Reviewed,
UniProtKB/Swiss-Prot O75888 (TNF13_HUMAN)
Last modified
November 25, 2008.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tumor necrosis factor ligand superfamily member 13 Alternative name(s): A proliferation-inducing ligand Short name=APRIL TNF- and APOL-related leukocyte expressed ligand 2 Short name=TALL-2 TNF-related death ligand 1 Short name=TRDL-1 CD_antigen=CD256 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 250 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. |
| Subunit structure | Homotrimer Potential. |
| Subcellular location | |
| Tissue specificity | Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages. |
| Induction | Down-regulated by phorbol myristate acetate/ionomycin treatment. |
| Post-translational modification | The precursor is cleaved by furin. |
| Sequence similarities | Belongs to the tumor necrosis factor family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Immune response |
| Cellular component | Secreted |
| Coding sequence diversity | Alternative splicing |
| Molecular function | Cytokine |
| PTM | Cleavage on pair of basic residues Glycoprotein |
Gene Ontology (GO) | |
| Biological process | positive regulation of cell proliferation Ref.1 Traceable author statement. Source: ProtInc positive regulation of isotype switching to IgA isotypesInferred from direct assay. Source: MGI signal transduction Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-KW membraneInferred from electronic annotation. Source: InterPro |
| Molecular function | tumor necrosis factor receptor binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Alpha (identifier: O75888-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Beta (identifier: O75888-2) The sequence of this isoform differs from the canonical sequence as follows: 113-129: KQHSVLHLVPINATSKD → N | ||||||
| Isoform Gamma (identifier: O75888-3) The sequence of this isoform differs from the canonical sequence as follows: 247-249: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Propeptide | 1 – 104 | 104 | PRO_0000034524 | ||||||||
| Chain | 105 – 250 | 146 | Tumor necrosis factor ligand superfamily member 13 | PRO_0000034525 | |||||||
Sites | |||||||||||
| Site | 104 – 105 | 2 | Cleavage; by furin | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 124 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 196 ↔ 211 | Potential | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 113 – 129 | 17 | KQHSV…ATSKD → N in isoform Beta. | VSP_006450 | |||||||
| Alternative sequence | 247 – 249 | 3 | Missing in isoform Gamma. | VSP_006451 | |||||||
Experimental info | |||||||||||
| Mutagenesis | 101 – 104 | 4 | RKRR → AKRA: Abolishes proteolytic processing | ||||||||
| Sequence conflict | 96 | 1 | N → S in AAH08042. Ref.7 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth." Hahne M., Kataoka T., Schroeter M., Hofmann K., Irmler M., Bodmer J.-L., Schneider P., Bornand T., Holler N., French L.E., Sordat B., Rimoldi D., Tschopp J. J. Exp. Med. 188:1185-1190(1998) [PubMed: 9743536] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Uterus. |
| [2] | "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." Shu H.-B., Hu W.-H., Johnson H. J. Leukoc. Biol. 65:680-683(1999) [PubMed: 10331498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Homo sapiens tumor necrosis factor homolog." Farrah T., Grant F., Haldeman B., Whitmore T., Gross J., O'Hara P. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death." Kelly K.A., Manos E.J., Jensen G.T., Nadauld L., Jones D.A. Cancer Res. 60:1021-1027(2000) [PubMed: 10706119] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA). |
| [5] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA). |
| [6] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA). |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA). Tissue: Ovary. |
| [8] | "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity." Yu G., Boone T., Delaney J., Hawkins N., Kelley M.J., Ramakrishnan M., McCabe S., Qiu W.R., Kornuc M., Xia X.-Z., Guo J., Stolina M., Boyle W.J., Sarosi I., Hsu H., Senaldi G., Theill L.E. Nat. Immunol. 1:252-256(2000) [PubMed: 10973284] [Abstract] Cited for: FUNCTION. |
| [9] | "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase." Lopez-Fraga M., Fernandez R., Albar J.P., Hahne M. EMBO Rep. 2:945-951(2001) [PubMed: 11571266] [Abstract] Cited for: PROTEOLYTIC PROCESSING BY FURIN, MUTAGENESIS OF 101-ARG--ARG-104, SUBCELLULAR LOCATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF046888 mRNA. Translation: AAC61312.1. AF136294 mRNA. Translation: AAD29422.1. AF184972 mRNA. Translation: AAF01321.1. AF114011 mRNA. Translation: AAF59828.1. AF114012 mRNA. Translation: AAF59829.1. AF114013 mRNA. Translation: AAF59830.1. AY358880 mRNA. Translation: AAQ89239.1. BT019561 mRNA. Translation: AAV38368.1. BC008042 mRNA. Translation: AAH08042.1. | |
| RefSeq | NP_003799.1. NP_742084.1. NP_742085.1. |
| UniGene | Hs.54673 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KXG based on UniProtKB Q9Y275. |
| SMR | O75888. Positions 114-250. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O75888. |
Genome annotation databases | |
| Ensembl | ENSG00000161955. Homo sapiens. [Contig view] |
| GeneID | 8741. |
| KEGG | hsa:8741. |
Organism-specific databases | |
| HGNC | HGNC:11928. TNFSF13. |
| HPA | HPA004863. |
| MIM | 604472. gene. |
| PharmGKB | PA36621. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | O75888. |
Gene expression databases | |
| ArrayExpress | O75888. |
| CleanEx | HS_TNFSF13. |
| GermOnline | ENSG00000161955. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006052. TNF_family. IPR008983. Tumour_necrosis_fac-like. [Graphical view] |
| Gene3D | G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit. |
| Pfam | PF00229. TNF. 1 hit. [Graphical view] |
| SMART | SM00207. TNF. 1 hit. [Graphical view] |
| PROSITE | PS00251. TNF_1. 1 hit. PS50049. TNF_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 32793. |
| SOURCE | Search... |
Entry information
| Entry name | TNF13_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O75888 Secondary accession number(s): Q96HV6, Q9P1M8, Q9P1M9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


