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O75908

- SOAT2_HUMAN

UniProt

O75908 - SOAT2_HUMAN

Protein

Sterol O-acyltransferase 2

Gene

SOAT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

    Catalytic activityi

    Acyl-CoA + cholesterol = CoA + cholesterol ester.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei434 – 4341Sequence Analysis

    GO - Molecular functioni

    1. cholesterol binding Source: BHF-UCL
    2. cholesterol O-acyltransferase activity Source: BHF-UCL
    3. fatty-acyl-CoA binding Source: BHF-UCL
    4. transferase activity, transferring acyl groups Source: ProtInc

    GO - Biological processi

    1. cholesterol efflux Source: BHF-UCL
    2. cholesterol esterification Source: BHF-UCL
    3. cholesterol homeostasis Source: BHF-UCL
    4. cholesterol metabolic process Source: BHF-UCL
    5. intestinal cholesterol absorption Source: BHF-UCL
    6. macrophage derived foam cell differentiation Source: BHF-UCL
    7. very-low-density lipoprotein particle assembly Source: BHF-UCL

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

    Enzyme and pathway databases

    BRENDAi2.3.1.26. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol O-acyltransferase 2 (EC:2.3.1.26)
    Alternative name(s):
    Acyl-coenzyme A:cholesterol acyltransferase 2
    Short name:
    ACAT-2
    Cholesterol acyltransferase 2
    Gene namesi
    Name:SOAT2
    Synonyms:ACACT2, ACAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:11178. SOAT2.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border Source: BHF-UCL
    2. endoplasmic reticulum Source: BHF-UCL
    3. endoplasmic reticulum membrane Source: BHF-UCL
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Sterol O-acyltransferase 2PRO_0000207645Add
    BLAST

    Proteomic databases

    PaxDbiO75908.
    PRIDEiO75908.

    PTM databases

    PhosphoSiteiO75908.

    Expressioni

    Gene expression databases

    ArrayExpressiO75908.
    BgeeiO75908.
    CleanExiHS_ACAT2.
    HS_SOAT2.
    GenevestigatoriO75908.

    Organism-specific databases

    HPAiHPA049462.

    Interactioni

    Subunit structurei

    May form homo- or heterodimers.By similarity

    Protein-protein interaction databases

    BioGridi114015. 2 interactions.
    STRINGi9606.ENSP00000301466.

    Structurei

    3D structure databases

    ProteinModelPortaliO75908.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei472 – 49221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5056.
    HOGENOMiHOG000020782.
    HOVERGENiHBG058198.
    InParanoidiO75908.
    KOiK00637.
    OMAiLMEVQHF.
    PhylomeDBiO75908.
    TreeFamiTF315226.

    Family and domain databases

    InterProiIPR004299. MBOAT_fam.
    IPR014371. Oat_ACAT_DAG_ARE.
    [Graphical view]
    PANTHERiPTHR10408. PTHR10408. 1 hit.
    PfamiPF03062. MBOAT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000439. Oat_ACAT_DAG_ARE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O75908-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGGARLRL QRTEGLGGER ERQPCGDGNT ETHRAPDLVQ WTRHMEAVKA    50
    QLLEQAQGQL RELLDRAMRE AIQSYPSQDK PLPPPPPGSL SRTQEPSLGK 100
    QKVFIIRKSL LDELMEVQHF RTIYHMFIAG LCVFIISTLA IDFIDEGRLL 150
    LEFDLLIFSF GQLPLALVTW VPMFLSTLLA PYQALRLWAR GTWTQATGLG 200
    CALLAAHAVV LCALPVHVAV EHQLPPASRC VLVFEQVRFL MKSYSFLREA 250
    VPGTLRARRG EGIQAPSFSS YLYFLFCPTL IYRETYPRTP YVRWNYVAKN 300
    FAQALGCVLY ACFILGRLCV PVFANMSREP FSTRALVLSI LHATLPGIFM 350
    LLLIFFAFLH CWLNAFAEML RFGDRMFYRD WWNSTSFSNY YRTWNVVVHD 400
    WLYSYVYQDG LRLLGARARG VAMLGVFLVS AVAHEYIFCF VLGFFYPVML 450
    ILFLVIGGML NFMMHDQRTG PAWNVLMWTM LFLGQGIQVS LYCQEWYARR 500
    HCPLPQATFW GLVTPRSWSC HT 522
    Length:522
    Mass (Da):59,896
    Last modified:November 1, 1998 - v1
    Checksum:iEEAC2DB569FFE729
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221R → P in AAK48829. (PubMed:11401500)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141E → G.
    Corresponds to variant rs9658625 [ dbSNP | Ensembl ].
    VAR_020373
    Natural varianti254 – 2541T → I.2 Publications
    Corresponds to variant rs2272296 [ dbSNP | Ensembl ].
    VAR_020374

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF059203 mRNA. Translation: AAC63998.1.
    AF099031 mRNA. Translation: AAC78335.2.
    AF331516
    , AF331502, AF331503, AF331504, AF331505, AF331506, AF331507, AF331508, AF331509, AF331510, AF331511, AF331512, AF331513, AF331514, AF331515 Genomic DNA. Translation: AAK18275.1.
    AF332858, AF332857 Genomic DNA. Translation: AAK48829.1.
    BC096091 mRNA. Translation: AAH96091.1.
    BC096092 mRNA. Translation: AAH96092.1.
    CCDSiCCDS8847.1.
    RefSeqiNP_003569.1. NM_003578.3.
    UniGeneiHs.656544.

    Genome annotation databases

    EnsembliENST00000301466; ENSP00000301466; ENSG00000167780.
    GeneIDi8435.
    KEGGihsa:8435.
    UCSCiuc001sbv.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF059203 mRNA. Translation: AAC63998.1 .
    AF099031 mRNA. Translation: AAC78335.2 .
    AF331516
    , AF331502 , AF331503 , AF331504 , AF331505 , AF331506 , AF331507 , AF331508 , AF331509 , AF331510 , AF331511 , AF331512 , AF331513 , AF331514 , AF331515 Genomic DNA. Translation: AAK18275.1 .
    AF332858 , AF332857 Genomic DNA. Translation: AAK48829.1 .
    BC096091 mRNA. Translation: AAH96091.1 .
    BC096092 mRNA. Translation: AAH96092.1 .
    CCDSi CCDS8847.1.
    RefSeqi NP_003569.1. NM_003578.3.
    UniGenei Hs.656544.

    3D structure databases

    ProteinModelPortali O75908.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114015. 2 interactions.
    STRINGi 9606.ENSP00000301466.

    Chemistry

    BindingDBi O75908.
    ChEMBLi CHEMBL4465.

    PTM databases

    PhosphoSitei O75908.

    Proteomic databases

    PaxDbi O75908.
    PRIDEi O75908.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301466 ; ENSP00000301466 ; ENSG00000167780 .
    GeneIDi 8435.
    KEGGi hsa:8435.
    UCSCi uc001sbv.3. human.

    Organism-specific databases

    CTDi 8435.
    GeneCardsi GC12P053497.
    HGNCi HGNC:11178. SOAT2.
    HPAi HPA049462.
    MIMi 601311. gene.
    neXtProti NX_O75908.
    PharmGKBi PA36016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5056.
    HOGENOMi HOG000020782.
    HOVERGENi HBG058198.
    InParanoidi O75908.
    KOi K00637.
    OMAi LMEVQHF.
    PhylomeDBi O75908.
    TreeFami TF315226.

    Enzyme and pathway databases

    BRENDAi 2.3.1.26. 2681.

    Miscellaneous databases

    GeneWikii SOAT2.
    GenomeRNAii 8435.
    NextBioi 31558.
    PROi O75908.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75908.
    Bgeei O75908.
    CleanExi HS_ACAT2.
    HS_SOAT2.
    Genevestigatori O75908.

    Family and domain databases

    InterProi IPR004299. MBOAT_fam.
    IPR014371. Oat_ACAT_DAG_ARE.
    [Graphical view ]
    PANTHERi PTHR10408. PTHR10408. 1 hit.
    Pfami PF03062. MBOAT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000439. Oat_ACAT_DAG_ARE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes."
      Oelkers P., Behari A., Cromley D., Billheimer J.T., Sturley S.L.
      J. Biol. Chem. 273:26765-26771(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-254.
      Tissue: Intestine.
    3. "Structure of the human acyl-CoA:cholesterol acyltransferase-2 (ACAT-2) gene and its relation to dyslipidemia."
      Katsuren K., Tamura T., Arashiro R., Takata K., Matsuura T., Niikawa N., Ohta T.
      Biochim. Biophys. Acta 1531:230-240(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Organization of human ACAT-2 gene and its cell-type-specific promoter activity."
      Song B.L., Qi W., Yang X.Y., Chang C.C.Y., Zhu J.Q., Chang T.Y., Li B.L.
      Biochem. Biophys. Res. Commun. 282:580-588(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-254.

    Entry informationi

    Entry nameiSOAT2_HUMAN
    AccessioniPrimary (citable) accession number: O75908
    Secondary accession number(s): Q4VB99, Q96TD4, Q9UNR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3