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Protein

Gamma-aminobutyric acid type B receptor subunit 2

Gene

GABBR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.5 Publications

GO - Molecular functioni

  • G-protein coupled GABA receptor activity Source: ProtInc

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • gamma-aminobutyric acid signaling pathway Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • negative regulation of adenylate cyclase activity Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136928-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).
R-HSA-977444. GABA B receptor activation.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Protein family/group databases

TCDBi9.A.14.15.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid type B receptor subunit 2
Short name:
GABA-B receptor 2
Short name:
GABA-B-R2
Short name:
GABA-BR2
Short name:
GABABR2
Short name:
Gb2
Alternative name(s):
G-protein coupled receptor 51
HG20
Gene namesi
Name:GABBR2
Synonyms:GPR51, GPRC3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:4507. GABBR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 483ExtracellularSequence analysisAdd BLAST442
Transmembranei484 – 504Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini505 – 522CytoplasmicSequence analysisAdd BLAST18
Transmembranei523 – 543Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini544 – 551ExtracellularSequence analysis8
Transmembranei552 – 572Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini573 – 597CytoplasmicSequence analysisAdd BLAST25
Transmembranei598 – 618Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini619 – 654ExtracellularSequence analysisAdd BLAST36
Transmembranei655 – 675Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini676 – 691CytoplasmicSequence analysisAdd BLAST16
Transmembranei692 – 712Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini713 – 720ExtracellularSequence analysis8
Transmembranei721 – 741Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini742 – 941CytoplasmicSequence analysisAdd BLAST200

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: Ensembl
  • G-protein coupled receptor heterodimeric complex Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • neuron projection Source: Ensembl
  • plasma membrane Source: Reactome
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi118Y → A: Impairs interaction with GABBR1. Decreases signaling via G-proteins. 1 Publication1

Organism-specific databases

DisGeNETi9568.
MalaCardsiGABBR2.
OpenTargetsiENSG00000136928.
PharmGKBiPA28896.

Chemistry databases

ChEMBLiCHEMBL5034.
DrugBankiDB00181. Baclofen.

Polymorphism and mutation databases

BioMutaiGABBR2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Sequence analysisAdd BLAST41
ChainiPRO_000001295242 – 941Gamma-aminobutyric acid type B receptor subunit 2Add BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...)1 Publication1
Disulfide bondi108 ↔ 135
Disulfide bondi237 ↔ 266
Disulfide bondi265 ↔ 302
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Glycosylationi389N-linked (GlcNAc...)1 Publication1
Glycosylationi404N-linked (GlcNAc...)2 Publications1
Glycosylationi453N-linked (GlcNAc...)1 Publication1
Modified residuei776PhosphoserineBy similarity1
Modified residuei779PhosphoserineBy similarity1
Modified residuei819PhosphothreonineBy similarity1
Modified residuei884PhosphoserineBy similarity1
Modified residuei893PhosphoserineBy similarity1
Modified residuei913PhosphoserineBy similarity1
Modified residuei916PhosphoserineBy similarity1
Modified residuei920PhosphoserineBy similarity1
Modified residuei924PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO75899.
PeptideAtlasiO75899.
PRIDEiO75899.

PTM databases

iPTMnetiO75899.
PhosphoSitePlusiO75899.

Expressioni

Tissue specificityi

Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.3 Publications

Gene expression databases

BgeeiENSG00000136928.
CleanExiHS_GABBR2.
ExpressionAtlasiO75899. baseline and differential.
GenevisibleiO75899. HS.

Organism-specific databases

HPAiHPA013820.
HPA031684.

Interactioni

Subunit structurei

Heterodimer of GABBR1 and GABBR2. Homodimers may form, but are inactive. Interacts with ATF4 via its C-terminal region.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GABBR1Q9UBS52EBI-715469,EBI-724156
NSFP464594EBI-715469,EBI-712251

Protein-protein interaction databases

BioGridi114938. 6 interactors.
DIPiDIP-42851N.
IntActiO75899. 6 interactors.
MINTiMINT-1398863.
STRINGi9606.ENSP00000259455.

Chemistry databases

BindingDBiO75899.

Structurei

Secondary structure

1941
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi55 – 62Combined sources8
Beta strandi66 – 68Combined sources3
Helixi71 – 90Combined sources20
Turni91 – 96Combined sources6
Beta strandi98 – 105Combined sources8
Helixi110 – 123Combined sources14
Beta strandi128 – 132Combined sources5
Helixi136 – 145Combined sources10
Helixi146 – 149Combined sources4
Beta strandi152 – 157Combined sources6
Helixi161 – 164Combined sources4
Turni166 – 168Combined sources3
Beta strandi172 – 176Combined sources5
Helixi179 – 181Combined sources3
Helixi182 – 192Combined sources11
Beta strandi197 – 205Combined sources9
Helixi206 – 219Combined sources14
Turni220 – 223Combined sources4
Beta strandi225 – 234Combined sources10
Helixi237 – 245Combined sources9
Beta strandi250 – 254Combined sources5
Helixi257 – 269Combined sources13
Beta strandi278 – 283Combined sources6
Turni287 – 290Combined sources4
Helixi304 – 311Combined sources8
Beta strandi315 – 319Combined sources5
Helixi335 – 345Combined sources11
Turni346 – 348Combined sources3
Helixi355 – 372Combined sources18
Helixi378 – 387Combined sources10
Helixi393 – 404Combined sources12
Beta strandi407 – 410Combined sources4
Beta strandi413 – 418Combined sources6
Beta strandi421 – 423Combined sources3
Beta strandi425 – 431Combined sources7
Beta strandi436 – 443Combined sources8
Turni444 – 447Combined sources4
Beta strandi448 – 451Combined sources4
Turni453 – 455Combined sources3
Beta strandi459 – 462Combined sources4
Helixi780 – 816Combined sources37

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F11X-ray2.38A42-466[»]
4F12X-ray3.02A42-466[»]
4MQEX-ray2.35B42-466[»]
4MQFX-ray2.22B42-466[»]
4MR7X-ray2.15B42-466[»]
4MR8X-ray2.15B42-466[»]
4MR9X-ray2.35B42-466[»]
4MRMX-ray2.86B42-466[»]
4MS1X-ray2.25B42-466[»]
4MS3X-ray2.50B42-466[»]
4MS4X-ray1.90B42-466[»]
4PASX-ray1.62B779-819[»]
ProteinModelPortaliO75899.
SMRiO75899.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili781 – 819Sequence analysisAdd BLAST39

Domaini

Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR1.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
GeneTreeiENSGT00530000063129.
HOVERGENiHBG080355.
InParanoidiO75899.
KOiK04615.
OMAiKTPYIKQ.
OrthoDBiEOG091G01WG.
PhylomeDBiO75899.
TreeFamiTF313965.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR002455. GPCR3_GABA-B.
IPR000337. GPCR_3.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR002457. GPCR_3_GABA_rcpt_B2.
IPR028082. Peripla_BP_I.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PTHR10519:SF40. PTHR10519:SF40. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
[Graphical view]
PRINTSiPR01178. GABAB2RECPTR.
PR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRSSGQP GPPPPPPPPP ARLLLLLLLP LLLPLAPGAW GWARGAPRPP
60 70 80 90 100
PSSPPLSIMG LMPLTKEVAK GSIGRGVLPA VELAIEQIRN ESLLRPYFLD
110 120 130 140 150
LRLYDTECDN AKGLKAFYDA IKYGPNHLMV FGGVCPSVTS IIAESLQGWN
160 170 180 190 200
LVQLSFAATT PVLADKKKYP YFFRTVPSDN AVNPAILKLL KHYQWKRVGT
210 220 230 240 250
LTQDVQRFSE VRNDLTGVLY GEDIEISDTE SFSNDPCTSV KKLKGNDVRI
260 270 280 290 300
ILGQFDQNMA AKVFCCAYEE NMYGSKYQWI IPGWYEPSWW EQVHTEANSS
310 320 330 340 350
RCLRKNLLAA MEGYIGVDFE PLSSKQIKTI SGKTPQQYER EYNNKRSGVG
360 370 380 390 400
PSKFHGYAYD GIWVIAKTLQ RAMETLHASS RHQRIQDFNY TDHTLGRIIL
410 420 430 440 450
NAMNETNFFG VTGQVVFRNG ERMGTIKFTQ FQDSREVKVG EYNAVADTLE
460 470 480 490 500
IINDTIRFQG SEPPKDKTII LEQLRKISLP LYSILSALTI LGMIMASAFL
510 520 530 540 550
FFNIKNRNQK LIKMSSPYMN NLIILGGMLS YASIFLFGLD GSFVSEKTFE
560 570 580 590 600
TLCTVRTWIL TVGYTTAFGA MFAKTWRVHA IFKNVKMKKK IIKDQKLLVI
610 620 630 640 650
VGGMLLIDLC ILICWQAVDP LRRTVEKYSM EPDPAGRDIS IRPLLEHCEN
660 670 680 690 700
THMTIWLGIV YAYKGLLMLF GCFLAWETRN VSIPALNDSK YIGMSVYNVG
710 720 730 740 750
IMCIIGAAVS FLTRDQPNVQ FCIVALVIIF CSTITLCLVF VPKLITLRTN
760 770 780 790 800
PDAATQNRRF QFTQNQKKED SKTSTSVTSV NQASTSRLEG LQSENHRLRM
810 820 830 840 850
KITELDKDLE EVTMQLQDTP EKTTYIKQNH YQELNDILNL GNFTESTDGG
860 870 880 890 900
KAILKNHLDQ NPQLQWNTTE PSRTCKDPIE DINSPEHIQR RLSLQLPILH
910 920 930 940
HAYLPSIGGV DASCVSPCVS PTASPRHRHV PPSFRVMVSG L
Length:941
Mass (Da):105,821
Last modified:November 1, 1998 - v1
Checksum:i09F1773DB0673C5D
GO

Sequence cautioni

The sequence AAH35071 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6S → R in AAC99345 (PubMed:10087195).Curated1
Sequence conflicti12P → R in AAC99345 (PubMed:10087195).Curated1
Sequence conflicti424G → E in AAD30389 (Ref. 5) Curated1
Sequence conflicti797R → H in AAH35071 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049280163L → P.Corresponds to variant rs35449008dbSNPEnsembl.1
Natural variantiVAR_010148628Y → F.1 Publication1
Natural variantiVAR_010149869T → A.1 PublicationCorresponds to variant rs10985765dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012188 mRNA. Translation: CAA09942.1.
AF069755 mRNA. Translation: AAC99345.1.
AF099033 mRNA. Translation: AAD45867.1.
AF056085 mRNA. Translation: AAC63228.1.
AF095784 mRNA. Translation: AAD30389.1.
AF074483 mRNA. Translation: AAD03336.1.
AL445495
, AL353782, AL356282, AL591502 Genomic DNA. Translation: CAD13322.2.
AL353782
, AL356282, AL445495, AL591502 Genomic DNA. Translation: CAH71298.1.
AL356282
, AL353782, AL445495, AL591502 Genomic DNA. Translation: CAH72233.1.
AL591502
, AL353782, AL356282, AL445495 Genomic DNA. Translation: CAI12581.1.
BC035071 mRNA. Translation: AAH35071.2. Different initiation.
CCDSiCCDS6736.1.
RefSeqiNP_005449.5. NM_005458.7.
UniGeneiHs.198612.

Genome annotation databases

EnsembliENST00000259455; ENSP00000259455; ENSG00000136928.
GeneIDi9568.
KEGGihsa:9568.
UCSCiuc004ays.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012188 mRNA. Translation: CAA09942.1.
AF069755 mRNA. Translation: AAC99345.1.
AF099033 mRNA. Translation: AAD45867.1.
AF056085 mRNA. Translation: AAC63228.1.
AF095784 mRNA. Translation: AAD30389.1.
AF074483 mRNA. Translation: AAD03336.1.
AL445495
, AL353782, AL356282, AL591502 Genomic DNA. Translation: CAD13322.2.
AL353782
, AL356282, AL445495, AL591502 Genomic DNA. Translation: CAH71298.1.
AL356282
, AL353782, AL445495, AL591502 Genomic DNA. Translation: CAH72233.1.
AL591502
, AL353782, AL356282, AL445495 Genomic DNA. Translation: CAI12581.1.
BC035071 mRNA. Translation: AAH35071.2. Different initiation.
CCDSiCCDS6736.1.
RefSeqiNP_005449.5. NM_005458.7.
UniGeneiHs.198612.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F11X-ray2.38A42-466[»]
4F12X-ray3.02A42-466[»]
4MQEX-ray2.35B42-466[»]
4MQFX-ray2.22B42-466[»]
4MR7X-ray2.15B42-466[»]
4MR8X-ray2.15B42-466[»]
4MR9X-ray2.35B42-466[»]
4MRMX-ray2.86B42-466[»]
4MS1X-ray2.25B42-466[»]
4MS3X-ray2.50B42-466[»]
4MS4X-ray1.90B42-466[»]
4PASX-ray1.62B779-819[»]
ProteinModelPortaliO75899.
SMRiO75899.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114938. 6 interactors.
DIPiDIP-42851N.
IntActiO75899. 6 interactors.
MINTiMINT-1398863.
STRINGi9606.ENSP00000259455.

Chemistry databases

BindingDBiO75899.
ChEMBLiCHEMBL5034.
DrugBankiDB00181. Baclofen.

Protein family/group databases

TCDBi9.A.14.15.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiO75899.
PhosphoSitePlusiO75899.

Polymorphism and mutation databases

BioMutaiGABBR2.

Proteomic databases

PaxDbiO75899.
PeptideAtlasiO75899.
PRIDEiO75899.

Protocols and materials databases

DNASUi9568.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259455; ENSP00000259455; ENSG00000136928.
GeneIDi9568.
KEGGihsa:9568.
UCSCiuc004ays.4. human.

Organism-specific databases

CTDi9568.
DisGeNETi9568.
GeneCardsiGABBR2.
HGNCiHGNC:4507. GABBR2.
HPAiHPA013820.
HPA031684.
MalaCardsiGABBR2.
MIMi607340. gene.
neXtProtiNX_O75899.
OpenTargetsiENSG00000136928.
PharmGKBiPA28896.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
GeneTreeiENSGT00530000063129.
HOVERGENiHBG080355.
InParanoidiO75899.
KOiK04615.
OMAiKTPYIKQ.
OrthoDBiEOG091G01WG.
PhylomeDBiO75899.
TreeFamiTF313965.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136928-MONOMER.
ReactomeiR-HSA-1296041. Activation of G protein gated Potassium channels.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).
R-HSA-977444. GABA B receptor activation.
R-HSA-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

ChiTaRSiGABBR2. human.
GeneWikiiGABBR2.
GenomeRNAii9568.
PROiO75899.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136928.
CleanExiHS_GABBR2.
ExpressionAtlasiO75899. baseline and differential.
GenevisibleiO75899. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR002455. GPCR3_GABA-B.
IPR000337. GPCR_3.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR002457. GPCR_3_GABA_rcpt_B2.
IPR028082. Peripla_BP_I.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PTHR10519:SF40. PTHR10519:SF40. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
[Graphical view]
PRINTSiPR01178. GABAB2RECPTR.
PR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGABR2_HUMAN
AccessioniPrimary (citable) accession number: O75899
Secondary accession number(s): O75974
, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1, Q9UNS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.