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O75891

- AL1L1_HUMAN

UniProt

O75891 - AL1L1_HUMAN

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Protein
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Gene
ALDH1L1, FTHFD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Proton donor By similarity
Binding sitei142 – 1421Substrate
Sitei142 – 1421Essential for catalytic activity By similarity
Active sitei673 – 6731Proton acceptor By similarity
Active sitei707 – 7071Proton donor By similarity
Binding sitei757 – 7571NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi571 – 5733NADP By similarity
Nucleotide bindingi597 – 6004NADP By similarity
Nucleotide bindingi630 – 6356NADP By similarity
Nucleotide bindingi650 – 6512NADP By similarity
Nucleotide bindingi804 – 8063NADP By similarity

GO - Molecular functioni

  1. catalytic activity Source: ProtInc
  2. formyltetrahydrofolate dehydrogenase activity Source: UniProtKB-EC
  3. hydroxymethyl-, formyl- and related transferase activity Source: InterPro
  4. methyltransferase activity Source: InterPro
  5. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. 10-formyltetrahydrofolate catabolic process Source: ProtInc
  2. biosynthetic process Source: InterPro
  3. one-carbon metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS07217-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic 10-formyltetrahydrofolate dehydrogenase (EC:1.5.1.6)
Short name:
10-FTHFDH
Short name:
FDH
Alternative name(s):
Aldehyde dehydrogenase family 1 member L1
Gene namesi
Name:ALDH1L1
Synonyms:FTHFD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:3978. ALDH1L1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 902902Cytosolic 10-formyltetrahydrofolate dehydrogenase
PRO_0000199419Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-succinyllysine By similarity
Modified residuei354 – 3541O-(pantetheine 4'-phosphoryl)serine; alternate By similarity
Modified residuei354 – 3541Phosphoserine; alternate By similarity
Modified residuei767 – 7671N6-succinyllysine By similarity

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiO75891.
PaxDbiO75891.
PRIDEiO75891.

PTM databases

PhosphoSiteiO75891.

Expressioni

Tissue specificityi

Highly expressed in liver, pancreas and kidney.1 Publication

Gene expression databases

ArrayExpressiO75891.
BgeeiO75891.
CleanExiHS_ALDH1L1.
GenevestigatoriO75891.

Organism-specific databases

HPAiHPA036900.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000377083.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65
Helixi9 – 2113
Beta strandi25 – 317
Helixi41 – 499
Beta strandi53 – 553
Helixi67 – 748
Beta strandi79 – 857
Helixi92 – 954
Beta strandi102 – 1087
Turni110 – 1134
Beta strandi114 – 1163
Helixi118 – 1247
Beta strandi128 – 1369
Beta strandi139 – 1424
Beta strandi146 – 1538
Helixi160 – 1667
Turni167 – 1693
Helixi170 – 18516
Helixi206 – 2094
Helixi217 – 2259
Turni226 – 2316
Beta strandi234 – 2374
Beta strandi240 – 24910
Beta strandi258 – 2614
Beta strandi270 – 2734
Beta strandi276 – 2805
Beta strandi286 – 2938
Beta strandi299 – 3013
Helixi302 – 3043
Helixi320 – 33415
Helixi347 – 3515
Helixi356 – 36712
Helixi375 – 3806
Helixi384 – 39714

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BW0X-ray1.70A1-307[»]
2CFIX-ray1.85A1-307[»]
2CQ8NMR-A305-401[»]
ProteinModelPortaliO75891.
SMRiO75891. Positions 1-401, 406-902.

Miscellaneous databases

EvolutionaryTraceiO75891.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini323 – 39270Acyl carrier
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 203203GART
Add
BLAST
Regioni88 – 903Substrate binding
Regioni417 – 902486Aldehyde dehydrogenase
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the GART family.
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.

Phylogenomic databases

eggNOGiCOG1012.
HOVERGENiHBG051668.
InParanoidiO75891.
KOiK00289.
OMAiMASTFGD.
OrthoDBiEOG7MSMN7.
PhylomeDBiO75891.
TreeFamiTF354242.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.10.25.10. 1 hit.
3.40.309.10. 1 hit.
3.40.50.170. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR011407. 10_FTHF_DH.
IPR009081. Acyl_carrier_prot-like.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF036489. 10-FTHFDH. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF53720. SSF53720. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75891-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKIAVIGQSL FGQEVYCHLR KEGHEVVGVF TVPDKDGKAD PLGLEAEKDG    50
VPVFKYSRWR AKGQALPDVV AKYQALGAEL NVLPFCSQFI PMEIISAPRH 100
GSIIYHPSLL PRHRGASAIN WTLIHGDKKG GFSIFWADDG LDTGDLLLQK 150
ECEVLPDDTV STLYNRFLFP EGIKGMVQAV RLIAEGKAPR LPQPEEGATY 200
EGIQKKETAK INWDQPAEAI HNWIRGNDKV PGAWTEACEQ KLTFFNSTLN 250
TSGLVPEGDA LPIPGAHRPG VVTKAGLILF GNDDKMLLVK NIQLEDGKMI 300
LASNFFKGAA SSVLELTEAE LVTAEAVRSV WQRILPKVLE VEDSTDFFKS 350
GAASVDVVRL VEEVKELCDG LELENEDVYM ASTFGDFIQL LVRKLRGDDE 400
EGECSIDYVE MAVNKRTVRM PHQLFIGGEF VDAEGAKTSE TINPTDGSVI 450
CQVSLAQVTD VDKAVAAAKD AFENGRWGKI SARDRGRLMY RLADLMEQHQ 500
EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI QGSTIPINQA 550
RPNRNLTLTR KEPVGVCGII IPWNYPLMML SWKTAACLAA GNTVVIKPAQ 600
VTPLTALKFA ELTLKAGIPK GVVNVLPGSG SLVGQRLSDH PDVRKIGFTG 650
STEVGKHIMK SCAISNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF 700
FNKGENCIAA GRLFVEDSIH DEFVRRVVEE VRKMKVGNPL DRDTDHGPQN 750
HHAHLVKLME YCQHGVKEGA TLVCGGNQVP RPGFFFEPTV FTDVEDHMFI 800
AKEESFGPVM IISRFADGDL DAVLSRANAT EFGLASGVFT RDINKALYVS 850
DKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRVKTVTF 900
EY 902
Length:902
Mass (Da):98,829
Last modified:February 15, 2005 - v2
Checksum:iD92CB2930617F7CF
GO
Isoform 2 (identifier: O75891-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-218: Missing.

Note: No experimental confirmation available.

Show »
Length:801
Mass (Da):87,602
Checksum:i2749168F3D76D548
GO
Isoform 3 (identifier: O75891-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGPSNPPATM

Show »
Length:912
Mass (Da):99,753
Checksum:i4703ADF87C0467D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti254 – 2541L → P.
Corresponds to variant rs3796191 [ dbSNP | Ensembl ].
VAR_052290
Natural varianti330 – 3301V → F.
Corresponds to variant rs2886059 [ dbSNP | Ensembl ].
VAR_052291
Natural varianti429 – 4291E → A.
Corresponds to variant rs9282691 [ dbSNP | Ensembl ].
VAR_052292
Natural varianti436 – 4361A → T.
Corresponds to variant rs9282692 [ dbSNP | Ensembl ].
VAR_052293
Natural varianti436 – 4361A → V.
Corresponds to variant rs9282693 [ dbSNP | Ensembl ].
VAR_052294
Natural varianti448 – 4481S → N.
Corresponds to variant rs9282697 [ dbSNP | Ensembl ].
VAR_052295
Natural varianti481 – 4811S → G.
Corresponds to variant rs2276724 [ dbSNP | Ensembl ].
VAR_052296
Natural varianti511 – 5111A → V in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036101
Natural varianti793 – 7931D → G.
Corresponds to variant rs1127717 [ dbSNP | Ensembl ].
VAR_052297
Natural varianti803 – 8031E → K.
Corresponds to variant rs9282689 [ dbSNP | Ensembl ].
VAR_052298
Natural varianti812 – 8121I → V.
Corresponds to variant rs4646750 [ dbSNP | Ensembl ].
VAR_052299

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MAGPSNPPATM in isoform 3.
VSP_047260
Alternative sequencei118 – 218101Missing in isoform 2.
VSP_045569Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631G → A in AAC35000. 1 Publication
Sequence conflicti85 – 851F → S in AAC35000. 1 Publication
Sequence conflicti176 – 1761M → V in AAC35000. 1 Publication
Sequence conflicti195 – 1951E → K in AAC35000. 1 Publication
Sequence conflicti470 – 4701D → G in AAC35000. 1 Publication
Sequence conflicti472 – 4721F → L in BAG57647. 1 Publication
Sequence conflicti677 – 6771K → E in AAC35000. 1 Publication
Sequence conflicti680 – 6801L → F in AAC35000. 1 Publication
Sequence conflicti702 – 7021N → S in AAC35000. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052732 mRNA. Translation: AAC35000.1.
AK294392 mRNA. Translation: BAG57647.1.
CR749807 mRNA. Translation: CAH18667.1.
AC079848 Genomic DNA. No translation available.
CCDSiCCDS3034.1. [O75891-1]
CCDS58850.1. [O75891-2]
CCDS58851.1. [O75891-3]
RefSeqiNP_001257293.1. NM_001270364.1. [O75891-3]
NP_001257294.1. NM_001270365.1. [O75891-2]
NP_036322.2. NM_012190.3. [O75891-1]
XP_006713544.1. XM_006713481.1. [O75891-1]
UniGeneiHs.434435.

Genome annotation databases

EnsembliENST00000273450; ENSP00000273450; ENSG00000144908. [O75891-3]
ENST00000393434; ENSP00000377083; ENSG00000144908. [O75891-1]
ENST00000452905; ENSP00000395881; ENSG00000144908. [O75891-2]
ENST00000472186; ENSP00000420293; ENSG00000144908. [O75891-1]
GeneIDi10840.
KEGGihsa:10840.
UCSCiuc003eim.2. human. [O75891-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF052732 mRNA. Translation: AAC35000.1 .
AK294392 mRNA. Translation: BAG57647.1 .
CR749807 mRNA. Translation: CAH18667.1 .
AC079848 Genomic DNA. No translation available.
CCDSi CCDS3034.1. [O75891-1 ]
CCDS58850.1. [O75891-2 ]
CCDS58851.1. [O75891-3 ]
RefSeqi NP_001257293.1. NM_001270364.1. [O75891-3 ]
NP_001257294.1. NM_001270365.1. [O75891-2 ]
NP_036322.2. NM_012190.3. [O75891-1 ]
XP_006713544.1. XM_006713481.1. [O75891-1 ]
UniGenei Hs.434435.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BW0 X-ray 1.70 A 1-307 [» ]
2CFI X-ray 1.85 A 1-307 [» ]
2CQ8 NMR - A 305-401 [» ]
ProteinModelPortali O75891.
SMRi O75891. Positions 1-401, 406-902.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000377083.

Chemistry

DrugBanki DB00116. Tetrahydrofolic acid.

PTM databases

PhosphoSitei O75891.

Proteomic databases

MaxQBi O75891.
PaxDbi O75891.
PRIDEi O75891.

Protocols and materials databases

DNASUi 10840.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273450 ; ENSP00000273450 ; ENSG00000144908 . [O75891-3 ]
ENST00000393434 ; ENSP00000377083 ; ENSG00000144908 . [O75891-1 ]
ENST00000452905 ; ENSP00000395881 ; ENSG00000144908 . [O75891-2 ]
ENST00000472186 ; ENSP00000420293 ; ENSG00000144908 . [O75891-1 ]
GeneIDi 10840.
KEGGi hsa:10840.
UCSCi uc003eim.2. human. [O75891-1 ]

Organism-specific databases

CTDi 10840.
GeneCardsi GC03M125822.
HGNCi HGNC:3978. ALDH1L1.
HPAi HPA036900.
MIMi 600249. gene.
neXtProti NX_O75891.
PharmGKBi PA28393.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1012.
HOVERGENi HBG051668.
InParanoidi O75891.
KOi K00289.
OMAi MASTFGD.
OrthoDBi EOG7MSMN7.
PhylomeDBi O75891.
TreeFami TF354242.

Enzyme and pathway databases

BioCyci MetaCyc:HS07217-MONOMER.

Miscellaneous databases

EvolutionaryTracei O75891.
GeneWikii ALDH1L1.
GenomeRNAii 10840.
NextBioi 41156.
PROi O75891.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75891.
Bgeei O75891.
CleanExi HS_ALDH1L1.
Genevestigatori O75891.

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.10.25.10. 1 hit.
3.40.309.10. 1 hit.
3.40.50.170. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR011407. 10_FTHF_DH.
IPR009081. Acyl_carrier_prot-like.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF036489. 10-FTHFDH. 1 hit.
SUPFAMi SSF47336. SSF47336. 1 hit.
SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF53720. SSF53720. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hong M.H., Lee Y., Kim J.W., Kang B.S., Choe I.S.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Colon carcinoma.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase."
    Krupenko N.I., Dubard M.E., Strickland K.C., Moxley K.M., Oleinik N.V., Krupenko S.A.
    J. Biol. Chem. 285:23056-23063(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Solution structure of RSGI RUH-033, a PP-binding domain of 10-FTHFDH from human cDNA."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 303-405.
  7. "Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue."
    Kursula P., Schuler H., Flodin S., Nilsson-Ehle P., Ogg D.J., Savitsky P., Nordlund P., Stenmark P.
    Acta Crystallogr. D 62:1294-1299(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1-307 IN COMPLEX WITH 6-FORMYLTETRAHYDROPTERIN, ACTIVE SITE.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-511.

Entry informationi

Entry nameiAL1L1_HUMAN
AccessioniPrimary (citable) accession number: O75891
Secondary accession number(s): B4DG36, E9PBX3, Q68CS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 15, 2005
Last modified: July 9, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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