O75896 (TUSC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor suppressor candidate 2

Alternative name(s):
Fusion 1 protein
Short name=Fus-1 protein
PDGFA-associated protein 2

Gene names

Name:	TUSC2
Synonyms:	C3orf11, FUS1, LGCC, PDAP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
Tissue specificity	Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.
Post-translational modification	Myristoylation is required for tumor suppressor activity.
Sequence similarities	Belongs to the TUSC2 family.

Ontologies

Keywords
Biological process	Cell cycle
Disease	Tumor suppressor
PTM	Lipoprotein Myristate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell maturation Inferred from electronic annotation. Source: Compara cell proliferation Traceable author statement PubMed 8780057. Source: ProtInc cell-cell signaling Traceable author statement PubMed 8780057. Source: ProtInc interleukin-15 production Inferred from electronic annotation. Source: Compara natural killer cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL	P00521	1	EBI-1052725,EBI-1550592	From a different organism.
GK006	Q6P2I7	1	EBI-1052725,EBI-1047027
HSPA4L	O95757	1	EBI-1052725,EBI-358652
LRBA	P50851	1	EBI-1052725,EBI-1052167
SGOL2	Q562F6	1	EBI-1052725,EBI-989213

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 110	110	Tumor suppressor candidate 2		PRO_0000148170
Amino acid modifications
	Modified residue	50	1	Phosphoserine Ref.6
	Lipidation	2	1	N-myristoyl glycine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O75896 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 9503BD10637C1504	FASTA	110	12,074
	10 20 30 40 50 60 MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS MFYDEDGDLA 70 80 90 100 110 HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH VDFPVILYEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells." Kondo M., Ji L., Kamibayashi C., Tomizawa Y., Randle D., Sekido Y., Yokota J., Kashuba V., Zabarovsky E., Kuzmin I., Lerman M., Roth J., Minna J.D. Oncogene 20:6258-6262(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Subthalamic nucleus.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells." Uno F., Sasaki J., Nishizaki M., Carboni G., Xu K., Atkinson E.N., Kondo M., Minna J.D., Roth J.A., Ji L. Cancer Res. 64:2969-2976(2004) [PubMed] [Europe PMC] [Abstract] Cited for: MYRISTOYLATION AT GLY-2.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF055479 mRNA. Translation: AAC35497.1. AK311998 mRNA. Translation: BAG34936.1. CH471055 Genomic DNA. Translation: EAW65097.1. BC023976 mRNA. Translation: AAH23976.1.
IPI	IPI00027248.
RefSeq	NP_009206.1. NM_007275.1.
UniGene	Hs.517981.
3D structure databases
ProteinModelPortal	O75896.
ModBase	Search...
Protein-protein interaction databases
IntAct	O75896. 2 interactions.
STRING	9606.ENSP00000232496.
PTM databases
PhosphoSite	O75896.
Proteomic databases
PaxDb	O75896.
PRIDE	O75896.
Protocols and materials databases
DNASU	11334.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000232496; ENSP00000232496; ENSG00000114383. ENST00000575920; ENSP00000459657; ENSG00000262485.
GeneID	11334.
KEGG	hsa:11334.
UCSC	uc003czy.1. human.
Organism-specific databases
CTD	11334.
GeneCards	GC03M050357.
HGNC	HGNC:17034. TUSC2.
HPA	HPA030116.
MIM	607052. gene.
neXtProt	NX_O75896.
PharmGKB	PA134968273.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG71519.
HOGENOM	HOG000007342.
HOVERGEN	HBG054202.
InParanoid	O75896.
OMA	TRRGSMY.
OrthoDB	EOG454915.
PhylomeDB	O75896.
Gene expression databases
ArrayExpress	O75896.
Bgee	O75896.
CleanEx	HS_TUSC2.
Genevestigator	O75896.
GermOnline	ENSG00000114383. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	11334.
NextBio	43061.
SOURCE	Search...

Entry information

Entry name

TUSC2_HUMAN

Accession

Primary (citable) accession number: O75896
Secondary accession number(s): B2R4Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.