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O75891

- AL1L1_HUMAN

UniProt

O75891 - AL1L1_HUMAN

Protein

Cytosolic 10-formyltetrahydrofolate dehydrogenase

Gene

ALDH1L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei106 – 1061Proton donorBy similarity
    Binding sitei142 – 1421Substrate
    Sitei142 – 1421Essential for catalytic activityBy similarity
    Active sitei673 – 6731Proton acceptorPROSITE-ProRule annotation
    Active sitei707 – 7071Proton donorBy similarity
    Binding sitei757 – 7571NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi571 – 5733NADPBy similarity
    Nucleotide bindingi597 – 6004NADPBy similarity
    Nucleotide bindingi630 – 6356NADPBy similarity
    Nucleotide bindingi650 – 6512NADPBy similarity
    Nucleotide bindingi804 – 8063NADPBy similarity

    GO - Molecular functioni

    1. catalytic activity Source: ProtInc
    2. formyltetrahydrofolate dehydrogenase activity Source: UniProtKB-EC
    3. hydroxymethyl-, formyl- and related transferase activity Source: InterPro
    4. methyltransferase activity Source: InterPro
    5. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. 10-formyltetrahydrofolate catabolic process Source: ProtInc
    2. biosynthetic process Source: InterPro
    3. one-carbon metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:HS07217-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytosolic 10-formyltetrahydrofolate dehydrogenase (EC:1.5.1.6)
    Short name:
    10-FTHFDH
    Short name:
    FDH
    Alternative name(s):
    Aldehyde dehydrogenase family 1 member L1
    Gene namesi
    Name:ALDH1L1
    Synonyms:FTHFD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:3978. ALDH1L1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28393.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 902902Cytosolic 10-formyltetrahydrofolate dehydrogenasePRO_0000199419Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei38 – 381N6-succinyllysineBy similarity
    Modified residuei354 – 3541O-(pantetheine 4'-phosphoryl)serine; alternatePROSITE-ProRule annotation
    Modified residuei354 – 3541Phosphoserine; alternateBy similarity
    Modified residuei767 – 7671N6-succinyllysineBy similarity

    Keywords - PTMi

    Phosphopantetheine, Phosphoprotein

    Proteomic databases

    MaxQBiO75891.
    PaxDbiO75891.
    PRIDEiO75891.

    PTM databases

    PhosphoSiteiO75891.

    Expressioni

    Tissue specificityi

    Highly expressed in liver, pancreas and kidney.1 Publication

    Gene expression databases

    ArrayExpressiO75891.
    BgeeiO75891.
    CleanExiHS_ALDH1L1.
    GenevestigatoriO75891.

    Organism-specific databases

    HPAiHPA036900.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000377083.

    Structurei

    Secondary structure

    1
    902
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 65
    Helixi9 – 2113
    Beta strandi25 – 317
    Helixi41 – 499
    Beta strandi53 – 553
    Helixi67 – 748
    Beta strandi79 – 857
    Helixi92 – 954
    Beta strandi102 – 1087
    Turni110 – 1134
    Beta strandi114 – 1163
    Helixi118 – 1247
    Beta strandi128 – 1369
    Beta strandi139 – 1424
    Beta strandi146 – 1538
    Helixi160 – 1667
    Turni167 – 1693
    Helixi170 – 18516
    Helixi206 – 2094
    Helixi217 – 2259
    Turni226 – 2316
    Beta strandi234 – 2374
    Beta strandi240 – 24910
    Beta strandi258 – 2614
    Beta strandi270 – 2734
    Beta strandi276 – 2805
    Beta strandi286 – 2938
    Beta strandi299 – 3013
    Helixi302 – 3043
    Helixi320 – 33415
    Helixi347 – 3515
    Helixi356 – 36712
    Helixi375 – 3806
    Helixi384 – 39714

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BW0X-ray1.70A1-307[»]
    2CFIX-ray1.85A1-307[»]
    2CQ8NMR-A305-401[»]
    ProteinModelPortaliO75891.
    SMRiO75891. Positions 1-401, 406-902.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO75891.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini323 – 39270Acyl carrierPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 203203GARTAdd
    BLAST
    Regioni88 – 903Substrate binding
    Regioni417 – 902486Aldehyde dehydrogenaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the GART family.Curated
    In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.Curated
    Contains 1 acyl carrier domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOVERGENiHBG051668.
    InParanoidiO75891.
    KOiK00289.
    OMAiMASTFGD.
    OrthoDBiEOG7MSMN7.
    PhylomeDBiO75891.
    TreeFamiTF354242.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    3.10.25.10. 1 hit.
    3.40.309.10. 1 hit.
    3.40.50.170. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR011407. 10_FTHF_DH.
    IPR009081. Acyl_carrier_prot-like.
    IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036489. 10-FTHFDH. 1 hit.
    SUPFAMiSSF47336. SSF47336. 1 hit.
    SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    SSF53720. SSF53720. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    PS00373. GART. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75891-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKIAVIGQSL FGQEVYCHLR KEGHEVVGVF TVPDKDGKAD PLGLEAEKDG    50
    VPVFKYSRWR AKGQALPDVV AKYQALGAEL NVLPFCSQFI PMEIISAPRH 100
    GSIIYHPSLL PRHRGASAIN WTLIHGDKKG GFSIFWADDG LDTGDLLLQK 150
    ECEVLPDDTV STLYNRFLFP EGIKGMVQAV RLIAEGKAPR LPQPEEGATY 200
    EGIQKKETAK INWDQPAEAI HNWIRGNDKV PGAWTEACEQ KLTFFNSTLN 250
    TSGLVPEGDA LPIPGAHRPG VVTKAGLILF GNDDKMLLVK NIQLEDGKMI 300
    LASNFFKGAA SSVLELTEAE LVTAEAVRSV WQRILPKVLE VEDSTDFFKS 350
    GAASVDVVRL VEEVKELCDG LELENEDVYM ASTFGDFIQL LVRKLRGDDE 400
    EGECSIDYVE MAVNKRTVRM PHQLFIGGEF VDAEGAKTSE TINPTDGSVI 450
    CQVSLAQVTD VDKAVAAAKD AFENGRWGKI SARDRGRLMY RLADLMEQHQ 500
    EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI QGSTIPINQA 550
    RPNRNLTLTR KEPVGVCGII IPWNYPLMML SWKTAACLAA GNTVVIKPAQ 600
    VTPLTALKFA ELTLKAGIPK GVVNVLPGSG SLVGQRLSDH PDVRKIGFTG 650
    STEVGKHIMK SCAISNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF 700
    FNKGENCIAA GRLFVEDSIH DEFVRRVVEE VRKMKVGNPL DRDTDHGPQN 750
    HHAHLVKLME YCQHGVKEGA TLVCGGNQVP RPGFFFEPTV FTDVEDHMFI 800
    AKEESFGPVM IISRFADGDL DAVLSRANAT EFGLASGVFT RDINKALYVS 850
    DKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRVKTVTF 900
    EY 902
    Length:902
    Mass (Da):98,829
    Last modified:February 15, 2005 - v2
    Checksum:iD92CB2930617F7CF
    GO
    Isoform 2 (identifier: O75891-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         118-218: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:801
    Mass (Da):87,602
    Checksum:i2749168F3D76D548
    GO
    Isoform 3 (identifier: O75891-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MAGPSNPPATM

    Show »
    Length:912
    Mass (Da):99,753
    Checksum:i4703ADF87C0467D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631G → A in AAC35000. 1 PublicationCurated
    Sequence conflicti85 – 851F → S in AAC35000. 1 PublicationCurated
    Sequence conflicti176 – 1761M → V in AAC35000. 1 PublicationCurated
    Sequence conflicti195 – 1951E → K in AAC35000. 1 PublicationCurated
    Sequence conflicti470 – 4701D → G in AAC35000. 1 PublicationCurated
    Sequence conflicti472 – 4721F → L in BAG57647. (PubMed:14702039)Curated
    Sequence conflicti677 – 6771K → E in AAC35000. 1 PublicationCurated
    Sequence conflicti680 – 6801L → F in AAC35000. 1 PublicationCurated
    Sequence conflicti702 – 7021N → S in AAC35000. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti254 – 2541L → P.
    Corresponds to variant rs3796191 [ dbSNP | Ensembl ].
    VAR_052290
    Natural varianti330 – 3301V → F.
    Corresponds to variant rs2886059 [ dbSNP | Ensembl ].
    VAR_052291
    Natural varianti429 – 4291E → A.
    Corresponds to variant rs9282691 [ dbSNP | Ensembl ].
    VAR_052292
    Natural varianti436 – 4361A → T.
    Corresponds to variant rs9282692 [ dbSNP | Ensembl ].
    VAR_052293
    Natural varianti436 – 4361A → V.
    Corresponds to variant rs9282693 [ dbSNP | Ensembl ].
    VAR_052294
    Natural varianti448 – 4481S → N.
    Corresponds to variant rs9282697 [ dbSNP | Ensembl ].
    VAR_052295
    Natural varianti481 – 4811S → G.
    Corresponds to variant rs2276724 [ dbSNP | Ensembl ].
    VAR_052296
    Natural varianti511 – 5111A → V in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036101
    Natural varianti793 – 7931D → G.
    Corresponds to variant rs1127717 [ dbSNP | Ensembl ].
    VAR_052297
    Natural varianti803 – 8031E → K.
    Corresponds to variant rs9282689 [ dbSNP | Ensembl ].
    VAR_052298
    Natural varianti812 – 8121I → V.
    Corresponds to variant rs4646750 [ dbSNP | Ensembl ].
    VAR_052299

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MAGPSNPPATM in isoform 3. 1 PublicationVSP_047260
    Alternative sequencei118 – 218101Missing in isoform 2. 1 PublicationVSP_045569Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF052732 mRNA. Translation: AAC35000.1.
    AK294392 mRNA. Translation: BAG57647.1.
    CR749807 mRNA. Translation: CAH18667.1.
    AC079848 Genomic DNA. No translation available.
    CCDSiCCDS3034.1. [O75891-1]
    CCDS58850.1. [O75891-2]
    CCDS58851.1. [O75891-3]
    RefSeqiNP_001257293.1. NM_001270364.1. [O75891-3]
    NP_001257294.1. NM_001270365.1. [O75891-2]
    NP_036322.2. NM_012190.3. [O75891-1]
    XP_006713544.1. XM_006713481.1. [O75891-1]
    UniGeneiHs.434435.

    Genome annotation databases

    EnsembliENST00000273450; ENSP00000273450; ENSG00000144908. [O75891-3]
    ENST00000393434; ENSP00000377083; ENSG00000144908. [O75891-1]
    ENST00000452905; ENSP00000395881; ENSG00000144908. [O75891-2]
    ENST00000472186; ENSP00000420293; ENSG00000144908. [O75891-1]
    GeneIDi10840.
    KEGGihsa:10840.
    UCSCiuc003eim.2. human. [O75891-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF052732 mRNA. Translation: AAC35000.1 .
    AK294392 mRNA. Translation: BAG57647.1 .
    CR749807 mRNA. Translation: CAH18667.1 .
    AC079848 Genomic DNA. No translation available.
    CCDSi CCDS3034.1. [O75891-1 ]
    CCDS58850.1. [O75891-2 ]
    CCDS58851.1. [O75891-3 ]
    RefSeqi NP_001257293.1. NM_001270364.1. [O75891-3 ]
    NP_001257294.1. NM_001270365.1. [O75891-2 ]
    NP_036322.2. NM_012190.3. [O75891-1 ]
    XP_006713544.1. XM_006713481.1. [O75891-1 ]
    UniGenei Hs.434435.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BW0 X-ray 1.70 A 1-307 [» ]
    2CFI X-ray 1.85 A 1-307 [» ]
    2CQ8 NMR - A 305-401 [» ]
    ProteinModelPortali O75891.
    SMRi O75891. Positions 1-401, 406-902.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000377083.

    Chemistry

    DrugBanki DB00116. Tetrahydrofolic acid.

    PTM databases

    PhosphoSitei O75891.

    Proteomic databases

    MaxQBi O75891.
    PaxDbi O75891.
    PRIDEi O75891.

    Protocols and materials databases

    DNASUi 10840.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273450 ; ENSP00000273450 ; ENSG00000144908 . [O75891-3 ]
    ENST00000393434 ; ENSP00000377083 ; ENSG00000144908 . [O75891-1 ]
    ENST00000452905 ; ENSP00000395881 ; ENSG00000144908 . [O75891-2 ]
    ENST00000472186 ; ENSP00000420293 ; ENSG00000144908 . [O75891-1 ]
    GeneIDi 10840.
    KEGGi hsa:10840.
    UCSCi uc003eim.2. human. [O75891-1 ]

    Organism-specific databases

    CTDi 10840.
    GeneCardsi GC03M125822.
    HGNCi HGNC:3978. ALDH1L1.
    HPAi HPA036900.
    MIMi 600249. gene.
    neXtProti NX_O75891.
    PharmGKBi PA28393.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1012.
    HOVERGENi HBG051668.
    InParanoidi O75891.
    KOi K00289.
    OMAi MASTFGD.
    OrthoDBi EOG7MSMN7.
    PhylomeDBi O75891.
    TreeFami TF354242.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS07217-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O75891.
    GeneWikii ALDH1L1.
    GenomeRNAii 10840.
    NextBioi 41156.
    PROi O75891.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75891.
    Bgeei O75891.
    CleanExi HS_ALDH1L1.
    Genevestigatori O75891.

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    3.10.25.10. 1 hit.
    3.40.309.10. 1 hit.
    3.40.50.170. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR011407. 10_FTHF_DH.
    IPR009081. Acyl_carrier_prot-like.
    IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036489. 10-FTHFDH. 1 hit.
    SUPFAMi SSF47336. SSF47336. 1 hit.
    SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    SSF53720. SSF53720. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    PS00373. GART. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hong M.H., Lee Y., Kim J.W., Kang B.S., Choe I.S.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Amygdala.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Colon carcinoma.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase."
      Krupenko N.I., Dubard M.E., Strickland K.C., Moxley K.M., Oleinik N.V., Krupenko S.A.
      J. Biol. Chem. 285:23056-23063(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Solution structure of RSGI RUH-033, a PP-binding domain of 10-FTHFDH from human cDNA."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 303-405.
    7. "Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue."
      Kursula P., Schuler H., Flodin S., Nilsson-Ehle P., Ogg D.J., Savitsky P., Nordlund P., Stenmark P.
      Acta Crystallogr. D 62:1294-1299(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1-307 IN COMPLEX WITH 6-FORMYLTETRAHYDROPTERIN, ACTIVE SITE.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-511.

    Entry informationi

    Entry nameiAL1L1_HUMAN
    AccessioniPrimary (citable) accession number: O75891
    Secondary accession number(s): B4DG36, E9PBX3, Q68CS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3