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O75911

- DHRS3_HUMAN

UniProt

O75911 - DHRS3_HUMAN

Protein

Short-chain dehydrogenase/reductase 3

Gene

DHRS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.1 Publication

    Catalytic activityi

    All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei175 – 1751SubstrateBy similarity
    Active sitei188 – 1881Proton acceptorBy similarity

    GO - Molecular functioni

    1. electron carrier activity Source: UniProtKB
    2. NADP-retinol dehydrogenase activity Source: UniProtKB-EC
    3. nucleotide binding Source: ProtInc

    GO - Biological processi

    1. phototransduction, visible light Source: Reactome
    2. retinoid metabolic process Source: Reactome
    3. retinol metabolic process Source: UniProtKB
    4. visual perception Source: ProtInc

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000162496-MONOMER.
    BRENDAi1.1.1.105. 2681.
    ReactomeiREACT_160083. The retinoid cycle in cones (daylight vision).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short-chain dehydrogenase/reductase 3 (EC:1.1.1.300)
    Alternative name(s):
    DD83.1
    Retinal short-chain dehydrogenase/reductase 1
    Short name:
    retSDR1
    Gene namesi
    Name:DHRS3
    ORF Names:UNQ2424/PRO4983
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17693. DHRS3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. photoreceptor outer segment membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134952810.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Short-chain dehydrogenase/reductase 3PRO_0000054644Add
    BLAST

    Proteomic databases

    MaxQBiO75911.
    PaxDbiO75911.
    PeptideAtlasiO75911.
    PRIDEiO75911.

    PTM databases

    PhosphoSiteiO75911.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.2 Publications

    Inductioni

    By retinoic acid.1 Publication

    Gene expression databases

    ArrayExpressiO75911.
    BgeeiO75911.
    CleanExiHS_DHRS3.
    GenevestigatoriO75911.

    Organism-specific databases

    HPAiHPA010844.

    Interactioni

    Protein-protein interaction databases

    BioGridi114675. 2 interactions.
    IntActiO75911. 1 interaction.
    STRINGi9606.ENSP00000365397.

    Structurei

    3D structure databases

    ProteinModelPortaliO75911.
    SMRiO75911. Positions 34-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG051352.
    InParanoidiO75911.
    KOiK11146.
    OMAiWTMHALI.
    OrthoDBiEOG7Z3F50.
    PhylomeDBiO75911.
    TreeFamiTF312837.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75911-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVWKRLGALV MFPLQMIYLV VKAAVGLVLP AKLRDLSREN VLITGGGRGI    50
    GRQLAREFAE RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR 100
    EEVYQTAKAV REKVGDITIL VNNAAVVHGK SLMDSDDDAL LKSQHINTLG 150
    QFWTTKAFLP RMLELQNGHI VCLNSVLALS AIPGAIDYCT SKASAFAFME 200
    SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP LKPETVARRT 250
    VEAVQLNQAL LLLPWTMHAL VILKSILPQA ALEEIHKFSG TYTCMNTFKG 300
    RT 302
    Length:302
    Mass (Da):33,548
    Last modified:March 29, 2005 - v2
    Checksum:i8FB4A735278E242E
    GO
    Isoform 2 (identifier: O75911-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         115-167: GDITILVNNA...FLPRMLELQN → CSLGGSIPST...DSPMKLAPVT
         168-302: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:167
    Mass (Da):18,675
    Checksum:i803F9C15FF4F826F
    GO

    Sequence cautioni

    The sequence AAQ88460.1 differs from that shown. Reason: Frameshift at position 15.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21V → A.3 Publications
    Corresponds to variant rs1128251 [ dbSNP | Ensembl ].
    VAR_067443

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei115 – 16753GDITI…LELQN → CSLGGSIPSTADHRLIPGKE NILMWPGRELCLWQNGFARG TFGDSPMKLAPVT in isoform 2. 1 PublicationVSP_013256Add
    BLAST
    Alternative sequencei168 – 302135Missing in isoform 2. 1 PublicationVSP_013257Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061741 mRNA. Translation: AAC63263.1.
    AF179237
    , AF179234, AF179235, AF179236 Genomic DNA. Translation: AAD55402.1.
    AY358093 mRNA. Translation: AAQ88460.1. Frameshift.
    AK312961 mRNA. Translation: BAG35800.1.
    BX648476 mRNA. Translation: CAI46033.1.
    AL513016, AL645761 Genomic DNA. Translation: CAH74172.1.
    AL645761, AL513016 Genomic DNA. Translation: CAI14999.1.
    CH471130 Genomic DNA. Translation: EAW71743.1.
    BC002730 mRNA. Translation: AAH02730.1.
    CCDSiCCDS146.1. [O75911-1]
    RefSeqiNP_004744.2. NM_004753.6. [O75911-1]
    UniGeneiHs.289347.

    Genome annotation databases

    EnsembliENST00000376223; ENSP00000365397; ENSG00000162496. [O75911-1]
    GeneIDi9249.
    KEGGihsa:9249.
    UCSCiuc001aub.3. human. [O75911-1]
    uc001aud.4. human. [O75911-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061741 mRNA. Translation: AAC63263.1 .
    AF179237
    , AF179234 , AF179235 , AF179236 Genomic DNA. Translation: AAD55402.1 .
    AY358093 mRNA. Translation: AAQ88460.1 . Frameshift.
    AK312961 mRNA. Translation: BAG35800.1 .
    BX648476 mRNA. Translation: CAI46033.1 .
    AL513016 , AL645761 Genomic DNA. Translation: CAH74172.1 .
    AL645761 , AL513016 Genomic DNA. Translation: CAI14999.1 .
    CH471130 Genomic DNA. Translation: EAW71743.1 .
    BC002730 mRNA. Translation: AAH02730.1 .
    CCDSi CCDS146.1. [O75911-1 ]
    RefSeqi NP_004744.2. NM_004753.6. [O75911-1 ]
    UniGenei Hs.289347.

    3D structure databases

    ProteinModelPortali O75911.
    SMRi O75911. Positions 34-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114675. 2 interactions.
    IntActi O75911. 1 interaction.
    STRINGi 9606.ENSP00000365397.

    Chemistry

    DrugBanki DB00162. Vitamin A.

    PTM databases

    PhosphoSitei O75911.

    Proteomic databases

    MaxQBi O75911.
    PaxDbi O75911.
    PeptideAtlasi O75911.
    PRIDEi O75911.

    Protocols and materials databases

    DNASUi 9249.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376223 ; ENSP00000365397 ; ENSG00000162496 . [O75911-1 ]
    GeneIDi 9249.
    KEGGi hsa:9249.
    UCSCi uc001aub.3. human. [O75911-1 ]
    uc001aud.4. human. [O75911-2 ]

    Organism-specific databases

    CTDi 9249.
    GeneCardsi GC01M012627.
    HGNCi HGNC:17693. DHRS3.
    HPAi HPA010844.
    MIMi 612830. gene.
    neXtProti NX_O75911.
    PharmGKBi PA134952810.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG051352.
    InParanoidi O75911.
    KOi K11146.
    OMAi WTMHALI.
    OrthoDBi EOG7Z3F50.
    PhylomeDBi O75911.
    TreeFami TF312837.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000162496-MONOMER.
    BRENDAi 1.1.1.105. 2681.
    Reactomei REACT_160083. The retinoid cycle in cones (daylight vision).

    Miscellaneous databases

    GeneWikii DHRS3.
    GenomeRNAii 9249.
    NextBioi 34675.
    PROi O75911.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75911.
    Bgeei O75911.
    CleanExi HS_DHRS3.
    Genevestigatori O75911.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal."
      Haeseleer F., Huang J., Lebioda L., Saari J.C., Palczewski K.
      J. Biol. Chem. 273:21790-21799(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT ALA-2.
      Tissue: Retina.
    2. "Structure of retinal short-chain dehydrogenase/reductase retSDR1 gene."
      Haeseleer F., Palczewski K.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-2.
      Tissue: Retina.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-2.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon endothelium.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    9. "retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines."
      Cerignoli F., Guo X., Cardinali B., Rinaldi C., Casaletto J., Frati L., Screpanti I., Gudas L.J., Gulino A., Thiele C.J., Giannini G.
      Cancer Res. 62:1196-1204(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiDHRS3_HUMAN
    AccessioniPrimary (citable) accession number: O75911
    Secondary accession number(s): B2R7F3
    , Q5VUY3, Q6UY38, Q9BUC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3