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Protein

Sulfotransferase 1C4

Gene

SULT1C4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei115Proton acceptorBy similarity1
Binding sitei137PAPS1 Publication1
Binding sitei145PAPS1 Publication1
Binding sitei200PAPS1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi55 – 60PAPS1 Publication6
Nucleotide bindingi234 – 239PAPS1 Publication6
Nucleotide bindingi262 – 266PAPS1 Publication5

GO - Molecular functioni

  • aryl sulfotransferase activity Source: Reactome
  • sulfotransferase activity Source: UniProtKB

GO - Biological processi

  • 3'-phosphoadenosine 5'-phosphosulfate metabolic process Source: Reactome
  • sulfation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172996-MONOMER.
BRENDAi2.8.2.1. 2681.
ReactomeiR-HSA-156584. Cytosolic sulfonation of small molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1C4 (EC:2.8.2.-)
Short name:
ST1C4
Alternative name(s):
Sulfotransferase 1C2
Short name:
SULT1C#2
Gene namesi
Name:SULT1C4
Synonyms:SULT1C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11457. SULT1C4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi27233.
OpenTargetsiENSG00000198075.
PharmGKBiPA162405070.

Chemistry databases

ChEMBLiCHEMBL1743296.

Polymorphism and mutation databases

BioMutaiSULT1C4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851371 – 302Sulfotransferase 1C4Add BLAST302

Proteomic databases

MaxQBiO75897.
PaxDbiO75897.
PeptideAtlasiO75897.
PRIDEiO75897.

PTM databases

iPTMnetiO75897.
PhosphoSitePlusiO75897.

Expressioni

Tissue specificityi

Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord.

Gene expression databases

BgeeiENSG00000198075.
CleanExiHS_SULT1C2.
HS_SULT1C4.
GenevisibleiO75897. HS.

Organism-specific databases

HPAiHPA034530.

Interactioni

Protein-protein interaction databases

BioGridi118082. 4 interactors.
STRINGi9606.ENSP00000272452.

Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 22Combined sources4
Beta strandi25 – 28Combined sources4
Helixi29 – 33Combined sources5
Helixi35 – 39Combined sources5
Beta strandi48 – 53Combined sources6
Helixi58 – 69Combined sources12
Helixi74 – 77Combined sources4
Helixi82 – 85Combined sources4
Turni94 – 96Combined sources3
Helixi99 – 105Combined sources7
Beta strandi111 – 114Combined sources4
Helixi118 – 120Combined sources3
Helixi124 – 127Combined sources4
Beta strandi131 – 136Combined sources6
Helixi139 – 152Combined sources14
Helixi162 – 170Combined sources9
Helixi179 – 189Combined sources11
Beta strandi192 – 199Combined sources8
Helixi200 – 205Combined sources6
Helixi207 – 218Combined sources12
Helixi224 – 233Combined sources10
Helixi236 – 240Combined sources5
Turni243 – 245Combined sources3
Turni252 – 254Combined sources3
Turni257 – 259Combined sources3
Helixi270 – 273Combined sources4
Helixi277 – 290Combined sources14
Helixi295 – 299Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AD1X-ray2.00A7-302[»]
2GWHX-ray1.80A/B7-302[»]
ProteinModelPortaliO75897.
SMRiO75897.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75897.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 115Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiO75897.
KOiK01025.
OMAiFPFLEMK.
OrthoDBiEOG091G0D5F.
PhylomeDBiO75897.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75897-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALHDMEDFT FDGTKRLSVN YVKGILQPTD TCDIWDKIWN FQAKPDDLLI
60 70 80 90 100
STYPKAGTTW TQEIVELIQN EGDVEKSKRA PTHQRFPFLE MKIPSLGSGL
110 120 130 140 150
EQAHAMPSPR ILKTHLPFHL LPPSLLEKNC KIIYVARNPK DNMVSYYHFQ
160 170 180 190 200
RMNKALPAPG TWEEYFETFL AGKVCWGSWH EHVKGWWEAK DKHRILYLFY
210 220 230 240 250
EDMKKNPKHE IQKLAEFIGK KLDDKVLDKI VHYTSFDVMK QNPMANYSSI
260 270 280 290 300
PAEIMDHSIS PFMRKGAVGD WKKHFTVAQN ERFDEDYKKK MTDTRLTFHF

QF
Length:302
Mass (Da):35,520
Last modified:March 7, 2006 - v2
Checksum:i905E1820A6E222F3
GO
Isoform 2 (identifier: O75897-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-173: Missing.

Show »
Length:227
Mass (Da):26,841
Checksum:iA66BD789AE8FF92F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0254045D → E.2 PublicationsCorresponds to variant rs1402467dbSNPEnsembl.1
Natural variantiVAR_06188968I → M.1 PublicationCorresponds to variant rs41322445dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05625599 – 173Missing in isoform 2. 2 PublicationsAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055584 mRNA. Translation: AAC95519.1.
AF186263 Genomic DNA. Translation: AAF72810.1.
AK297851 mRNA. Translation: BAG60183.1.
DQ987914 Genomic DNA. Translation: ABI75348.1.
AC068941 Genomic DNA. Translation: AAY14742.1.
CH471182 Genomic DNA. Translation: EAW53886.1.
BC125043 mRNA. Translation: AAI25044.1.
CCDSiCCDS2077.1. [O75897-1]
CCDS82492.1. [O75897-2]
RefSeqiNP_001308699.1. NM_001321770.1. [O75897-2]
NP_006579.2. NM_006588.3. [O75897-1]
UniGeneiHs.312644.

Genome annotation databases

EnsembliENST00000272452; ENSP00000272452; ENSG00000198075. [O75897-1]
ENST00000409309; ENSP00000387225; ENSG00000198075. [O75897-2]
GeneIDi27233.
KEGGihsa:27233.
UCSCiuc002tea.2. human. [O75897-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055584 mRNA. Translation: AAC95519.1.
AF186263 Genomic DNA. Translation: AAF72810.1.
AK297851 mRNA. Translation: BAG60183.1.
DQ987914 Genomic DNA. Translation: ABI75348.1.
AC068941 Genomic DNA. Translation: AAY14742.1.
CH471182 Genomic DNA. Translation: EAW53886.1.
BC125043 mRNA. Translation: AAI25044.1.
CCDSiCCDS2077.1. [O75897-1]
CCDS82492.1. [O75897-2]
RefSeqiNP_001308699.1. NM_001321770.1. [O75897-2]
NP_006579.2. NM_006588.3. [O75897-1]
UniGeneiHs.312644.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AD1X-ray2.00A7-302[»]
2GWHX-ray1.80A/B7-302[»]
ProteinModelPortaliO75897.
SMRiO75897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118082. 4 interactors.
STRINGi9606.ENSP00000272452.

Chemistry databases

ChEMBLiCHEMBL1743296.

PTM databases

iPTMnetiO75897.
PhosphoSitePlusiO75897.

Polymorphism and mutation databases

BioMutaiSULT1C4.

Proteomic databases

MaxQBiO75897.
PaxDbiO75897.
PeptideAtlasiO75897.
PRIDEiO75897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272452; ENSP00000272452; ENSG00000198075. [O75897-1]
ENST00000409309; ENSP00000387225; ENSG00000198075. [O75897-2]
GeneIDi27233.
KEGGihsa:27233.
UCSCiuc002tea.2. human. [O75897-1]

Organism-specific databases

CTDi27233.
DisGeNETi27233.
GeneCardsiSULT1C4.
H-InvDBHIX0029964.
HGNCiHGNC:11457. SULT1C4.
HPAiHPA034530.
MIMi608357. gene.
neXtProtiNX_O75897.
OpenTargetsiENSG00000198075.
PharmGKBiPA162405070.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiO75897.
KOiK01025.
OMAiFPFLEMK.
OrthoDBiEOG091G0D5F.
PhylomeDBiO75897.
TreeFamiTF321745.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172996-MONOMER.
BRENDAi2.8.2.1. 2681.
ReactomeiR-HSA-156584. Cytosolic sulfonation of small molecules.

Miscellaneous databases

EvolutionaryTraceiO75897.
GeneWikiiSULT1C4.
GenomeRNAii27233.
PROiO75897.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198075.
CleanExiHS_SULT1C2.
HS_SULT1C4.
GenevisibleiO75897. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiST1C4_HUMAN
AccessioniPrimary (citable) accession number: O75897
Secondary accession number(s): Q069I8, Q08AS5, Q53S63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.