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Protein

Tumor necrosis factor ligand superfamily member 13

Gene

TNFSF13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.1 Publication

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

  • immune response Source: InterPro
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of isotype switching to IgA isotypes Source: MGI
  • regulation of mRNA stability Source: Reactome
  • signal transduction Source: ProtInc
  • tumor necrosis factor-mediated signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161955-MONOMER.
ReactomeiR-HSA-450520. HuR (ELAVL1) binds and stabilizes mRNA.
R-HSA-5669034. TNFs bind their physiological receptors.
SIGNORiO75888.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 13
Alternative name(s):
A proliferation-inducing ligand
Short name:
APRIL
TNF- and APOL-related leukocyte expressed ligand 2
Short name:
TALL-2
TNF-related death ligand 1
Short name:
TRDL-1
CD_antigen: CD256
Gene namesi
Name:TNFSF13
Synonyms:APRIL, TALL2, ZTNF2
ORF Names:UNQ383/PRO715
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11928. TNFSF13.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB-KW
  • membrane Source: InterPro
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi101 – 104RKRR → AKRA: Abolishes proteolytic processing. 1 Publication4

Organism-specific databases

DisGeNETi8741.
OpenTargetsiENSG00000161955.
PharmGKBiPA36621.

Polymorphism and mutation databases

BioMutaiTNFSF13.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000345241 – 104Add BLAST104
ChainiPRO_0000034525105 – 250Tumor necrosis factor ligand superfamily member 13Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi196 ↔ 211Sequence analysis

Post-translational modificationi

The precursor is cleaved by furin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei104 – 105Cleavage; by furin2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75888.
PeptideAtlasiO75888.
PRIDEiO75888.

PTM databases

iPTMnetiO75888.
PhosphoSitePlusiO75888.

Expressioni

Tissue specificityi

Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

Inductioni

Down-regulated by phorbol myristate acetate/ionomycin treatment.

Gene expression databases

BgeeiENSG00000161955.
CleanExiHS_TNFSF13.
ExpressionAtlasiO75888. baseline and differential.
GenevisibleiO75888. HS.

Organism-specific databases

HPAiHPA004863.

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi114278. 10 interactors.
IntActiO75888. 4 interactors.
STRINGi9606.ENSP00000343505.

Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi117 – 126Combined sources10
Beta strandi132 – 150Combined sources19
Beta strandi152 – 159Combined sources8
Beta strandi161 – 171Combined sources11
Beta strandi175 – 185Combined sources11
Beta strandi190 – 199Combined sources10
Beta strandi209 – 219Combined sources11
Beta strandi224 – 229Combined sources6
Turni240 – 242Combined sources3
Beta strandi243 – 249Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZCHX-ray2.43A/B115-250[»]
ProteinModelPortaliO75888.
SMRiO75888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Phylogenomic databases

eggNOGiENOG410II60. Eukaryota.
ENOG410Y4KC. LUCA.
GeneTreeiENSGT00530000063837.
HOGENOMiHOG000036810.
HOVERGENiHBG104367.
InParanoidiO75888.
KOiK05475.
OMAiKGPPGNM.
OrthoDBiEOG091G0GBQ.
PhylomeDBiO75888.
TreeFamiTF332331.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: O75888-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPASSPFLLA PKGPPGNMGG PVREPALSVA LWLSWGAALG AVACAMALLT
60 70 80 90 100
QQTELQSLRR EVSRLQGTGG PSQNGEGYPW QSLPEQSSDA LEAWENGERS
110 120 130 140 150
RKRRAVLTQK QKKQHSVLHL VPINATSKDD SDVTEVMWQP ALRRGRGLQA
160 170 180 190 200
QGYGVRIQDA GVYLLYSQVL FQDVTFTMGQ VVSREGQGRQ ETLFRCIRSM
210 220 230 240 250
PSHPDRAYNS CYSAGVFHLH QGDILSVIIP RARAKLNLSP HGTFLGFVKL
Length:250
Mass (Da):27,433
Last modified:November 1, 1998 - v1
Checksum:iAE1A6B9457F6E298
GO
Isoform Beta (identifier: O75888-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-129: KQHSVLHLVPINATSKD → N

Show »
Length:234
Mass (Da):25,678
Checksum:i9F0012E23EBC0780
GO
Isoform Gamma (identifier: O75888-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-249: Missing.

Show »
Length:247
Mass (Da):27,059
Checksum:iBAB7F6E2989D9DC8
GO
Isoform 4 (identifier: O75888-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-113: Missing.

Note: No experimental confirmation available.
Show »
Length:222
Mass (Da):24,151
Checksum:iBF3EA9A2F5AB4106
GO
Isoform TWE-PRIL (identifier: O43508-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry O43508.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:330
Mass (Da):36,589
GO
Isoform 5 (identifier: O75888-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.
     87-114: Missing.

Note: Gene prediction based on EST data.
Show »
Length:205
Mass (Da):22,488
Checksum:i98217A3D1F58D3FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05258667G → R.1 PublicationCorresponds to variant rs11552708dbSNPEnsembl.1
Natural variantiVAR_05258796N → S.1 PublicationCorresponds to variant rs3803800dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0467251 – 17Missing in isoform 5. CuratedAdd BLAST17
Alternative sequenceiVSP_04315486 – 113Missing in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_04672687 – 114Missing in isoform 5. CuratedAdd BLAST28
Alternative sequenceiVSP_006450113 – 129KQHSV…ATSKD → N in isoform Beta. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_006451247 – 249Missing in isoform Gamma. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046888 mRNA. Translation: AAC61312.1.
AF136294 mRNA. Translation: AAD29422.1.
AF184972 mRNA. Translation: AAF01321.1.
AF114011 mRNA. Translation: AAF59828.1.
AF114012 mRNA. Translation: AAF59829.1.
AF114013 mRNA. Translation: AAF59830.1.
AY358880 mRNA. Translation: AAQ89239.1.
AY081050 mRNA. Translation: AAL90442.1.
AB222992 Genomic DNA. Translation: BAE16556.1.
AK301221 mRNA. Translation: BAG62794.1.
BT019561 mRNA. Translation: AAV38368.1.
BT019562 mRNA. Translation: AAV38369.1.
AC016876 Genomic DNA. No translation available.
BC008042 mRNA. Translation: AAH08042.1.
CCDSiCCDS11111.1. [O75888-1]
CCDS11112.1. [O75888-2]
CCDS42256.1. [O75888-3]
CCDS56018.1. [O75888-4]
CCDS56019.1. [O75888-5]
RefSeqiNP_001185552.1. NM_001198623.1. [O75888-4]
NP_001185553.1. NM_001198624.1. [O75888-5]
NP_003799.1. NM_003808.3. [O75888-1]
NP_742084.1. NM_172087.2. [O75888-2]
NP_742085.1. NM_172088.2. [O75888-3]
UniGeneiHs.54673.

Genome annotation databases

EnsembliENST00000338784; ENSP00000343505; ENSG00000161955. [O75888-1]
ENST00000349228; ENSP00000314455; ENSG00000161955. [O75888-2]
ENST00000396542; ENSP00000379792; ENSG00000161955. [O75888-5]
ENST00000396545; ENSP00000379794; ENSG00000161955. [O75888-3]
ENST00000625791; ENSP00000486052; ENSG00000161955. [O75888-4]
GeneIDi8741.
KEGGihsa:8741.
UCSCiuc002ghj.3. human. [O75888-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046888 mRNA. Translation: AAC61312.1.
AF136294 mRNA. Translation: AAD29422.1.
AF184972 mRNA. Translation: AAF01321.1.
AF114011 mRNA. Translation: AAF59828.1.
AF114012 mRNA. Translation: AAF59829.1.
AF114013 mRNA. Translation: AAF59830.1.
AY358880 mRNA. Translation: AAQ89239.1.
AY081050 mRNA. Translation: AAL90442.1.
AB222992 Genomic DNA. Translation: BAE16556.1.
AK301221 mRNA. Translation: BAG62794.1.
BT019561 mRNA. Translation: AAV38368.1.
BT019562 mRNA. Translation: AAV38369.1.
AC016876 Genomic DNA. No translation available.
BC008042 mRNA. Translation: AAH08042.1.
CCDSiCCDS11111.1. [O75888-1]
CCDS11112.1. [O75888-2]
CCDS42256.1. [O75888-3]
CCDS56018.1. [O75888-4]
CCDS56019.1. [O75888-5]
RefSeqiNP_001185552.1. NM_001198623.1. [O75888-4]
NP_001185553.1. NM_001198624.1. [O75888-5]
NP_003799.1. NM_003808.3. [O75888-1]
NP_742084.1. NM_172087.2. [O75888-2]
NP_742085.1. NM_172088.2. [O75888-3]
UniGeneiHs.54673.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZCHX-ray2.43A/B115-250[»]
ProteinModelPortaliO75888.
SMRiO75888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114278. 10 interactors.
IntActiO75888. 4 interactors.
STRINGi9606.ENSP00000343505.

PTM databases

iPTMnetiO75888.
PhosphoSitePlusiO75888.

Polymorphism and mutation databases

BioMutaiTNFSF13.

Proteomic databases

PaxDbiO75888.
PeptideAtlasiO75888.
PRIDEiO75888.

Protocols and materials databases

DNASUi8741.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338784; ENSP00000343505; ENSG00000161955. [O75888-1]
ENST00000349228; ENSP00000314455; ENSG00000161955. [O75888-2]
ENST00000396542; ENSP00000379792; ENSG00000161955. [O75888-5]
ENST00000396545; ENSP00000379794; ENSG00000161955. [O75888-3]
ENST00000625791; ENSP00000486052; ENSG00000161955. [O75888-4]
GeneIDi8741.
KEGGihsa:8741.
UCSCiuc002ghj.3. human. [O75888-1]

Organism-specific databases

CTDi8741.
DisGeNETi8741.
GeneCardsiTNFSF13.
HGNCiHGNC:11928. TNFSF13.
HPAiHPA004863.
MIMi604472. gene.
neXtProtiNX_O75888.
OpenTargetsiENSG00000161955.
PharmGKBiPA36621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II60. Eukaryota.
ENOG410Y4KC. LUCA.
GeneTreeiENSGT00530000063837.
HOGENOMiHOG000036810.
HOVERGENiHBG104367.
InParanoidiO75888.
KOiK05475.
OMAiKGPPGNM.
OrthoDBiEOG091G0GBQ.
PhylomeDBiO75888.
TreeFamiTF332331.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161955-MONOMER.
ReactomeiR-HSA-450520. HuR (ELAVL1) binds and stabilizes mRNA.
R-HSA-5669034. TNFs bind their physiological receptors.
SIGNORiO75888.

Miscellaneous databases

GeneWikiiTNFSF13.
GenomeRNAii8741.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161955.
CleanExiHS_TNFSF13.
ExpressionAtlasiO75888. baseline and differential.
GenevisibleiO75888. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNF13_HUMAN
AccessioniPrimary (citable) accession number: O75888
Secondary accession number(s): A8MYD5
, B4DVT2, Q541E1, Q5U0G8, Q96HV6, Q9P1M8, Q9P1M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.