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O75911

- DHRS3_HUMAN

UniProt

O75911 - DHRS3_HUMAN

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Protein
Short-chain dehydrogenase/reductase 3
Gene
DHRS3, UNQ2424/PRO4983
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.1 Publication

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei175 – 1751Substrate By similarity
Active sitei188 – 1881Proton acceptor By similarity

GO - Molecular functioni

  1. NADP-retinol dehydrogenase activity Source: UniProtKB-EC
  2. electron carrier activity Source: UniProtKB
  3. nucleotide binding Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. phototransduction, visible light Source: Reactome
  2. retinoid metabolic process Source: Reactome
  3. retinol metabolic process Source: UniProtKB
  4. visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000162496-MONOMER.
BRENDAi1.1.1.105. 2681.
ReactomeiREACT_160083. The retinoid cycle in cones (daylight vision).

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase 3 (EC:1.1.1.300)
Alternative name(s):
DD83.1
Retinal short-chain dehydrogenase/reductase 1
Short name:
retSDR1
Gene namesi
Name:DHRS3
ORF Names:UNQ2424/PRO4983
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:17693. DHRS3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Reviewed prediction
Add
BLAST
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Transmembranei195 – 21521Helical; Reviewed prediction
Add
BLAST
Transmembranei253 – 27321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. photoreceptor outer segment membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Short-chain dehydrogenase/reductase 3
PRO_0000054644Add
BLAST

Proteomic databases

MaxQBiO75911.
PaxDbiO75911.
PeptideAtlasiO75911.
PRIDEiO75911.

PTM databases

PhosphoSiteiO75911.

Expressioni

Tissue specificityi

Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.2 Publications

Inductioni

By retinoic acid.1 Publication

Gene expression databases

ArrayExpressiO75911.
BgeeiO75911.
CleanExiHS_DHRS3.
GenevestigatoriO75911.

Organism-specific databases

HPAiHPA010844.

Interactioni

Protein-protein interaction databases

BioGridi114675. 2 interactions.
IntActiO75911. 1 interaction.
STRINGi9606.ENSP00000365397.

Structurei

3D structure databases

ProteinModelPortaliO75911.
SMRiO75911. Positions 34-297.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1028.
HOVERGENiHBG051352.
InParanoidiO75911.
KOiK11146.
OMAiWTMHALI.
OrthoDBiEOG7Z3F50.
PhylomeDBiO75911.
TreeFamiTF312837.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75911-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVWKRLGALV MFPLQMIYLV VKAAVGLVLP AKLRDLSREN VLITGGGRGI    50
GRQLAREFAE RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR 100
EEVYQTAKAV REKVGDITIL VNNAAVVHGK SLMDSDDDAL LKSQHINTLG 150
QFWTTKAFLP RMLELQNGHI VCLNSVLALS AIPGAIDYCT SKASAFAFME 200
SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP LKPETVARRT 250
VEAVQLNQAL LLLPWTMHAL VILKSILPQA ALEEIHKFSG TYTCMNTFKG 300
RT 302
Length:302
Mass (Da):33,548
Last modified:March 29, 2005 - v2
Checksum:i8FB4A735278E242E
GO
Isoform 2 (identifier: O75911-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-167: GDITILVNNA...FLPRMLELQN → CSLGGSIPST...DSPMKLAPVT
     168-302: Missing.

Note: No experimental confirmation available.

Show »
Length:167
Mass (Da):18,675
Checksum:i803F9C15FF4F826F
GO

Sequence cautioni

The sequence AAQ88460.1 differs from that shown. Reason: Frameshift at position 15.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21V → A.3 Publications
Corresponds to variant rs1128251 [ dbSNP | Ensembl ].
VAR_067443

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei115 – 16753GDITI…LELQN → CSLGGSIPSTADHRLIPGKE NILMWPGRELCLWQNGFARG TFGDSPMKLAPVT in isoform 2.
VSP_013256Add
BLAST
Alternative sequencei168 – 302135Missing in isoform 2.
VSP_013257Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061741 mRNA. Translation: AAC63263.1.
AF179237
, AF179234, AF179235, AF179236 Genomic DNA. Translation: AAD55402.1.
AY358093 mRNA. Translation: AAQ88460.1. Frameshift.
AK312961 mRNA. Translation: BAG35800.1.
BX648476 mRNA. Translation: CAI46033.1.
AL513016, AL645761 Genomic DNA. Translation: CAH74172.1.
AL645761, AL513016 Genomic DNA. Translation: CAI14999.1.
CH471130 Genomic DNA. Translation: EAW71743.1.
BC002730 mRNA. Translation: AAH02730.1.
CCDSiCCDS146.1. [O75911-1]
RefSeqiNP_004744.2. NM_004753.6. [O75911-1]
UniGeneiHs.289347.

Genome annotation databases

EnsembliENST00000376223; ENSP00000365397; ENSG00000162496. [O75911-1]
GeneIDi9249.
KEGGihsa:9249.
UCSCiuc001aub.3. human. [O75911-1]
uc001aud.4. human. [O75911-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061741 mRNA. Translation: AAC63263.1 .
AF179237
, AF179234 , AF179235 , AF179236 Genomic DNA. Translation: AAD55402.1 .
AY358093 mRNA. Translation: AAQ88460.1 . Frameshift.
AK312961 mRNA. Translation: BAG35800.1 .
BX648476 mRNA. Translation: CAI46033.1 .
AL513016 , AL645761 Genomic DNA. Translation: CAH74172.1 .
AL645761 , AL513016 Genomic DNA. Translation: CAI14999.1 .
CH471130 Genomic DNA. Translation: EAW71743.1 .
BC002730 mRNA. Translation: AAH02730.1 .
CCDSi CCDS146.1. [O75911-1 ]
RefSeqi NP_004744.2. NM_004753.6. [O75911-1 ]
UniGenei Hs.289347.

3D structure databases

ProteinModelPortali O75911.
SMRi O75911. Positions 34-297.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114675. 2 interactions.
IntActi O75911. 1 interaction.
STRINGi 9606.ENSP00000365397.

Chemistry

DrugBanki DB00162. Vitamin A.

PTM databases

PhosphoSitei O75911.

Proteomic databases

MaxQBi O75911.
PaxDbi O75911.
PeptideAtlasi O75911.
PRIDEi O75911.

Protocols and materials databases

DNASUi 9249.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376223 ; ENSP00000365397 ; ENSG00000162496 . [O75911-1 ]
GeneIDi 9249.
KEGGi hsa:9249.
UCSCi uc001aub.3. human. [O75911-1 ]
uc001aud.4. human. [O75911-2 ]

Organism-specific databases

CTDi 9249.
GeneCardsi GC01M012627.
HGNCi HGNC:17693. DHRS3.
HPAi HPA010844.
MIMi 612830. gene.
neXtProti NX_O75911.
PharmGKBi PA134952810.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1028.
HOVERGENi HBG051352.
InParanoidi O75911.
KOi K11146.
OMAi WTMHALI.
OrthoDBi EOG7Z3F50.
PhylomeDBi O75911.
TreeFami TF312837.

Enzyme and pathway databases

BioCyci MetaCyc:ENSG00000162496-MONOMER.
BRENDAi 1.1.1.105. 2681.
Reactomei REACT_160083. The retinoid cycle in cones (daylight vision).

Miscellaneous databases

GeneWikii DHRS3.
GenomeRNAii 9249.
NextBioi 34675.
PROi O75911.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75911.
Bgeei O75911.
CleanExi HS_DHRS3.
Genevestigatori O75911.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal."
    Haeseleer F., Huang J., Lebioda L., Saari J.C., Palczewski K.
    J. Biol. Chem. 273:21790-21799(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT ALA-2.
    Tissue: Retina.
  2. "Structure of retinal short-chain dehydrogenase/reductase retSDR1 gene."
    Haeseleer F., Palczewski K.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-2.
    Tissue: Retina.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-2.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon endothelium.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  9. "retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines."
    Cerignoli F., Guo X., Cardinali B., Rinaldi C., Casaletto J., Frati L., Screpanti I., Gudas L.J., Gulino A., Thiele C.J., Giannini G.
    Cancer Res. 62:1196-1204(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiDHRS3_HUMAN
AccessioniPrimary (citable) accession number: O75911
Secondary accession number(s): B2R7F3
, Q5VUY3, Q6UY38, Q9BUC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 29, 2005
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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