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Protein

Cyclin-K

Gene

CCNK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-75955 RNA Polymerase II Transcription Elongation
SignaLinkiO75909
SIGNORiO75909

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-K
Gene namesi
Name:CCNK
Synonyms:CPR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000090061.17
HGNCiHGNC:1596 CCNK
MIMi603544 gene
neXtProtiNX_O75909

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8812
OpenTargetsiENSG00000090061
PharmGKBiPA26161

Chemistry databases

ChEMBLiCHEMBL3038475

Polymorphism and mutation databases

BioMutaiCCNK

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804781 – 580Cyclin-KAdd BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei324PhosphoserineCombined sources1
Modified residuei328PhosphoserineBy similarity1
Modified residuei329PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75909
PaxDbiO75909
PeptideAtlasiO75909
PRIDEiO75909

PTM databases

iPTMnetiO75909
PhosphoSitePlusiO75909

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest levels in testis.1 Publication

Gene expression databases

BgeeiENSG00000090061
CleanExiHS_CCNK
ExpressionAtlasiO75909 baseline and differential
GenevisibleiO75909 HS

Organism-specific databases

HPAiHPA000645

Interactioni

Subunit structurei

Regulatory subunit of cyclin-dependent kinases. Identified in a complex with a kinase and the RNA polymerase II holoenzyme. Interacts with POLR2A. Interacts with CDK12 and CDK13. Interacts with CDK9 according to PubMed:10574912; does not interact with CDK9 according to PubMed:22012619.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein kinase binding Source: MGI

Protein-protein interaction databases

BioGridi11433939 interactors.
CORUMiO75909
DIPiDIP-50081N
IntActiO75909 51 interactors.
STRINGi9606.ENSP00000374529

Chemistry databases

BindingDBiO75909

Structurei

Secondary structure

1580
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 23Combined sources3
Helixi28 – 33Combined sources6
Helixi35 – 38Combined sources4
Helixi43 – 63Combined sources21
Helixi68 – 81Combined sources14
Turni82 – 84Combined sources3
Turni87 – 89Combined sources3
Helixi92 – 106Combined sources15
Helixi113 – 123Combined sources11
Helixi126 – 129Combined sources4
Helixi130 – 132Combined sources3
Helixi136 – 150Combined sources15
Turni151 – 153Combined sources3
Helixi160 – 169Combined sources10
Helixi175 – 192Combined sources18
Turni193 – 196Combined sources4
Helixi197 – 199Combined sources3
Helixi203 – 218Combined sources16
Helixi222 – 225Combined sources4
Beta strandi226 – 228Combined sources3
Helixi234 – 237Combined sources4
Beta strandi239 – 241Combined sources3
Helixi244 – 255Combined sources12
Turni256 – 258Combined sources3
Beta strandi259 – 261Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I53X-ray1.50A11-267[»]
4CXAX-ray3.15B/D11-267[»]
4NSTX-ray2.20B/D1-267[»]
4UN0X-ray3.15A/B11-267[»]
5ACBX-ray2.70A/B11-267[»]
5EFQX-ray2.00B/D1-267[»]
6B3EX-ray3.06B/D1-267[»]
ProteinModelPortaliO75909
SMRiO75909
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75909

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi312 – 315Poly-Gln4

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

eggNOGiKOG0834 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOGENOMiHOG000220828
HOVERGENiHBG050836
InParanoidiO75909
OMAiNSYMSGE
OrthoDBiEOG091G0H4W
TreeFamiTF101010

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75909-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKENKENSSP SVTSANLDHT KPCWYWDKKD LAHTPSQLEG LDPATEARYR
60 70 80 90 100
REGARFIFDV GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL
110 120 130 140 150
FLAGKVEETP KKCKDIIKTA RSLLNDVQFG QFGDDPKEEV MVLERILLQT
160 170 180 190 200
IKFDLQVEHP YQFLLKYAKQ LKGDKNKIQK LVQMAWTFVN DSLCTTLSLQ
210 220 230 240 250
WEPEIIAVAV MYLAGRLCKF EIQEWTSKPM YRRWWEQFVQ DVPVDVLEDI
260 270 280 290 300
CHQILDLYSQ GKQQMPHHTP HQLQQPPSLQ PTPQVPQVQQ SQPSQSSEPS
310 320 330 340 350
QPQQKDPQQP AQQQQPAQQP KKPSPQPSSP RQVKRAVVVS PKEENKAAEP
360 370 380 390 400
PPPKIPKIET THPPLPPAHP PPDRKPPLAA ALGEAEPPGP VDATDLPKVQ
410 420 430 440 450
IPPPAHPAPV HQPPPLPHRP PPPPPSSYMT GMSTTSSYMS GEGYQSLQSM
460 470 480 490 500
MKTEGPSYGA LPPAYGPPAH LPYHPHVYPP NPPPPPVPPP PASFPPPAIP
510 520 530 540 550
PPTPGYPPPP PTYNPNFPPP PPRLPPTHAV PPHPPPGLGL PPASYPPPAV
560 570 580
PPGGQPPVPP PIPPPGMPPV GGLGRAAWMR
Length:580
Mass (Da):64,240
Last modified:December 16, 2008 - v2
Checksum:i8A945E90359AD9F8
GO
Isoform 2 (identifier: O75909-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-354: QQPAQQQQPA...NKAAEPPPPK → LILLQGWACR...QLGGWGGQPG
     355-580: Missing.

Show »
Length:354
Mass (Da):40,788
Checksum:i39D8F18FC9429207
GO
Isoform 3 (identifier: O75909-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-357: PPPKIPK → APSQHLW
     358-580: Missing.

Show »
Length:357
Mass (Da):41,293
Checksum:iFA7DD89035A66105
GO
Isoform 4 (identifier: O75909-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: V → VSGLKQALGRAGFPGGGNTQV

Show »
Length:600
Mass (Da):66,137
Checksum:iA79E4E8B190E7199
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191D → T in BAD92610 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010830308 – 354QQPAQ…PPPPK → LILLQGWACRQPATHLLPSP LEDSLLCPRPFPHPACLQLG GWGGQPG in isoform 2. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_035970338V → VSGLKQALGRAGFPGGGNTQ V in isoform 4. 2 Publications1
Alternative sequenceiVSP_035971351 – 357PPPKIPK → APSQHLW in isoform 3. 1 Publication7
Alternative sequenceiVSP_035972355 – 580Missing in isoform 2. 2 PublicationsAdd BLAST226
Alternative sequenceiVSP_035973358 – 580Missing in isoform 3. 1 PublicationAdd BLAST223

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060515 mRNA Translation: AAD09978.1
BT006950 mRNA Translation: AAP35596.1
AF542236 Genomic DNA Translation: AAN06829.1
AL110504 Genomic DNA No translation available.
BC015935 mRNA Translation: AAH15935.1
AH009612 Genomic DNA Translation: AAF82290.1
BX247958 mRNA Translation: CAD62298.1
AB209373 Transcribed RNA Translation: BAD92610.1
CCDSiCCDS45160.1 [O75909-3]
RefSeqiNP_001092872.1, NM_001099402.1 [O75909-3]
XP_005268211.1, XM_005268154.4 [O75909-3]
XP_011535577.1, XM_011537275.2 [O75909-3]
UniGeneiHs.510409

Genome annotation databases

EnsembliENST00000389879; ENSP00000374529; ENSG00000090061 [O75909-3]
GeneIDi8812
KEGGihsa:8812
UCSCiuc001ygi.5 human [O75909-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCNK_HUMAN
AccessioniPrimary (citable) accession number: O75909
Secondary accession number(s): Q59FT6
, Q86U16, Q96B63, Q9NNY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 16, 2008
Last modified: March 28, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome