Reviewed, UniProtKB/Swiss-Prot O75896 (TUSC2_HUMAN)

Names and origin

Protein names

Recommended name:
    Tumor suppressor candidate 2
Alternative name(s):
    PDGFA-associated protein 2
    Fusion 1 protein
      Short name=Fus-1 protein

Gene names

Name:	TUSC2
Synonyms:	FUS1, LGCC, PDAP2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
Tissue specificity	Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.
Post-translational modification	Myristoylation is required for tumor suppressor activity.
Sequence similarities	Belongs to the TUSC2 family.

Ontologies

Keywords
Biological process	Cell cycle
Disease	Tumor suppressor
PTM	Lipoprotein Myristate Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Traceable author statement. Source: ProtInc cell-cell signaling Traceable author statement. Source: ProtInc negative regulation of cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL	P00521	1	EBI-1052725,EBI-1550592	From a different organism.
GK006	Q6P2I7	1	EBI-1052725,EBI-1047027
HSPA4L	O95757	1	EBI-1052725,EBI-358652
LRBA	P50851	1	EBI-1052725,EBI-1052167
SGOL2	Q562F6	1	EBI-1052725,EBI-989213

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 110	109	Tumor suppressor candidate 2		PRO_0000148170
Amino acid modifications
	Modified residue	50	1	Phosphoserine By similarity
	Lipidation	2	1	N-myristoyl glycine

Sequences

	Sequence		Length	Mass (Da)
	O75896-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 9503BD10637C1504	FASTA	110	12,074
	10 20 30 40 50 60 MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS MFYDEDGDLA 70 80 90 100 110 HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH VDFPVILYEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells." Kondo M., Ji L., Kamibayashi C., Tomizawa Y., Randle D., Sekido Y., Yokota J., Kashuba V., Zabarovsky E., Kuzmin I., Lerman M., Roth J., Minna J.D. Oncogene 20:6258-6262(2001) [PubMed: 11593436] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells." Uno F., Sasaki J., Nishizaki M., Carboni G., Xu K., Atkinson E.N., Kondo M., Minna J.D., Roth J.A., Ji L. Cancer Res. 64:2969-2976(2004) [PubMed: 15126327] [Abstract] Cited for: MYRISTOYLATION AT GLY-2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF055479 mRNA. Translation: AAC35497.1. BC023976 mRNA. Translation: AAH23976.1.
IPI	IPI00027248.
RefSeq	NP_009206.1.
UniGene	Hs.517981
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O75896. 6 interactions.
PTM databases
PhosphoSite	O75896.
Genome annotation databases
Ensembl	ENSG00000114383. Homo sapiens. [Contig view]
GeneID	11334.
KEGG	hsa:11334.
UCSC	uc003czy.1. human.
Organism-specific databases
GeneCards	GC03M050338.
H-InvDB	HIX0003313.
HGNC	HGNC:17034. TUSC2.
MIM	607052. gene.
PharmGKB	PA134968273.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O75896.
HOVERGEN	O75896.
OMA	O75896. QKNLIPQ.
Gene expression databases
ArrayExpress	O75896.
Bgee	O75896.
CleanEx	HS_TUSC2.
GermOnline	ENSG00000114383. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	43061.
SOURCE	Search...

Entry information

Entry name

TUSC2_HUMAN

Accession

Primary (citable) accession number: O75896

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2007
Last modified:	July 7, 2009
This is version 65 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)