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Protein

Tumor suppressor candidate 2

Gene

TUSC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 2
Alternative name(s):
Fusion 1 protein
Short name:
Fus-1 protein
PDGFA-associated protein 2
Gene namesi
Name:TUSC2
Synonyms:C3orf11, FUS1, LGCC, PDAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114383.9.
HGNCiHGNC:17034. TUSC2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi11334.
OpenTargetsiENSG00000114383.
PharmGKBiPA134968273.

Polymorphism and mutation databases

BioMutaiTUSC2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001481702 – 110Tumor suppressor candidate 2Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei50PhosphoserineCombined sources1

Post-translational modificationi

Myristoylation is required for tumor suppressor activity.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiO75896.
MaxQBiO75896.
PaxDbiO75896.
PeptideAtlasiO75896.
PRIDEiO75896.

PTM databases

iPTMnetiO75896.
PhosphoSitePlusiO75896.

Expressioni

Tissue specificityi

Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.

Gene expression databases

BgeeiENSG00000114383.
CleanExiHS_TUSC2.
ExpressionAtlasiO75896. baseline and differential.
GenevisibleiO75896. HS.

Organism-specific databases

HPAiHPA030116.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116462. 16 interactors.
IntActiO75896. 10 interactors.
STRINGi9606.ENSP00000232496.

Structurei

3D structure databases

ProteinModelPortaliO75896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUSC2 family.Curated

Phylogenomic databases

eggNOGiENOG410IYM4. Eukaryota.
ENOG4111PVZ. LUCA.
GeneTreeiENSGT00390000008040.
HOGENOMiHOG000007342.
HOVERGENiHBG054202.
InParanoidiO75896.
OMAiSKSKGFW.
OrthoDBiEOG091G16LU.
PhylomeDBiO75896.
TreeFamiTF314634.

Family and domain databases

InterProiView protein in InterPro
IPR029393. FUS1.
PANTHERiPTHR15453. PTHR15453. 1 hit.
PfamiView protein in Pfam
PF15000. TUSC2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS
60 70 80 90 100
MFYDEDGDLA HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH
110
VDFPVILYEV
Length:110
Mass (Da):12,074
Last modified:January 23, 2007 - v3
Checksum:i9503BD10637C1504
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055479 mRNA. Translation: AAC35497.1.
AK311998 mRNA. Translation: BAG34936.1.
CH471055 Genomic DNA. Translation: EAW65097.1.
BC023976 mRNA. Translation: AAH23976.1.
CCDSiCCDS2819.1.
RefSeqiNP_009206.1. NM_007275.2.
UniGeneiHs.517981.

Genome annotation databases

EnsembliENST00000232496; ENSP00000232496; ENSG00000114383.
GeneIDi11334.
KEGGihsa:11334.
UCSCiuc003czy.2. human.

Similar proteinsi

Entry informationi

Entry nameiTUSC2_HUMAN
AccessioniPrimary (citable) accession number: O75896
Secondary accession number(s): B2R4Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families