Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O75896 (TUSC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor suppressor candidate 2
Alternative name(s):
Fusion 1 protein
Short name=Fus-1 protein
PDGFA-associated protein 2
Gene names
Name:TUSC2
Synonyms:C3orf11, FUS1, LGCC, PDAP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length110 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

Tissue specificity

Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.

Post-translational modification

Myristoylation is required for tumor suppressor activity.

Sequence similarities

Belongs to the TUSC2 family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 110109Tumor suppressor candidate 2
PRO_0000148170

Amino acid modifications

Modified residue501Phosphoserine Ref.6
Lipidation21N-myristoyl glycine Ref.5

Sequences

Sequence LengthMass (Da)Tools
O75896 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 9503BD10637C1504

FASTA11012,074
        10         20         30         40         50         60 
MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS MFYDEDGDLA 

        70         80         90        100        110 
HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH VDFPVILYEV 

« Hide

References

« Hide 'large scale' references
[1]"Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells."
Kondo M., Ji L., Kamibayashi C., Tomizawa Y., Randle D., Sekido Y., Yokota J., Kashuba V., Zabarovsky E., Kuzmin I., Lerman M., Roth J., Minna J.D.
Oncogene 20:6258-6262(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Subthalamic nucleus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[5]"Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells."
Uno F., Sasaki J., Nishizaki M., Carboni G., Xu K., Atkinson E.N., Kondo M., Minna J.D., Roth J.A., Ji L.
Cancer Res. 64:2969-2976(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: MYRISTOYLATION AT GLY-2.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF055479 mRNA. Translation: AAC35497.1.
AK311998 mRNA. Translation: BAG34936.1.
CH471055 Genomic DNA. Translation: EAW65097.1.
BC023976 mRNA. Translation: AAH23976.1.
RefSeqNP_009206.1. NM_007275.1.
UniGeneHs.517981.

3D structure databases

ProteinModelPortalO75896.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116462. 5 interactions.
IntActO75896. 2 interactions.
STRING9606.ENSP00000232496.

PTM databases

PhosphoSiteO75896.

Proteomic databases

PaxDbO75896.
PRIDEO75896.

Protocols and materials databases

DNASU11334.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000232496; ENSP00000232496; ENSG00000114383.
ENST00000575920; ENSP00000459657; ENSG00000262485.
GeneID11334.
KEGGhsa:11334.
UCSCuc003czy.1. human.

Organism-specific databases

CTD11334.
GeneCardsGC03M050357.
HGNCHGNC:17034. TUSC2.
HPAHPA030116.
MIM607052. gene.
neXtProtNX_O75896.
PharmGKBPA134968273.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG71519.
HOGENOMHOG000007342.
HOVERGENHBG054202.
InParanoidO75896.
OMATRRGSMY.
PhylomeDBO75896.
TreeFamTF314634.

Gene expression databases

ArrayExpressO75896.
BgeeO75896.
CleanExHS_TUSC2.
GenevestigatorO75896.

Family and domain databases

ProtoNetSearch...

Other

GeneWikiTUSC2.
GenomeRNAi11334.
NextBio43061.
PROO75896.
SOURCESearch...

Entry information

Entry nameTUSC2_HUMAN
AccessionPrimary (citable) accession number: O75896
Secondary accession number(s): B2R4Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM