Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O75896

- TUSC2_HUMAN

UniProt

O75896 - TUSC2_HUMAN

Protein

Tumor suppressor candidate 2

Gene

TUSC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell cycle Source: UniProtKB-KW
    3. cell maturation Source: Ensembl
    4. cell proliferation Source: ProtInc
    5. chemokine (C-C motif) ligand 5 production Source: Ensembl
    6. inflammatory response Source: Ensembl
    7. interleukin-15 production Source: Ensembl
    8. natural killer cell differentiation Source: Ensembl
    9. regulation of mitochondrial membrane potential Source: Ensembl
    10. regulation of reactive oxygen species metabolic process Source: Ensembl

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor suppressor candidate 2
    Alternative name(s):
    Fusion 1 protein
    Short name:
    Fus-1 protein
    PDGFA-associated protein 2
    Gene namesi
    Name:TUSC2
    Synonyms:C3orf11, FUS1, LGCC, PDAP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:17034. TUSC2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA134968273.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 110109Tumor suppressor candidate 2PRO_0000148170Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine1 Publication
    Modified residuei50 – 501Phosphoserine1 Publication

    Post-translational modificationi

    Myristoylation is required for tumor suppressor activity.1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    MaxQBiO75896.
    PaxDbiO75896.
    PRIDEiO75896.

    PTM databases

    PhosphoSiteiO75896.

    Expressioni

    Tissue specificityi

    Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.

    Gene expression databases

    ArrayExpressiO75896.
    BgeeiO75896.
    CleanExiHS_TUSC2.
    GenevestigatoriO75896.

    Organism-specific databases

    HPAiHPA030116.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABLP005211EBI-1052725,EBI-1550592From a different organism.
    GK006Q6P2I71EBI-1052725,EBI-1047027
    HSPA4LO957571EBI-1052725,EBI-358652
    LRBAP508511EBI-1052725,EBI-1052167
    SGOL2Q562F61EBI-1052725,EBI-989213

    Protein-protein interaction databases

    BioGridi116462. 5 interactions.
    IntActiO75896. 2 interactions.
    STRINGi9606.ENSP00000232496.

    Structurei

    3D structure databases

    ProteinModelPortaliO75896.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TUSC2 family.Curated

    Phylogenomic databases

    eggNOGiNOG71519.
    HOGENOMiHOG000007342.
    HOVERGENiHBG054202.
    InParanoidiO75896.
    OMAiTRRGSMY.
    PhylomeDBiO75896.
    TreeFamiTF314634.

    Family and domain databases

    InterProiIPR029393. FUS1.
    [Graphical view]
    PANTHERiPTHR15453. PTHR15453. 1 hit.
    PfamiPF15000. TUSC2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75896-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS    50
    MFYDEDGDLA HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH 100
    VDFPVILYEV 110
    Length:110
    Mass (Da):12,074
    Last modified:January 23, 2007 - v3
    Checksum:i9503BD10637C1504
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055479 mRNA. Translation: AAC35497.1.
    AK311998 mRNA. Translation: BAG34936.1.
    CH471055 Genomic DNA. Translation: EAW65097.1.
    BC023976 mRNA. Translation: AAH23976.1.
    CCDSiCCDS2819.1.
    RefSeqiNP_009206.1. NM_007275.1.
    UniGeneiHs.517981.

    Genome annotation databases

    EnsembliENST00000232496; ENSP00000232496; ENSG00000114383.
    GeneIDi11334.
    KEGGihsa:11334.
    UCSCiuc003czy.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055479 mRNA. Translation: AAC35497.1 .
    AK311998 mRNA. Translation: BAG34936.1 .
    CH471055 Genomic DNA. Translation: EAW65097.1 .
    BC023976 mRNA. Translation: AAH23976.1 .
    CCDSi CCDS2819.1.
    RefSeqi NP_009206.1. NM_007275.1.
    UniGenei Hs.517981.

    3D structure databases

    ProteinModelPortali O75896.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116462. 5 interactions.
    IntActi O75896. 2 interactions.
    STRINGi 9606.ENSP00000232496.

    PTM databases

    PhosphoSitei O75896.

    Proteomic databases

    MaxQBi O75896.
    PaxDbi O75896.
    PRIDEi O75896.

    Protocols and materials databases

    DNASUi 11334.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000232496 ; ENSP00000232496 ; ENSG00000114383 .
    GeneIDi 11334.
    KEGGi hsa:11334.
    UCSCi uc003czy.1. human.

    Organism-specific databases

    CTDi 11334.
    GeneCardsi GC03M050357.
    HGNCi HGNC:17034. TUSC2.
    HPAi HPA030116.
    MIMi 607052. gene.
    neXtProti NX_O75896.
    PharmGKBi PA134968273.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG71519.
    HOGENOMi HOG000007342.
    HOVERGENi HBG054202.
    InParanoidi O75896.
    OMAi TRRGSMY.
    PhylomeDBi O75896.
    TreeFami TF314634.

    Miscellaneous databases

    GeneWikii TUSC2.
    GenomeRNAii 11334.
    NextBioi 43061.
    PROi O75896.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75896.
    Bgeei O75896.
    CleanExi HS_TUSC2.
    Genevestigatori O75896.

    Family and domain databases

    InterProi IPR029393. FUS1.
    [Graphical view ]
    PANTHERi PTHR15453. PTHR15453. 1 hit.
    Pfami PF15000. TUSC2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells."
      Kondo M., Ji L., Kamibayashi C., Tomizawa Y., Randle D., Sekido Y., Yokota J., Kashuba V., Zabarovsky E., Kuzmin I., Lerman M., Roth J., Minna J.D.
      Oncogene 20:6258-6262(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Subthalamic nucleus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. "Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells."
      Uno F., Sasaki J., Nishizaki M., Carboni G., Xu K., Atkinson E.N., Kondo M., Minna J.D., Roth J.A., Ji L.
      Cancer Res. 64:2969-2976(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: MYRISTOYLATION AT GLY-2.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiTUSC2_HUMAN
    AccessioniPrimary (citable) accession number: O75896
    Secondary accession number(s): B2R4Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3