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O75888

- TNF13_HUMAN

UniProt

O75888 - TNF13_HUMAN

Protein

Tumor necrosis factor ligand superfamily member 13

Gene

TNFSF13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei104 – 1052Cleavage; by furin

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. gene expression Source: Reactome
    2. immunoglobulin production in mucosal tissue Source: Ensembl
    3. mRNA metabolic process Source: Reactome
    4. positive regulation of cell proliferation Source: ProtInc
    5. positive regulation of germinal center formation Source: Ensembl
    6. positive regulation of isotype switching to IgA isotypes Source: MGI
    7. RNA metabolic process Source: Reactome
    8. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_25218. HuR stabilizes mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 13
    Alternative name(s):
    A proliferation-inducing ligand
    Short name:
    APRIL
    TNF- and APOL-related leukocyte expressed ligand 2
    Short name:
    TALL-2
    TNF-related death ligand 1
    Short name:
    TRDL-1
    CD_antigen: CD256
    Gene namesi
    Name:TNFSF13
    Synonyms:APRIL, TALL2, ZTNF2
    ORF Names:UNQ383/PRO715
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11928. TNFSF13.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProt
    2. cytosol Source: Reactome
    3. external side of plasma membrane Source: Ensembl
    4. extracellular space Source: UniProtKB-KW
    5. extracellular vesicular exosome Source: UniProt
    6. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi101 – 1044RKRR → AKRA: Abolishes proteolytic processing. 1 Publication

    Organism-specific databases

    PharmGKBiPA36621.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 104104PRO_0000034524Add
    BLAST
    Chaini105 – 250146Tumor necrosis factor ligand superfamily member 13PRO_0000034525Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi196 ↔ 211Sequence Analysis

    Post-translational modificationi

    The precursor is cleaved by furin.1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO75888.
    PRIDEiO75888.

    PTM databases

    PhosphoSiteiO75888.

    Expressioni

    Tissue specificityi

    Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

    Inductioni

    Down-regulated by phorbol myristate acetate/ionomycin treatment.

    Gene expression databases

    BgeeiO75888.
    CleanExiHS_TNFSF13.
    GenevestigatoriO75888.

    Organism-specific databases

    HPAiHPA004863.

    Interactioni

    Subunit structurei

    Homotrimer.Curated

    Protein-protein interaction databases

    BioGridi114278. 10 interactions.
    IntActiO75888. 2 interactions.
    STRINGi9606.ENSP00000343505.

    Structurei

    3D structure databases

    ProteinModelPortaliO75888.
    SMRiO75888. Positions 114-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Phylogenomic databases

    eggNOGiNOG45253.
    HOGENOMiHOG000036810.
    HOVERGENiHBG104367.
    KOiK05475.
    OMAiKGPPGNM.
    OrthoDBiEOG7T4MM3.
    PhylomeDBiO75888.
    TreeFamiTF332331.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: O75888-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPASSPFLLA PKGPPGNMGG PVREPALSVA LWLSWGAALG AVACAMALLT    50
    QQTELQSLRR EVSRLQGTGG PSQNGEGYPW QSLPEQSSDA LEAWENGERS 100
    RKRRAVLTQK QKKQHSVLHL VPINATSKDD SDVTEVMWQP ALRRGRGLQA 150
    QGYGVRIQDA GVYLLYSQVL FQDVTFTMGQ VVSREGQGRQ ETLFRCIRSM 200
    PSHPDRAYNS CYSAGVFHLH QGDILSVIIP RARAKLNLSP HGTFLGFVKL 250
    Length:250
    Mass (Da):27,433
    Last modified:November 1, 1998 - v1
    Checksum:iAE1A6B9457F6E298
    GO
    Isoform Beta (identifier: O75888-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         113-129: KQHSVLHLVPINATSKD → N

    Show »
    Length:234
    Mass (Da):25,678
    Checksum:i9F0012E23EBC0780
    GO
    Isoform Gamma (identifier: O75888-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         247-249: Missing.

    Show »
    Length:247
    Mass (Da):27,059
    Checksum:iBAB7F6E2989D9DC8
    GO
    Isoform 4 (identifier: O75888-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         86-113: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:222
    Mass (Da):24,151
    Checksum:iBF3EA9A2F5AB4106
    GO
    Isoform TWE-PRIL (identifier: O43508-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry O43508.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:330
    Mass (Da):36,589
    GO
    Isoform 5 (identifier: O75888-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: Missing.
         87-114: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:205
    Mass (Da):22,488
    Checksum:i98217A3D1F58D3FA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671G → R.1 Publication
    Corresponds to variant rs11552708 [ dbSNP | Ensembl ].
    VAR_052586
    Natural varianti96 – 961N → S.1 Publication
    Corresponds to variant rs3803800 [ dbSNP | Ensembl ].
    VAR_052587

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1717Missing in isoform 5. CuratedVSP_046725Add
    BLAST
    Alternative sequencei86 – 11328Missing in isoform 4. 1 PublicationVSP_043154Add
    BLAST
    Alternative sequencei87 – 11428Missing in isoform 5. CuratedVSP_046726Add
    BLAST
    Alternative sequencei113 – 12917KQHSV…ATSKD → N in isoform Beta. 1 PublicationVSP_006450Add
    BLAST
    Alternative sequencei247 – 2493Missing in isoform Gamma. 2 PublicationsVSP_006451

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF046888 mRNA. Translation: AAC61312.1.
    AF136294 mRNA. Translation: AAD29422.1.
    AF184972 mRNA. Translation: AAF01321.1.
    AF114011 mRNA. Translation: AAF59828.1.
    AF114012 mRNA. Translation: AAF59829.1.
    AF114013 mRNA. Translation: AAF59830.1.
    AY358880 mRNA. Translation: AAQ89239.1.
    AY081050 mRNA. Translation: AAL90442.1.
    AB222992 Genomic DNA. Translation: BAE16556.1.
    AK301221 mRNA. Translation: BAG62794.1.
    BT019561 mRNA. Translation: AAV38368.1.
    BT019562 mRNA. Translation: AAV38369.1.
    AC016876 Genomic DNA. No translation available.
    BC008042 mRNA. Translation: AAH08042.1.
    CCDSiCCDS11111.1. [O75888-1]
    CCDS11112.1. [O75888-2]
    CCDS42256.1. [O75888-3]
    CCDS56018.1. [O75888-4]
    CCDS56019.1. [O75888-5]
    RefSeqiNP_001185552.1. NM_001198623.1. [O75888-4]
    NP_001185553.1. NM_001198624.1. [O75888-5]
    NP_003799.1. NM_003808.3. [O75888-1]
    NP_742084.1. NM_172087.2. [O75888-2]
    NP_742085.1. NM_172088.2. [O75888-3]
    UniGeneiHs.54673.

    Genome annotation databases

    EnsembliENST00000338784; ENSP00000343505; ENSG00000161955. [O75888-1]
    ENST00000349228; ENSP00000314455; ENSG00000161955. [O75888-2]
    ENST00000380535; ENSP00000369908; ENSG00000161955. [O75888-4]
    ENST00000396542; ENSP00000379792; ENSG00000161955. [O75888-5]
    ENST00000396545; ENSP00000379794; ENSG00000161955. [O75888-3]
    GeneIDi8741.
    KEGGihsa:8741.
    UCSCiuc002ghj.2. human. [O75888-3]
    uc002ghk.2. human. [O75888-1]
    uc002ghl.2. human. [O75888-2]
    uc010vua.1. human. [O75888-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF046888 mRNA. Translation: AAC61312.1 .
    AF136294 mRNA. Translation: AAD29422.1 .
    AF184972 mRNA. Translation: AAF01321.1 .
    AF114011 mRNA. Translation: AAF59828.1 .
    AF114012 mRNA. Translation: AAF59829.1 .
    AF114013 mRNA. Translation: AAF59830.1 .
    AY358880 mRNA. Translation: AAQ89239.1 .
    AY081050 mRNA. Translation: AAL90442.1 .
    AB222992 Genomic DNA. Translation: BAE16556.1 .
    AK301221 mRNA. Translation: BAG62794.1 .
    BT019561 mRNA. Translation: AAV38368.1 .
    BT019562 mRNA. Translation: AAV38369.1 .
    AC016876 Genomic DNA. No translation available.
    BC008042 mRNA. Translation: AAH08042.1 .
    CCDSi CCDS11111.1. [O75888-1 ]
    CCDS11112.1. [O75888-2 ]
    CCDS42256.1. [O75888-3 ]
    CCDS56018.1. [O75888-4 ]
    CCDS56019.1. [O75888-5 ]
    RefSeqi NP_001185552.1. NM_001198623.1. [O75888-4 ]
    NP_001185553.1. NM_001198624.1. [O75888-5 ]
    NP_003799.1. NM_003808.3. [O75888-1 ]
    NP_742084.1. NM_172087.2. [O75888-2 ]
    NP_742085.1. NM_172088.2. [O75888-3 ]
    UniGenei Hs.54673.

    3D structure databases

    ProteinModelPortali O75888.
    SMRi O75888. Positions 114-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114278. 10 interactions.
    IntActi O75888. 2 interactions.
    STRINGi 9606.ENSP00000343505.

    PTM databases

    PhosphoSitei O75888.

    Proteomic databases

    PaxDbi O75888.
    PRIDEi O75888.

    Protocols and materials databases

    DNASUi 8741.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338784 ; ENSP00000343505 ; ENSG00000161955 . [O75888-1 ]
    ENST00000349228 ; ENSP00000314455 ; ENSG00000161955 . [O75888-2 ]
    ENST00000380535 ; ENSP00000369908 ; ENSG00000161955 . [O75888-4 ]
    ENST00000396542 ; ENSP00000379792 ; ENSG00000161955 . [O75888-5 ]
    ENST00000396545 ; ENSP00000379794 ; ENSG00000161955 . [O75888-3 ]
    GeneIDi 8741.
    KEGGi hsa:8741.
    UCSCi uc002ghj.2. human. [O75888-3 ]
    uc002ghk.2. human. [O75888-1 ]
    uc002ghl.2. human. [O75888-2 ]
    uc010vua.1. human. [O75888-4 ]

    Organism-specific databases

    CTDi 8741.
    GeneCardsi GC17P007461.
    HGNCi HGNC:11928. TNFSF13.
    HPAi HPA004863.
    MIMi 604472. gene.
    neXtProti NX_O75888.
    PharmGKBi PA36621.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45253.
    HOGENOMi HOG000036810.
    HOVERGENi HBG104367.
    KOi K05475.
    OMAi KGPPGNM.
    OrthoDBi EOG7T4MM3.
    PhylomeDBi O75888.
    TreeFami TF332331.

    Enzyme and pathway databases

    Reactomei REACT_25218. HuR stabilizes mRNA.

    Miscellaneous databases

    GeneWikii TNFSF13.
    GenomeRNAii 8741.
    NextBioi 32793.
    PROi O75888.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75888.
    CleanExi HS_TNFSF13.
    Genevestigatori O75888.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Uterus.
    2. "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens."
      Shu H.-B., Hu W.-H., Johnson H.
      J. Leukoc. Biol. 65:680-683(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Homo sapiens tumor necrosis factor homolog."
      Farrah T., Grant F., Haldeman B., Whitmore T., Gross J., O'Hara P.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death."
      Kelly K.A., Manos E.J., Jensen G.T., Nadauld L., Jones D.A.
      Cancer Res. 60:1021-1027(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA).
    5. "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein."
      Pradet-Balade B., Medema J.P., Lopez-Fraga M., Lozano J.C., Kolfschoten G.M., Picard A., Martinez-A C., Garcia-Sanz J.A., Hahne M.
      EMBO J. 21:5711-5720(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    6. "Polymorphisms of human APRIL gene."
      Kawasaki A., Tsuchiya N., Kusaoi M., Murakami T., Fukazawa T., Matsuta K., Hashimoto H., Tokunaga K.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Spleen.
    9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA), VARIANT ARG-67.
    10. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA), VARIANT SER-96.
      Tissue: Ovary.
    12. Cited for: FUNCTION.
    13. "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase."
      Lopez-Fraga M., Fernandez R., Albar J.P., Hahne M.
      EMBO Rep. 2:945-951(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING BY FURIN, MUTAGENESIS OF 101-ARG--ARG-104, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTNF13_HUMAN
    AccessioniPrimary (citable) accession number: O75888
    Secondary accession number(s): A8MYD5
    , B4DVT2, Q541E1, Q5U0G8, Q96HV6, Q9P1M8, Q9P1M9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3