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Protein

Ras association domain-containing protein 9

Gene

RASSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulating vesicuar trafficking in cells.By similarity

GO - Molecular functioni

  • transporter activity Source: UniProtKB

GO - Biological processi

  • endosomal transport Source: UniProtKB
  • protein targeting Source: UniProtKB
  • signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 9
Alternative name(s):
PAM COOH-terminal interactor protein 1
Short name:
P-CIP1
Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor
Gene namesi
Name:RASSF9
Synonyms:PAMCI, PCIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:15739. RASSF9.

Subcellular locationi

  • Endosome

  • Note: Accumulates on perinuclear endosomes.By similarity

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • endosome Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • trans-Golgi network transport vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400725.

Polymorphism and mutation databases

BioMutaiRASSF9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Ras association domain-containing protein 9PRO_0000299452Add
BLAST

Proteomic databases

MaxQBiO75901.
PaxDbiO75901.
PeptideAtlasiO75901.
PRIDEiO75901.

PTM databases

iPTMnetiO75901.

Expressioni

Gene expression databases

BgeeiO75901.
CleanExiHS_RASSF9.
GenevisibleiO75901. HS.

Organism-specific databases

HPAiHPA039428.
HPA039678.

Interactioni

Subunit structurei

Interacts with PAM.By similarity

Protein-protein interaction databases

BioGridi114619. 37 interactions.
IntActiO75901. 34 interactions.
STRINGi9606.ENSP00000354884.

Structurei

3D structure databases

ProteinModelPortaliO75901.
SMRiO75901. Positions 24-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11995Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili195 – 29096Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1574. Eukaryota.
ENOG410XPWB. LUCA.
GeneTreeiENSGT00510000047164.
HOGENOMiHOG000065674.
HOVERGENiHBG053178.
InParanoidiO75901.
KOiK09856.
OMAiEVKSVCI.
OrthoDBiEOG7MSMNT.
PhylomeDBiO75901.
TreeFamiTF326923.

Family and domain databases

InterProiIPR033593. N-RASSF.
IPR000159. RA_dom.
IPR033633. RASSF9.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR15286. PTHR15286. 1 hit.
PTHR15286:SF10. PTHR15286:SF10. 1 hit.
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPFGRNLLK TRHKNRSPTK DMDSEEKEIV VWVCQEEKLV CGLTKRTTSA
60 70 80 90 100
DVIQALLEEH EATFGEKRFL LGKPSDYCII EKWRGSERVL PPLTRILKLW
110 120 130 140 150
KAWGDEQPNM QFVLVKADAF LPVPLWRTAE AKLVQNTEKL WELSPANYMK
160 170 180 190 200
TLPPDKQKRI VRKTFRKLAK IKQDTVSHDR DNMETLVHLI ISQDHTIHQQ
210 220 230 240 250
VKRMKELDLE IEKCEAKFHL DRVENDGENY VQDAYLMPSF SEVEQNLDLQ
260 270 280 290 300
YEENQTLEDL SESDGIEQLE ERLKYYRILI DKLSAEIEKE VKSVCIDINE
310 320 330 340 350
DAEGEAASEL ESSNLESVKC DLEKSMKAGL KIHSHLSGIQ KEIKYSDSLL
360 370 380 390 400
QMKAKEYELL AKEFNSLHIS NKDGCQLKEN RAKESEVPSS NGEIPPFTQR
410 420 430
VFSNYTNDTD SDTGISSNHS QDSETTVGDV VLLST
Length:435
Mass (Da):50,021
Last modified:September 11, 2007 - v2
Checksum:iC9CF3E1C482AAA18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391L → F in AAD03250 (PubMed:9837933).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti285 – 2851A → T.
Corresponds to variant rs7397266 [ dbSNP | Ensembl ].
VAR_034820

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056209 mRNA. Translation: AAD03250.1.
AK022089 mRNA. Translation: BAG51066.1.
CH471054 Genomic DNA. Translation: EAW97399.1.
BC031589 mRNA. Translation: AAH31589.1.
CCDSiCCDS44950.1.
RefSeqiNP_005438.2. NM_005447.3.
UniGeneiHs.527881.

Genome annotation databases

EnsembliENST00000361228; ENSP00000354884; ENSG00000198774.
GeneIDi9182.
KEGGihsa:9182.
UCSCiuc001taf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056209 mRNA. Translation: AAD03250.1.
AK022089 mRNA. Translation: BAG51066.1.
CH471054 Genomic DNA. Translation: EAW97399.1.
BC031589 mRNA. Translation: AAH31589.1.
CCDSiCCDS44950.1.
RefSeqiNP_005438.2. NM_005447.3.
UniGeneiHs.527881.

3D structure databases

ProteinModelPortaliO75901.
SMRiO75901. Positions 24-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114619. 37 interactions.
IntActiO75901. 34 interactions.
STRINGi9606.ENSP00000354884.

PTM databases

iPTMnetiO75901.

Polymorphism and mutation databases

BioMutaiRASSF9.

Proteomic databases

MaxQBiO75901.
PaxDbiO75901.
PeptideAtlasiO75901.
PRIDEiO75901.

Protocols and materials databases

DNASUi9182.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361228; ENSP00000354884; ENSG00000198774.
GeneIDi9182.
KEGGihsa:9182.
UCSCiuc001taf.2. human.

Organism-specific databases

CTDi9182.
GeneCardsiRASSF9.
HGNCiHGNC:15739. RASSF9.
HPAiHPA039428.
HPA039678.
MIMi610383. gene.
neXtProtiNX_O75901.
PharmGKBiPA162400725.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1574. Eukaryota.
ENOG410XPWB. LUCA.
GeneTreeiENSGT00510000047164.
HOGENOMiHOG000065674.
HOVERGENiHBG053178.
InParanoidiO75901.
KOiK09856.
OMAiEVKSVCI.
OrthoDBiEOG7MSMNT.
PhylomeDBiO75901.
TreeFamiTF326923.

Miscellaneous databases

GeneWikiiRASSF9.
GenomeRNAii9182.
PROiO75901.
SOURCEiSearch...

Gene expression databases

BgeeiO75901.
CleanExiHS_RASSF9.
GenevisibleiO75901. HS.

Family and domain databases

InterProiIPR033593. N-RASSF.
IPR000159. RA_dom.
IPR033633. RASSF9.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR15286. PTHR15286. 1 hit.
PTHR15286:SF10. PTHR15286:SF10. 1 hit.
SMARTiSM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes."
    Chen L., Johnson R.C., Milgram S.L.
    J. Biol. Chem. 273:33524-33532(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis."
    Sherwood V., Manbodh R., Sheppard C., Chalmers A.D.
    Mol. Biol. Cell 19:1772-1782(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiRASF9_HUMAN
AccessioniPrimary (citable) accession number: O75901
Secondary accession number(s): B3KMQ4, Q8N5U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 6, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.