMAi SANENDM.
    OrthoDBi EOG7CK36J.
    PhylomeDBi O75914.
    TreeFami TF105351.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 2681.
    Reactomei REACT_19226. Activation of Rac.
    SignaLinki O75914.

    Miscellaneous databases

    GeneWikii PAK3.
    GenomeRNAii 5063.
    NextBioi 19502.
    PROi O75914.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75914.
    Bgeei O75914.
    Genevestigatori O75914.

    Family and domain databases

    Gene3Di 3.90.810.10. 1 hit.
    InterProi IPR000095. CRIB_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00786. PBD. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00285. PBD. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50108. CRIB. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INVOLVEMENT IN MRX30.
    2. "A novel gene expressed in the human adrenal gland."
      Jiang C., Gu J., Fu S., Ren S., Gu Y., Huang Q., Dong H., Yu Y., Fu G., Wang Y., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Adrenal gland.
    3. "Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees."
      Kitano T., Schwarz C., Nickel B., Paeaebo S.
      Mol. Biol. Evol. 20:1281-1289(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties."
      Kreis P., Rousseau V., Thevenot E., Combeau G., Barnier J.V.
      J. Neurochem. 106:1184-1197(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    6. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity."
      Chong C., Tan L., Lim L., Manser E.
      J. Biol. Chem. 276:17347-17353(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: AUTOPHOSPHORYLATION.
    9. "Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases."
      Feng Q., Albeck J.G., Cerione R.A., Yang W.
      J. Biol. Chem. 277:5644-5650(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARHGEF6 AND ARHGEF7.
    10. "DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3."
      McPhie D.L., Coopersmith R., Hines-Peralta A., Chen Y., Ivins K.J., Manly S.P., Kozlowski M.R., Neve K.A., Neve R.L.
      J. Neurosci. 23:6914-6927(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Development and validation of a method for profiling post-translational modification activities using protein microarrays."
      Del Rincon S.V., Rogers J., Widschwendter M., Sun D., Sieburg H.B., Spruck C.
      PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NEDDYLATION.
    12. "Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway."
      Deleris P., Trost M., Topisirovic I., Tanguay P.L., Borden K.L., Thibault P., Meloche S.
      J. Biol. Chem. 286:6470-6478(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF MAPK4 AND MAPK6.
    13. "PAK signalling in neuronal physiology."
      Kreis P., Barnier J.V.
      Cell. Signal. 21:384-393(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    14. Cited for: VARIANT MRX30 CYS-67.
    15. "X-linked mild non-syndromic mental retardation with neuropsychiatric problems and the missense mutation A365E in PAK3."
      Gedeon A.K., Nelson J., Gecz J., Mulley J.C.
      Am. J. Med. Genet. A 120:509-517(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MRX30 GLU-380.
    16. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-440.

    Entry informationi

    Entry nameiPAK3_HUMAN
    AccessioniPrimary (citable) accession number: O75914
    Secondary accession number(s): A8K389
    , B1GX77, B1GX78, B1GX79, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3